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Quantification of urinary allantoin by capillary zone electrophoresis during recombinant urate oxydase (rasburicase) therapy.

Abstract：

OBJECTIVES:Rasburicase (Fasturtec) is used to prevent or treat hyperuricemia associated with chemotherapy. We developed a capillary zone electrophoresis method to measure urinary allantoin, the degradation product of uric acid by rasburicase. DESIGN AND METHODS:Electrophoresis was performed using a P/ACE 5500 system (Beckman) with a fused silica capillary tube and a UV-visible detector set at 214 nm. Urine samples from 10 patients with non-Hodgkin's lymphoma were analyzed to validate the technique. RESULTS:Using a sodium tetraborate running buffer, urinary allantoin was separated from related compounds and internal standard in less than 30 min. The method was linear up to 1.25 g/L (quantification limit: 30 mg/L); precision was below 10%. The total amount of allantoin excreted in patients treated by rasburicase ranged from 1.5 g to 7.9 g/4 days. CONCLUSION:This CZE assay is a simple, rapid and reproducible method to measure allantoin in urine. Different elimination profiles have been found in patients treated with rasburicase.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Kattygnarath D,Mounier N,Madelaine-Chambrin I,Gourmel B,Le Bricon T,Gisselbrecht C,Faure P,Houzé P

doi

10.1016/j.clinbiochem.2005.09.013

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

86-90

issue

1

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(05)00297-3

journal_volume

39

pub_type

杂志文章

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