Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization.

abstract：BACKGROUND:The countercurrent arrangement of capillary blood flow in the medulla of mammalian kidneys generates a gradient of oxygen tension between the renal cortex and the papillary tip that results in a state of relative hypoxia within the renal medulla. Exploration of the pathophysiological implications of medullar...

journal_title：Circulation

authors： Prasad PV,Edelman RR,Epstein FH

更新日期：1996-12-15 00:00:00

abstract：BACKGROUND:The estrogen receptor-alpha (ER-alpha) IVS1-401 polymorphism identifies a group of women (approximately 20%) who have augmented effects of hormone replacement therapy (HRT) on levels of HDL cholesterol. This study sought to determine if this augmentation extends to HRT regulation of E-selectin and C-reactive...

journal_title：Circulation

authors： Herrington DM,Howard TD,Brosnihan KB,McDonnell DP,Li X,Hawkins GA,Reboussin DM,Xu J,Zheng SL,Meyers DA,Bleecker ER

更新日期：2002-04-23 00:00:00

abstract：:The mechanism of atrial flutter is controversial. A 76-year-old woman with rheumatic heart disease was referred to our clinic with an unusual rhythm disturbance which initially appeared to be classic atrial flutter at a rate of 300 beats/min. Later tracings, however, demonstrated a rate exactly one-half that of the ea...

journal_title：Circulation

authors： Homcy CJ,Lorell B,Yurchak PM

更新日期：1979-09-01 00:00:00

abstract：:The effect of stenosis of the left main and proximal anterior descending coronary arteries on anterior left ventricular wall dynamics was investigated in 70 patients with ischemic heart disease by the use of roentgen videometric analysis of left ventricular angiograms. In all patients with ischemic heart disease, mean...

journal_title：Circulation

authors： St John Sutton MG,Frye RL,Smith HC,Chesebro JH,Ritman EL

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:Endothelins are recently characterized vasoconstrictor peptides. As chronic heart failure (CHF) is characterized by peripheral arteriolar and renal vasoconstriction, we have measured venous plasma endothelin-like immunoreactivity ("endothelin") in patients with this syndrome. METHODS AND RESULTS:Compared wi...

journal_title：Circulation

authors： McMurray JJ,Ray SG,Abdullah I,Dargie HJ,Morton JJ

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:CD4+CD28null T cells are present in increased numbers in the peripheral blood of patients with acute coronary syndrome (ACS) compared with patients with chronic stable angina (CSA). The triggers of activation and expansion of these cells to date remain unclear. METHODS AND RESULTS:Twenty-one patients with A...

journal_title：Circulation

authors： Zal B,Kaski JC,Arno G,Akiyu JP,Xu Q,Cole D,Whelan M,Russell N,Madrigal JA,Dodi IA,Baboonian C

更新日期：2004-03-16 00:00:00

abstract：:The influence of chest compression rate on initial resuscitation success and 24 hr survival after prolonged manual cardiopulmonary resuscitation (CPR) was investigated in 26 morphine-anesthetized dogs (17 to 30 kg). After placement of aortic and right atrial micromanometers and induction of ventricular fibrillation, m...

journal_title：Circulation

authors： Feneley MP,Maier GW,Kern KB,Gaynor JW,Gall SA Jr,Sanders AB,Raessler K,Muhlbaier LH,Rankin JS,Ewy GA

更新日期：1988-01-01 00:00:00

abstract：:Acute myocardial ischemia leads to a gradual increase in beta-adrenergic receptors at the cell surface. This increase occurs rapidly after onset of global ischemia (15 minutes) and persists even after prolonged periods of global ischemia. This alteration can be observed both in vivo and in vitro in isolated perfused h...

journal_title：Circulation

authors： Strasser RH,Marquetant R,Kübler W

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Patients with repaired coarctation are at increased risk of hypertension and cardiovascular disease despite successful repair. We studied the function of conduit arteries in upper and lower limbs of patients late after successful coarctation repair and its relation to age at surgery. METHODS AND RESULTS:Flo...

journal_title：Circulation

authors： de Divitiis M,Pilla C,Kattenhorn M,Zadinello M,Donald A,Leeson P,Wallace S,Redington A,Deanfield JE

更新日期：2001-09-18 00:00:00

abstract：BACKGROUND:Little information is available regarding the occurrence of perioperative and late cardiac events in women with vascular disease. The current study was performed to examine whether sex-specific differences exist in these outcomes in a large population of vascular surgery patients and to determine the value o...

journal_title：Circulation

authors： Hendel RC,Chen MH,L'Italien GJ,Newell JB,Paul SD,Eagle KA,Leppo JA

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:Hyperhomocysteinemia is an independent risk factor for coronary heart disease (CHD). Dietary supplementation with B vitamins lowers plasma homocysteine by up to 30%. However, little is known about the potential beneficial effects of homocysteine lowering on vascular function in patients with CHD. METHODS AN...

journal_title：Circulation

authors： Chambers JC,Ueland PM,Obeid OA,Wrigley J,Refsum H,Kooner JS

更新日期：2000-11-14 00:00:00

abstract：BACKGROUND:Beta-blockers improve clinical outcome when administered early after acute myocardial infarction. However, whether beta-blockers actually reduce the myocardial infarction size is still in dispute. Cardiac magnetic resonance imaging can accurately depict the left ventricular (LV) ischemic myocardium at risk (...

journal_title：Circulation

authors： Ibanez B,Prat-González S,Speidl WS,Vilahur G,Pinero A,Cimmino G,García MJ,Fuster V,Sanz J,Badimon JJ

更新日期：2007-06-12 00:00:00

abstract：BACKGROUND:Contrast agents can cause a reduction in renal function that may be due to the generation of reactive oxygen species. Conflicting evidence suggests that administration of the antioxidant acetylcysteine prevents this renal impairment. The action of other antioxidant agents has not been investigated. METHODS ...

journal_title：Circulation

authors： Spargias K,Alexopoulos E,Kyrzopoulos S,Iokovis P,Greenwood DC,Manginas A,Voudris V,Pavlides G,Buller CE,Kremastinos D,Cokkinos DV

更新日期：2004-11-02 00:00:00

abstract：BACKGROUND:Conversion of chronic atrial fibrillation (AF) is associated with atrial stunning, but the short-term effect of a brief episode of AF on left atrial appendage (LAA) emptying velocity is unknown. The purpose of this study was to determine whether a short episode of AF affects left atrial function and whether ...

journal_title：Circulation

authors： Daoud EG,Marcovitz P,Knight BP,Goyal R,Man KC,Strickberger SA,Armstrong WF,Morady F

更新日期：1999-06-15 00:00:00

abstract：BACKGROUND:Aerobic power declines with age. The degree to which this decline is reversible remains unclear. In a 30-year longitudinal follow-up study, the cardiovascular adaptations to exercise training in 5 middle-aged men previously trained in 1966 were evaluated to assess the degree to which the age-associated decli...

journal_title：Circulation

authors： McGuire DK,Levine BD,Williamson JW,Snell PG,Blomqvist CG,Saltin B,Mitchell JH

更新日期：2001-09-18 00:00:00

abstract：:The nitrovasodilators are a diverse group of pharmacological agents that produce vascular relaxation by releasing nitric oxide. The mechanisms by which these compounds release nitric oxide vary, depending on their chemical structure. Compounds with lower oxidation states of nitrogen such as nitroprusside, nitrosamines...

journal_title：Circulation

authors： Harrison DG,Bates JN

更新日期：1993-05-01 00:00:00

abstract：:The thienopyridines ticlopidine and clopidogrel are inhibitors of platelet function in vivo. Their mode of action has not been defined, but it appears that they require conversion to as yet unidentified metabolites that are noncompetitive antagonists of the platelet ADP receptor. Inhibition of platelet aggregation wit...

journal_title：Circulation

authors： Quinn MJ,Fitzgerald DJ

更新日期：1999-10-12 00:00:00

abstract：:A patient who had disabling supraventricular tachycardia showed electrophysiologic evidence of coexistent right and left Kent bundles. The supraventricular tachycardia was accelerated by sequential antegrade and retrograde conduction over the right and left Kent bundles, respectively. Spontaneous blocking of the condu...

journal_title：Circulation

authors： Cinca J,Valle V,Gutierrez L,Figueras J,Rius J

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND:The Na+-H+ exchanger figures prominently in cardiac ischemia-reperfusion injury. Several experimental and clinical studies have demonstrated a cardioprotective effect of Na+-H+ exchanger inhibition; however, the precise mechanisms have not been established. METHODS AND RESULTS:We examined the effects of car...

journal_title：Circulation

authors： Teshima Y,Akao M,Jones SP,Marbán E

更新日期：2003-11-04 00:00:00

abstract：:To assess the effects of angioplasty (PTCA) and intracoronary streptokinase (ICSK) on relative myocardial perfusion, we administered 99mTc-macroaggregated albumin (MAA) to the uninvolved coronary artery before successful PTCA in 33 patients and before successful infusion of ICSK in eight patients and of 111In-MAA into...

journal_title：Circulation

authors： Wahr DW,Ports TA,Botvinick EH,Dae M,Schechtmann N,Huberty J,Hattner RS,O'Connell JW,Turley K

更新日期：1985-08-01 00:00:00

abstract：:The efficacy of a single oral dose combination of 120 mg diltiazem and 160 mg propranolol in terminating paroxysmal supraventricular tachycardia (PSVT) was evaluated in 15 patients. All 15 patients underwent electrical induction of PSVT that lasted longer than 15 min, and all underwent randomized crossover placebo and...

journal_title：Circulation

authors： Yeh SJ,Lin FC,Chou YY,Hung JS,Wu D

更新日期：1985-01-01 00:00:00

abstract：:For half a century the systolic click and late systolic murmur lay dormant as innocent auscultatory curiosities. The thirteen years since Barlow related these phenomena to mitral leaflet prolapse have witnessed an astonishing information explosion. We have sought to bring together the accumulated data in this review. ...

journal_title：Circulation

authors： Devereux RB,Perloff JK,Reichek N,Josephson ME

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND:An estimated 275,000 patients undergo heart valve replacement each year. However, existing solutions for valve replacement are complicated by the morbidity associated with lifelong anticoagulation of mechanical valves and the limited durability of bioprostheses. Recent advances in tissue engineering and our ...

journal_title：Circulation

authors： Sutherland FW,Perry TE,Yu Y,Sherwood MC,Rabkin E,Masuda Y,Garcia GA,McLellan DL,Engelmayr GC Jr,Sacks MS,Schoen FJ,Mayer JE Jr

更新日期：2005-05-31 00:00:00

abstract：BACKGROUND:Spontaneous transient outward potassium currents (STOCs) induce myogenic relaxation in small cerebral vessels. We found STOCs in human coronary artery vascular smooth muscle cells (VSMCs) and studied their regulation. METHODS AND RESULTS:K+ currents were recorded in human coronary VSMCs by current- and volt...

journal_title：Circulation

authors： Bychkov R,Gollasch M,Ried C,Luft FC,Haller H

更新日期：1997-01-21 00:00:00

abstract：:In a series of 416 women with congenital heart disease seen in the Royal Brompton National Heart and Lung Hospital, London, and the Hospital Giovanni Bosco, Torino, Italy, there were 822 pregnancies. The outcomes of 96 pregnancies in 44 patients with cyanotic congenital heart disease were studied. Patients with the Ei...

journal_title：Circulation

authors： Presbitero P,Somerville J,Stone S,Aruta E,Spiegelhalter D,Rabajoli F

更新日期：1994-06-01 00:00:00

abstract：:Digital vasospastic phenomena have been reported to result from use of nonselective and cardioselective beta-adrenoreceptor-blocking drugs. The effects of 80 mg/day propranolol and 100 mg/day metoprolol on finger hemodynamics and clinical responses were compared with those of placebo in 16 patients with Raynaud's phen...

journal_title：Circulation

authors： Coffman JD,Rasmussen HM

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:We investigated whether decreased myofilament calcium contractile activation may, in part, contribute to heart failure. METHODS AND RESULTS:Calcium concentration required for 50% activation and Hill coefficient for fibers from nonfailing and failing human hearts at pH 7.1 were not different. Maximum calcium...

journal_title：Circulation

authors： Hajjar RJ,Schwinger RH,Schmidt U,Kim CS,Lebeche D,Doye AA,Gwathmey JK

更新日期：2000-04-11 00:00:00

abstract：BACKGROUND:L-arginine is the precursor of endothelium-derived nitric oxide, an endogenous vasodilator. L-arginine supplementation improves vascular reactivity and functional capacity in peripheral arterial disease (PAD) in small, short-term studies. We aimed to determine the effects of long-term administration of L-arg...

journal_title：Circulation

authors： Wilson AM,Harada R,Nair N,Balasubramanian N,Cooke JP

更新日期：2007-07-10 00:00:00

abstract：BACKGROUND:Cardiovascular disease is the major cause of death in older women. Information on the relation of menopause and hormone replacement therapy with carotid atherosclerosis is limited. METHODS AND RESULTS:We examined cross-sectionally the association of menopausal status, years since last menstruation, and horm...

journal_title：Circulation

authors： Nabulsi AA,Folsom AR,Szklo M,White A,Higgins M,Heiss G

更新日期：1996-10-15 00:00:00

abstract：BACKGROUND:This study was designed to define myocardial viability and establish practical cut-off values for differentiating normal myocardial tissue from subendocardial and transmural scar tissue by using electromechanical mapping (EMM). We validated our results by delayed-enhancement cardiac MRI (DE-MRI). METHODS AN...

journal_title：Circulation

authors： Perin EC,Silva GV,Sarmento-Leite R,Sousa AL,Howell M,Muthupillai R,Lambert B,Vaughn WK,Flamm SD

更新日期：2002-08-20 00:00:00