Abstract:
:The altered expression of the SOX2 transcription factor is associated with oncogenic or tumor suppressor functions in human cancers. This factor regulates the migration and invasion of different cancer cells. In this study we investigated the effect of constitutive SOX2 overexpression on the migration and adhesion capacity of embryonal teratocarcinoma NT2/D1 cells derived from a metastasis of a human testicular germ cell tumor. We detected that increased SOX2 expression changed the speed, mode and path of cell migration, but not the adhesion ability of NT2/D1 cells. Additionally, we demonstrated that SOX2 overexpression increased the expression of the tumor suppressor protein p53 and the HDM2 oncogene. Our results contribute to the better understanding of the effect of SOX2 on the behavior of tumor cells originating from a human testicular germ cell tumor. Considering that NT2/D1 cells resemble cancer stem cells in many features, our results could contribute to the elucidation of the role of SOX2 in cancer stem cells behavior and the process of metastasis.
journal_name
An Acad Bras Ciencjournal_title
Anais da Academia Brasileira de Cienciasauthors
Drakulic D,Vicentic JM,Schwirtlich M,Tosic J,Krstic A,Klajn A,Stevanovic Mdoi
10.1590/0001-3765201520140352subject
Has Abstractpub_date
2015-03-01 00:00:00pages
389-404issue
1eissn
0001-3765issn
1678-2690pii
S0001-37652015005000325journal_volume
87pub_type
杂志文章abstract::The Cyperaceae species are present in different ecosystems and constitute the herbaceous extract. Of the approximately 5,500 species of the family; a third has Kranz anatomy, representing an important characteristic of the taxonomy and phylogeny of the group. In Cyperus laxus L. (non-Kranz) and Fimbristylis dichotoma ...
journal_title:Anais da Academia Brasileira de Ciencias
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