Abstract:
:A coordinated study of the dispersal of water between the various body compartments (stomach and gut, blood stream and tissue) and the similar dispersal kinetics of ethanol and its metabolism has been carried out involving two healthy volunteers using flowing afterglow mass spectrometry, FA-MS, and selected ion flow tube mass spectrometry, SIFT-MS. Thus, using these techniques, the variations of HDO and ethanol in breath, measured in successive single exhalations, were followed in real time after the ingestion of measured quantities of D2O and ethanol in proportion to the body weights of the subjects at the dose rates D2O approximately 0.283 g kg-1, ethanol approximately 0.067 g kg-1. During the FA-MS experimental periods (about 2 h), the dispersion of HDO into the body water and finally its equilibration in the total body water is observed from which total body water for each subject was determined. In the SIFT-MS measurements, the dispersion of ethanol into the body water and its loss via metabolism was observed until the physiological (pre-dose) breath level of ethanol for each individual was restored. A simple linear transformation is used to derive the time variations of the blood levels of HDO and ethanol. This has allowed a comparison of the fractions of the ingested ethanol that are metabolized during first-pass metabolism for the two subjects. Thus, in one subject 30% and in the other subject 40% of the ingested alcohol is metabolized in the first 20 min following ingestion. The good time resolution allowed by non-invasive breath analysis ensures that the rates of processes such as ethanol metabolism can be accurately measured. Simultaneous measurements of breath acetaldehyde (largely formed via the ethanol metabolism) and acetone were also performed during the SIFT-MS single breath exhalations.
journal_name
Physiol Measjournal_title
Physiological measurementauthors
Spanel P,Wang T,Smith Ddoi
10.1088/0967-3334/26/4/011subject
Has Abstractpub_date
2005-08-01 00:00:00pages
447-57issue
4eissn
0967-3334issn
1361-6579pii
S0967-3334(05)90424-3journal_volume
26pub_type
杂志文章abstract::Vascular and clinical assessments of arterio-venous fistula (AVF) function and access are important in patients undergoing or preparing to undergo renal dialysis. Objective assessment techniques include colour duplex ultrasound and more recently medical infrared thermography. Ideally, these should help assess problems...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/27/1/005
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:PaCO2 affects cerebral blood flow (CBF) and its regulatory mechanisms, but the effects of CO2 measurement technique on cerebrovascular parameters are unknown. In order to determine if the two most commonly used approaches, face mask (FM) or nasal cannulae (NC), are interchangeable or not, we tested the hypoth...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aa6f9f
更新日期:2017-06-22 00:00:00
abstract::A method was developed for simultaneously measuring plasma resistance, cell interior resistance and cell membrane capacitance of blood. A three-element circuit model for simulating the impedance of blood was evaluated by comparing measured and calculated impedance frequency curves and was found feasible. The values of...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/14/2/006
更新日期:1993-05-01 00:00:00
abstract::Although cardiac arrhythmias have been studied extensively, little is known about arrhythmic phenomena in the gastrointestinal (GI) system. In this study, we demonstrate for the first time that the onset of GI arrhythmias is associated with statistically significant fluctuations in the information dimension of the ass...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/29/5/N01
更新日期:2008-05-01 00:00:00
abstract::Analysis of human eye pupil reactivity is a very valuable diagnostic method used mainly for evaluation of the condition of the autonomic nervous system and the visual system. The paper presents an experimental pupillometer built in the Institute of Physics of the Wroclaw University of Technology. The apparatus makes i...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/28/1/006
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:Sleep-stage scoring is important for sleep-quality evaluation and the diagnosis of related diseases. In this study, an automatic sleep-stage scoring method using photoplethysmographic (PPG) signals was proposed. APPROACH:To construct the classification model, we extracted 14 time-domain features, 17 frequenc...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab921d
更新日期:2020-06-30 00:00:00
abstract::When used in large, national surveillance programmes, objective measurement tools provide prevalence estimates of low physical activity guideline compliance and high amounts of sedentary time. There are undoubtedly a plethora of reasons for this but one possible contributing factor is the current lack of behavioural c...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/37/10/1834
更新日期:2016-10-01 00:00:00
abstract::Previous studies have proved that the baroreceptor reflex (baroreflex) control of heart rate can be used for stratification of post-infarction population and, in general, cardiovascular disease populations. Many methods have been proposed to estimate the so-called baroreflex sensitivity (BRS) expressed as ms mmhg-1. M...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/38/1/63
更新日期:2017-01-01 00:00:00
abstract::This study compared sitting time measured by a questionnaire (International Physical Activity Questionnaire; IPAQ) with concurrently measured objective sitting time from an accelerometer-based measure of thigh inclination (activPAL).Adults (n = 69), wore an activPAL for a week, and then completed the long-form 7 d rec...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/11/2319
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To compare a novel cardiovascular magnetic resonance technique for the assessment of left ventricular (LV) mechanical discoordination by characterizing the endocardial center motion (ECM) in short-axis cine MRI in healthy volunteers and heart failure patients with left bundle branch block (HF-LBBB). APPROACH...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aaaaa0
更新日期:2018-02-28 00:00:00
abstract::A new algorithm for classifying ECG recording quality based on the detection of commonly observed ECG contaminants which often render the ECG unusable for diagnostic purposes was evaluated. Contaminants (baseline drift, flat line, QRS-artefact, spurious spikes, amplitude stepwise changes, noise) were detected on indiv...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/33/9/1435
更新日期:2012-09-01 00:00:00
abstract::Health is one of the most important non-material assets and thus also has an enormous influence on material values, since treating and preventing diseases is expensive. The number one cause of death worldwide today originates in cardiovascular diseases. For these reasons the aim of understanding the functions and the ...
journal_title:Physiological measurement
pub_type: 杂志文章,评审
doi:10.1088/0967-3334/37/5/R46
更新日期:2016-05-01 00:00:00
abstract::The point spread function (PSF) is the most widely used tool for quantifying the spatial resolution of imaging systems. However, prerequisites for the proper use of this tool are linearity and space invariance. Because EIT is non-linear it is only possible to compare different reconstruction algorithms using a standar...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/16/3a/021
更新日期:1995-08-01 00:00:00
abstract::The left atrium (LA) plays an important role in the maintenance of hemodynamic and electrical stability of the heart. One of the conditions altering the atrial mechanical function is atrial fibrillation (AF), leading to an increased thromboembolic risk due to impaired mechanical function. Preserving the regions of the...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/5/763
更新日期:2014-05-01 00:00:00
abstract::The paper describes the development of an electrical impedance tomography (EIT) system for gynecologic research. The GIT (gynecological impedance tomography) system has 48 electrodes and is embedded on a small space (30 mm diameter and 20 mm height) inside of the vaginal probe. The system provides real-time (one shot ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/33/5/849
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:The Actiwatch 2 (AW2) is a wrist-worn accelerometer typically used to measure sleep. Although it can measure physical activity, there is limited evidence supporting its validity. We assessed the validity and reliability of the AW2 to measure sedentary behavior and physical activity (light, moderate, vigorous ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aba80f
更新日期:2020-09-04 00:00:00
abstract::Monitoring the brain state in anaesthesia is crucial for clinical doctors. In this study, we propose a novel nonlinear method, the permutation Lempel-Ziv complexity (PLZC) index, which describes the complexity in the electroencephalographic (EEG) signal to quantify the effect of GABAergic anaesthetics on brain activit...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/36/12/2483
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:Electrical impedance tomography (EIT) is a functional imaging technique in which cross-sectional images of structures are reconstructed based on boundary trans-impedance measurements. Continuous functional thorax monitoring using EIT has been extensively researched. Increasing the number of electrodes, number...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab0daa
更新日期:2019-04-03 00:00:00
abstract::We present an adaptive algorithm for solving the inverse problem in electrical impedance tomography. To strike a balance between the accuracy of the reconstructed images and the computational efficiency of the forward and inverse solvers, we propose to combine an adaptive mesh refinement technique with the adaptive Ka...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/6/1111
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:Currently, continuous blood pressure (BP) measurements are mostly based on multi-sensor combinations and datasets with limited BP ranges. Besides, most BP-related features derive from the photoplethysmogram (PPG) signal. The mechanism of PPG signal formation is not considered. We aimed to design a noninvasive...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/abc8dd
更新日期:2021-01-01 00:00:00
abstract::A major problem confronting application of impedance techniques to studies of disease is the extraction of intrinsic properties of the tissue from the measured impedances, which unavoidably involve geometric factors as well. Amongst the foremost are the sizes and locations of the measuring electrode arrays, and this p...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/34/11/1513
更新日期:2013-11-01 00:00:00
abstract::This paper describes the design, construction, and testing of a multi-channel fetal electrocardiogram (fECG) signal generator based on LabVIEW. Special attention is paid to the fetal heart development in relation to the fetus' anatomy, physiology, and pathology. The non-invasive signal generator enables many parameter...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/37/2/238
更新日期:2016-02-01 00:00:00
abstract::The postural stability of 30 normal subjects in the age range 15 to 64 years was measured on five separate occasions, using the sway magnetometry technique, to determine the day-to-day repeatability of this measurement technique. On each occasion the pathlength and area enclosed by movement of the hips in a horizontal...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/19/2/003
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of maternal hyperoxygenation on fetal heart rate (FHR) when applied for suspected fetal distress during the second stage of term labor. APPROACH:A single-center randomized controlled trial was conducted in a tertiary care hospital in The Netherlands. Participants were included durin...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/abc0b6
更新日期:2020-12-11 00:00:00
abstract:OBJECTIVE:Physical activity has been shown to impact future health outcomes in adults, but little is known about the long-term impact of physical activity in toddlers. Accurately measuring the specific types and amounts of physical activity in toddlers will help us to understand, predict, and better affect their future...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab6ebb
更新日期:2020-03-06 00:00:00
abstract:OBJECTIVE:Video and sound acquisition and processing technologies have seen great improvements in recent decades, with many applications in the biomedical area. The aim of this paper is to review the overall state of the art of advances within these topics in paediatrics and to evaluate their potential application for ...
journal_title:Physiological measurement
pub_type: 杂志文章,评审
doi:10.1088/1361-6579/ab0096
更新日期:2019-02-26 00:00:00
abstract::In nine healthy subjects, magnetic resonance imaging was used to measure blood flow waveforms in the common (CCA), internal (ICA) and external (ECA) carotid arteries. Useful data were acquired from 14 carotid arteries in total. Flow rates were determined from regions of interest placed over the arteries in CINE-phase ...
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/25/3/009
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:In this study, electroencephalography activity recorded during monotonous driving was investigated to examine the predictive capability of monopolar EEG analysis for fatigue/sleepiness in a cohort of train drivers. APPROACH:Sixty-three train drivers participated in the study, where 32- lead monopolar EEG dat...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aae42e
更新日期:2018-10-30 00:00:00
abstract::This paper describes an open loop feedback intelligent system for neonatal intensive care management. The system provides a tool enabling the user to make the final decision to accept or reject the advice given. The system collects 18 parameters from the bedside monitor and ventilator using a Medical Information Bus (...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/26/4/019
更新日期:2005-08-01 00:00:00
abstract::Muscle stiffness is known to vary as a result of a variety of disease states, yet current clinical methods for quantifying muscle stiffness have limitations including cost and availability. We investigated the capability of shear wave elastography (SWE) to measure variations in gastrocnemius shear wave speed induced v...
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/34/6/713
更新日期:2013-06-01 00:00:00