Abstract:
AIMS/HYPOTHESIS:We examined the prevalence of islet autoantibodies and their relationship to glycaemic control over 10 years in patients diagnosed clinically with new-onset type 2 diabetes. METHODS:Patient clinical characteristics and autoantibody status were determined at entry to the UK Prospective Diabetes Study (UKPDS) before randomisation to different glucose control policies. Patients were followed for 10 years. RESULTS:Data available on 4,545 of the 5,102 UKPDS patients showed that 11.6% had antibodies to at least one of three antigens: islet cell cytoplasm, glutamic acid decarboxylase and islet autoantibody 2A (IA-2A). Autoantibody-positive patients were younger, more often Caucasian and leaner, with lower beta cell function and higher insulin sensitivity than autoantibody-negative patients. They also had higher HbA1c, and HDL-cholesterol levels, and lower blood pressure, total cholesterol and plasma triglyceride levels. Despite relative hyperglycaemia, autoantibody-positive patients were less likely to have the metabolic syndrome (as defined by the National Cholesterol Education Program Adult Treatment Program III), reflecting a more beneficial overall risk factor profile. Of 3,867 patients with post-dietary run-in fasting plasma glucose (FPG) values between 6.0 and 14.9 mmol/l and no hyperglycaemic symptoms, 9.4% were autoantibody-positive, compared with 25.1% of 678 patients with FPG values of 15.0 mmol/l or higher, or hyperglycaemic symptoms. In both groups, no differences were seen between those with and without autoantibodies in changes to HbA1c over time, but autoantibody-positive patients required insulin treatment earlier, irrespective of the allocated therapy (p<0.0001). CONCLUSIONS/INTERPRETATION:Autoantibody-positive patients can be treated initially with sulphonylurea, but are likely to require insulin earlier than autoantibody-negative patients.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Davis TM,Wright AD,Mehta ZM,Cull CA,Stratton IM,Bottazzo GF,Bosi E,Mackay IR,Holman RRdoi
10.1007/s00125-005-1690-xsubject
Has Abstractpub_date
2005-04-01 00:00:00pages
695-702issue
4eissn
0012-186Xissn
1432-0428journal_volume
48pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
DIABETOLOGIA文献大全abstract::Demographic and biological data were collected from all Caucasian Type 1 diabetic patients (n = 279) who were recruited at clinical onset by the Belgian Diabetes Registry over 34 months. The male/female ratio was significantly higher for onset between age 20 and 40 years (2.4) than before age 20 years (1.0); no age-or...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00401060
更新日期:1993-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:The therapeutic benefit of physical activity to prevent and treat type 2 diabetes is commonly accepted. However, the impact of the disease on the acute metabolic response is less clear. To this end, we investigated the effect of type 2 diabetes on exercise-induced plasma metabolite changes and the muscu...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3584-x
更新日期:2015-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:There has been much focus on the potential role of mitochondria in the aetiology of type 2 diabetes and the metabolic syndrome, and many case-control mitochondrial association studies have been undertaken for these conditions. We tested for a potential association between common mitochondrial variants a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1510-9
更新日期:2009-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Mesenchymal stem cells (MSCs) have been shown to abrogate in vitro the proinflammatory response in type 1 diabetes. The mechanism involves paracrine factors, which may include microvesicles (MVs). We evaluated whether MVs derived from heterologous bone-marrow MSCs exert an immunomodulatory effect on T c...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3262-4
更新日期:2014-08-01 00:00:00
abstract::Glucagon-like peptide-1 and glucagon-like peptide-2 are encoded by the m-RNA of pancreatic preproglucagon. They show high conservation in different species and substantial sequence homology to glucagon. Because no definite biological activity of these peptides has been reported, we investigated the effect of synthetic...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00291980
更新日期:1985-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:The molecular factors that cause an acute wound in diabetic patients to become chronic have not yet been established. Wound healing is known to require a balance between the accumulation of collagenous and non-collagenous extracellular matrix components and their remodelling by matrix metalloproteinases...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-002-0868-8
更新日期:2002-07-01 00:00:00
abstract::We examined changes in guanosine triphosphate-dependent signal transduction mechanisms in the retina from the early stages of the streptozotocin-diabetic rat, a model for Type 1 (insulin-dependent) diabetes mellitus. Guanosine triphosphate binding, guanosine triphosphatase activity, and binding of (azido) guanosine tr...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400253
更新日期:1992-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Pancreatic islet transplantation (PIT) offers a physiological treatment for type 1 diabetes, but the failure of islet engraftment hinders its application. The female hormone 17β-oestradiol (E2) favours islet survival and stimulates angiogenesis, raising the possibility that E2 may enhance islet engraftm...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2764-1
更新日期:2013-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Patients treated with human immunodeficiency virus-1 protease inhibitors often develop impaired glucose tolerance or diabetes, most likely due to an induction of insulin resistance. We therefore investigated whether the protease inhibitor indinavir alters insulin signalling. METHODS:We incubated HepG2 ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051505
更新日期:2000-09-01 00:00:00
abstract::Blood glucose values close to normal reduce the microvascular complications of insulin-dependent diabetes mellitus. The Stockholm study of this effect continued after the initial 7.5-year period in order to see what happened when intensively treated patients were left to control their own treatment while treatment was...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s001250050602
更新日期:1996-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:A growing body of research suggests that the prevalence of major depressive disorder (MDD) in children and youth with type 1 diabetes mellitus is significantly higher than that of youth without type 1 diabetes and is associated with increased illness severity. The objective of this article is to review ...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-011-2240-3
更新日期:2011-10-01 00:00:00
abstract::Urinary albumin excretion has been assessed in 585 newly-presenting Type 2 (non-insulin-dependent) diabetic patients (aged 53 (8) years, 67% male) at diagnosis with fasting plasma glucose 10.3 (3.2) mmol/l and over 3 years of dietary treatment. Urinary albumin at diagnosis, geometric mean (1 SD interval) corrected for...
journal_title:Diabetologia
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Intraportal human islet cell grafts do not consistently and sustainably induce insulin-independency in type 1 diabetic patients. The reasons for losses in donor cells are difficult to assess in patients. This study in streptozotocin-diabetic nude rats examines whether outcome is better in an extra-hepat...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1721-0
更新日期:2010-08-01 00:00:00
abstract::In order to characterize pancreatic beta cell function in Geneva bred spiny mice (acomys cahirinus), the dynamics of immunoreactive insulin release were examined during perifusion of pancreatic islets isolated from normoglycemic acomys. The initial insulin response of acomys was slow: no clear-cut early (1 to 10 min) ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00429916
更新日期:1975-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Distal diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes with many patients showing a reduction of intraepidermal nerve fibre density (IENFD) from skin biopsy, a validated and sensitive diagnostic tool for the assessment of DSP. Axonal swelling ratio is a morphological quan...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05352-9
更新日期:2021-01-23 00:00:00
abstract::Polycystic ovary syndrome (PCOS), the most common hormonal disorder among women of reproductive age, has various metabolic and reproductive consequences. Metformin was originally shown to lower testosterone levels in women with PCOS in the 1990s, an effect presumably related to its insulin sensitising actions. However...
journal_title:Diabetologia
pub_type: 社论
doi:10.1007/s00125-017-4306-3
更新日期:2017-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesit...
journal_title:Diabetologia
pub_type: 杂志文章,meta分析
doi:10.1007/s00125-011-2370-7
更新日期:2012-04-01 00:00:00
abstract::498 diabetics were discovered in a survey of ischaemic heart disease in 10,059 men aged 40 years and over in Israel. -The diabetics were divided into previously known and newly diagnosed. -During a 5 year follow-up period, the incidence rates of fatal and non-fatal myocardial infarction and the incidence of intermitte...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01219704
更新日期:1977-05-01 00:00:00
abstract::The development of diabetic glomerulopathy in kidneys transplanted to diabetic patients was estimated in transplant biopsies and evaluated in relation to suspected clinical risk factors for diabetic nephropathy. Surgical biopsies were taken at baseline and at 24-36 months post-transplantation in 16 Type 1 (insulin-dep...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400997
更新日期:1991-09-01 00:00:00
abstract:AIM/HYPOTHESIS:Altered adipose tissue secretory profile contributes to insulin resistance and type 2 diabetes in obesity. Preclinical studies have identified senescent cells as a cellular source of proinflammatory factors in adipose tissue of obese mice. In humans, potential links with obesity comorbidities are poorly ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05307-0
更新日期:2021-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Insulin-like growth factor-1 is a major childhood growth factor and promotes pancreatic islet cell survival and growth in vitro. We hypothesised that genetic variation in IGF1 might be associated with childhood growth, glucose metabolism and type 1 diabetes risk. We therefore examined the association be...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-0970-7
更新日期:2008-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucose and the peptide growth factors insulin, IGF-I and IGF-II strongly regulate beta cell mass. Furthermore, beta cell expression of IGF-I receptor (Igf1r) and insulin receptor (Insr) is mandatory for several steps of insulin secretion. MATERIALS AND METHODS:We hypothesised that glucose concentratio...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1860-x
更新日期:2005-09-01 00:00:00
abstract::The symptoms caused by gastrointestinal autonomic neuropathy in diabetes mellitus is important to highlight since it affects a large proportion of people with diabetes, regardless of whether this is type 1 or type 2. Gastroparesis and general signs of bowel dysfunction, such as constipation, diarrhoea and abdominal pa...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-015-3828-9
更新日期:2016-03-01 00:00:00
abstract::An inconsistency has come to light between the conclusion of Lucassen et al. that IDDM2 (11p15.5) must lie within a 4.1 kilobase (kb) segment at the insulin (INS) locus and their own data showing statistically significant associations between insulin-dependent diabetes mellitus (IDDM) and markers beyond the boundaries...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00403307
更新日期:1996-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Fractal analysis of the retinal vasculature provides a global measure of the complexity and density of retinal vessels summarised as a single variable: the fractal dimension. We investigated fractal dimensions as long-term predictors of microvasculopathy in type 1 diabetes. METHODS:We included 180 pati...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3317-6
更新日期:2014-10-01 00:00:00
abstract::Pancreatic beta cells are clustered in islets of Langerhans together with alpha cells in an arrangement that facilitates the tight coordination of insulin and glucagon secretion at the source of their release. Other secretory cells, including somatostatin-secreting delta cells and pancreatic polypeptide cells, co-loca...
journal_title:Diabetologia
pub_type: 评论,杂志文章
doi:10.1007/s00125-015-3567-y
更新日期:2015-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:We determined the response of selected genes to in vivo insulin in adipose tissue in 21 non-diabetic women. MATERIALS AND METHODS:The women were divided into insulin-sensitive and -resistant groups based on their median whole-body insulin sensitivity (8.7+/-0.4 vs 4.2+/-0.3 mg kg(-1) min(-1) for insuli...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-0075-5
更新日期:2006-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Insulin-mediated glucose transport and utilisation are decreased in skeletal muscle from type 2 diabetic and glucose-intolerant individuals because of alterations in insulin receptor signalling, GLUT4 translocation to the plasma membrane and microvascular blood flow. Catalytic activity of the muscle-spe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-3084-9
更新日期:2014-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone released from gut K cells. While the predominant form is GIP(1-42), a shorter form, GIP(1-30), is produced by pancreatic alpha cells and promotes insulin secretion in a paracrine manner. Here, we elucidated whether GIP(1-30) express...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3842-y
更新日期:2016-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The objective of this study was to investigate the association between laparoscopically confirmed endometriosis and risk of type 2 diabetes. METHODS:We used data from the Nurses' Health Study II, a prospective cohort of female nurses followed for >25 years (N = 112,037). We used Cox proportional hazard...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05347-6
更新日期:2021-01-05 00:00:00