Abstract:
BACKGROUND:The use of biopesticides in agriculture may implicate new risks of work-related allergic reactions. METHODS:Sera were tested from the BIOGART project, a longitudinal respiratory health study among >300 Danish greenhouse workers. IgE was measured by enzyme immunoassay (EIA) with extracts of biopesticide products containing Bacillus thuringiensis (BT) or Verticillium lecanii (Vert). RESULTS:Many sera had detectable IgE to BT (23-29%) or Vert (9-21%). IgE titers from the 2- and 3-year follow-up (n=230) were highly correlated, with discordant results in <15%. IgE titers to different BT, or to different Verticillium products were also significantly correlated (both r >0.70), whereas IgE anti-BT and anti-Verticillium showed no correlation at all. CONCLUSIONS:Exposure to these microbial biopesticides may confer a risk of IgE-mediated sensitization. In future research there is a need to identify allergenic components in the preparations, perform studies on non-exposed controls and analyze the relation between sensitization and health parameters.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Doekes G,Larsen P,Sigsgaard T,Baelum Jdoi
10.1002/ajim.20086subject
Has Abstractpub_date
2004-10-01 00:00:00pages
404-7issue
4eissn
0271-3586issn
1097-0274journal_volume
46pub_type
杂志文章abstract::Conventional occupational mortality analysis, using underlying cause of death coding, underestimates the contribution of those chronic diseases which are mentioned on the death certificate but which usually do not appear as underlying cause of death. Proportionate occupational mortality analysis, using all the mention...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700140311
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
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journal_title:American journal of industrial medicine
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更新日期:2013-04-01 00:00:00
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journal_title:American journal of industrial medicine
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doi:
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pub_type: 杂志文章,多中心研究
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