Abstract:
OBJECTIVE:The status of isocitrate dehydrogenase 1 (IDH1) is highly correlated with the development, treatment and prognosis of glioma. We explored a noninvasive method to reveal IDH1 status by using a quantitative radiomics approach for grade II glioma. METHODS:A primary cohort consisting of 110 patients pathologically diagnosed with grade II glioma was retrospectively studied. The radiomics method developed in this paper includes image segmentation, high-throughput feature extraction, radiomics sequencing, feature selection and classification. Using the leave-one-out cross-validation (LOOCV) method, the classification result was compared with the real IDH1 situation from Sanger sequencing. Another independent validation cohort containing 30 patients was utilised to further test the method. RESULTS:A total of 671 high-throughput features were extracted and quantized. 110 features were selected by improved genetic algorithm. In LOOCV, the noninvasive IDH1 status estimation based on the proposed approach presented an estimation accuracy of 0.80, sensitivity of 0.83 and specificity of 0.74. Area under the receiver operating characteristic curve reached 0.86. Further validation on the independent cohort of 30 patients produced similar results. CONCLUSIONS:Radiomics is a potentially useful approach for estimating IDH1 mutation status noninvasively using conventional T2-FLAIR MRI images. The estimation accuracy could potentially be improved by using multiple imaging modalities. KEY POINTS:• Noninvasive IDH1 status estimation can be obtained with a radiomics approach. • Automatic and quantitative processes were established for noninvasive biomarker estimation. • High-throughput MRI features are highly correlated to IDH1 states. • Area under the ROC curve of the proposed estimation method reached 0.86.
journal_name
Eur Radioljournal_title
European radiologyauthors
Yu J,Shi Z,Lian Y,Li Z,Liu T,Gao Y,Wang Y,Chen L,Mao Ydoi
10.1007/s00330-016-4653-3subject
Has Abstractpub_date
2017-08-01 00:00:00pages
3509-3522issue
8eissn
0938-7994issn
1432-1084pii
10.1007/s00330-016-4653-3journal_volume
27pub_type
杂志文章abstract::We describe a new dedicated ultrasound system for computer-guided large core breast biopsy (LCBB) and report our first clinical experience in 45 female patients. After an initial 30 biopsy procedures on a US breast phantom, LCBB using this new system was performed in 45 non-palpable surgically verified breast lesions....
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300101010
更新日期:2001-01-01 00:00:00
abstract::Our purpose was to assess the effect of computer-aided detection (CAD) on lesion detection as a second reader in computed tomographic colonography, and to compare the influence of CAD on the performance of readers with different levels of expertise. Fifty-two CT colonography patient data-sets (37 patients: 55 endoscop...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-007-0608-z
更新日期:2007-10-01 00:00:00
abstract::Multidetector computed tomography (CT) plays an important role in the detection, risk stratification and prognosis evaluation of acute pulmonary embolism. This review will discuss the technical improvements for imaging peripheral pulmonary arteries, the methods of assessing pulmonary embolism severity based on CT find...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-015-3679-2
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:Complications following colorectal cancer resection are common. The degree of aortic calcification (AC) on CT has been proposed as a predictor of complications, particularly anastomotic leak. This study assessed the relationship between AC and complications in patients undergoing colorectal cancer resection....
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07189-7
更新日期:2020-11-17 00:00:00
abstract:PURPOSE:Cortical biopsy is the cornerstone to reveal a cause of unexplained dysfunction of the kidney transplant. Nevertheless, only a few studies have reported the biopsy technique with its performance. We described a novel technique of ultrasound (US)-guided kidney transplant biopsy using cortex-only view and analyze...
journal_title:European radiology
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doi:10.1007/s00330-018-5910-4
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:To evaluate a whole body (WB) continuous-table-movement (CTM) MR protocol for the assessment of multiple myeloma (MM) in comparison to a step-by-step WB protocol. METHODS:Eighteen patients with MM were examined at 1.5T using a WB CTM protocol (axial T2-w fs BLADE, T1-w GRE sequence) and a step-by-step WB pr...
journal_title:European radiology
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doi:10.1007/s00330-010-1865-9
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVES:To investigate the clinical and chest CT characteristics of COVID-19 pneumonia and explore the radiological differences between COVID-19 and influenza. MATERIALS AND METHODS:A total of 122 patients (61 men and 61 women, 48 ± 15 years) confirmed with COVID-19 and 48 patients (23 men and 25 women, 47 ± 19 yea...
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abstract:OBJECTIVE:To investigate the prognostic significance of T1 mapping using T1 long and short in hypertrophic cardiomyopathy (HCM) patients. METHODS:A total of 263 consecutive patients with HCM referred for cardiovascular magnetic resonance (CMR) imaging were enrolled in this study. The imaging protocol consisted of cine...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07650-7
更新日期:2021-01-15 00:00:00
abstract:INTRODUCTION:The aim of the study was to extract anthropometric measures from CT by deep learning and to evaluate their prognostic value in patients with non-small-cell lung cancer (NSCLC). METHODS:A convolutional neural network was trained to perform automatic segmentation of subcutaneous adipose tissue (SAT), viscer...
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journal_title:European radiology
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更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The prognosis of patients with non-small cell lung cancer (NSCLC) is important, as patients with resectable disease and poor prognostic variables might benefit from neoadjuvant therapy. The goal of this study is to evaluate SUVmax, SUVmax ratio, CT volume (CTvol), metabolic tumour volume (MTV) and total lesi...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3754-8
更新日期:2015-11-01 00:00:00
abstract::To assess the practical feasibility and effectiveness of real-time magnetic resonance (MR) temperature monitoring for the radiofrequency (RF) ablation of liver tumours in a clinical setting, nine patients (aged 49-87 years, five men and four women) with one malignant tumour (14-50 mm, eight hepatocellular carcinomas a...
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doi:10.1007/s00330-009-1532-1
更新日期:2010-01-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2244-x
更新日期:2012-01-01 00:00:00
abstract::Varicocele can be very easily diagnosed by physical examination and subsequently treated when it is painful or associated with testicular hypotrophy. However, palpability of the spermatic vein and reflux in low grade or even questionable varicoceles can be difficult to assess without imaging modalities. This can be a ...
journal_title:European radiology
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
abstract::A retrospective evaluation of the imaging of 13 patients with a diagnosis of osteoid osteoma (OO) of the spine was undertaken. Available imaging included radiographs (n=10), computed tomography (CT) (n=13), bone scintigraphy (n=5) and magnetic resonance imaging (MRI) (n=13). MRI features evaluated were pattern of neur...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2816-8
更新日期:2005-12-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3293-8
更新日期:2014-10-01 00:00:00
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doi:10.1007/s00330-014-3186-x
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doi:10.1007/s00330-012-2754-1
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doi:10.1007/s003300050796
更新日期:1999-01-01 00:00:00
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journal_title:European radiology
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更新日期:2019-10-01 00:00:00
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更新日期:2018-10-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2240-1
更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00330-018-5363-9
更新日期:2018-10-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
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abstract::Positron emission tomography (PET) is a powerful molecular imaging technique for the human body-imaging applications currently available. As altered glucose metabolism is characteristic for many malignancies, FDG-PET is mostly used in oncology for staging and therapy control. Although PET is a sensitive tool for detec...
journal_title:European radiology
pub_type: 杂志文章,评审
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abstract::The aim of this study was to analyze the precision of tibial cartilage morphometry, by using a fast, coronal water-excitation sequence with high spatial resolution, to compare the reproducibility of 3D thickness vs volume estimates, and to test the technique in patients with severe osteoarthritis. The tibiae of 8 heal...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050047
更新日期:2000-01-01 00:00:00