Contrasting effects of metal ions on S-nitrosoglutathione, related to coordination equilibria: GSNO decomposition assisted by Ni(II) vs stability Increase in the presence of Zn(II) and Cd(II).

abstract：:Electronic cigarette liquids (e-liquids) with sweetener additives such as sucralose, a synthetic chlorinated disaccharide, are popular among some e-cigarette consumers; sucralose can be added either by the manufacturer or by the consumer. The prevalence of sucralose in commercial e-liquids is not known, nor is the typ...

journal_title：Chemical research in toxicology

authors： Duell AK,McWhirter KJ,Korzun T,Strongin RM,Peyton DH

更新日期：2019-06-17 00:00:00

abstract：:Isoeugenol is widely used by the cosmetic and fragrance industries, but it also represents a known cause of skin sensitization adverse effects. Although devoid of a structural alert, isoeugenol has been classified as prehapten in virtue of the presence of a pre-Michael acceptor domain. Isoeugenol oxidation could theor...

journal_title：Chemical research in toxicology

authors： Ahn J,Avonto C,Chittiboyina AG,Khan IA

更新日期：2020-04-20 00:00:00

abstract：:Nitric oxide can be introduced slowly and steadily into aqueous solutions, including cell culture media, over extended periods of time via semipermeable Silastic (a registered trademark of the Dow Corning Corp.) polymer membranes. The rates of introduction are predictable and reproducible and can approach rates of nit...

journal_title：Chemical research in toxicology

authors： Tamir S,Lewis RS,de Rojas Walker T,Deen WM,Wishnok JS,Tannenbaum SR

更新日期：1993-11-01 00:00:00

abstract：:Graphene oxide derivatives (GODs) have superb physical/chemical properties with promise for applications in biomedicine. Shape, size, and chemistry of the GODs are identified as the key parameters that impact any biological system. In this work, the GODs with a wide range of shapes (sheets, helical/longitudinal ribbon...

journal_title：Chemical research in toxicology

authors： Lu P,Zehtab Yazdi A,Han XX,Al Husaini K,Haime J,Waye N,Chen P

更新日期：2020-09-21 00:00:00

abstract：:Smoked cigarettes are the most prevalent form of litter worldwide, often finding their way into oceans and inland waterways. Cigarette smoke contains more than 4000 individual chemicals, some of them carcinogenic or otherwise toxic. We examined the cytotoxicity, genotoxicity, aryl hydrocarbon receptor (AhR), estrogen ...

journal_title：Chemical research in toxicology

authors： Xu EG,Richardot WH,Li S,Buruaem L,Wei HH,Dodder NG,Schick SF,Novotny T,Schlenk D,Gersberg RM,Hoh E

更新日期：2019-08-19 00:00:00

abstract：:The mechanisms underlying aryl hydrocarbon receptor (AHR) activation by agonists and circumstances that increase the sensitivity toward agonists and AHR inhibition by antagonists are diverse and still not fully understood. AHR antagonist, 2-methyl-2 H-pyrazole-3-carboxylic acid (2-methyl-4- o-tolylazo-phenyl)-amide, C...

journal_title：Chemical research in toxicology

authors： Mohammadi-Bardbori A,Omidi M,Arabnezhad MR

更新日期：2019-04-15 00:00:00

abstract：:Spin-trapping with 5,5-dimethyl-1-pyrroline 1-oxide (DMPO) was used to demonstrate that 3-nitrotyrosine (nitrotyrosine) promotes the formation of substantial amounts of reactive oxygen species (O2.- and *OH), when incubated with NAD(H)-cytochrome c reductase and a corresponding electron donor. Spin adduct formation is...

journal_title：Chemical research in toxicology

authors： Krainev AG,Williams TD,Bigelow DJ

更新日期：1998-05-01 00:00:00

abstract：:The ToxCast EPA challenge was managed by TopCoder in Spring 2014. The goal of the challenge was to develop a model to predict the lowest effect level (LEL) concentration based on in vitro measurements and calculated in silico descriptors. This article summarizes the computational steps used to develop the Rank-I model...

journal_title：Chemical research in toxicology

authors： Novotarskyi S,Abdelaziz A,Sushko Y,Körner R,Vogt J,Tetko IV

更新日期：2016-05-16 00:00:00

abstract：:Dimethylarsinic acid (DMAs(V)), the major urinary metabolite of inorganic arsenic, is weakly cytotoxic, whereas its reduced form, dimethylarsinous acid (DMAs(III)), is highly toxic. Although glutathione S-transferase omega 1 (GSTO1) and arsenic methyltransferase have been shown or thought to catalyze DMAs(V) reduction...

journal_title：Chemical research in toxicology

authors： Németi B,Gregus Z

更新日期：2013-03-18 00:00:00

abstract：:Benzo[a]pyrene, a potent human carcinogen, is metabolized in vivo to a diol epoxide that reacts with the N2-position of guanine to produce N2-BP-dG adducts. These adducts are mutagenic causing G to T transversions. These adducts block replicative polymerases but can be bypassed by the Y-family translesion synthesis po...

journal_title：Chemical research in toxicology

authors： Gowda ASP,Krzeminski J,Amin S,Suo Z,Spratt TE

更新日期：2017-05-15 00:00:00

abstract：:1-Fluoro-1,1,2-trichloroethane (HCFC-131a), 1,2-dichloro-1,1-difluoroethane (HCFC-132b), and 1,1,1-trifluoro-2-chloroethane (HCFC-133a) were chosen as models for comparative metabolism studies on 1,1,1,2-tetrahaloethanes, which are under consideration as replacements for ozone-depleting chlorofluorocarbons (CFCs). Mal...

journal_title：Chemical research in toxicology

authors： Yin H,Jones JP,Anders MW

更新日期：1995-03-01 00:00:00

abstract：:1,2,3,4-Diepoxybutane (DEB) is a prominent carcinogenic metabolite of 1,3-butadiene (1,3-BD), an important industrial chemical and an environmental pollutant found in cigarette smoke and automobile exhaust. DEB is capable of inducing a variety of genotoxic effects, including point mutations, large deletions, and chrom...

journal_title：Chemical research in toxicology

authors： Park S,Hodge J,Anderson C,Tretyakova N

更新日期：2004-12-01 00:00:00

abstract：:The bifunctional alkylating agent, melphalan, forms adducts on DNA that are recognized by two previously described monoclonal antibodies, MP5/73 and Amp4/42. Immunoreactivity to MP5/73 was lost when alkylated DNA was exposed to alkaline pH, while Amp4/42 only recognized the structures formed after the alkali treatment...

journal_title：Chemical research in toxicology

authors： McCartney H,Martin AM,Middleton PG,Tilby MJ

更新日期：2001-01-01 00:00:00

abstract：:There is strong epidemiologic evidence linking chronic exposure to inorganic arsenic (iAs) to myriad adverse health effects, including cancer of the bladder. We set out to identify DNA methylation patterns associated with arsenic and its metabolites in exfoliated urothelial cells (EUCs) that originate primarily from t...

journal_title：Chemical research in toxicology

authors： Rager JE,Tilley SK,Tulenko SE,Smeester L,Ray PD,Yosim A,Currier JM,Ishida MC,González-Horta Mdel C,Sánchez-Ramírez B,Ballinas-Casarrubias L,Gutiérrez-Torres DS,Drobná Z,Del Razo LM,García-Vargas GG,Kim WY,Zhou YH,Wright

更新日期：2015-06-15 00:00:00

abstract：:Structure-function relationships for the inhibition of human cytochrome P450s (P450s) 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives were studied. Thirty-two of the 33 flavonoids tested produced reverse type I binding spectra with P450 1B1, and the potencies of binding were correlated with the abilities to in...

journal_title：Chemical research in toxicology

authors： Shimada T,Tanaka K,Takenaka S,Murayama N,Martin MV,Foroozesh MK,Yamazaki H,Guengerich FP,Komori M

更新日期：2010-12-20 00:00:00

abstract：:This study addresses the detection and characterization of the modification of human serum albumin (HSA) by amoxicillin (AX) in ex vivo samples from healthy subjects under oral amoxicillin administration (acute intake of 1 g every 8 h for 48 h). To reach this goal, we used an analytical strategy based on targeted and ...

journal_title：Chemical research in toxicology

authors： Garzon D,Ariza A,Regazzoni L,Clerici R,Altomare A,Sirtori FR,Carini M,Torres MJ,Pérez-Sala D,Aldini G

更新日期：2014-09-15 00:00:00

abstract：:8-Oxo-7,8-dihydroguanine (G(O), 8-hydroxyguanine) in DNA is one of the most important oxidatively damaged bases and causes G:C → T:A substitution mutations. The Werner syndrome protein (WRN) is a cancer-related RecQ DNA helicase and plays many roles in DNA replication and repair. To examine the relationships between G...

journal_title：Chemical research in toxicology

authors： Kamiya H,Yamazaki D,Nakamura E,Makino T,Kobayashi M,Matsuoka I,Harashima H

更新日期：2015-04-20 00:00:00

abstract：:Liver microsomes from uninduced hogs catalyzed the NADPH-dependent N-oxidation of the hydroxylamine (Z)-3-(4-bromophenyl)-N-hydroxy-N-methyl-3-(3-pyridyl)allylamine. The conjugated nitrone N-[(2Z)-3-(4-bromophenyl)-3-(3-pyridyl)-2-propenylidene]methylamin e N-oxide was the principal product and accounted for 90-95% of...

journal_title：Chemical research in toxicology

authors： Cashman JR,Yang ZC,Högberg T

更新日期：1990-09-01 00:00:00

abstract：:Nanoparticles can reach the blood and cause inflammation, suggesting that nanoparticles-endothelial cells interactions may be pathogenically relevant. We evaluated the effect of titanium dioxide nanoparticles (TiO₂) on proliferation, death, and responses related with inflammatory processes such as monocytic adhesion a...

journal_title：Chemical research in toxicology

authors： Montiel-Dávalos A,Ventura-Gallegos JL,Alfaro-Moreno E,Soria-Castro E,García-Latorre E,Cabañas-Moreno JG,del Pilar Ramos-Godinez M,López-Marure R

更新日期：2012-04-16 00:00:00

abstract：:The 2'-deoxyguanosine adduct of the dietary mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) has been synthesized and incorporated into DNA using solid state synthesis technology. The key step to obtaining the C8-dG adduct is a palladium (Xantphos-chelated)-catalyzed N-arylation (Buchwald-Hartwig reactio...

journal_title：Chemical research in toxicology

authors： Bonala R,Torres MC,Iden CR,Johnson F

更新日期：2006-06-01 00:00:00

abstract：:Flucloxacillin, an isoxazolyl-penicillin, causes cholestasis and biliary epithelium injury. The aim of the study was to determine whether flucloxacillin, either directly or through metabolite formation, may induce cytotoxicity in hepatic or biliary cells. Cytotoxicity was assessed by lactate dehydrogenase release in p...

journal_title：Chemical research in toxicology

authors： Lakehal F,Dansette PM,Becquemont L,Lasnier E,Delelo R,Balladur P,Poupon R,Beaune PH,Housset C

更新日期：2001-06-01 00:00:00

abstract：:Hepatotoxicity of allyl alcohol involves its bioactivation to acrolein and subsequent protein sulfhydryl loss and lipid peroxidation. However, the links between these events and hepatocellular death are not known. The purpose of these studies was to examine whether specific signal transduction pathways are associated ...

journal_title：Chemical research in toxicology

authors： Maddox JF,Roth RA,Ganey PE

更新日期：2003-05-01 00:00:00

abstract：:Exposure assessment in in vitro cell-based bioassays is challenging for ionizable organic chemicals (IOCs), because they are present as more than one chemical species in the bioassay medium. Furthermore, compared to neutral organic chemicals, their binding to medium proteins and lipids is driven by more complex molecu...

journal_title：Chemical research in toxicology

authors： Huchthausen J,Mühlenbrink M,König M,Escher BI,Henneberger L

更新日期：2020-07-20 00:00:00

abstract：:Many of the protective responses observed for flavonoids in the gastrointestinal track resemble aryl hydrocarbon receptor (AhR)-mediated effects. Therefore, we examined the structure-activity relationships of isoflavones and isomeric flavone and flavanones as AhR ligands on the basis of their induction of CYP1A1, CYP1...

journal_title：Chemical research in toxicology

authors： Park H,Jin UH,Orr AA,Echegaray SP,Davidson LA,Allred CD,Chapkin RS,Jayaraman A,Lee K,Tamamis P,Safe S

更新日期：2019-11-18 00:00:00

abstract：:Furan has been found in a number of heated food items and is carcinogenic in the liver of rats and mice. Estimates of human exposure on the basis of concentrations measured in food are not reliable because of the volatility of furan. A biomarker approach is therefore indicated. We searched for metabolites excreted in ...

journal_title：Chemical research in toxicology

authors： Kellert M,Wagner S,Lutz U,Lutz WK

更新日期：2008-03-01 00:00:00

abstract：:Furanoid 8-epidiosbulbin E acetate (EEA) is one of the most abundant diterpenoid lactones in herbal medicine Dioscorea bulbifera L. (DB). Our early work proved that EEA could be metabolized to EEA-derived cis-enedial (EDE), a reactive intermediate, which is required for the hepatotoxicity observed in experimental anim...

journal_title：Chemical research in toxicology

authors： Zhou S,Zhang N,Hu Z,Lin D,Li W,Peng Y,Zheng J

更新日期：2020-07-20 00:00:00

abstract：:Aryl radicals can react at the C8-site of 2'-deoxyguanosine (dG) to produce DNA adducts with a C8-C linkage (denoted C-linked). Such adducts are structurally distinct from those possessing a flexible amine (N-linked) or ether (O-linked) linkage, which separates the C8-aryl moiety from the guanine nucleobase. In the cu...

journal_title：Chemical research in toxicology

authors： Sproviero M,Verwey AM,Witham AA,Manderville RA,Sharma P,Wetmore SD

更新日期：2015-08-17 00:00:00

abstract：:Recent reports by Galeazzi and co-workers demonstrated the susceptibility of Abeta(1-42) to undergo dityrosine formation via peroxidase-catalyzed tyrosine cross-linking. We have formed dityrosine cross-links in Abeta(1-40) using these enzymatic conditions as well as a copper-H(2)O(2) method. The efficiency of dityrosi...

journal_title：Chemical research in toxicology

authors： Yoburn JC,Tian W,Brower JO,Nowick JS,Glabe CG,Van Vranken DL

更新日期：2003-04-01 00:00:00

abstract：:The process of disinfecting drinking water inadvertently leads to the formation of numerous disinfection byproducts (DBPs). Some of these are mutagenic, genotoxic, teratogenic, and cytotoxic, as well as potentially carcinogenic both in vivo and in vitro. We investigated the in vitro biological activity of five DBPs: t...

journal_title：Chemical research in toxicology

authors： Procházka E,Escher BI,Plewa MJ,Leusch FD

更新日期：2015-10-19 00:00:00

abstract：:The preparation and DNA binding characteristics of a structural analog of Hoechst 33258 bearing two pyridinic nitrogen atoms are described. The 1H NMR signals of the complex formed between the new ligand 1 and decadeoxyribonucleotide d(CATGGCCATG)2 were assigned by employing one- and two-dimensional NMR techniques. In...

journal_title：Chemical research in toxicology

authors： Singh MP,Joseph T,Kumar S,Bathini Y,Lown JW

更新日期：1992-09-01 00:00:00