Calcitonin gene-related peptide in hepatorenal syndrome. A possible mediator of peripheral vasodilation?

Abstract:

:In advanced cirrhosis and hepatorenal syndrome, peripheral vasodilation is a prominent feature and may be pathophysiologically relevant. To determine whether the potent vasodilator, calcitonin gene-related peptide (CGRP), circulates at abnormal levels in patients with these disorders, we observed eight patients with alcoholic cirrhosis and hepatorenal syndrome, seven with alcoholic cirrhosis and ascites without hepatorenal syndrome, and 10 healthy controls. Plasma CGRP levels were higher in patients with alcoholic cirrhosis and hepatorenal syndrome (364 +/- 166 pg/ml) than in healthy controls (143 +/- 54 pg/ml, p less than 0.01). In patients with cirrhosis and ascites without hepatorenal syndrome, plasma CGRP levels were less elevated (291 +/- 257 pg/ml, NS). The identity of immunoreactive CGRP and synthetic hCGRP was confirmed by high performance liquid chromatography. These results suggest that CGRP may play a role in hepatorenal syndrome. However, to establish whether circulating CGRP contributes to the hemodynamic change in hepatorenal syndrome requires study of a larger number of patients and additional control groups.

journal_name

J Clin Gastroenterol

authors

Gupta S,Morgan TR,Gordan GS

doi

10.1097/00004836-199203000-00010

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

122-6

issue

2

eissn

0192-0790

issn

1539-2031

journal_volume

14

pub_type

杂志文章
  • The Cronkhite-Canada syndrome with focus on immunity and infection. Report of a case.

    abstract::A 64-year-old man developed diffuse gastrointestinal polyposis, protein-losing enteropathy, skin pigmentation, hair loss, and unique nail changes. He also exhibited pulmonary tuberculosis and impaired immunity with skin anergy, poor lymphocyte mitogens stimulation test, and low serum immunoglobulin. We discuss the rel...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198710000-00018

    authors: Lin HJ,Tsai YT,Lee SD,Lai KH,Ng WW,Tam TN,Lin HC,Liou LB,Tsay SH

    更新日期:1987-10-01 00:00:00

  • The effect of chronic aspirin use on duodenal and gastric ulcer hospitalizations.

    abstract::Aspirin is commonly accepted as a risk factor for gastric ulcer; however, there is little published evidence linking aspirin consumption to duodenal ulcer. The effect of 1 g of aspirin per day on site-specific ulcer hospitalizations was examined using data from a 3-year randomized, double-blind, placebo-controlled tri...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-199006000-00005

    authors: Kurata JH,Abbey DE

    更新日期:1990-06-01 00:00:00

  • Cruveilhier-Baumgarten syndrome without esophageal varices: ultrasonographic diagnosis and echo-Doppler study.

    abstract::Two cases of Cruveilhier-Baumgarten syndrome not clinically evident and without esophageal varices in patients with liver cirrhosis and portal hypertension are presented. The diagnosis was made by real-time ultrasonography, which showed echographic caput medusae with large afferent umbilical veins and efferent inferio...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Caturelli E,Sperandeo G,Squillante MM,Mangia A,Gabbrielli L

    更新日期:1989-06-01 00:00:00

  • Cumulative experience with short- and long-term toxicity to 6-mercaptopurine in the treatment of Crohn's disease and ulcerative colitis.

    abstract:BACKGROUND AND AIMS:The efficacy of 6-mercaptopurine (6-MP) in the treatment and long-term maintenance of remission of inflammatory bowel disease and prevention of recurrence after resection in Crohn's disease have been established. Concern about 6-MP toxicity remains, especially the development of neoplasm. The aim of...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200309000-00006

    authors: Warman JI,Korelitz BI,Fleisher MR,Janardhanam R

    更新日期:2003-09-01 00:00:00

  • Mechanisms of action of sucralfate.

    abstract::Sucralfate binds to duodenal and gastric ulcers and to gastric erosions produced by ethanol and anti-inflammatory drugs. The affinity of sucralfate for defective mucosa is explained by the drug's viscous adhesiveness and the formation of polyvalent bridges between the negatively charged sucralfate polyanions and posit...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Nagashima R

    更新日期:1981-01-01 00:00:00

  • Probiotics in critically ill patients.

    abstract::Severe sepsis with associated multisystem organ dysfunction is a leading cause of death in patients hospitalized in intensive care units. The gastrointestinal system plays a key role in the pathogenesis of multisystem organ dysfunction owing to a breakdown of intestinal barrier function and increased translocation of ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e31817283cb

    authors: Madsen K

    更新日期:2008-09-01 00:00:00

  • Polymerase chain reaction in gastroenterology.

    abstract::Polymerase chain reaction (PCR) has had a major impact on molecular biology and is beginning to change our perception of certain disease processes and diagnostic tests. PCR allows the identification and amplification of very rare nucleic acid sequences. This is resulting in our identification of previously elusive inf...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199306000-00014

    authors: Hayashi PH,Zeldis JB

    更新日期:1993-06-01 00:00:00

  • Acute pancreatitis associated with anomalous union of the pancreaticobiliary ductal system.

    abstract::Between 1978 and 1989, 13 of 48 patients with anomalous union of the pancreaticobiliary ductal system (AUPBD) were diagnosed as having acute pancreatitis. We have studied the clinical, radiologic, and surgical features of these 13 patients. A transient rise in the intraductal pressure of the pancreatic duct during an ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199112000-00012

    authors: Mori K,Nagakawa T,Ohta T,Nakano T,Kadoya N,Kayahara M,Kanno M,Akiyama T,Ueno K,Konishi I

    更新日期:1991-12-01 00:00:00

  • Predicting clinical recovery from alcoholic liver disease.

    abstract::We postulated that three tests could be used to advantage in the prognosis of patients with alcoholic liver disease. Ninety-eight patients who entered the hospital in hepatic failure, and who survived that illness, were observed for an average of 3.5 years after discharge. At the time of entry, most had jaundice, asci...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198308000-00003

    authors: Patek AJ Jr,Koff RS

    更新日期:1983-08-01 00:00:00

  • Usefulness of serum N-terminal-ProBNP in distinguishing ascites due to cirrhosis from ascites due to heart failure.

    abstract:BACKGROUND:Ascites due to cirrhosis may be difficult to distinguish from ascites due to heart failure by clinical features alone. More invasive testing is usually necessary, such as measurement of the hepatic venous pressure gradient, or paracentesis with measurement of the ascitic fluid total protein. AIM:The aim of ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318198113b

    authors: Sheer TA,Joo E,Runyon BA

    更新日期:2010-01-01 00:00:00

  • Modified barium swallow does not affect how often PEGs are placed after stroke.

    abstract::Dysphagia frequently follows stroke, but often resolves quickly. Percutaneous endoscopic gastrostomy (PEG) or other feeding tubes are placed to improve nutrition and hydration, and reduce the risk of aspiration pneumonitis. We evaluated the impact of modified barium swallow in determining PEG placements and the influe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199703000-00005

    authors: Akpunonu BE,Mutgi AB,Roberts C,Khuder SA,Federman DJ,Lee L

    更新日期:1997-03-01 00:00:00

  • Psychosocial factors are the most common contraindications for antiviral therapy at initial evaluation in veterans with chronic hepatitis C.

    abstract:GOALS:To understand the degree to which psychosocial factors were preventing veterans with chronic hepatitis C virus from being eligible for antiviral treatment. BACKGROUND:Nearly 2% of the US population is infected with hepatitis C. Antiviral treatment requires substantial adherence despite challenging side effects. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000123203.36471.70

    authors: Rowan PJ,Tabasi S,Abdul-Latif M,Kunik ME,El-Serag HB

    更新日期:2004-07-01 00:00:00

  • Heterotopic pancreas mimicking carcinoma of the head of the pancreas: a rare cause of obstructive jaundice.

    abstract::A 61-year-old man developed obstructive jaundice and had ultrasonographic and cholangiopancreatographic findings consistent with carcinoma of the pancreas. However, pathologically the obstruction proved to be from heterotopic pancreatic tissue compressing the common bile duct. This patient and eight previously reporte...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198304000-00014

    authors: O'Reilly DJ,Craig RM,Lorenzo G,Yokoo H

    更新日期:1983-04-01 00:00:00

  • Combined duodenal and colonic necrosis. An unusual sequela of caustic ingestion.

    abstract::Two unusual cases of liquid caustic ingestion that resulted in gangrene of the duodenum and adjacent colon, and burns of the esophagus, stomach, and pancreas are presented. The routine evaluation of the oropharynx, esophagus, and stomach after liquid caustic ingestion can seriously underestimate the extent of injury t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199412000-00009

    authors: Guth AA,Pachter HL,Albanese C,Kim U

    更新日期:1994-12-01 00:00:00

  • Gunshot cholecystitis.

    abstract::A 15-year-old boy developed traumatic cholecystitis from a BB shot that lodged in his gallbladder. This is an unusual cause of gallbladder disease, and we review the literature. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199512000-00016

    authors: Petersen JM,Knight TT

    更新日期:1995-12-01 00:00:00

  • Hypoxic hepatitis caused by severe hypoxemia from obstructive sleep apnea.

    abstract::Cardiac and circulatory failure are the main causes of hypoxic hepatitis. In a prospective study of 142 cases of hypoxic hepatitis collected during a 10-year period, we encountered two cases resulting from extreme arterial hypoxemia without congestive heart failure, cor pulmonale, or circulatory failure. Both patients...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199706000-00013

    authors: Henrion J,Colin L,Schapira M,Heller FR

    更新日期:1997-06-01 00:00:00

  • The symptomatic and histologic response to a gluten-free diet in patients with borderline enteropathy.

    abstract:GOALS:A clinical problem is posed by patients with symptoms suggestive of gluten sensitivity (diarrhea, weight loss, unresponsive iron-deficiency anemia, etc.); however, small intestinal biopsies reveal only minor abnormalities, such as lymphocytosis with or without crypt hyperplasia (Marsh I-II). Our aim was to assess...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200301000-00006

    authors: Tursi A,Brandimarte G

    更新日期:2003-01-01 00:00:00

  • Androgenic/Anabolic steroid-induced toxic hepatitis.

    abstract::Athletes and bodybuilders often misuse androgenic/anabolic steroids. When used in therapeutic doses, these drugs produce clinical jaundice in just a small number of recipients. We present a 26-year-old male bodybuilder who self-administered high doses of androgenic/anabolic steroids that induced liver damage. One mont...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200210000-00013

    authors: Stimac D,Milić S,Dintinjana RD,Kovac D,Ristić S

    更新日期:2002-10-01 00:00:00

  • Biliary atresia: recent progress.

    abstract::Extrahepatic biliary atresia (EHBA), an inflammatory sclerosing cholangiopathy, is the leading indication for liver transplantation in children. The cause is still unknown, although possible infectious, genetic, and immunologic etiologies have received much recent focus. These theories are often dependent on each othe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3181646730

    authors: Bassett MD,Murray KF

    更新日期:2008-07-01 00:00:00

  • Enteral self-expandable metal stent for malignant luminal obstruction of the upper and lower gastrointestinal tract: a prospective multicentric study.

    abstract:BACKGROUND:Self-expanding metal stents (SEMSs) are used to treat malignant stenosis of the gastrointestinal (GI) tract, as a safe, feasible, and minimally invasive option for reestablishing luminal patency. However, the literature offers scant prospective data on the clinical outcome of these patients. AIM:To assess t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCG.0b013e318033d30a

    authors: Masci E,Viale E,Mangiavillano B,Contin G,Lomazzi A,Buffoli F,Gatti M,Repaci G,Teruzzi V,Fasoli R,Ravelli P,Testoni PA

    更新日期:2008-04-01 00:00:00

  • Reversing Hyperammonemia in Neuroendocrine Tumors.

    abstract::Ammonia is a neurotoxin that is normally cleared by the intact liver and if not, hyperammonemia results in hepatic encephalopathy. Hyperammonemia may be owing to primary or secondary causes. Early diagnosis is important to prevent permanent brain damage. Advanced malignancy involving the liver is associated with hyper...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181d96aad

    authors: Broadbridge V,Townsend A,Pittman K,Kimber R,Patterson W,Sukumaran S,Price TJ

    更新日期:2010-09-01 00:00:00

  • Gastrointestinal and hepatic manifestations of Sjogren syndrome.

    abstract::Sjogren syndrome (SS) is an autoimmune disease that affects exocrine glands and therefore may affect the gastrointestinal system, from the mouth, esophagus, and bowel to the liver and pancreas. Oral involvement in SS is mainly characterized by dryness, with a wide spectrum of symptoms, from mild-to-severe xerostomia w...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3182329d9c

    authors: Ebert EC

    更新日期:2012-01-01 00:00:00

  • Orocecal transit time and bacterial overgrowth in patients with Crohn's disease.

    abstract::Bacterial overgrowth is frequent in patients with Crohn's disease (CD) and can contribute to symptoms. Motility abnormalities can predispose to bacterial overgrowth. The hydrogen (H2) and methane (CH4) breath test is a sensitive and simple tool for the diagnosis of bacterial overgrowth and for the evaluation of orocec...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200007000-00015

    authors: Castiglione F,Del Vecchio Blanco G,Rispo A,Petrelli G,Amalfi G,Cozzolino A,Cuccaro I,Mazzacca G

    更新日期:2000-07-01 00:00:00

  • Endoscopic diagnosis of duodenal neoplasms causing upper gastrointestinal bleeding.

    abstract::Duodenal neoplasms are a rare and not often considered cause of massive upper gastrointestinal bleeding. During a 4-year period, 859 endoscopies in patients with upper gastrointestinal bleeding revealed a duodenal tumor to be the cause of bleeding in eight patients. Three patients had a primary duodenal neoplasm, two ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198202000-00006

    authors: Sharon P,Stalnikovicz R,Rachmilewitz D

    更新日期:1982-02-01 00:00:00

  • Barrett esophagus in sexagenarian identical twins.

    abstract::Identical twins presented as sexagenarians with heartburn, regurgitation, and dysphagia; each had a Barrett esophagus remarkably similar to the other. This instance suggests a hereditary influence upon the development of mucosal dysplasia in some patients with this condition. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198306000-00011

    authors: Gelfand MD

    更新日期:1983-06-01 00:00:00

  • Strongly positive tissue transglutaminase antibodies are associated with Marsh 3 histopathology in adult and pediatric celiac disease.

    abstract:GOALS:Our objective was to determine whether high serologic IgA tissue transglutaminase antibodies (TTGA) are exclusively associated with celiac disease (CD). BACKGROUND:IgA TTGA are found in the serum of most individuals with CD. This serologic marker is used to screen individuals with suspected CD for duodenal biops...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCG.0b013e31802e70b1

    authors: Donaldson MR,Book LS,Leiferman KM,Zone JJ,Neuhausen SL

    更新日期:2008-03-01 00:00:00

  • Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of taiwan: metabolic significance of nonalcoholic fatty liver disease in nonobese adults.

    abstract:BACKGROUND:The prevalence of nonalcoholic fatty liver disease (NAFLD) is rarely reported in Taiwan. GOALS:To determine the prevalence and risk factors of NAFLD in an adult population of Taiwan. STUDY:The cross-sectional community study examined 3245 adults in a rural village of Taiwan. The diagnostic criteria for NAF...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200609000-00016

    authors: Chen CH,Huang MH,Yang JC,Nien CK,Yang CC,Yeh YH,Yueh SK

    更新日期:2006-09-01 00:00:00

  • Are Anti-Tumor Necrosis Factor Trough Levels Predictive of Mucosal Healing in Patients With Inflammatory Bowel Disease?: A Systematic Review and Meta-Analysis.

    abstract:GOALS:Our primary goal was to evaluate whether anti-tumor necrosis factor (TNF)-α trough levels above author-determined thresholds are associated with increased rates of mucosal healing among patients with Crohn's disease and ulcerative colitis. BACKGROUND:The introduction of anti-TNF agents has considerably advanced ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MCG.0000000000000441

    authors: Barnes EL,Allegretti JR

    更新日期:2016-10-01 00:00:00

  • The pathogenesis of hemorrhoids and their treatment by anorectal bandotomy.

    abstract::The role of the anorectal band in the genesis of hemorrhoids is studied. The anorectal band is a fibroepithelial tube which is a remnant of the anorectal sinus. Seventy-six hemorrhoid patients and 32 controls were studied. Rectal neck pressure recording was done for all subjects. Two biopsies were taken from the lower...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198404000-00006

    authors: Shafik A

    更新日期:1984-04-01 00:00:00

  • Alcohol-related injury to peribiliary glands is a cause of peribiliary cysts: based on analysis of clinical and autopsy cases.

    abstract:BACKGROUND AND GOAL:Peribiliary cysts, which are known to be associated with various hepatobiliary diseases including alcoholic liver disease, have been reported to originate in the peribiliary glands along the biliary tree. The causal relationship between the peribiliary cysts and alcohol-related hepatic and pancreati...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e318299c8c1

    authors: Matsubara T,Sato Y,Igarashi S,Matsui O,Gabata T,Nakanuma Y

    更新日期:2014-02-01 00:00:00