Sucralose-Enhanced Degradation of Electronic Cigarette Liquids during Vaping.

abstract：:Lapatinib (LAP), an oral tyrosine kinase inhibitor for the treatment of metastatic breast cancer, has been associated with idiosyncractic hepatotoxicity. Recent investigations have implicated the importance of P450 3A4/5 enzymes in the formation of an electrophilic quinone imine (LAPQI) metabolite generated through fu...

journal_title：Chemical research in toxicology

authors： Eno MR,El-Gendy Bel-D,Cameron MD

更新日期：2016-05-16 00:00:00

abstract：:The primary products of one-electron oxidation of clozapine and olanzapine, very effective atypical antipsychotic drugs, have been spectroscopically characterized. The oxidation process has been studied under glassy matrix conditions and by a pulse radiolysis technique in aqueous solution. The rate constants for the o...

journal_title：Chemical research in toxicology

authors： Sikora A,Adamus J,Marcinek A

更新日期：2007-08-01 00:00:00

abstract：:The site specifically modified oligonucleotides 5'-d(TCCTCCTG1G2CCTCTC) (I) and 5'-d(CTATG1G2G3TATC) (II) were synthesized with single modified guanine residues at positions G1, G2, or G3, derived from the covalent binding reaction of 7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene ((+)-anti-BPDE) with ...

journal_title：Chemical research in toxicology

authors： Liu T,Xu J,Tsao H,Li B,Xu R,Yang C,Amin S,Moriya M,Geacintov NE

更新日期：1996-01-01 00:00:00

abstract：:Mouse models are powerful tools to study the developmental neurotoxicity of polychlorinated biphenyls (PCBs); however, studies of the oxidation of chiral PCB congeners to potentially neurotoxic hydroxylated metabolites (OH-PCBs) in mice have not been reported. Here, we investigate the atropselective oxidation of chira...

journal_title：Chemical research in toxicology

authors： Wu X,Duffel M,Lehmler HJ

更新日期：2013-11-18 00:00:00

abstract：:Previous studies suggested that lamotrigene (LTG) underwent bioactivation to a reactive aryl epoxide intermediate in rats. Nevertheless, definitive structures of these thioether conjugates, which are often needed to substantiate the mechanism of bioactivation and identity of reactive intermediate(s), were not fully es...

journal_title：Chemical research in toxicology

authors： Chen H,Grover S,Yu L,Walker G,Mutlib A

更新日期：2010-01-01 00:00:00

abstract：:By the action of UVA light, fluphenazine reacted with nucleophiles through a mechanism involving defluorination of its trifluoromethyl group, giving rise to carboxylic acid derivatives that were easily detected by electrospray mass spectrometry. This photoreaction took place with alcohols, sulphydryls, and amines. Whe...

journal_title：Chemical research in toxicology

authors： Caffieri S,Miolo G,Seraglia R,Dalzoppo D,Toma FM,van Henegouwen GM

更新日期：2007-10-01 00:00:00

abstract：:The trichothecene mycotoxin T-2 toxin, which is produced by fungi of the Fusarium species, is a worldwide occurring contaminant of cereal based food and feed. The cytotoxic properties of T-2 toxin are already well described with apoptosis being a major mechanism of action in various cell lines as well as in primary ce...

journal_title：Chemical research in toxicology

authors： Weidner M,Lenczyk M,Schwerdt G,Gekle M,Humpf HU

更新日期：2013-03-18 00:00:00

abstract：:Capillary liquid chromatography/microelectrospray mass spectrometry has been applied to the detection of deoxyribonucleoside adducts of the food-derived mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) from in vitro and in vivo sources. Constant neutral loss (CNL) and selective reaction monitoring (SRM) techniques...

journal_title：Chemical research in toxicology

authors： Gangl ET,Turesky RJ,Vouros P

更新日期：1999-10-01 00:00:00

abstract：:Among the cellular components that can react directly with peroxynitrite in the presence of physiological CO(2) concentrations are sulfur-, selenium-, and metal-containing proteins, in particular hemoproteins. We have previously shown that the reactions of peroxynitrite with oxymyoglobin (MbFeO(2)) and oxyhemoglobin p...

journal_title：Chemical research in toxicology

authors： Herold S,Exner M,Boccini F

更新日期：2003-03-01 00:00:00

abstract：:Ferroptosis is a form of cell death that requires phospholipid peroxidation and has attracted increased attention, both as a means to eradicate tumors resistant to standard chemotherapy and for its potential contribution to tissue damage such as in ischemia/reperfusion. The center stage taken by phospholipid peroxidat...

journal_title：Chemical research in toxicology

authors： Friedmann Angeli JP,Miyamoto S,Schulze A

更新日期：2019-03-18 00:00:00

abstract：:Previously, we reported a new animal model of an idiosyncratic drug reaction in which nevirapine causes a skin rash in some rats that has characteristics similar to the reaction that occurs in humans. Strong evidence that the reaction is immune-mediated was found; specifically, low-dose pretreatment induced tolerance,...

journal_title：Chemical research in toxicology

authors： Shenton JM,Popovic M,Chen J,Masson MJ,Uetrecht JP

更新日期：2005-12-01 00:00:00

abstract：:At high doses, green tea extracts and green tea's major active constituent, (-)-epigallocatechin gallate (EGCG), despite their generally perceived health benefits, have been suspected to cause hepatotoxicity in certain human populations. It has been reported that o-quinone metabolites of gallic acid or EGCG are causat...

journal_title：Chemical research in toxicology

authors： Pandey P,Avula B,Khan IA,Khan SI,Navarro VJ,Doerksen RJ,Chittiboyina AG

更新日期：2020-11-16 00:00:00

abstract：:Many herbal medicines such as epimedium have been reported to cause adverse effects, and icaritin is the common aglycone of many glucosides in epimedium. Our present work aimed at the clarification of the metabolic activation of icaritin possibly responsible for the adverse effects of epimedium. A quinone methide meta...

journal_title：Chemical research in toxicology

authors： Chen Y,Guo X,Ma Y,Hu X,Peng Y,Zheng J

更新日期：2019-06-17 00:00:00

abstract：:MXenes have attracted extensive attention due to their unique physicochemical properties. Especially, the flexibility and good conductivity endow MXenes with a great application prospect in the neural interfaces. However, the cytotoxicity of MXenes to nervous system remains unclear. In this study, we evaluated the cyt...

journal_title：Chemical research in toxicology

authors： Wu W,Ge H,Zhang L,Lei X,Yang Y,Fu Y,Feng H

更新日期：2020-12-21 00:00:00

abstract：:The mechanism of aromatic hydroxylation of estrogens by cytochrome P450 enzymes has been examined by comparing the oxidation of estrone with that of substrates carrying additional aromaticity such as equilenin and the structural analog 2-naphthol. Hamster liver microsomes preferentially catalyzed the conversion of est...

journal_title：Chemical research in toxicology

authors： Sarabia SF,Zhu BT,Kurosawa T,Tohma M,Liehr JG

更新日期：1997-07-01 00:00:00

abstract：:Available studies, while limited in number, suggest that e-cigarette vaping induces oxidative stress, with one potential mechanism being the direct formation of reactive oxygen species (ROS) in e-vapor. In the present studies, we measured the formation of hydroxyl radical (•OH), the most destructive ROS, in e-vapor un...

journal_title：Chemical research in toxicology

authors： Son Y,Mishin V,Laskin JD,Mainelis G,Wackowski OA,Delnevo C,Schwander S,Khlystov A,Samburova V,Meng Q

更新日期：2019-06-17 00:00:00

abstract：:Sulfamethoxazole (SMX) is an important antibiotic in the management of patients with cystic fibrosis, but allergic reactions may develop thus restricting therapy. The aim of this study was to utilize drug (metabolite) antigens to diagnose SMX-mediated allergic reactions in patients with cystic fibrosis. Lymphocytes fr...

journal_title：Chemical research in toxicology

authors： Lavergne SN,Whitaker P,Peckham D,Conway S,Park BK,Naisbitt DJ

更新日期：2010-06-21 00:00:00

abstract：:The worldwide outbreak of COVID-19 has drastically increased pressure on medical resources and highlighted the need for rapidly available, large-scale, and low-cost personal protective equipment (PPE). In this work, an alternative full-face mask is adapted from a modified snorkel mask to be used as PPE with two medica...

journal_title：Chemical research in toxicology

authors： Schmitt J,Jones LS,Aeby EA,Gloor C,Moser B,Wang J

更新日期：2021-01-18 00:00:00

abstract：:The binding conformations of single anti- and syn-BPDE-N2-dG adducts in oligonucleotides of varying base composition have been studied by induced circular dichroism (ICD) and light absorption spectroscopy. The sign of the ICD in single-stranded oligonucleotide adducts correlates with the absolute configuration of the ...

journal_title：Chemical research in toxicology

authors： Pradhan P,Jernström B,Seidel A,Nordén B,Gräslund A

更新日期：1999-05-01 00:00:00

abstract：:Notopterygium forbesii Boiss (NF) has been used as a traditional Chinese medicine for the treatment of common cold and rheumatism. However, there has been limited research on the biological properties of NF, and the mechanisms of action remain unknown. Here, we aimed to study the mechanism of NF-induced heme oxygenase...

journal_title：Chemical research in toxicology

authors： Tang SY,Wang H,Zhang W,Halliwell B

更新日期：2008-12-01 00:00:00

abstract：:Pesticide biotransformation, especially by cytochrome P450 enzymes (CYPs), may produce metabolites with substantially altered toxicological and physicochemical profiles, which has drawn great attention as a basis for environmental risk assessment. CYPs are active in the metabolism of various reactions of pesticides, a...

journal_title：Chemical research in toxicology

authors： Chai L,Ji S,Zhang S,Yu H,Zhao M,Ji L

更新日期：2020-06-15 00:00:00

abstract：:Polyunsaturated fatty acids (PUFA) are primary targets of free radical damage during oxidative stress. Diffusible electrophilic alpha,beta-unsaturated aldehydes, such as 4-hydroxynonenal (HNE), have been shown to modify proteins that mediate cell signaling (e.g., IKK and Keap1) and alter gene expression pathways respo...

journal_title：Chemical research in toxicology

authors： Vila A,Tallman KA,Jacobs AT,Liebler DC,Porter NA,Marnett LJ

更新日期：2008-02-01 00:00:00

abstract：:As COVID-19 swept across the world, it created a global pandemic and an unpredictable and challenging job market. This article discusses the future of the 2020-2021 job market in both academia and industry in the midst and aftermath of this pandemic. ...

journal_title：Chemical research in toxicology

authors： Perera HM,Griffin WC,Kankanamage RNT,Pathira Kankanamge LS

更新日期：2020-12-23 00:00:00

abstract：:Thioureas are oxygenated by flavin-containing monooxygenases (FMOs), forming reactive sulfenic and/or sulfinic acids. Sulfenic acids can reversibly react with GSH and drive oxidative stress through a redox cycle. For this reason, thiourea S-oxygenation is an example of FMO-dependent bioactivation of a xenobiotic. Func...

journal_title：Chemical research in toxicology

authors： Henderson MC,Krueger SK,Stevens JF,Williams DE

更新日期：2004-05-01 00:00:00

abstract：:Studies on the metabolic bioactivation of the psychotomimetic amine phencyclidine have been pursued through the characterization of a new metabolite which is formed via initial cytochrome P-450 catalyzed oxidation of the parent drug to the corresponding iminium species. CI mass spectrometric and diode array UV and 1H ...

journal_title：Chemical research in toxicology

authors： Hoag MK,Schmidt-Peetz M,Lampen P,Trevor A,Castagnoli N Jr

更新日期：1988-03-01 00:00:00

abstract：:Depleted uranium (DU) is commonly used in military armor and munitions, and thus, exposure of soldiers and non-combatants is potentially frequent and widespread. DU is considered a suspected human carcinogen, affecting the bronchial cells of the lung. However, few investigations have studied DU in human bronchial cell...

journal_title：Chemical research in toxicology

authors： Wise SS,Thompson WD,Aboueissa AM,Mason MD,Wise JP Sr

更新日期：2007-05-01 00:00:00

abstract：:The wide pH range reported for electronic cigarette (ECIG) liquids indicates that nicotine may be present in one or more chemical forms. The nicotine form affects the bioavailability and delivery of nicotine from inhaled products. Protonated nicotine is normally associated with counteranions in tobacco products. The c...

journal_title：Chemical research in toxicology

authors： El-Hellani A,El-Hage R,Salman R,Talih S,Shihadeh A,Saliba NA

更新日期：2017-08-21 00:00:00

abstract：:The crystal structure of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) has been determined by single-crystal X-ray crystallography. Crystals grown by evaporation of an aqueous solution form in the monoclinic space group P2(1)/n with two molecules of PhIP per asymmetric unit, along with six w...

journal_title：Chemical research in toxicology

authors： Parkin S,Marsch GA,Hope H,Whitney E,Winter NW,Colvin ME,Felton JS,Turteltaub KW

更新日期：1996-04-01 00:00:00

abstract：:Exposure of individual histone proteins (H1, H2A, H2B, H3, or H4) and histone octamers (consisting of two molecules each of H2A, H2B, H3, and H4) to hydroxyl radicals, generated by gamma-irradiation, in the presence of O(2) generates protein-bound hydroperoxides in a dose-dependent fashion; this is in accord with prev...

journal_title：Chemical research in toxicology

authors： Luxford C,Dean RT,Davies MJ

更新日期：2000-07-01 00:00:00

abstract：:Jay Amin hydroxamic acid (JAHA; N8-ferrocenylN1-hydroxy-octanediamide) is a ferrocene-containing analogue of the histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA). JAHA's cytotoxic activity on MDA-MB231 triple negative breast cancer (TNBC) cells at 72 h has been previously demonstrated with ...

journal_title：Chemical research in toxicology

authors： Librizzi M,Caradonna F,Cruciata I,Dębski J,Sansook S,Dadlez M,Spencer J,Luparello C

更新日期：2017-12-18 00:00:00