Administering ascorbic acid to rats undergoing ageing processes: effects on myosin-V immunoreactive myenteric neurons.

Abstract:

:During the ageing process the enteric nervous system undergoes morphofunctional changes, such as enteric neurodegeneration. Neuronal death can be attributed to increase radicals free, and ascorbic acid (AA), known antioxidant, could minimize damage cause by oxidative stress. The objective of this study is to analyse the behaviour of morphoquantative myenteric neurons in the duodenum of adult Wistar rats with aged 90 (C90), 345 (E345) and 428 (E428) days, as well as animals of the same age who received ascorbic acid supplementation for 120 days (EA345 and EA428). Whole-mount preparations of muscle layer from the duodenum of the animals were immunostained by the method myosin V. 80 microscopic fields were quantified (14.8 mm2/animal) and measured 100 neuronal cell bodies per animal. During the aging process, there was a reduction in neuronal density in all animals groups, indicating that the effects of age were not attenuated with AA supplementation. The increase in the neuronal area of the cell bodies in 428-day-old animals proved the influence of age on this parameter. There was no observed a neuroprotective effect of AA (1 mL/g body weight) on the neuronal population myenteric myosin V immunoreactive.

journal_name

An Acad Bras Cienc

authors

Mello SA,Marese AC,Brancalhão RM,Zanoni JN,Natali MR

doi

10.1590/S0001-37652013005000002

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

337-47

issue

1

eissn

0001-3765

issn

1678-2690

pii

S0001-37652013000100337

journal_volume

85

pub_type

杂志文章
  • Quantification of anti-nutritional factors and their correlations with protein and oil in soybeans.

    abstract::Soybeans contain about 30% carbohydrate, mainly consisting of non-starch polysaccharides (NSP) and oligosaccharides. NSP are not hydrolyzed in the gastrointestinal tract of monogastric animals. These NSP negatively affect the development of these animals, especially the soluble fraction. This work aimed to establish a...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820140465

    authors: Bueno RD,Borges LL,God PIVG,Piovesan ND,Teixeira AI,Cruz CD,Barros EG

    更新日期:2018-01-01 00:00:00

  • Macro and micro minerals: are frozen fruits a good source?

    abstract::Fruits are rich in minerals, which are essential for a wide variety of metabolic and physiologic processes in the human body. The use of frozen fruits has greatly spread in the last years not only in the preparation of juices, but also as raw material for yogurts, candies, cookies, cakes, ice creams, and children's fo...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652010000400008

    authors: Spada PD,Bortolin GV,Prá D,Santos CE,Dias JF,Henriques JA,Salvador M

    更新日期:2010-12-01 00:00:00

  • Flavonoids from leaves of Derris urucu: assessment of potential effects on seed germination and development of weeds.

    abstract::In some previous studies, we described the isolation of nine compounds from leaves of Derris urucu, a species found widely in the Amazon rainforest, identified as five stilbenes and four dihydroflavonols. In this work, three of these dihydroflavonols [urucuol A (1), urucuol B (2) and isotirumalin (3)] were evaluated t...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/S0001-37652013000300004

    authors: Silva EA,Lôbo LT,Silva GA,Souza Filho AP,Da Silva MN,Arruda AC,Guilhon GM,Santos LS,Arruda MS

    更新日期:2013-09-01 00:00:00

  • Intellectual property rights related to the genetically modified glyphosate tolerant soybeans in Brazil.

    abstract::The present work analyzes the different modalities of protection of the intellectual creations in the biotechnology agricultural field. Regarding the Brazilian legislations related to the theme (the Industrial Property Law - no. 9. 279/96 and the Plant Variety Protection Law - no. 9. 456/97), and based in the internat...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652011000200029

    authors: Rodrigues RL,Lage CL,Vasconcellos AG

    更新日期:2011-06-01 00:00:00

  • Voltammetric characteristics of miconazole and its cathodic stripping voltammetric determination.

    abstract::Miconazole is reduced at mercury electrode above pH 6 involving organometallic compound formation, responsible for an anomalous polarographic behavior. The electrodic process presents a large contribution of the adsorption effects. The drug can be determined by cathodic stripping voltammetry from 8.0 x 10(-8) to 1, 5 ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652002000300005

    authors: Pereira FC,Stradiotto NR,Zanoni MV

    更新日期:2002-09-01 00:00:00

  • Immature stages of Spodoptera albula (Walker) (Lepidoptera: Noctuidae): developmental parameters and host plants.

    abstract::This study aimed to detail the temporal and morphological parameters of the immature stages of Spodoptera albula (Walker 1857) under controlled conditions (25 ± 1°C, 70 ± 10% RH and 14 hour photophase) and to gather information about their larval host plants. For this purpose, a new rearing method and artificial diet ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652013000100013

    authors: Montezano DG,Specht A,Bortolin TM,Fronza E,Sosa-Gómez DR,Roque-Specht VF,Pezzi P,Luz PC,Barros NM

    更新日期:2013-03-01 00:00:00

  • Tracking atmospheric dispersion of metals in Rio de Janeiro Metropolitan region (Brazil) with epiphytes as bioindicators.

    abstract::The atmospheric dispersion atmospheric plume of the metropolitan region and neighborhoods of the city of Rio de Janeiro was investigated through elemental analyzes (Na, K, Al, Mn, Pb, Ni, Cr) and stable lead isotopes in two epiphytes; the lichen Parmotrema crinitum (Ach.) and the bromeliad Tillandsia usneoides (L.). A...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170905

    authors: Marques Junior AN,Panetto DP,Lamego F,Nepomuceno FO,Monna F,Losno R,Guillon R

    更新日期:2018-07-01 00:00:00

  • Taxonomic notes on Lyroglossa and Pteroglossa (Orchidaceae: Spiranthinae): two new generic records for the flora of Rio Grande do Sul.

    abstract::Lyroglossa and Pteroglossa (Orchidaceae: Spiranthinae) are first recorded for Rio Grande do Sul. Descriptions, illustrations, taxonomic notes and distribution are presented. We also provide an artificial key to distinguish the genera of the "Stenorrhynchos Clade" reported so far in Rio Grande do Sul. ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Buzatto CR,Singer RB,Bordignon SAL

    更新日期:2014-06-01 00:00:00

  • The classic episode of biological invasion: Cochliomyia macellaria (Fabricius, 1775) versus Chrysomya megacephala (Fabricius, 1794) (Diptera: Calliphoridae) - evaluation of the biotic potential.

    abstract::The classic episode of biological invasion: Cochliomyia macellaria (Fabricius, 1775) versus Chrysomya megacephala (Fabricius, 1794) (Diptera: Calliphoridae) - evaluation of the biotic potential. The biotic of the native fly Cochliomyia macellaria and the exotic Chrysomya megacephala was compared, through the reproduct...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150270

    authors: Barbosa LS,Couri MS,Coelho VM,Avelino-Capistrano F

    更新日期:2016-09-01 00:00:00

  • The theorical-methodological construction of theses and dissertations and their epistemological problems.

    abstract::This essay discusses the problem of the lack of dialogue between theory/empirical reality in the construction of the theoretical structure of dissertations and doctorates in Human Sciences in Brazil; taking Geography as an example, Santos (2000) observed this problem, which persists at the national level. The proposal...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920171020

    authors: Gomes RD

    更新日期:2019-01-01 00:00:00

  • Reproductive biology of the Green Ground Snake Erythrolamprus poecilogyrus sublineatus (Serpentes: Dipsadidae) in Subtropical Brazil.

    abstract::We investigated reproductive features of the dipsadid snake Erythrolamprus poecilogyrus sublineatus in the southernmost Brazilian coast, a subtropical region characterized by well-marked seasons. Females are significantly smaller than males, have a shorter tail, and reach sexual maturity at later times along their dev...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720160805

    authors: Quintela FM,Marques WC,Loebmann D

    更新日期:2017-01-01 00:00:00

  • The behavior of Aphis gossypii and Aphis craccivora (Hemiptera: Aphididae) and of their predator Cycloneda sanguinea (Coleoptera: Coccinellidae) in cotton-cowpea intercropping systems.

    abstract::The intercropping is an important cultural practice commonly used in pest management. It is based on the principle that increased plant diversity in the agro-ecosystem can lead to reductions of pest populations in the crop. The current study aimed to assess the impact the colored fiber cotton-cowpea intercropped syste...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820160212

    authors: Fernandes FS,Godoy WAC,Ramalho FS,Malaquias JB,Santos BDB

    更新日期:2018-01-01 00:00:00

  • Antifungal and antitumor models of bioactive protective peptides.

    abstract::Peptides are remarkably reactive molecules produced by a great variety of species and able to display a number of functions in uni-and multicellular organisms as mediators, agonists and regulating substances. Some of them exert cytotoxic effects on cells other than those that produced them, and may have a role in cont...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652009000300015

    authors: Rodrigues EG,Dobroff AS,Taborda CP,Travassos LR

    更新日期:2009-09-01 00:00:00

  • S-(+)- and R-(-)-linalool: a comparison of the in vitro anti-Aeromonas hydrophila activity and anesthetic properties in fish.

    abstract::Linalool is the main compound of many essential oils and occurs in two isomeric forms: S-(+)- and R-(-)-linalool. This study aimed to determine if linalool isomers have different antimicrobial and anesthetic properties in fish. For this purpose, these compounds were previously isolated from Lippia alba (Mill.)N. E. Br...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720150643

    authors: Silva LL,Balconi LS,Gressler LT,Garlet QI,Sutili FJ,Vargas APC,Baldisserotto B,Morel AF,Heinzmann BM

    更新日期:2017-01-01 00:00:00

  • Modulation of diabetes and dyslipidemia in diabetic insulin-resistant rats by mangiferin: role of adiponectin and TNF-α.

    abstract::Mangiferin, present in Mangifera indica bark, was reported to produce hypoglycemic and antidiabetic activity in an animal model of genetic type 2 diabetes and in streptozotocin diabetic rats. Its effect on diabetic insulin-resistant animals has not been investigated. The current work aimed to explore the effect of man...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201420140212

    authors: Saleh S,El-Maraghy N,Reda E,Barakat W

    更新日期:2014-12-01 00:00:00

  • Membrane protein patterns of three Azospirillum species and Herbaspirillum seropedicae.

    abstract::Membrane protein patterns in SDS-PAGE clearly characterized Azospirillum amazonense, A. brasilense, A. lipoferum, and Herbaspirillum seropedicae. Each species showed also a typical major band with approximate molecular weights (AMWs) of 44, 39.5, 35.5, and 37.5 Kdaltons for the four species respectively. Characteristi...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Dianese JC,Döbereiner J,Dos Santos LT

    更新日期:1989-06-01 00:00:00

  • Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes.

    abstract::The objective of this work was to study the reduction in the capsaicin toxicity by encapsulation in liposomes. Capsaicin was extracted from peppers and characterized with high performance liquid chromatography (HPLC). We determined the zeta potential, polydispersivity index (PdI) and vesicle size of liposomes. Wistar ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150309

    authors: Cirino LM,Vergne DM,Santana PF,Almeida ED,Costa LP,Albuquerque-Júnior RL,Lima-Verde IB,Padilha FF,Cardoso JC

    更新日期:2016-09-01 00:00:00

  • Bromophenol concentrations in fish from Salvador, BA, Brazil.

    abstract::The main objective of this work is to evaluate the occurrence of bromophenols (2bromophenol, 4bromophenol, 2,4dibromophenol, 2,6dibromophenol and 2,4,6tribromophenol), in the flesh and guts in two species of the LutjanidaeFamily: Lutjanus synagris and Ocyurus chrysurus. The bromophenols were extracted by steam distill...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652009000200002

    authors: Oliveira AS,Silva VM,Veloso MC,Santos GV,Andrade JB

    更新日期:2009-06-01 00:00:00

  • Approaches to the mechanisms of song memorization and singing provide evidence for a procedural memory.

    abstract::There is growing evidence that, during song learning, birds do not only acquire 'what to sing' (the inventory of behavior), but also 'how to sing' (the singing program), including order-features of song sequencing. Common Nightingales Luscinia megarhynchos acquire such serial information by segmenting long strings of ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652004000200005

    authors: Hultsch H,Todt D

    更新日期:2004-06-01 00:00:00

  • The synergetic modulation of the excitability of central gray matter by a neuropeptide: two protocols using excitation waves in chick retina.

    abstract::The isolated chick retina provides an in vitro tissue model, in which two protocols were developed to verify the efficacy of a peptide in the excitability control of the central gray matter. In the first, extra-cellular potassium homeostasis is challenged at long intervals and in the second, a wave is trapped in a rin...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652009000100006

    authors: Lima VM,Piqueira JR,Hanke W

    更新日期:2009-03-01 00:00:00

  • Genotoxic and Genoprotective Potential of Black Mulberry (Morus nigra) Fruit.

    abstract::Black Mulberry (Morus nigra L.) belongs to Moraceae family. The present study evaluated the possible genotoxic and/or protective activities of black mulberry fruit juice (BMFJ), in vitro, using mitomycin C (MMC) as a positive control, by chromosomal aberrations and micronucleus assays. Human lymphocytes were treated w...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920190337

    authors: Yilmaz S,Uçar A,Göktaş B

    更新日期:2019-10-28 00:00:00

  • Effects of primaquine and chloroquine on oxidative stress parameters in rats.

    abstract::Primaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7, 14 and 21 days of ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201520140637

    authors: Giovanella F,Ferreira GK,de Prá SD,Carvalho-Silva M,Gomes LM,Scaini G,Gonçalves RC,Michels M,Galant LS,Longaretti LM,Dajori AL,Andrade VM,Dal-Pizzol F,Streck EL,de Souza RP

    更新日期:2015-08-01 00:00:00

  • Community structure of the ichthyofauna associated with seagrass beds in Formoso River estuary - Pernambuco, Brazil.

    abstract::Seagrass beds are used by juvenile fishes in different ways, generally as nursery sites, shelter from predators, reducing competition and increasing availability of food resources, thus establishing a relationship of connectivity with other ecosystems. In the present study, the community structure of the ichthyofauna ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652010000300009

    authors: Pereira PH,Ferreira BP,Rezende SM

    更新日期:2010-09-01 00:00:00

  • Germination responses of the invasive Calotropis procera (Ait.) R. Br. (Apocynaceae): comparisons with seeds from two ecosystems in Northeastern Brazil.

    abstract::Life history traits are considered key indicators of plant invasibility. Among them, the germination behavior of seeds is of major relevance because it is influenced by environmental factors of invaded ecosystem. Here, we investigated how seed traits and seed tolerance to environmental factors on seed germination of C...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/S0001-37652013000300013

    authors: Leal LC,Meiado MV,Lopes AV,Leal IR

    更新日期:2013-09-01 00:00:00

  • Radiopharmaceuticals drug interactions: a critical review.

    abstract::Radiopharmaceuticals play a critical role in modern medicine primarily for diagnostic purposes, but also for monitoring disease progression and response to treatment. As the use of image has been increased, so has the use of prescription medications. These trends increase the risk of interactions between medications a...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/s0001-37652008000400008

    authors: Santos-Oliveira R,Smith SW,Carneiro-Leão AM

    更新日期:2008-12-01 00:00:00

  • Bioethanol production with different dosages of the commercial Acrylamide polymer compared to a Bioextract in clarifying sugarcane juice.

    abstract::One of the most important steps is to clarify the juice, which are added synthetic polymer acrylamide base, aiming the fast settling of impurities present in the juice. However, this input is expensive and may have carcinogenic and neurotoxic actions to humans. The search for new natural flocculants that have similari...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720170473

    authors: Freita CM,Freita LA,Tralli LF,Silva AF,Mendes FQ,Teixeira V,Mutton MJR

    更新日期:2017-10-01 00:00:00

  • Strawberry (Fragaria X ananassa Duch.) yield as affected by the soil pH.

    abstract::Two-year trials (20062007) suggested that the use of calcium oxide (CaO) on acid soils increased soil pH and yields in strawberry cultivars Marmolada, Selena and Senga Sengana, under the environmental conditions of Cacak (Western Serbia). The highest yield was obtained when CaO was applied at 750 kg ha-1 rate. Further...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652009000200012

    authors: Milosevic TM,Milosevic NT,Glisic IP

    更新日期:2009-06-01 00:00:00

  • Feeding preference of Plutella xylostella for leaves treated with plant extracts.

    abstract::Plutella xylostella L. is one of the main agents to cause damages to plants of Brassica genus, provoking negative impacts in cultures. The use of botanical extracts in plants protection has been related in literature, however, their use in the species analyzed in this study is not yet reported. We assessed the effect ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150236

    authors: Couto IF,Fuchs ML,Pereira FF,Mauad M,Scalon SP,Dresch DM,Mussury RM

    更新日期:2016-01-01 00:00:00

  • Effect of phosphorus on the toxicity of zinc to the microalga Raphidocelis subcapitata.

    abstract::The aim of this study was to evaluate the effect of phosphorus (P) on the toxicity of zinc (Zn) for the alga Raphidocelis subcapitata. P was provided in three concentrations: 2.3 x 10-4 mol L-1, 2.3 x 10-6 mol L-1 and 1.0 x 10-6 mol L-1. Algal cells were acclimated to the specific P concentrations before the start of ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020190050

    authors: Rodgher S,Contador TM,Rocha GS,Espindola ELG

    更新日期:2020-11-06 00:00:00

  • Sodium reduction in margarine using NaCl substitutes.

    abstract::Sodium chloride is traditionally used as a food additive in food processing. However, because of its high sodium content, NaCl has been associated with chronic diseases. Margarine is a popular product that is used in several preparations, but it includes high sodium content; therefore, it is among the products whose s...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720150618

    authors: Gonçalves C,Rodrigues J,Júnior H,Carneiro J,Freire T,Freire L

    更新日期:2017-01-01 00:00:00