Abstract:
:Modern liver imaging of cancer patients requires an imaging modality that is not only highly sensitive in detecting lesions but also provides reliable characterisation of lesions and thus allows differentiation of metastases from frequently found benign lesions. Conventional ultrasound (US) has a relatively poor sensitivity and specificity for imaging liver metastases and US used to be inferior to CT and MRI mainly due to a lack of contrast agents. This has changed with the advent of microbubble contrast agents for US. The use of recent contrast agents such as SonoVue (Bracco, Italy) combined with low mechanical index contrast-specific imaging techniques such as Contrast Pulse Sequencing provides dynamic real time imaging of focal liver lesions in the arterial, portal venous and delayed phase. This improves lesion detection and characterisation. To investigate the benefit of SonoVue for detecting liver metastases we studied 40 cancer patients with liver lesions on reference imaging (CT or MRI), 37 of them had metastases. The mean number of reference confirmed metastases per patient increased from 1.85+/-1.79 on conventional ultrasound to 2.73+/-2.50 post SonoVue (p < 0.05). CEUS showed more individual metastases than baseline in 12 (34%) patients. Using CT or MRI as the reference, the mean sensitivity to individual metastases increased from 69% on baseline US to 90% post contrast (p < 0.0005). The role of SonoVue in characterisation of focal liver lesions was evaluated in 63 patients. One lesion was studied per patient. Based on standardised dynamic enhancement criteria for each lesion type, the number of correctly diagnosed lesions improved from 41 (65%) on baseline US to 58 (92%) post contrast (p < 0.001). On CEUS all 27 metastases were correctly diagnosed, while baseline US misinterpreted 2 of these. The number of correctly diagnosed benign lesions (n = 28) increased from 12 (43%) on baseline to 25 (89%) post SonoVue. In conclusion, detection and characterisation of focal liver lesions by US are markedly improved by the use of SonoVue. Contrast agents add a new dimension to sonography allowing it to rival CT and MRI, especially for lesion characterisation.
journal_name
Eur Radioljournal_title
European radiologyauthors
Albrecht T,Hohmann J,Oldenburg A,Skrok J,Wolf KJdoi
10.1007/s10406-004-0088-zsubject
Has Abstractpub_date
2004-10-01 00:00:00pages
P25-33eissn
0938-7994issn
1432-1084journal_volume
14 Suppl 8pub_type
杂志文章abstract:OBJECTIVE:To assess feasibility and image quality (IQ) of a new post-processing algorithm for retrospective extraction of an optimised multi-phase CT (time-resolved CT) of the liver from volumetric perfusion imaging. METHODS:Sixteen patients underwent clinically indicated perfusion CT using 4D spiral mode of dual-sour...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2992-x
更新日期:2014-01-01 00:00:00
abstract::Developmental nasal midline masses in children are rare lesions. Neuroimaging is essential to characterise these lesions, to determine the exact location of the lesion and most importantly to exclude a possible intracranial extension or connection. Our objective was to evaluate CT and MRI in the diagnosis of developme...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-003-2008-3
更新日期:2004-02-01 00:00:00
abstract::The aim of this study was to evaluate feasibility, safety, and effectiveness of radio-frequency (RF) thermal ablation, performed by using a cooled-tip electrode needle, in the treatment of liver metastases. Twenty-nine patients (20 males and 9 females; age range 43-77 years) with one to four hepatic metastases 1.1-4.8...
journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s003300050536
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To systematically review the literature on the Bosniak classification system in CT to determine its diagnostic performance to diagnose malignant cystic lesions and the prevalence of malignancy in Bosniak categories. METHODS:A predefined database search was performed from 1 January 1986 to 18 January 2016. Tw...
journal_title:European radiology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00330-016-4631-9
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:This study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against (15)O-H₂O positron-emission tomography (PET) and assesses the CFRs of coronary artery d...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-014-3164-3
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To compare the performance of synthetic mammography (SM) and digital mammography (DM) with digital breast tomosynthesis (DBT) or alone for the evaluation of microcalcifications. METHODS:This retrospective study includes 198 mammography cases, all with DM, SM, and DBT images, from January to October 2013. Thr...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5585-x
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:To compare the diagnostic accuracy and sensitivity of Gd-EOB-DTPA MRI and diffusion-weighted (DWI) imaging alone and in combination for detecting colorectal liver metastases in patients who had undergone preoperative chemotherapy. METHODS:Thirty-two consecutive patients with a total of 166 liver lesions wer...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2658-0
更新日期:2013-03-01 00:00:00
abstract::Over the past decade, significant advances have been made in the field of subarachnoid haemorrhage (SAH). Prompt diagnosis with high-resolution CT and intensive critical care support remain key aspects of good patient management. Early identification and definitive treatment of underlying ruptured aneurysms is general...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-005-2665-5
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:The status of isocitrate dehydrogenase 1 (IDH1) is highly correlated with the development, treatment and prognosis of glioma. We explored a noninvasive method to reveal IDH1 status by using a quantitative radiomics approach for grade II glioma. METHODS:A primary cohort consisting of 110 patients pathological...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4653-3
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:Normative brain volume reports (NBVRs) are becoming more and more available for the workup of dementia patients in clinical routine. However, it is yet unknown how this information can be used in the radiological decision-making process. The present study investigates the diagnostic value of NBVRs for detect...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06602-0
更新日期:2020-05-01 00:00:00
abstract::Rapid clinical dissemination of CT colonography (CTC) is occurring in parallel with continued research into technique optimisation and diagnostic performance. A need exists therefore for current guidance as to basic prerequisites for effective clinical implementation. A questionnaire detailing CTC technique, analysis,...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-006-0407-y
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVES:To evaluate early post-operative magnetic resonance (EPMR) as a prognostic tool after resection of glioblastoma. METHODS:Sixty EPMR examinations were evaluated for perioperative infarct, tumour growth between diagnosis and EPMR, contrast enhancement pattern, and extent of resection (EOR). The EOR was approa...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3914-x
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:To evaluate whether post-contrast cone-beam breast CT (CBBCT) alone is comparable to the current standard of combined pre- and post-contrast CBBCT regarding diagnostic accuracy and superior regarding radiation exposure. MATERIAL AND METHODS:This study included 49 women (61 breasts) with median age 57.9 year...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5854-8
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between MRI-derived changes in whole-brain and ventricular volume with change in cognitive scores in Alzheimer's disease (AD), mild cognitive impairment (MCI) and control subjects. MATERIAL AND METHODS:In total 131 control, 231 MCI and 99 AD subjects from the Alzheimer's Disease Ne...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1581-5
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVES:To evaluate an image-navigated isotropic high-resolution 3D late gadolinium enhancement (LGE) prototype sequence with compressed sensing and Dixon water-fat separation in a clinical routine setting. MATERIAL AND METHODS:Forty consecutive patients scheduled for cardiac MRI were enrolled prospectively and exa...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07517-x
更新日期:2020-12-02 00:00:00
abstract::Bronchioloalveolar carcinoma (BAC) is a polymorphic lung cancer the incidence of which is rising. The presence of intratumoral radiolucencies is an important feature of bronchioloalveolar carcinoma. The aim of this study was to present pictorially the spectrum of intratumoral radiolucencies visible in BAC. In 57 BACs ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050627
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the feasibility of T1w-3D black-blood turbo spin echo (TSE) sequence with variable flip angles for the diagnosis of thoracic large vessel vasculitis (LVV). METHODS:Thirty-five patients with LVV, diagnosed according to the current standard of reference, and 35 controls were imaged at 3.0T using 1...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4525-x
更新日期:2017-05-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. COPD is defined by irreversible airflow obstruction. It is a heterogeneous disease affecting the airways (i.e. chronic bronchitis, airway collapse), the parenchyma (i.e. hyperinflation, air trapping and emph...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-007-0772-1
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVES:To evaluate time-resolved interleaved stochastic trajectories (TWIST) contrast-enhanced 4D magnetic resonance angiography (MRA) and compare it with 3D FLASH MRA in patients with congenital heart and vessel anomalies. METHODS:Twenty-six patients with congenital heart and vessel anomalies underwent contrast-e...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2845-7
更新日期:2013-09-01 00:00:00
abstract::N-acetylaspartate/creatine (NAA/Cr) ratios, assessed with proton magnetic resonance spectroscopy, are increasingly used as a surrogate marker for axonal dysfunction and degeneration in multiple sclerosis (MS). The purpose of this study was to test short-time reproducibility of NAA/Cr ratios in patients with clinically...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-0925-x
更新日期:2008-08-01 00:00:00
abstract::The aim of this study was to compare the performance of CT and MRI in the diagnosis of longitudinal stress fracture of the tibia (LSFT). A retrospective study of imaging findings was performed in 15 patients with LSFT. The CT and MR images were compared for detection of fracture line, callus, bone marrow edema, and so...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050442
更新日期:1998-01-01 00:00:00
abstract::To assess both sensitivity and specificity of digital chest radiography alone and in conjunction with dual-exposure dual-energy chest radiography for the detection and classification of pulmonary nodules. One hundred patients with a total of 149 lung nodules (3-45 mm; median, 11 mm) confirmed by CT were included in th...
journal_title:European radiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00330-008-0945-6
更新日期:2008-09-01 00:00:00
abstract:PROPOSE:To establish evidence-based recommendations for musculoskeletal kinematic 4D-CT on wide area-detector CT. MATERIALS AND METHODS:In order to assess factors influencing image quality in kinematic CT studies, a phantom consisting of a polymethylmethacrylate rotating disk with round wells of different sizes was im...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-016-4362-y
更新日期:2017-02-01 00:00:00
abstract::The appearance of hepatocellular carcinoma (HCC) with contrast-enhanced ultrasound (CEUS) in the vascular phase is described and evaluated as to whether the enhancement pattern correlates with the degree of cellular differentiation. One hundred four HCCs were prospectively evaluated with CEUS using coherent-contrast i...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-004-2298-0
更新日期:2004-06-01 00:00:00
abstract::The use of the posteroanterior (PA) technique as a means of dose reduction has been used effectively in radiology departments for chest and abdominal examinations. The aim of this investigation was to establish if the PA lumbar spine projection offers any advantages over the traditional anteroposterior (AP) view in te...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003309900272
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the changes in mammographic density after tamoxifen discontinuation in premenopausal women with oestrogen receptor-positive breast cancers and the underlying factors METHODS: A total of 213 consecutive premenopausal women with breast cancer who received tamoxifen treatment after curative surgery ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5293-y
更新日期:2018-08-01 00:00:00
abstract::The primitive hypoglossal artery (PHA) is a rare persistent carotid-basilar anastomosis. Usually it is found incidentally on angiography, but detection may be of importance for patient management. In the presented case MR- and CT angiography, which to our knowledge have not yet been reported in PHA, provided important...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050322
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:To compare the three-dimensional (3D)-fast spin-echo (FSE)-Cube with a conventional imaging protocol in evaluation of dacryostenosis. METHODS:Thirty-three patients with epiphora underwent examinations using Cube magnetic resonance dacryocystography (MRD) and a conventional protocol, which included 3D fast-r...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3462-9
更新日期:2015-03-01 00:00:00
abstract::The purpose of the present study was to evaluate the usefulness of a new gray-scale test pattern (NGTP) that was developed to easily adjust the gradients of thoracic CT imaging and enable visual consistency. The Society of Motion Picture and Television Engineers (SMPTE) pattern and the NGTP were used for comparison. T...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-004-2315-3
更新日期:2004-12-01 00:00:00
abstract::We describe the pace of recruitment of iron-oxide-labeled macrophages to the site of different stages of infection by in vivo magnetic resonance (MR) imaging. Peritoneal macrophages were labeled with superparamagnetic iron oxide ex vivo and administered through the tail vein 6 (acute) or 48 (subacute) h after bacteria...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-0975-0
更新日期:2008-10-01 00:00:00