Biological monitoring of a worker acutely exposed to MBOCA.

Abstract:

:A 30 year-old male polyurethane worker was exposed to an accidental spill of 4,4'-methylene-bis-2-chloroaniline (MBOCA) at a plant producing MBOCA-cured plastic products. Exposure to MBOCA is significant in that this compound is a known animal carcinogen and a suspected human carcinogen. The employee was sprayed over his upper body and extremities with molten MBOCA while cleaning out a clogged hose from a MBOCA and polymer mixing machine. The subsequent environmental and medical evaluation of this episode included serial urinary MBOCA samples from the worker over a 2 week period to allow the calculation of a biological half-life for this compound. This worker experienced a very high dose of MBOCA as judged by his urinary MBOCA levels (peak value of 1,700 ppb 4 hours after exposure). There were no acute symptoms or other laboratory abnormalities noted. The kinetic evaluation resulted in a biological half-life for MBOCA in urine of approximately 23 hours. Assuming a one-compartment model, approximately 94% of an initial MBOCA dose will be eliminated within four days. This is the first report of kinetic analysis on urinary MBOCA excretion in humans. This information suggests that biological monitoring of the urine MBOCA concentrations in exposed workers may miss peak levels following an acute exposure unless the analyses of the urinary MBOCA are performed in a timely fashion. Recommendations to the company included: 1) installation of a warning system or lock-out device on the mixing machine to prevent the opening of the MBOCA hose prior to the release of pressure; and 2) annual medical surveillance of this individual for bladder cancer with urinalysis and urine cytology.

journal_name

Am J Ind Med

authors

Osorio AM,Clapp D,Ward E,Wilson HK,Cocker J

doi

10.1002/ajim.4700180508

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

577-89

issue

5

eissn

0271-3586

issn

1097-0274

journal_volume

18

pub_type

杂志文章
  • Subclinical neurophysiological effects of lead: A review on peripheral, central, and autonomic nervous system effects in lead workers.

    abstract:BACKGROUND:The peripheral nerve conduction velocity (NCV), distribution of nerve conduction velocities (DCV), somatosensory, visual, and brainstem auditory evoked potentials (SEP, VEP, and BAEP, respectively), event-related potential (P300), computerized static posturography with spectral analysis (postural balance), a...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-0274(200002)37:2<193::aid-ajim5

    authors: Araki S,Sato H,Yokoyama K,Murata K

    更新日期:2000-02-01 00:00:00

  • Projections of leukemia risk associated with occupational exposure to benzene.

    abstract::In 1982, White et al published an assessment of quantitative leukemia risk associated with lifetime occupational exposure to benzene. At about the same time, IARC (1982) published estimates of quantitative cancer risk associated with industrial chemicals. Benzene was one of the two chemicals selected by IARC for its r...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,评审

    doi:10.1002/ajim.4700070507

    authors: Infante PF,White MC

    更新日期:1985-01-01 00:00:00

  • Respiratory symptoms associated with the use of azodicarbonamide foaming agent in a plastics injection molding facility.

    abstract::Respiratory health variables were studied cross-sectionally in 227 employees of a plastics molding facility where numerous complaints had been apparently associated with the use of azodicarbonamide foaming agent in injection molding. Pre- and postshift respiratory status measures and azodicarbonamide concentrations we...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700110109

    authors: Whitehead LW,Robins TG,Fine LJ,Hansen DJ

    更新日期:1987-01-01 00:00:00

  • Toxic health effects including reversible macrothrombocytosis in workers exposed to asphalt fumes.

    abstract::We investigated an outbreak of irritative and neurotoxic symptoms associated with exposure to asphalt fumes in a commercial lighting factory; 27 symptomatic female workers were clinically assessed including hematologic testing. When compared with a laboratory reference group (n = 107), the workers' mean platelet volum...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700250214

    authors: Chase RM,Liss GM,Cole DC,Heath B

    更新日期:1994-02-01 00:00:00

  • Potential years of life lost (PYLL) caused by asbestos-related diseases in the world.

    abstract:BACKGROUND:We applied the well-established, but rather under-utilized, indicator of Potential Years of Life Lost (PYLL) to estimate the global burden of mesothelioma and asbestosis. METHODS:We analyzed all deaths caused by mesothelioma and asbestosis that were reported by 82 and 55 countries, respectively, to the Worl...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22206

    authors: Diandini R,Takahashi K,Park EK,Jiang Y,Movahed M,Le GV,Lee LJ,Delgermaa V,Kim R

    更新日期:2013-09-01 00:00:00

  • Comparison of fatal and severe nonfatal traumatic work-related injuries in Washington state.

    abstract:OBJECTIVE:To compare fatal and hospitalized nonfatal work-related traumatic injuries by occupation and cause. METHODS:Fatal and hospitalized nonfatal injuries occurring from 1991-1995 were identified from Washington State workers' compensation claims data. Nonfatal injuries were classified as severe if they had at lea...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0274(199908)36:2<317::aid-ajim1

    authors: Alexander BH,Franklin GM,Fulton-Kehoe D

    更新日期:1999-08-01 00:00:00

  • A cohort mortality study of construction workers.

    abstract::This report presents a mortality study among the 17,344 members of the Construction Workers' Health Insurance Society of Mie Prefecture in Japan. The study period was between 1973 and 1993. During this period, 480 members died. Age-specific mortality rates of Mie Prefecture were used as comparison standards. Significa...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0274(199707)32:1<35::aid-ajim5>

    authors: Sun J,Shibata E,Hisanaga N,Kamijima M,Ichihara G,Huang J,Toida M,Takeuchi Y

    更新日期:1997-07-01 00:00:00

  • Application of two secondary documentary sources to identify the underreporting of fatal occupational injuries in Cape Town, South Africa.

    abstract::We reviewed 8,502 deaths registered at the Salt River state mortuary, Cape Town (medical examiner records) for an 18-month period (1/1/90-6/30/91). When fatal occupational injuries located from this data source were matched with the records of the occupational safety inspectorate of the Department of Manpower, it was ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700260409

    authors: Lerer LB,Myers JE

    更新日期:1994-10-01 00:00:00

  • Evaluation of toolbox safety training in construction: The impact of narratives.

    abstract:BACKGROUND:Construction is a dangerous industry with a large number of small businesses. Because they require minimal resources to deliver, toolbox talks may be an ideal training format for small construction contractors. METHODS:Eight toolbox talks were developed, each with two versions. One version of each toolbox t...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ajim.22919

    authors: Eggerth DE,Keller BM,Cunningham TR,Flynn MA

    更新日期:2018-12-01 00:00:00

  • Utility of a routine medical surveillance program with benzene exposed workers.

    abstract:BACKGROUND:A medical surveillance program of benzene-exposed workers has to be established in such a way as to observe early signs of benzene-induced cytopenia, pancytopenia, or leukemia. This study evaluates the utility of routine medical survey applied to benzene-exposed workers by analyzing the hematological, immuno...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.10296

    authors: Bogadi-Sare A,Zavalić M,Turk R

    更新日期:2003-11-01 00:00:00

  • Occupation-level automation probability is associated with psychosocial work conditions and workers' health: A multilevel study.

    abstract:OBJECTIVE:Work automation is increasing worldwide, and the probability of job automation has been associated with workers' adverse health outcomes. This study aimed to examine the association of occupation-level automation probability with work stress and workers' health. METHODS:We used data from a national survey of...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.23210

    authors: Cheng WJ,Pien LC,Cheng Y

    更新日期:2021-02-01 00:00:00

  • Mortality study of British pathologists.

    abstract::Pathologists eligible for inclusion in the study were identified from the membership lists of the Royal College of Pathologists from 1974 to 1987, establishing a population of 4,512 members. Overall mortality was lower among the study group compared with the general population of England and Wales, although there were...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700200108

    authors: Hall A,Harrington JM,Aw TC

    更新日期:1991-01-01 00:00:00

  • Occupational laryngitis caused by formaldehyde: a case report.

    abstract::Formaldehyde is commonly accepted to be an allergen and irritant. However, specifically diagnosed occupational respiratory diseases caused by formaldehyde are relatively rare. Occupational laryngitis was diagnosed in a 47-year-old dairy foreman. He had been exposed for 9 years to formaldehyde emitted from a milk-packi...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,评审

    doi:10.1002/(SICI)1097-0274(199603)29:3<275::AID-AJIM7

    authors: Roto P,Sala E

    更新日期:1996-03-01 00:00:00

  • Smoking as a confounder in case-control studies of occupational bladder cancer in women.

    abstract:BACKGROUND:In studies in men, risk estimates on occupation and bladder cancer are distorted by about 10% when not adjusting for smoking. We examined the degree to which occupational risk estimates for bladder cancer in women are confounded by smoking, and the degree of residual confounding by inadequate control of this...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,meta分析

    doi:10.1002/(sici)1097-0274(199907)36:1<75::aid-ajim11

    authors: 't Mannetje A,Kogevinas M,Chang-Claude J,Cordier S,González CA,Hours M,Jöckel KH,Bolm-Audorff U,Lynge E,Porru S,Donato F,Ranft U,Serra C,Tzonou A,Vineis P,Wahrendorf J,Boffetta P

    更新日期:1999-07-01 00:00:00

  • The economic burden of carpal tunnel syndrome: long-term earnings of CTS claimants in Washington State.

    abstract:BACKGROUND:The long-term earnings losses borne by injured workers, beyond those covered by workers' compensation insurance, are rarely estimated. The post-claim earnings of a cohort of carpal tunnel syndrome (CTS) claimants are tracked over a period of 6 years and compared to the earnings of claimants with either upper...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20430

    authors: Foley M,Silverstein B,Polissar N

    更新日期:2007-03-01 00:00:00

  • Occupational exposures in the oil and gas extraction industry: State of the science and research recommendations.

    abstract::The oil and gas extraction industry is rapidly growing due to horizontal drilling and high volume hydraulic fracturing (HVHF). This growth has provided new jobs and economic stimulus. The industry occupational fatality rate is 2.5 times higher than the construction industry and 7 times higher than general industry; ho...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,评审

    doi:10.1002/ajim.22316

    authors: Witter RZ,Tenney L,Clark S,Newman LS

    更新日期:2014-07-01 00:00:00

  • Occupational allergy and asthma among salt water fish processing workers.

    abstract:BACKGROUND:Fish processing is a common economic activity in Southern Africa. The aim of this study was to determine the prevalence and host determinants of allergic symptoms, allergic sensitization, bronchial hyper-responsiveness and asthma among workers processing saltwater fish. METHODS:A cross-sectional study was c...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20635

    authors: Jeebhay MF,Robins TG,Miller ME,Bateman E,Smuts M,Baatjies R,Lopata AL

    更新日期:2008-12-01 00:00:00

  • "Felony assault should stick:" Assaulted EMS responders' frustration and dissatisfaction with the legal system.

    abstract:INTRODUCTION:The prevalence of violence to first responders is reported in ranges of approximately 40% to 90%. Pennsylvania has a felonious assault statute to address such violence, but the prosecutorial process has been noted to cause first-responder dissatisfaction. METHODS:An exploratory qualitative study using ind...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.23036

    authors: Wright JY,Davis AL,Brandt-Rauf S,Taylor JA

    更新日期:2019-11-01 00:00:00

  • Rheumatoid arthritis in low-level toluene-exposed workers based on nationwide medical surveillance data in Korea.

    abstract:BACKGROUND:There is growing evidence that exposure to organic solvents can play a role in the etiology of rheumatoid arthritis (RA). This prospective cohort study aimed to investigate the association between RA and toluene exposure. METHODS:The study cohort consisted of Korea Occupational Safety and Health Agency data...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.23226

    authors: Min YS,Lee S,Kim M,Ahn YS

    更新日期:2021-01-29 00:00:00

  • Occupational magnetic field exposure and the risk of acoustic neuroma.

    abstract:BACKGROUND:Acoustic neuroma is the intracranial tumor subtype showing the highest relative risk in relation to ionizing radiation but other environmental risk factors are largely unknown. This study was performed to investigate the effect of power frequency magnetic fields. METHOD:A total of 793 cases between 1987 and...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20251

    authors: Forssén UM,Lönn S,Ahlbom A,Savitz DA,Feychting M

    更新日期:2006-02-01 00:00:00

  • The changing patterns of psychosocial exposures at work in the south of Europe: Spain as a labor market laboratory.

    abstract:AIMS:To examine the pattern of psychosocial risk exposures at work among wage-earners in Spain in 2005 and 2010, and to analyze changes in exposure inequalities by gender and job category. METHODS:Psychosocial exposures were compared using the COPSOQ-ISTAS21 method, based on two surveys representative of the Spanish w...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22334

    authors: Utzet M,Moncada S,Molinero E,Llorens C,Moreno N,Navarro A

    更新日期:2014-09-01 00:00:00

  • Post-offer, pre-placement testing in industry.

    abstract:BACKGROUND:Pre-placement testing was implemented during World War II. Its current use has been reshaped by economic factors, litigation, legislation, and advances in medicine. In response to a request from a local industry intent upon lowering their work-related injuries, a post-offer screening program was developed an...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20150

    authors: Harbin G,Olson J

    更新日期:2005-04-01 00:00:00

  • Cancer incidence in the United Farmworkers of America (UFW), 1987-1997.

    abstract:BACKGROUND:The purpose of this study was to evaluate cancer incidence in the membership a largely Hispanic farmworker labor union in California, the United Farmworkers of America (UFW) and to examine cancer-site specific distributions as well as histology and stage of cancer at diagnosis in this group. METHODS:An elec...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.1125

    authors: Mills PK,Kwong S

    更新日期:2001-11-01 00:00:00

  • Global estimates of fatal work-related diseases.

    abstract:BACKGROUND:Work-related mortality is a relatively new concept which aims to widen occupational health and safety; to take into account not only recognized fatal occupational accidents and diseases but also other work-related deaths. Few countries in the world have a register for work-related diseases. METHODS:Estimate...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20411

    authors: Hämäläinen P,Takala J,Saarela KL

    更新日期:2007-01-01 00:00:00

  • Fatal asthma in a baker: a case report.

    abstract::A case of baker's asthma with a fatal outcome is described. Clinical features and the circumstances of death are recounted. While the case documents the potential severity of occupational asthma, it also illustrates the difficulties of managing occupational asthma in the absence of good social security. ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700260608

    authors: Ehrlich RI

    更新日期:1994-12-01 00:00:00

  • Preventing falls in residential construction: Effectiveness of engaging partners for a national social marketing campaign.

    abstract:BACKGROUND:Falls are the leading cause of fatalities in construction. The Safety Pays, Falls Cost campaign aims to prevent falls in residential construction. A critical component of our social marketing approach was to involve 70 partners in reaching target audiences. METHODS:We assessed partner engagement April 2012-...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22458

    authors: Macario E,Hannon SW,Baker R,Branche CM,Trahan C

    更新日期:2015-08-01 00:00:00

  • Mortality in a cohort of antimony smelter workers.

    abstract::Animal studies show that antimony may cause lung cancer and heart and lung disease in rodents. In exposed humans, ECG abnormalities and heart and lung disease have been reported. This mortality study of 1,014 men employed between 1937 and 1971 in a Texas antimony smelter consisted primarily of workers of Spanish ances...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700270510

    authors: Schnorr TM,Steenland K,Thun MJ,Rinsky RA

    更新日期:1995-05-01 00:00:00

  • Mortality among female registered nurses and school teachers in British Columbia.

    abstract::The mortality profile of female nurses and teachers in British Columbia (BC) was examined using age-standardized proportional mortality ratios (PMRs) calculated for the period 1950-1984. Lowered overall mortality among nurses was seen for degenerative heart disease and for cerebrovascular accidents. Significantly elev...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700260111

    authors: King AS,Threlfall WJ,Band PR,Gallagher RP

    更新日期:1994-07-01 00:00:00

  • A model for assessing occupational exposure to extremely low-frequency magnetic fields in fabrication rooms in the Semiconductor Health Study.

    abstract::A model was created to assess occupational exposure to extremely low-frequency magnetic fields (ELF-MF) among semiconductor fabrication-room (fab) workers. This model was based on the assumption that each subject's exposure arose from being near identifiable ELF-MF sources or being in areas with high ELF-MF levels. To...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700280608

    authors: Abdollahzadeh S,Hammond SK,Schenker MB

    更新日期:1995-12-01 00:00:00

  • Characterizing emergency department patients who reported work-related injuries and illnesses.

    abstract:BACKGROUND:Per a Congressional directive and funding, this study describes worker and workplace characteristics of emergency department (ED) patients who reported their injury/illness to their employer. The study also responds to Congress's request to enumerate injured/ill self-employed workers and workers with chronic...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22607

    authors: Bhandari R,Marsh SM,Reichard AA,Tonozzi TR

    更新日期:2016-08-01 00:00:00