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Delayed enhancement imaging of myocardial viability: low-dose high-pitch CT versus MRI.

Abstract：

OBJECTIVES:To evaluate the accuracy of high-pitch delayed enhancement (DE) CT for the assessment of myocardial viability with MRI as the reference standard. METHODS:Twenty-four patients (mean age 66.9 ± 9.2 years) with coronary artery disease underwent DE imaging with 128-slice dual-source CT (prospective electrocardiography (ECG)-triggering) and MRI at 1.5 T. Two observers assessed DE transmurality per segment, and measured signal intensity (MRI) or attenuation (CT) in infarcted and healthy myocardium and noise in the left ventricular blood pool for calculating contrast-to-noise ratios (CNR). RESULTS:75/408 (18.4%) segments in 18/24 patients (75.0%) showed DE in MRI, of which 28 segments in 10/24 (41.7%) patients were non-viable (scar tissue transmurality >50%). Sensitivity, specificity and accuracy of CT for diagnosis of non-viability were 60.7%, 96.8% and 94.4% per segment, and 90.0%, 92.9% and 91.7% per patient. CNR was significantly higher in MR (7.4 ± 3.0 vs. 4.6 ± 1.5; p = 0.018), and image noise significantly lower (11.6 ± 5.7 vs.15.0 ± 4.5; p = 0.019). Radiation dose of DECT was 0.89 ± 0.07 mSv. CONCLUSIONS:CTDE imaging in the high-pitch mode enables myocardial viability assessment at a low radiation dose and good accuracy compared with MR, although associated with a lower CNR and higher noise.

journal_name

Eur Radiol

journal_title

European radiology

authors

Goetti R,Feuchtner G,Stolzmann P,Donati OF,Wieser M,Plass A,Frauenfelder T,Leschka S,Alkadhi H

doi

10.1007/s00330-011-2149-8

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

2091-9

issue

10

eissn

0938-7994

issn

1432-1084

journal_volume

21

pub_type

杂志文章

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