当前位置： SCI文献检索 > AMERICAN JOURNAL OF INDUSTRIAL MEDICINE期刊下所有文献 > Diesel exhaust and lung cancer in the trucking industry: exposure-response analyses and risk assessment.

Diesel exhaust and lung cancer in the trucking industry: exposure-response analyses and risk assessment.

Abstract：

BACKGROUND:Diesel exhaust is considered a probable human carcinogen by the International Agency for Research on Cancer (IARC). The epidemiologic evidence rests on studies of lung cancer among truck drivers, bus drivers, shipyard workers, and railroad workers. The general public is exposed to diesel exhaust in ambient air. Two regulatory agencies are now considering regulating levels of diesel exhaust: the California EPA (ambient levels) and the Mine Safety Health Administration (MSHA) (occupational levels). To date, there have been few quantitative exposure-response analyses of diesel and lung cancer based on human data. METHODS:We conducted exposure-response analyses among workers in the trucking industry, adjusted for smoking. Diesel exhaust exposure was estimated based on a 1990 industrial hygiene survey. Past exposures were estimated assuming that they were a function of 1) the number of heavy duty trucks on the road, 2) the particulate emissions (grams/mile) of diesel engines over time, and 3) leaks from trucks' exhaust systems for long-haul drivers. RESULTS:Regardless of assumptions about past exposure, all analyses resulted in significant positive trends in lung cancer risk with increasing cumulative exposure. A male truck driver exposed to 5 micrograms/m3 of elemental carbon (a typical exposure in 1990, approximately five times urban background levels) would have a lifetime excess risk of lung cancer of 1-2% above a background risk of 5%. CONCLUSIONS:We found a lifetime excess risk ten times higher than the 1 per 1,000 excess risk allowed by OSHA in setting regulations. There are about 2.8 million truck drivers in the U.S. Our results depend on estimates about unknown past exposures, and should be viewed as exploratory. They conform reasonably well to recent estimates for diesel-exposed railroad workers done by the California EPA, although those results themselves have been disputed.

journal_name

Am J Ind Med

journal_title

American journal of industrial medicine

authors

Steenland K,Deddens J,Stayner L

doi

10.1002/(sici)1097-0274(199809)34:3<220::aid-ajim3

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

220-8

issue

eissn

0271-3586

issn

1097-0274

pii

10.1002/(SICI)1097-0274(199809)34:3<220::AID-AJIM3

journal_volume

pub_type

杂志文章

在线工具

Diesel exhaust and lung cancer in the trucking industry: exposure-response analyses and risk assessment.