Abstract:
OBJECTIVE:To assess the relationship between MRI-derived changes in whole-brain and ventricular volume with change in cognitive scores in Alzheimer's disease (AD), mild cognitive impairment (MCI) and control subjects. MATERIAL AND METHODS:In total 131 control, 231 MCI and 99 AD subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort with T1-weighted volumetric MRIs from baseline and 12-month follow-up were used to derive volume changes. Mini mental state examination (MMSE), Alzheimer's disease assessment scale (ADAS)-cog and trails test changes were calculated over the same period. RESULTS:Brain atrophy rates and ventricular enlargement differed between subject groups (p < 0.0005) and in MCI and AD were associated with MMSE changes. Both measures were additionally associated with ADAS-cog and trails-B in MCI patients, and ventricular expansion was associated with ADAS-cog in AD patients. Brain atrophy (p < 0.0005) and ventricular expansion rates (p = 0.001) were higher in MCI subjects who progressed to AD within 12 months of follow-up compared with MCI subjects who remained stable. MCI subjects who progressed to AD within 12 months had similar atrophy rates to AD subjects. CONCLUSION:Whole-brain atrophy rates and ventricular enlargement differed between patient groups and healthy controls, and tracked disease progression and psychological decline, demonstrating their relevance as biomarkers.
journal_name
Eur Radioljournal_title
European radiologyauthors
Evans MC,Barnes J,Nielsen C,Kim LG,Clegg SL,Blair M,Leung KK,Douiri A,Boyes RG,Ourselin S,Fox NC,Alzheimer's Disease Neuroimaging Initiative.doi
10.1007/s00330-009-1581-5subject
Has Abstractpub_date
2010-03-01 00:00:00pages
674-82issue
3eissn
0938-7994issn
1432-1084journal_volume
20pub_type
杂志文章abstract::A "quadraphasic" imaging technique is described for imaging malignancies of the abdomen (liver, kidneys and pancreas). With this technique images are acquired during four different phases relative to the administration of contrast agent: pre-contrast (baseline), during the capillary (arterial, pre-sinusoidal) phase, d...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/pl00006899
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To compare cardiac left ventricular (LV) parameters in simultaneously acquired hybrid fluorine-18-fluorodeoxyglucose ([18F] FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) in patients with residual tracer activity of upstream PET/CT. METHODS:Twenty-nine patients (23 men, age 58±17 year...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4896-7
更新日期:2017-12-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300051034
更新日期:2000-01-01 00:00:00
abstract::Magnetic resonance imaging can be used to measure the muscle volume of a given muscle or muscle group. The purpose of this study was to determine both the intra- and inter-observer variation of the manually outlined volume of the extensor muscles (tibialis anterior, extensor digitorum longus and extensor hallucis long...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1334-1
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:To investigate the diagnostic value of intravoxel incoherent motion (IVIM) DWI for placenta accreta by comparing diffusion and perfusion characteristics of placentas with accreta lesions (APs) with those of normal placentas (NPs). METHODS:Twenty-five pregnant women with AP and 24 with NP underwent 3-T magne...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07200-1
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更新日期:2008-07-01 00:00:00
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journal_title:European radiology
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pub_type: 杂志文章
doi:10.1007/s00330-018-5500-5
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journal_title:European radiology
pub_type: 杂志文章,评审
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journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00330-005-2817-7
更新日期:2006-01-01 00:00:00
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更新日期:2011-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s00330-008-1013-y
更新日期:2008-11-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07084-1
更新日期:2021-02-01 00:00:00
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更新日期:2002-01-01 00:00:00
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更新日期:2016-10-01 00:00:00
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更新日期:2019-02-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00