Genetic mapping in the human malaria parasite Plasmodium falciparum.

abstract：:Filamentous hemagglutinin (FHA) is a critically important virulence factor produced by Bordetella species that cause respiratory infections in humans and other animals. It is also a prototypical member of the widespread two partner secretion (TPS) pathway family of proteins. First synthesized as a ~370 kDa protein cal...

journal_title：Molecular microbiology

authors： Nash ZM,Cotter PA

更新日期：2019-09-01 00:00:00

abstract：:Experimental evidence suggests that apicomplexan parasites possess bipartite promoters with basal and regulated cis-elements similar to other eukaryotes. Using a dual luciferase model adapted for recombinational cloning and use in Toxoplasma gondii, we show that genomic regions flanking 16 parasite genes, which encomp...

journal_title：Molecular microbiology

authors： Behnke MS,Radke JB,Smith AT,Sullivan WJ Jr,White MW

更新日期：2008-06-01 00:00:00

abstract：:A 25 kbp DNA fragment from the chromosome of Rhodobacter capsulatus B10 carrying hydrogenase (hup) determinants was completely sequenced. Coding regions corresponding to 20 open reading frames were identified. The R. capsulatus hydrogenase-specific gene (hup and hyp) products bear significant structural identity to hy...

journal_title：Molecular microbiology

authors： Colbeau A,Richaud P,Toussaint B,Caballero FJ,Elster C,Delphin C,Smith RL,Chabert J,Vignais PM

更新日期：1993-04-01 00:00:00

abstract：:Members of the classes Bacilli and Clostridia are able to form endospores, with clostridia representing the ancestral phylogenetic line. In contrast to Bacillus subtilis, the process of sporulation initiation at the molecular level is less well understood in Clostridium acetobutylicum, the model organism of the clostr...

journal_title：Molecular microbiology

authors： Dürre P

更新日期：2011-05-01 00:00:00

abstract：:Natural transformation is a potent driver for genetic diversification in bacterial populations. It involves exogenous DNA binding, uptake, transport and internalization into the cytoplasm, where DNA can be processed and integrated into the host chromosome. Direct visualisation of transforming DNA (tDNA) has been limit...

journal_title：Molecular microbiology

authors： Corbinais C,Mathieu A,Kortulewski T,Radicella JP,Marsin S

更新日期：2016-09-01 00:00:00

abstract：:SpollE is an integral membrane protein that governs the establishment of cell-specific gene transcription during the process of sporulation in Bacillus subtilis. Synthesis of SpollE commences shortly after the onset of sporulation, after which the protein localizes at sites of potential cell division near both ends of...

journal_title：Molecular microbiology

authors： Levin PA,Losick R,Stragier P,Arigoni F

更新日期：1997-09-01 00:00:00

abstract：:Helicobacter pylori is a human gastric pathogen associated with gastric and duodenal ulcers as well as gastric cancer. Mounting evidence suggests this pathogen's motility is prerequisite for successful colonization of human gastric tissues. Here, we isolated an H. pylori G27 HP0518 mutant exhibiting altered motility i...

journal_title：Molecular microbiology

authors： Asakura H,Churin Y,Bauer B,Boettcher JP,Bartfeld S,Hashii N,Kawasaki N,Mollenkopf HJ,Jungblut PR,Brinkmann V,Meyer TF

更新日期：2010-12-01 00:00:00

abstract：:The Gram-positive pathogen Corynebacterium diphtheriae exports through the Sec apparatus many extracellular proteins that include the key virulence factors diphtheria toxin and the adhesive pili. How these proteins attain their native conformations after translocation as unfolded precursors remains elusive. The fact t...

journal_title：Molecular microbiology

authors： Reardon-Robinson ME,Osipiuk J,Jooya N,Chang C,Joachimiak A,Das A,Ton-That H

更新日期：2015-12-01 00:00:00

abstract：:The Escherichia coli regulatory proteins, EnvZ and OmpR, are crucially involved in expression of the outer membrane proteins OmpF/OmpC in response to the medium osmolarity. The EnvZ protein is presumably a membrane-located osmotic sensor (or signal transducer), which exhibits both kinase and phosphatase activities spe...

journal_title：Molecular microbiology

authors： Tokishita S,Mizuno T

更新日期：1994-08-01 00:00:00

abstract：:We have built a homology model of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli based on the crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein. The resulting model of the hexameric ring of the ATP-bound form of the AAA ATPase suggests a plausible mechan...

journal_title：Molecular microbiology

authors： Karata K,Verma CS,Wilkinson AJ,Ogura T

更新日期：2001-02-01 00:00:00

abstract：:The Leishmania major aquaglyceroporin, LmAQP1, is responsible for the transport of antimonite [Sb(III)], an activated form of Pentostam or Glucantime. Downregulation of LmAQP1 provides resistance to trivalent antimony compounds and increased expression of LmAQP1 in drug-resistant parasites can reverse the resistance. ...

journal_title：Molecular microbiology

authors： Uzcategui NL,Zhou Y,Figarella K,Ye J,Mukhopadhyay R,Bhattacharjee H

更新日期：2008-12-01 00:00:00

abstract：:In '5'-translational blockage', significantly reduced yields of proteins are synthesized in Escherichia coli when consecutive low-usage codons are inserted near translation starts of messages (with reduced or no effect when these same codons are inserted downstream). We tested the hypothesis that ribosomes encounterin...

journal_title：Molecular microbiology

authors： Gao W,Tyagi S,Kramer FR,Goldman E

更新日期：1997-08-01 00:00:00

abstract：:The Helicobacter pylori genome contains a gene (hp1338 or nikR) that encodes a nickel-dependent regulator that is homologous to the Escherichia coli nickel-responsive regulator, NikR. The H. pylori nikR product acts as a pleiotropic metal-dependent regulator. We constructed a non-polar isogenic mutant deleted for the ...

journal_title：Molecular microbiology

authors： Contreras M,Thiberge JM,Mandrand-Berthelot MA,Labigne A

更新日期：2003-08-01 00:00:00

abstract：:The archaeal transcription apparatus is chimeric: its core components (RNA polymerase and basal factors) closely resemble those of eukaryotic RNA polymerase II, but the putative archaeal transcriptional regulators are overwhelmingly of bacterial type. Particular interest attaches to how these bacterial-type effectors,...

journal_title：Molecular microbiology

authors： Ouhammouch M,Langham GE,Hausner W,Simpson AJ,El-Sayed NM,Geiduschek EP

更新日期：2005-05-01 00:00:00

abstract：:Only one species of Shigella, Shigella dysenteriae 1, has been demonstrated to produce Shiga toxin (Stx). Stx is closely related to the toxins produced by Shiga toxin-producing Escherichia coli (STEC). In STEC, these toxins are often encoded on lambdoid bacteriophages and are major virulence factors for these organism...

journal_title：Molecular microbiology

authors： McDonough MA,Butterton JR

更新日期：1999-12-01 00:00:00

abstract：:Maturation of c-type cytochromes in Escherichia coli is a complex process requiring eight membrane proteins encoded by the ccmABCDEFGH operon. CcmE is a mediator of haem delivery. It binds haem transiently at a conserved histidine residue and releases it for directed transfer to apocytochrome c. CcmC, an integral memb...

journal_title：Molecular microbiology

authors： Schulz H,Pellicioli EC,Thöny-Meyer L

更新日期：2000-09-01 00:00:00

abstract：:The Escherichia coli DNA glycosylase Mug excises 3,N(4)-ethenocytosines (epsilon C) and uracils from DNA, but its biological function is obscure. This is because epsilon C is not found in E. coli DNA, and uracil-DNA glycosylase (Ung), a distinct enzyme, is much more efficient at removing uracils from DNA than Mug. We ...

journal_title：Molecular microbiology

authors： Mokkapati SK,Fernández de Henestrosa AR,Bhagwat AS

更新日期：2001-09-01 00:00:00

abstract：:The assembly of the class 5 colonization factor antigen I (CFA/I) fimbriae of enterotoxigenic E. coli was proposed to proceed via the alternate chaperone-usher pathway. Here, we show that in the absence of the chaperone CfaA, CfaB, the major pilin subunit of CFA/I fimbriae, is able to spontaneously refold and polymeri...

journal_title：Molecular microbiology

authors： Bao R,Liu Y,Savarino SJ,Xia D

更新日期：2016-12-01 00:00:00

abstract：:Enteropathogenic Escherichia coli (EPEC) is a leading cause of infant diarrhoea. EPEC mediates several effects on host epithelial cells, including activation of signal-transduction pathways, cytoskeletal rearrangement along with pedestal and attaching/effacing lesion formation. It has been previously shown that the EP...

journal_title：Molecular microbiology

authors： Kenny B,Lai LC,Finlay BB,Donnenberg MS

更新日期：1996-04-01 00:00:00

abstract：:Mass spectrometry analyses of the complex polar flagella from Helicobacter pylori demonstrated that both FlaA and FlaB proteins are post-translationally modified with pseudaminic acid (Pse5Ac7Ac, 5,7-diacetamido-3,5,7,9-tetradeoxy-l-glycero-l-manno -n o n-ulosonic acid). Unlike Campylobacter, flagellar glycosylation i...

journal_title：Molecular microbiology

authors： Schirm M,Soo EC,Aubry AJ,Austin J,Thibault P,Logan SM

更新日期：2003-06-01 00:00:00

abstract：:One often compares cells to computers, and signalling proteins to transistors. Location and wiring of those molecular transistors is paramount in defining the function of the subcellular chips. The bacterial chemotactic sensing apparatus is a large, stable assembly consisting of thousands of receptors, signal transduc...

journal_title：Molecular microbiology

authors： Shimizu TS,Le Novère N

更新日期：2008-07-01 00:00:00

abstract：:F plasmid traY protein binding to wild-type or deleted regions containing the TraY-binding site, sbyA, was studied in vitro. The principal DNA-protein complex was formed with DNA segments including the sbyA site defined by footprinting and (with lesser affinity) with truncated segments that retained the leftward two-t...

journal_title：Molecular microbiology

authors： Luo Y,Gao Q,Deonier RC

更新日期：1994-02-01 00:00:00

abstract：:Integrated self-transmissible elements called conjugative transposons have been found in many different bacteria, but little is known about how they excise from the chromosome to form the circular intermediate, which is then transferred by conjugation. We have now identified a gene, exc, which is required for the exci...

journal_title：Molecular microbiology

authors： Cheng Q,Sutanto Y,Shoemaker NB,Gardner JF,Salyers AA

更新日期：2001-08-01 00:00:00

abstract：:The Escherichia coli nusG gene product is required for transcription termination by phage HK022 Nun protein at the lambda nutR site in vivo. We show that it is also essential for Nun termination at lambda nutL. Three recessive mis-sense nusG mutations have been isolated that inhibit termination by Nun at lambda nutR. ...

journal_title：Molecular microbiology

authors： Burova E,Hung SC,Chen J,Court DL,Zhou JG,Mogilnitskiy G,Gottesman ME

更新日期：1999-03-01 00:00:00

abstract：:Histidine kinases (HK) sense and transduce via phosphorylation events many intra- and extracellular signals in bacteria, archaea, slime moulds and plants. HK are also widespread in the fungal kingdom, but their precise roles in the regulation of physiological processes remain largely obscure. Expanding genomic resourc...

journal_title：Molecular microbiology

authors： Defosse TA,Sharma A,Mondal AK,Dugé de Bernonville T,Latgé JP,Calderone R,Giglioli-Guivarc'h N,Courdavault V,Clastre M,Papon N

更新日期：2015-03-01 00:00:00

abstract：:Mycobacterium tuberculosis infects one-third of the world's population and causes two million deaths annually. The unusually low permeability of its cell wall contributes to the ability of M. tuberculosis to grow within host macrophages, a property required for pathogenesis of infection. Mycobacterium marinum is an es...

journal_title：Molecular microbiology

authors： Gao LY,Laval F,Lawson EH,Groger RK,Woodruff A,Morisaki JH,Cox JS,Daffe M,Brown EJ

更新日期：2003-09-01 00:00:00

abstract：:Photorhabdus and Xenorhabdus bacteria colonize the intestines of the infective soil-dwelling stage of entomophagous nematodes, Heterorhabditis and Steinernema, respectively. These nematodes infect susceptible insect larvae and release the bacteria into the insect blood. The bacteria kill the insect larvae and convert ...

journal_title：Molecular microbiology

authors： Goodrich-Blair H,Clarke DJ

更新日期：2007-04-01 00:00:00

abstract：:HapR is a quorum sensing-regulated transcription factor that represses the virulence cascade in Vibrio cholerae by binding to a specific site centred at -71 in the aphA promoter, ultimately preventing activation of the tcpPH promoter on the Vibrio pathogenicity island. In an effort to elucidate the mechanism by which ...

journal_title：Molecular microbiology

authors： Lin W,Kovacikova G,Skorupski K

更新日期：2007-05-01 00:00:00

abstract：:Leishmania parasites target macrophages in their mammalian hosts and proliferate within the mature phagolysosome compartment of these cells. Intracellular amastigote stages are dependent on sugars as a major carbon source in vivo, but retain the capacity to utilize other carbon sources. To investigate whether amastigo...

journal_title：Molecular microbiology

authors： Saunders EC,Naderer T,Chambers J,Landfear SM,McConville MJ

更新日期：2018-04-01 00:00:00

abstract：:Periplasmic Cu,Zn-superoxide dismutases (Cu,Zn-SODs) are implicated in bacterial virulence. It has been proposed that some bacterial P(1B)-type ATPases supply copper to periplasmic cupro-proteins and such transporters have also been implicated in virulence. Here we show that either of two P(1B)-type ATPases, CopA or G...

journal_title：Molecular microbiology

authors： Osman D,Patterson CJ,Bailey K,Fisher K,Robinson NJ,Rigby SE,Cavet JS

更新日期：2013-02-01 00:00:00