Inhibition of cellular proliferation and induction of apoptosis by curcumin in human malignant astrocytoma cell lines.

abstract：:Transient cerebral hypoperfusion (TCH) has empirically been used to assist intraarterial (IA) drug delivery to brain tumors. Transient (<3 min) reduction of cerebral blood flow (CBF) occurs during many neuro- and cardiovascular interventions and has recently been used to better target IA drugs to brain tumors. In the ...

journal_title：Journal of neuro-oncology

authors： Joshi S,Singh-Moon RP,Wang M,Chaudhuri DB,Holcomb M,Straubinger NL,Bruce JN,Bigio IJ,Straubinger RM

更新日期：2014-05-01 00:00:00

abstract：:Proteasome activity is essential during cAMP-induced terminal differentiation of a murine neuroblastoma cell line (NBP2). However, the mechanisms through which proteasome affects NBP2 differentiation have not been characterized. We hypothesized that proteasome is required to implement the differentiation-mediated effe...

journal_title：Journal of neuro-oncology

authors： Nahreini P,Andreatta C,Hanson A,Prasad KN

更新日期：2003-05-01 00:00:00

abstract：INTRODUCTION:A previous study confirmed that a novel splicing variant of large vascular endothelial growth factor (L-VEGF) termed L-VEGF144, a nucleolus protein, is found in glioblastoma cells and specimens, but the actual biological function and clinical significance of L-VEGF144 remain unclear. METHODS:In this study...

journal_title：Journal of neuro-oncology

authors： Cheng WY,Shen CC,Chiao MT,Liang YJ,Mao TF,Liu BS,Chen JP

更新日期：2018-10-01 00:00:00

abstract：:The completion of the Human Genome Project resulted in discovery of many unknown novel genes. This feat paved the way for the future development of novel therapeutics for the treatment of human disease based on novel biological functions and pathways. Towards this aim, we undertook a bioinformatics analysis of in-hous...

journal_title：Journal of neuro-oncology

authors： Junes-Gill KS,Gallaher TK,Gluzman-Poltorak Z,Miller JD,Wheeler CJ,Fan X,Basile LA

更新日期：2011-04-01 00:00:00

abstract：:Thymidine analogs (TAs) are synthetic nucleosides that incorporate into newly synthesized DNA. Halogenated pyrimidines (HPs), such as bromodeoxyuridine (BrdU), are a class of TAs that can be detected with antibodies and are commonly used for birthdating individual cells and for assessing the proliferative index of cel...

journal_title：Journal of neuro-oncology

authors： Ross HH,Rahman M,Levkoff LH,Millette S,Martin-Carreras T,Dunbar EM,Reynolds BA,Laywell ED

更新日期：2011-12-01 00:00:00

abstract：:To determine the impact of delay between surgery and radiotherapy on overall survival (OS) in temozolomide treatmented patients with the incorporation of O6-methylguanine-DNA methyltransferase (MGMT). From 2000 to 2012, 345 consecutive glioblastoma patients were treated with surgery, radiotherapy, and temozolomide at ...

journal_title：Journal of neuro-oncology

authors： Spratt DE,Folkert M,Zumsteg ZS,Chan TA,Beal K,Gutin PH,Pentsova E,Yamada Y

更新日期：2014-01-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (STAT3) are activated by various cytokines and oncogenes; however, the activity and pathogenesis of STAT3 in diffuse large B cell lymphoma of the central nervous system have not been thoroughly elucidated. We investigated the phosphorylation levels of STAT3 in 40 sp...

journal_title：Journal of neuro-oncology

authors： Mizowaki T,Sasayama T,Tanaka K,Mizukawa K,Takata K,Nakamizo S,Tanaka H,Nagashima H,Nishihara M,Hirose T,Itoh T,Kohmura E

更新日期：2015-09-01 00:00:00

abstract：:Cancer is a leading cause of death in the United States. Despite the development of advanced treatment for many malignancies, a large number of patients will require evaluation and possible surgical intervention for lesions which have metastasized to or directly invaded the spinal column. The recommendations for opera...

journal_title：Journal of neuro-oncology

authors： Welch WC,Jacobs GB

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVES:To study the metabolic effects in vivo of L-2, 4 diaminobutyric acid (DAB) administered by retrograde microdialysis in glioblastoma and to evaluate the feasibility of the technique. METHODS:In 10 patients with glioblastoma, a stereotactic biopsy was performed followed by implantation of microdialysis cathet...

journal_title：Journal of neuro-oncology

authors： Bergenheim AT,Roslin M,Ungerstedt U,Waldenström A,Henriksson R,Ronquist G

更新日期：2006-12-01 00:00:00

abstract：:Immune checkpoint inhibitors have demonstrated remarkable benefits in cancer patients. However, concern regarding toxicity in the setting of stereotactic radiosurgery (SRS) is often raised. In this study, we characterize radiation necrosis (RN) following immunotherapy and SRS. Melanoma patients treated with SRS and an...

journal_title：Journal of neuro-oncology

authors： Fang P,Jiang W,Allen P,Glitza I,Guha N,Hwu P,Ghia A,Phan J,Mahajan A,Tawbi H,Li J

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:To analyze the surgical outcome of a consecutive and single center series of medulla oblongata (MO) and spinal cord hemangioblastomas (HB). PATIENT AND METHODS:We retrospectively reviewed the medical charts of all MO and spinal HB patients operated on in our institution between 1985 and 2002. All patients had ...

journal_title：Journal of neuro-oncology

authors： Parker F,Aghakhani N,Ducati LG,Yacubian-Fernandes A,Silva MV,David P,Richard S,Tadie M

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:Post-operative radiation therapy for brain metastases (BM) has become standard treatment. Concerns regarding the deleterious cognitive effects of Whole Brain Radiation Therapy spurred a trend to use focal therapies such as stereotactic radiosurgery (SRS). The purpose of this study was to prospectively evaluate ...

journal_title：Journal of neuro-oncology

authors： Berger A,Strauss I,Ben Moshe S,Corn BW,Limon D,Shtraus N,Shahar T,Kanner AA

更新日期：2018-11-01 00:00:00

abstract：:Gemistocytic astrocytoma still continues to be enigmatic; both in terms of definition and prognostic implications. The major issue of contention has been the clinical relevance of this pathological entity. The currently accepted definition of gemistocytic astrocytoma requires 20% or more gemistocytes, and considers th...

journal_title：Journal of neuro-oncology

authors： Tihan T,Vohra P,Berger MS,Keles GE

更新日期：2006-01-01 00:00:00

abstract：:Human melanoma proteoglycan (HMP), a melanoma-associated antigen, is expressed in both human melanomas and gliomas. We used HMP-specific monoclonal antibody (mAb) VT68.2 to investigate whether murine GL261 cerebral gliomas express the HMP homologue AN2 and to determine whether AN2 could be targeted for selective deliv...

journal_title：Journal of neuro-oncology

authors： Paul AK,Ciesielski MJ,Sajjad M,Wang X,Ferrone S,Abdel-Nabi H,Fenstermaker RA

更新日期：2009-08-01 00:00:00

abstract：:Central nervous system (brain or leptomeningeal) metastases (BLm) are considered rare in castration-resistant prostate cancer (CRPC) patients. Now that docetaxel has become the reference drug for first-line treatment of CRPC, patients whose disease is not controlled by hormonal manipulations may live much longer than ...

journal_title：Journal of neuro-oncology

authors： Caffo O,Gernone A,Ortega C,Sava T,Cartenì G,Facchini G,Re GL,Amadio P,Bortolus R,Pagliarulo V,Prati V,Veccia A,Galligioni E

更新日期：2012-03-01 00:00:00

abstract：:Sixteen immunocompetent patients, 10 of whom were previously reported, with primary non-Hodgkins lymphoma of the central nervous system (PCNSL) were treated and followed longitudinally by the Neuro-oncology Service at the University of California, San Francisco (UCSF) and the University of California, San Diego (UCSD)...

journal_title：Journal of neuro-oncology

authors： Chamberlain MC,Levin VA

更新日期：1992-11-01 00:00:00

abstract：INTRODUCTION:Recurrent intracranial epidermoid cysts may be difficult to address surgically given their proximity to critical neurovascular structures of the skull base. There are emerging reports of using radiotherapy (RT) for the treatment of recurrent epidermoid cysts. Here, we report a case series of adjuvant fract...

journal_title：Journal of neuro-oncology

authors： Morshed RA,Wu SY,Sneed PK,McDermott MW

更新日期：2019-08-01 00:00:00

abstract：:Children with recurrent high grade gliomas (HGG) have a dismal outcome with a median progression free survival (PFS) of 12 weeks. Adults with recurrent HGG treated with irinotecan and bevacizumab reportedly have a 63% response rate and a median PFS of 23 weeks. There is a paucity of corresponding published pediatric d...

journal_title：Journal of neuro-oncology

authors： Parekh C,Jubran R,Erdreich-Epstein A,Panigrahy A,Bluml S,Finlay J,Dhall G

更新日期：2011-07-01 00:00:00

abstract：INTRODUCTION:The standard treatment for primary central nervous system lymphoma (PCNSL) involves induction methotrexate-based chemotherapy with or without consolidation whole brain radiotherapy (WBRT). As WBRT carries a substantial risk for cognitive impairment, alternative consolidation treatments have been used to re...

journal_title：Journal of neuro-oncology

authors： Correa DD,Braun E,Kryza-Lacombe M,Ho KW,Reiner AS,Panageas KS,Yahalom J,Sauter CS,Abrey LE,DeAngelis LM,Omuro A

更新日期：2019-09-01 00:00:00

abstract：:Compared to classical oncological outcome measures such as time to progression and survival, the importance of cognitive functioning in patients with diffuse infiltrative brain tumors has only recently been recognized. Apart from the relatively low incidence and the invariably fatal outcome of gliomas, the general ass...

journal_title：Journal of neuro-oncology

authors： Klein M,Duffau H,De Witt Hamer PC

更新日期：2012-06-01 00:00:00

abstract：:A pilot study was performed combining cis-diamminedichloroplatinum (CDDP) and radiation therapy to treat patients with high-grade astrocytomas. CDDP at a dose of 40 mg/m2/week intravenously was given during the course of cranial irradiation. Following irradiation, CDDP was given every three weeks on a schedule of 35-4...

journal_title：Journal of neuro-oncology

authors： Feun LG,Stewart DJ,Maor M,Leavens M,Savaraj N,Burgess MA,Yung WK,Benjamin RS

更新日期：1983-01-01 00:00:00

abstract：:This study retrospectively reviewed our single institute experience to clarify the optimal indication and timing of salvage surgery. Retrospective analysis of 159 consecutive cases with germ cell tumors identified 20 cases with salvage surgery. These cases were classified based on the radiological response to neoadjuv...

journal_title：Journal of neuro-oncology

authors： Kanamori M,Kumabe T,Watanabe M,Chonan M,Saito R,Yamashita Y,Ogawa Y,Sonoda Y,Tominaga T

更新日期：2018-07-01 00:00:00

abstract：:The diagnosis of leptomeningeal metastases (LM) of solid tumors is complicated due to low sensitivities of both magnetic resonance imaging (MRI) and cytology. MRI has a sensitivity of 76% for the diagnosis of LM and cerebrospinal fluid (CSF) cytology has a sensitivity of 44-67% at first lumbar puncture which increases...

journal_title：Journal of neuro-oncology

authors： van Bussel MTJ,Pluim D,Bol M,Beijnen JH,Schellens JHM,Brandsma D

更新日期：2018-03-01 00:00:00

abstract：:Assessing central nervous system (CNS) involvement in patients with lymphoma or carcinoma is important in determining therapy and prognosis. Progranulin (PGRN) is a secreted glycosylated protein with roles in cancer growth and survival; it is highly expressed in aggressive cancer cell lines and specimens from many can...

journal_title：Journal of neuro-oncology

authors： Kimura A,Takemura M,Serrero G,Yoshikura N,Hayashi Y,Saito K,Inuzuka T

更新日期：2018-05-01 00:00:00

abstract：:One objection to using cell cultures for studying the proliferation of tumors is the potential for phenotypic changes that may occur in vitro. Here, we compared the antigen pattern expression of cultured meningioma cells with that of the primary tumor. Cell cultures established from 9 intracranial meningiomas and depa...

journal_title：Journal of neuro-oncology

authors： Pallini R,Casalbore P,Mercanti D,Maggiano N,Larocca LM

更新日期：2000-08-01 00:00:00

abstract：:To explore the antitumor mechanism of bacterial cytosine deaminase plus 5-fluorocytosine (CD/5-FCyt) in combination with interferons (IFNs), glioma cells were transduced with recombinant retroviruses expressing CD. The transduced glioma cells become sensitive to the nontoxic prodrug 5-FCyt. Apoptosis, DNA damage, byst...

journal_title：Journal of neuro-oncology

authors： Wang ZH,Samuels S,Gama Sosa MA,Kolodny EH

更新日期：1998-02-01 00:00:00

abstract：:Medulloblastomas (MB) are the most common central nervous system malignancies in children. Numerous publications describe certain efforts to identify predictive value of various patterns of MB pathology and immunohistochemistry but received data appear to be controversial. In the present study, the apoptotic index (AI...

journal_title：Journal of neuro-oncology

authors： Korshunov A,Savostikova M,Ozerov S

更新日期：2002-07-01 00:00:00

abstract：:CCAAT/enhancer binding protein (C/EBP) delta is a transcription factor which has been demonstrated to mediate the growth arrest of mammary and prostate cancer cell lines. It is induced by several stimuli including inflammatory cytokines. In this study, C/EBPdelta immunohistochemical expression was assessed in 49 menin...

journal_title：Journal of neuro-oncology

authors： Barresi V,Vitarelli E,Cerasoli S,Barresi G

更新日期：2010-04-01 00:00:00

abstract：:Radiation therapy (RT) for brain tumors is associated with neurocognitive toxicity which may be a result of damage to neural progenitor cells (NPCs). We present a novel technique to limit the radiation dose to NPC without compromising tumor coverage. A study was performed in mice to examine the rationale and another w...

journal_title：Journal of neuro-oncology

authors： Redmond KJ,Achanta P,Grossman SA,Armour M,Reyes J,Kleinberg L,Tryggestad E,Quinones-Hinojosa A,Ford EC

更新日期：2011-09-01 00:00:00

abstract：:The current study reports longitudinal coping responses among parents of children diagnosed with an embryonal brain tumor. Patients (n = 219) were enrolled on a treatment protocol for a pediatric embryonal brain tumor. Their parents (n = 251) completed the Coping Response Inventory at time of their child's diagnosis a...

journal_title：Journal of neuro-oncology

authors： Palmer SL,Lesh S,Wallace D,Bonner MJ,Swain M,Chapieski L,Janzen L,Mabbott D,Knight S,Boyle R,Armstrong CL,Gajjar A

更新日期：2011-11-01 00:00:00