当前位置： SCI文献检索 > AMERICAN JOURNAL OF OPHTHALMOLOGY期刊下所有文献 > Trabecular bypass stents decrease intraocular pressure in cultured human anterior segments.

Trabecular bypass stents decrease intraocular pressure in cultured human anterior segments.

Abstract：

PURPOSE:To determine the effect on intraocular pressure (IOP) of bypassing the trabecular meshwork in cultured human anterior segments. DESIGN:Prospective laboratory investigation using normal human eyes obtained at autopsy. METHODS:Anterior segments from 21 eyes were placed in perfusion culture, and trabecular bypass stents were inserted through the trabecular meshwork, with the lumen of the tube opening into Schlemm's canal. Eyes received from one to four stents, placed equidistant apart. In eyes receiving one or two stents, additional stents were later added to a maximum of four per eye. RESULTS:Intraocular pressure was lowered after placement of a single stent, from 21.4 +/- 3.8 mm Hg to 12.4 +/- 4.2 (P < .001). This corresponded to an 84% increase in facility of outflow. Eyes receiving more than one stent had final IOP of 11.9 +/- 3.7 mm Hg. Nine eyes had sequential addition of stents, and seven of these had a further decrease of IOP (13.6 +/- 4.1 to 10.0 +/- 4.3; P = .02). Excision of the entire meshwork, between stents, dropped IOP to 6.3 +/- 3.2 mm Hg, indicating some residual meshwork or canal resistance remained even after placement of three stents. CONCLUSIONS:Bypass of the trabecular meshwork lowers IOP in cultured human anterior segments. One stent produced the greatest change in pressure. The sequential addition of more stents further lowered pressure in seven of nine eyes. This technique holds promise as a new clinical surgery for glaucoma.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Bahler CK,Smedley GT,Zhou J,Johnson DH

doi

10.1016/j.ajo.2004.07.035

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

988-94

issue

6

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(04)00923-7

journal_volume

138

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF OPHTHALMOLOGY文献大全
  • Polymorphisms in Complement Factor H and Hemicentin-1 genes in a Japanese population with dry-type age-related macular degeneration.

    abstract：PURPOSE:To determine whether polymorphisms in the Complement Factor H (CFH) gene and the Hemicentin-1 gene at the ARMD1 locus are associated with dry age-related macular degeneration (AMD) in Japanese patients. DESIGN:Clinically relevant laboratory investigation. METHODS:Eighty unrelated Japanese patients with dry AM...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2006.07.030

    authors： Fuse N,Miyazawa A,Mengkegale M,Yoshida M,Wakusawa R,Abe T,Tamai M

    更新日期：2006-12-01 00:00:00

  • Corneal biopsy in the diagnosis of keratomycosis.

    abstract：:In two patients, a 55-year-old man and a 49-year-old man, who had fungal keratitis initially undiagnosed by corneal scrapings the condition was successfully diagnosed by corneal biopsy. We compared corneal biopsy specimens and corneal scraping in the diagnosis of keratomycosis in rabbits with experimental bilateral fu...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(86)90821-4

    authors： Ishibashi Y,Kaufman HE

    更新日期：1986-03-15 00:00:00

  • Central serous chorioretinopathy associated with administration of sympathomimetic agents.

    abstract：PURPOSE:To report central serous chorioretinopathy associated with excessive use of compounds with sympathomimetic activity. DESIGN:Observational case series. METHODS:Four patients presented with clinical and fluorescein angiographic evidence of central serous chorioretinopathy. All patients expressed a concomitant p...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(03)00076-x

    authors： Michael JC,Pak J,Pulido J,de Venecia G

    更新日期：2003-07-01 00:00:00

  • Mutations in the pre-mRNA splicing gene, PRPF31, in Japanese families with autosomal dominant retinitis pigmentosa.

    abstract：PURPOSE:To describe the clinical and genetic characteristics of three Japanese families with autosomal dominant retinitis pigmentosa (ADRP) associated with mutations in the PRPF31 gene. DESIGN:Case reports and results of DNA analysis. METHODS:Mutational screening of the PRPF31 gene was performed on 96 unrelated patie...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2005.02.050

    authors： Sato H,Wada Y,Itabashi T,Nakamura M,Kawamura M,Tamai M

    更新日期：2005-09-01 00:00:00

  • Immune responses in age-related macular degeneration and a possible long-term therapeutic strategy for prevention.

    abstract：PURPOSE:To describe the immune alterations associated with age-related macular degeneration (AMD); and, based on these findings, to offer an approach to possibly prevent the expression of late disease. DESIGN:Perspective. METHODS:Review of the existing literature dealing with epidemiology, models, and immunologic fin...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ajo.2014.03.014

    authors： Nussenblatt RB,Lee RW,Chew E,Wei L,Liu B,Sen HN,Dick AD,Ferris FL

    更新日期：2014-07-01 00:00:00

  • Complications of primary placement of motility post in porous polyethylene implants during enucleation.

    abstract：PURPOSE:To evaluate the complications associated with the primary placement of a motility coupling post (MCP) in spherical porous polyethylene (PP) implants at the time of enucleation. DESIGN:Retrospective, interventional case series. METHODS:The records of all patients who had undergone primary enucleation and spher...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2007.01.049

    authors： Yazici B,Akova B,Sanli O

    更新日期：2007-05-01 00:00:00

  • Deoxyribonucleic acid ploidy studies in choroidal melanomas.

    abstract：:In several tumors of different organ sites, the amount of DNA in a cell (ploidy) is associated with malignancy. We performed DNA quantitation in 21 choroidal melanomas and compared flow cytometry with image analysis in 11 of these melanomas. We modified our preparation technique to overcome problems with pigment and c...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)73592-5

    authors： Coleman K,Baak JP,Dorman A,Mullaney J,Curran B,Tiernan D,Farrell M,Fenton M,Leader M

    更新日期：1993-03-15 00:00:00

  • Association between the efficacy of photodynamic therapy and indocyanine green angiography findings for central serous chorioretinopathy.

    abstract：PURPOSE:To determine the efficacy of photodynamic therapy (PDT) and indocyanine green angiography (ICGA) findings for treating chronic central serous chorioretinopathy (CSC). DESIGN:Observational case series. METHODS:Thirty-two eyes of 27 patients with chronic CSC and symptoms for at least 6 months were recruited. Th...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2009.10.011

    authors： Inoue R,Sawa M,Tsujikawa M,Gomi F

    更新日期：2010-03-01 00:00:00

  • Correlation between intraocular pressure control and progressive glaucomatous damage in primary open-angle glaucoma.

    abstract：:Fifty-five patients with primary open-angle glaucoma and early glaucomatous damage who had medical therapy and laser trabeculoplasty were followed up for four to 11 years or until progressive glaucomatous damage was documented. Factors associated with the stability or progression of glaucoma were evaluated. Eyes with ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)76896-5

    authors： Mao LK,Stewart WC,Shields MB

    更新日期：1991-01-15 00:00:00

  • Vaccinia keratouveitis manifesting as a masquerade syndrome.

    abstract：:A patient who used contact lenses and had a history of blunt trauma developed vaccinia keratouveitis after accidental ocular autoinoculation from a recent vaccination site. Corneal and conjunctival cultures were taken for bacteria, fungi, Acanthamoeba, and viruses. Viral-like cytopathic effects became evident in tissu...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)70008-x

    authors： Lee SF,Buller R,Chansue E,Hanika WC,Brunt EM,Aquino T,Storch GA,Pepose JS

    更新日期：1994-04-15 00:00:00

  • Secretory component in human ocular tissues.

    abstract：:Lacrimal tissue and accessory lacrimal tissue from seven autopsy cases, lacrimal tissue from three patients undergoing orbital exploration, and biopsy specimens from conjunctiva of 14 subjects were examined for the presence and distribution of secretory component by three anti-secretory-component antisera. Secretory c...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(80)90004-5

    authors： Allansmith MR,Gillette TE

    更新日期：1980-03-01 00:00:00

  • Sarcoidosis-related Uveitis: Clinical Presentation, Disease Course, and Rates of Systemic Disease Progression After Uveitis Diagnosis.

    abstract：OBJECTIVE:To document the clinical presentation, treatment, and visual outcome of sarcoid uveitis and to determine the timing and potential risk factors of sarcoidosis progression to symptomatic systemic disease from the time of sarcoid uveitis diagnosis. DESIGN:Retrospective, interventional case series. METHODS:Subj...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2018.09.013

    authors： Ma SP,Rogers SL,Hall AJ,Hodgson L,Brennan J,Stawell RJ,Lim LL

    更新日期：2019-02-01 00:00:00

  • Lens capsule and epithelium in age-related cataract.

    abstract：:On the basis of preoperative assessment of patient characteristics, intraoperative obtainment of a lens-capsule and epithelium specimen, histopathologic investigation of lens capsule and epithelium, and biochemical analysis of glutathione reductase in lens epithelium, age-related cataract was studied in 50 adult patie...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)76729-7

    authors： Straatsma BR,Lightfoot DO,Barke RM,Horwitz J

    更新日期：1991-09-15 00:00:00

  • Contralateral trochlear nerve paresis and ipsilateral Horner's syndrome.

    abstract：:Two patients had paresis of the trochlear nerve contralateral to the site of lesions in the brainstem. Both patients had ipsilateral blepharoptosis and miosis suggesting oculosympathetic paresis from involvement of the descending sympathetic tract, adjacent to the fourth cranial nerve nucleus and its fascicles, in the...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(89)90818-0

    authors： Guy J,Day AL,Mickle JP,Schatz NJ

    更新日期：1989-01-15 00:00:00

  • Lack of evidence for protein AA reactivity in amyloid deposits of lattice corneal dystrophy and amyloid corneal degeneration.

    abstract：:Amyloid fibrils occurring in primary and myeloma-associated (AL), secondary (AA), and certain neuropathic hereditary forms of systemic amyloidosis can be distinguished biochemically or immunohistologically as being composed of immunoglobulin light chain, protein AA, or prealbumin respectively. All types of systemic an...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(87)90357-6

    authors： Gorevic PD,Rodrigues MM,Krachmer JH,Green C,Fujihara S,Glenner GG

    更新日期：1984-08-15 00:00:00

  • Retinal Ganglion Cell Layer Change in Patients Treated With Anti-Vascular Endothelial Growth Factor for Neovascular Age-related Macular Degeneration.

    abstract：PURPOSE:To evaluate macular retinal ganglion cell thickness in patients with neovascular age-related macular degeneration (AMD) and intravitreal anti-vascular endothelial growth factor (VEGF) therapy. DESIGN:Retrospective case series with fellow-eye comparison. METHODS:Patients with continuous unilateral anti-VEGF tr...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2016.04.003

    authors： Beck M,Munk MR,Ebneter A,Wolf S,Zinkernagel MS

    更新日期：2016-07-01 00:00:00

  • Gonioscopic differences between primary open-angle glaucoma and normal subjects over 40 years of age.

    abstract：:Gonioscopy was performed on 110 patients with primary open-angle glaucoma over 40 years of age and an equal number of normal sugjects, matched by race and age. The frequency distribution of various angle features differed in the two groups: in the glaucoma group, there were more iris processes at all levels of inserti...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(75)90869-7

    authors： Kimura R,Levene RZ

    更新日期：1975-07-01 00:00:00

  • Topiramate use and the risk of glaucoma development: a population-based follow-up study.

    abstract：PURPOSE:To investigate the risk of glaucoma development after being prescribed topiramate. DESIGN:A retrospective, population-based cohort study using an administrative database. METHODS:The study group comprised 1956 patients who received their first prescription of topiramate between 2001 and 2007. The comparison c...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2012.07.016

    authors： Ho JD,Keller JJ,Tsai CY,Liou SW,Chang CJ,Lin HC

    更新日期：2013-02-01 00:00:00

  • Changes in contrast sensitivity after surgery for macula-on rhegmatogenous retinal detachment.

    abstract：PURPOSE:To evaluate changes in contrast sensitivity after surgery for macula-on rhegmatogenous retinal detachment (RRD). DESIGN:Prospective, interventional, consecutive, case-control study. METHODS:This study included 84 eyes of 84 patients with unilateral macula-on RRD undergoing primary scleral buckling or vitrecto...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2013.05.017

    authors： Okamoto F,Sugiura Y,Okamoto Y,Hiraoka T,Oshika T

    更新日期：2013-10-01 00:00:00

  • Optic disk size correlated with refractive error.

    abstract：PURPOSE:To evaluate for which range of refractive error the optic disk size depends on, or is independent of, the refractive error. DESIGN:Clinical observational study. METHODS:The study included 1999 eyes of 1011 subjects with a mean refractive error of -0.97 +/- 2.72 diopters (range, -24.25 to +9.4 diopters). Optic...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2004.07.047

    authors： Jonas JB

    更新日期：2005-02-01 00:00:00

  • Expression of a mucin-like glycoprotein produced by ocular surface epithelium in normal and keratinized cells.

    abstract：PURPOSE:We previously characterized a monoclonal antibody (H185) to a mucin-like glycoprotein produced by human ocular surface epithelium. In the current study, we used H185 to investigate the pattern of the mucin-like glycoprotein in normal and keratinized apical cells of the ocular surface epithelium. METHODS:We com...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)71691-5

    authors： Watanabe H,Maeda N,Kiritoshi A,Hamano T,Shimomura Y,Tano Y

    更新日期：1997-12-01 00:00:00

  • Evolution of retinal detachment in posterior retinopathy of prematurity: impact on treatment approach.

    abstract：PURPOSE:To provide insight into the course of retinal detachment in eyes with aggressive posterior retinopathy of prematurity (APROP). DESIGN:Prospective, multicenter, masked clinical trial. METHODS:Multicenter trial based on serial digital photographic imaging detailing five infants (in the Photographic Screening fo...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ajo.2007.10.027

    authors： Vinekar A,Trese MT,Capone A Jr,Photographic Screening for Retinopathy of Prematurity (PHOTO-ROP) Cooperative Group.

    更新日期：2008-03-01 00:00:00

  • Pediatric Corneal Cross-linking: Comparison of Visual and Topographic Outcomes Between Conventional and Accelerated Treatment.

    abstract：PURPOSE:To compare visual and topographic outcomes 1 year after conventional (C-CXL) vs accelerated corneal cross-linking (A-CXL) in pediatric keratoconus (KC). DESIGN:Comparative, retrospective, consecutive case series. METHODS:Patients with topography-confirmed, progressive KC and a corneal thickness of ≥400 μm at ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2017.08.015

    authors： Baenninger PB,Bachmann LM,Wienecke L,Thiel MA,Kaufmann C

    更新日期：2017-11-01 00:00:00

  • The incidence of Graves' ophthalmopathy in Olmsted County, Minnesota.

    abstract：PURPOSE:To determine the incidence of Graves' ophthalmopathy. METHODS:A population-based cohort of all Olmsted County, Minnesota, residents who had ophthalmopathy associated with autoimmune thyroid disease between Jan. 1, 1976, and Dec. 31, 1990, was identified through the medical diagnostic index of the Mayo Clinic a...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)72666-2

    authors： Bartley GB,Fatourechi V,Kadrmas EF,Jacobsen SJ,Ilstrup DM,Garrity JA,Gorman CA

    更新日期：1995-10-01 00:00:00

  • Graft edema after suture removal.

    abstract：:Graft edema developed after removal of continuous monofilament sutures in six eyes of six patients in whom no wound dehiscence occurred. All sutures were removed at least one year after penetrating keratoplasty, and graft edema was noted one day after suture removal. In all cases, partial or total resolution of graft ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(79)90461-6

    authors： Goldberg DB,Schanzlin DJ,Mondino BJ,Brown SI

    更新日期：1979-08-01 00:00:00

  • A specific enzyme defect in gyrate atrophy.

    abstract：:To establish the enzyme defect in gyrate atrophy, we measured the activity of ornithine aminotransferase in phytohemagglutinin stimulated lymphocytes in a patient with gyrate atrophy, her daughter, and three normal controls. The patient's cells had no detectable ornithine aminotransferase activity and the daughter's c...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)75948-3

    authors： Kaiser-Kupfer MI,Valle D,Del Valle LA

    更新日期：1978-02-01 00:00:00

  • Biochmical aspects of contact lens wear.

    abstract：:Glycogen, adenosine triphosphate, and hydration were measured in rabbit corneal epithelium to determine whether the corneal epithelium glycogen decrease, increase in epithelial hydration, and decrease in epithelial adenosine triphosphate stores, seen as a result of contact lens wear, were secondary only to anoxia or m...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(75)90884-3

    authors： Thoft RA,Friend J

    更新日期：1975-07-01 00:00:00

  • Facial necrotizing fasciitis following acute dacryocystitis.

    abstract：PURPOSE:To report a case of progressive necrotizing fasciitis of the face following acute dacryocystitis. DESIGN:Interventional case report. METHODS:A 60-year-old woman presented with left acute dacryocystitis with abscess formation that had ruptured; a small wound remained. Erythematous swelling of the left eyelid a...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(03)00089-8

    authors： Lin PW,Lin HC

    更新日期：2003-07-01 00:00:00

  • Acute closed-angle glaucoma after arteriovenous fistulas.

    abstract：:Unilateral secondary acute closed-angle glaucoma was associated with a ciliochoroidal detachment in two patients. One patient, aged 17 years, had an orbital arteriovenous fistula. The other patient, aged 73 years, had a dural arteriovenous fistula that originated from branches of the right internal maxillary artery. I...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(89)90215-8

    authors： Fourman S

    更新日期：1989-02-15 00:00:00

  • Corneal injury from explosion of microwaved eggs.

    abstract：PURPOSE:To report two patients with ocular burns from explosion of microwaved eggs that caused direct vision-threatening corneal damage. METHODS:The initial examination and treatment of both patients are described. RESULTS:Both patients were initially examined with severe decrease in the visual acuity of both eyes. T...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(99)80153-6

    authors： Yoo RT,Rivera PM,Campbell JP,Butrus SI

    更新日期：1998-03-01 00:00:00