IgE sensitization to bacterial and fungal biopesticides in a cohort of Danish greenhouse workers: the BIOGART study.

Abstract:

BACKGROUND:The use of biopesticides in agriculture may implicate new risks of work-related allergic reactions. METHODS:Sera were tested from the BIOGART project, a longitudinal respiratory health study among >300 Danish greenhouse workers. IgE was measured by enzyme immunoassay (EIA) with extracts of biopesticide products containing Bacillus thuringiensis (BT) or Verticillium lecanii (Vert). RESULTS:Many sera had detectable IgE to BT (23-29%) or Vert (9-21%). IgE titers from the 2- and 3-year follow-up (n=230) were highly correlated, with discordant results in <15%. IgE titers to different BT, or to different Verticillium products were also significantly correlated (both r >0.70), whereas IgE anti-BT and anti-Verticillium showed no correlation at all. CONCLUSIONS:Exposure to these microbial biopesticides may confer a risk of IgE-mediated sensitization. In future research there is a need to identify allergenic components in the preparations, perform studies on non-exposed controls and analyze the relation between sensitization and health parameters.

journal_name

Am J Ind Med

authors

Doekes G,Larsen P,Sigsgaard T,Baelum J

doi

10.1002/ajim.20086

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

404-7

issue

4

eissn

0271-3586

issn

1097-0274

journal_volume

46

pub_type

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