Plasma concentration of urotensin II is raised in hypertension.

abstract：OBJECTIVE:This study evaluated the impact of prolonged circulatory unloading and subsequent left ventricular (LV) mass decrease on LV myocardial performance. Five-week head-down tilt (-6°) bed rest (HDTBR) was used as a model of prolonged circulatory unloading. METHODS:Ten young healthy male volunteers (age 23 ± 2 yea...

journal_title：Journal of hypertension

authors： Kozàkovà M,Malshi E,Morizzo C,Pedri S,Santini F,Biolo G,Pagani M,Palombo C

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To find an objective, sensitive method for quantifying microvascular alterations associated with level of blood pressure and age. DESIGN:A prospective cross-sectional study. SUBJECTS AND METHODS:Seventy-four previously untreated hypertensive patients, referred to a hospital outpatients department, and 26 no...

journal_title：Journal of hypertension

authors： Stanton AV,Mullaney P,Mee F,O'Brien ET,O'Malley K

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To investigate the role of an activated endothelin system in the renal dysfunction observed in chronic heart failure after myocardial infarction. METHODS:In rats with heart failure after myocardial infarction and in sham-operated animals (Sham), we investigated the effect on renal function of long-term oral ...

journal_title：Journal of hypertension

authors： Bauersachs J,Braun C,Fraccarollo D,Widder J,Ertl G,Schilling L,Kirchengast M,Rohmeiss P

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Despite data from animal models and observational studies that are generally supportive for the soy/isoflavones lowering blood pressure (BP) and improving vascular function, the current findings from clinical trials are still inconclusive. OBJECTIVES:To examine whether soy protein with isoflavones or isofla...

journal_title：Journal of hypertension

authors： Liu ZM,Ho SC,Chen YM,Woo J

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:To determine whether obese hypertensive patients manifest a diminished regional vasodilator response to an oral glucose challenge. METHODS:Nineteen obese hypertensives (body mass index 34.1 +/- 1.3 kg/m2, blood pressure 144 +/- 3/96 +/- 2 mmHg) and 13 lean controls (23.6 +/- 0.3 kg/m2, 127 +/- 4/83 +/- 3 mmH...

journal_title：Journal of hypertension

authors： Egan BM,Stepniakowski K

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Endogenous ouabain, an endogenous digitalis-like steroid, is synthesized in the adrenal glands and possibly in the hypothalamus. In vitro and in vivo, endogenous ouabain triggers growth and proliferation of cardiomyocytes. OBJECTIVE:We therefore investigated the association between left ventricular structur...

journal_title：Journal of hypertension

authors： Kuznetsova T,Manunta P,Casamassima N,Messaggio E,Jin Y,Thijs L,Richart T,Fagard RH,Bianchi G,Staessen JA

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Smoking is a risk factor for increased carotid artery intima-media thickness (IMT). The apolipoprotein E (apoE) 4 allele has been associated with cardiovascular diseases, but the role of apoE in regard to intima-media thickness (IMT) has remained controversial. The objective was to investigate whether there i...

journal_title：Journal of hypertension

authors： Karvonen J,Kauma H,Kervinen K,Ukkola O,Rantala M,Päivänsalo M,Savolainen MJ,Kesäniemi YA

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVES:Stroke is elevated in people of black African descent, but evidence for excess subclinical cerebrovascular disease is conflicting, and the role of risk factors in determining any ethnic differences observed unexplored. METHODS:We compared prevalence of brain infarcts, and severe white matter hyperintensitie...

journal_title：Journal of hypertension

authors： Shibata D,Tillin T,Beauchamp N,Heasman J,Hughes AD,Park C,Gedroyc W,Chaturvedi N

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:Development of internally quenched fluorogenic substrates for sensitive and continuous assays of angiotensin I-converting enzyme (ACE). DESIGN:We synthesized internally quenched fluorogenic bradykinin-related peptides introducing Abz (ortho-aminobenzoic acid) and EDDnp (N-[2,4-dinitrophenyl]-ethylenediamine)...

journal_title：Journal of hypertension

authors： Araujo MC,Melo RI,Del Nery E,Alves MF,Juliano MA,Casarini DE,Juliano L,Carmona AK

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Cardiovascular diseases represent the most common cause of death in the English-speaking Caribbean, and hypertension represents the most important predisposing condition. However, direct between-country comparative studies in the Caribbean have not previously been undertaken. OBJECTIVE:To obtain estimates o...

journal_title：Journal of hypertension

authors： Freeman V,Fraser H,Forrester T,Wilks R,Cruickshank J,Rotimi C,Cooper R

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Fibromuscular dysplasia (FMD) and atherosclerotic renal artery stenosis (ARAS) are the most common causes of renovascular hypertension. So far, FMD is believed to cause hypertension via similar mechanisms as in ARAS, that is, a decrease in renal blood flow, which subsequently leads to increased renin secreti...

journal_title：Journal of hypertension

authors： van Twist DJ,Houben AJ,de Haan MW,de Leeuw PW,Kroon AA

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVES:To investigate whether combined treatment with lisinopril, an angiotensin-converting enzyme (ACE) inhibitor and exercise training would have an additive effect in enhancing the capillary supply of the left ventricular (LV) myocardium in spontaneously hypertensive rats (SHR). DESIGN:Twelve-week-old male SHR ...

journal_title：Journal of hypertension

authors： Ziada AM,Hassan MO,Tahlilkar KI,Inuwa IM

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:Metabolic syndrome (MetS) is associated with uncontrolled blood pressure (BP), despite use of aggressive therapy. This study was performed to assess whether the use of different classes of antihypertensive drugs might influence this association. METHODS:We evaluated risk of uncontrolled BP (BP ≥ 140/90 mmHg ...

journal_title：Journal of hypertension

authors： De Marco M,de Simone G,Izzo R,Mancusi C,Sforza A,Giudice R,Trimarco B,De Luca N

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Currently, normative means and ranges of blood pressure (BP) and pulse rates in Japanese newborns are not available. The objective of the present study was to estimate BP, pulse rate, and their distribution among Japanese newborns. METHODS:Using oscillometric devices, arm or calf BP and pulse rate levels wer...

journal_title：Journal of hypertension

authors： Satoh M,Inoue R,Tada H,Hosaka M,Metoki H,Asayama K,Murakami T,Mano N,Ohkubo T,Yagihashi K,Hoshi K,Suzuki M,Imai Y

更新日期：2016-08-01 00:00:00

abstract：:Vascular Na-K pump activity (ouabain-sensitive 86Rb uptake) and cardiac Na,K-ATPase activity are decreased in rats with one-kidney, one clip and reduced renal mass-saline hypertension. In the present study we measured left ventricular, microsomal Na,K-ATPase activity in rats with two steroid forms of hypertension; one...

journal_title：Journal of hypertension

authors： Clough DL,Pamnani MB,Haddy FJ

更新日期：1984-04-01 00:00:00

abstract：AIMS:Monocyte/macrophages participate in inflammatory responses that may play an important role in mineralocorticoid-induced vascular damage. We hypothesized that monocyte/macrophages modulate aldosterone effects on oxidative stress, endothelial function, and ultimately vascular stiffness. METHODS:Adult heterozygous o...

journal_title：Journal of hypertension

authors： Leibovitz E,Ebrahimian T,Paradis P,Schiffrin EL

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:To investigate whether a dietary supplement of vitamin B6 could attenuate the elevation of systolic blood pressure (SBP) in Zucker obese or spontaneously hypertensive rats, or rats ingesting sucrose. METHODS:Zucker obese rats (fa/fa), Sprague-Dawley rats with sucrose-induced elevation of SBP, spontaneously h...

journal_title：Journal of hypertension

authors： Lal KJ,Dakshinamurti K,Thliveris J

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVE:To examine the associations among hypertension, insulin secretion, glucose tolerance and insulin resistance in vivo. DESIGN:Glucose tolerance and insulin secretion during an intravenous glucose tolerance test and action of insulin on whole-body glucose kinetics in the post-absorptive state and during hyperin...

journal_title：Journal of hypertension

authors： Holness MJ,Sugden MC

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:A genetic polymorphism in the angiotensin II type 2 receptor (AGTR2 +1675G/A) has been associated with left ventricular hypertrophy (LVH). We tested whether this polymorphism affects LVH and left ventricular geometry parameters in patients with essential hypertension and cardiovascular disease who are treated...

journal_title：Journal of hypertension

authors： Huber M,Völler H,Jakob S,Reibis R,Do V,Bolbrinker J,Zergibel I,Schmieder RE,Treszl A,Wegscheider K,Kreutz R

更新日期：2010-06-01 00:00:00

abstract：:The effects of essential fatty acid deficiency (EFAD) on vascular reactivity to vasoconstrictor stimuli were studied in rat autoperfused hindquarters. Weanling male Sprague-Dawley rats (aged 21 days) were fed diets containing 8% (weight/weight) of stearax plus 2% safflower oil (control diet) or 10% stearax (EFAD diet)...

journal_title：Journal of hypertension

authors： Kudo K,Dusting GJ,Loiacono RE,Sinclair AJ

更新日期：1988-02-01 00:00:00

abstract：OBJECTIVES:To investigate the mechanism of angiotensin II-induced apoptosis in cultured cardiomyocytes by determining which receptor subtype is involved, and what is the relationship between intracellular Ca2+ changes and apoptosis. DESIGN AND METHODS:Neonatal rat cardiomyocytes were pretreated with either the AT1 ant...

journal_title：Journal of hypertension

authors： Goldenberg I,Grossman E,Jacobson KA,Shneyvays V,Shainberg A

更新日期：2001-09-01 00:00:00

abstract：:: Altered blood pressure (BP) is a common phenomenon in acute ischemic stroke (AIS), with high BP being the most frequent scenario. The pathophysiology of BP changes in AIS is complex and only partially understood. The available evidence indicates that extremely high BP during AIS is associated with a poor outcome. Im...

journal_title：Journal of hypertension

authors： Gąsecki D,Coca A,Cunha P,Hering D,Manios E,Lovic D,Zaninelli A,Sierra C,Kwarciany M,Narkiewicz K,Karaszewski B

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that in the stroke-prone spontaneously hypertensive rat (SHRSP), the pressor effect of selective dietary chloride loading depends on a positive external sodium balance. METHODS:In 43 male SHRSP fed a Japanese style diet containing a low normal amount of NaCl (0.4%), we compared the eff...

journal_title：Journal of hypertension

authors： Schmidlin O,Tanaka M,Sebastian A,Morris RC Jr

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:During the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial, patients with hypertension who received amlodipine had similar cardiovascular risks as those who received candesartan. We conducted a post-trial study, the Candesartan Antihypertensive Survival Evaluation in Japan 10-year fol...

journal_title：Journal of hypertension

authors： Liu J,Yasuno S,Oba K,Konda M,Ichihara C,Kitao H,Kuwabara Y,Ueshima K

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:The existence and localization of renin in situ was examined in human arteries under non-pathological conditions. DESIGN:Biochemical and immunohistochemical procedures were adopted to examine the existence of renin in human gastroepiploic arteries using an antibody raised against human recombinant renin or a...

journal_title：Journal of hypertension

authors： Okamura T,Aimi Y,Kimura H,Murakami K,Toda N

更新日期：1992-01-01 00:00:00

abstract：:The response of blood pressure, heart rate and plasma catecholamines to a mental arithmetic and a cold pressor test was studied in 70 patients with mild essential hypertension and in 41 age- and sex-matched normotensives. Each group consisted of three prospectively stratified age classes: 20-29, 30-39 and 40-55 years....

journal_title：Journal of hypertension

authors： Lenders JW,Willemsen JJ,de Boo T,Lemmens WA,Thien T

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVE:To determine the long-term efficacy and safety of a fixed, very-low-dose tablet combining one-half the standard dose of perindopril with one-quarter the standard dose of indapamide as first-line treatment in elderly patients. DESIGN:Double-blind, randomized, placebo-controlled study in an outpatient setting....

journal_title：Journal of hypertension

authors： Chalmers J,Castaigne A,Morgan T,Chastang C

更新日期：2000-03-01 00:00:00

abstract：:Hypertension was induced in marmosets by ligating the minor branch of one renal artery. The blood pressure (BP), measured by a tail-cuff method, increased to hypertensive levels within 4-5 weeks and the maximum increases occurred after 4-15 weeks (BP, mean +/- s.e.m. was 120 +/- 3 and 152 +/- 6 mmHg before and 10 week...

journal_title：Journal of hypertension

authors： Neisius D,Wood JM

更新日期：1987-12-01 00:00:00

abstract：:Seventeen essential hypertensive patients with normal renal function were treated with a new non-sulphydryl orally active angiotensin converting enzyme (ACE) inhibitor, benazepril, 10 mg given once or twice daily, according to diastolic blood pressure levels, for 6 weeks. In all patients, changes in blood pressure, sy...

journal_title：Journal of hypertension

authors： Valvo E,Casagrande P,Bedogna V,Antiga L,Alberti D,Zamboni M,Perobelli L,Dal Santo F,Maschio G

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVES:Urocortin 1 (Ucn1) and the sympathetic nervous system both participate in cardiac and circulatory regulation, but little is known about their possible interactions. METHODS:We report the effects of Ucn1 on the cardiac sympathetic nerve activity (CSNA), haemodynamics and plasma catecholamines in normal sheep...

journal_title：Journal of hypertension

authors： Charles CJ,Jardine DL,Nicholls MG,Rademaker MT,Richards AM

更新日期：2008-01-01 00:00:00