Oxidation of polychlorinated biphenyls by liver tissue slices from phenobarbital-pretreated mice is congener-specific and atropselective.

abstract：:Carcinogens induce complex transcriptional responses in cells that may hold key mechanistic information. Benzo(a)pyrene (BaP) modulation of transcription may occur through the activation of the aryl hydrocarbon receptor (AHR) or through responses to DNA damage. To characterize further the expression profiles induced b...

journal_title：Chemical research in toxicology

authors： Hockley SL,Arlt VM,Brewer D,Te Poele R,Workman P,Giddings I,Phillips DH

更新日期：2007-12-01 00:00:00

abstract：:8-Hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, has been extensively studied to assess human exposure to carcinogenic compounds. Previous studies have associated levels of human urinary hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) with those of 8-OHdG. However, measurements of OH-...

journal_title：Chemical research in toxicology

authors： Fan R,Wang D,Ramage R,She J

更新日期：2012-02-20 00:00:00

abstract：:Naphtho[8,1,2- ghi]chrysene, commonly known as naphtho[1,2- e]pyrene (N[1,2- e]P) is a widespread environmental pollutant, identified in coal tar extract, air borne particulate matter, marine sediment, cigarette smoke condensate, and vehicle exhaust. Herein, we determined the ability of rat liver microsomes to metabol...

journal_title：Chemical research in toxicology

authors： Sharma AK,Gowdahalli K,Gimbor M,Amin S

更新日期：2008-05-01 00:00:00

abstract：:3-Chloro-4-(chloromethyl)-5-hydroxy-2(5H)-furanone (CMCF) is a strong direct acting bacterial mutagen found in chlorine-disinfected drinking water. We studied the reaction of CMCF with 2-deoxyadenosine in buffered aqueous solutions and found that three main adducts were formed. The adducts were isolated and purified b...

journal_title：Chemical research in toxicology

authors： Munter T,Le Curieux F,Sjöholm R,Kronberg L

更新日期：1999-12-01 00:00:00

abstract：:The reaction of chromium(VI) with hydrogen peroxide was studied in the presence of glutathione. In vitro, reaction of chromium(VI) with hydrogen peroxide alone led to production of hydroxyl radical as the significant reactive intermediate, while reaction of chromium(VI) with glutathione led to formation of two chromiu...

journal_title：Chemical research in toxicology

authors： Aiyar J,Berkovits HJ,Floyd RA,Wetterhahn KE

更新日期：1990-11-01 00:00:00

abstract：:Carbon-13 NMR spectroscopy was used to study the effects of the peroxisome proliferator perfluoro-n-decanoic acid (PFDA) on hepatic carbohydrate metabolism in male Fischer-344 rats. The data indicate that PFDA-treated rats display an inhibition in hepatic [1-13C]glucose and [3-13C]alanine utilization on day 5 posttrea...

journal_title：Chemical research in toxicology

authors： Goecke CM,Jarnot BM,Reo NV

更新日期：1994-01-01 00:00:00

abstract：:Pesticide biotransformation, especially by cytochrome P450 enzymes (CYPs), may produce metabolites with substantially altered toxicological and physicochemical profiles, which has drawn great attention as a basis for environmental risk assessment. CYPs are active in the metabolism of various reactions of pesticides, a...

journal_title：Chemical research in toxicology

authors： Chai L,Ji S,Zhang S,Yu H,Zhao M,Ji L

更新日期：2020-06-15 00:00:00

abstract：:In aqueous media at neutral pH, the binding of two cyanide molecules per cobinamide can be described by two formation constants, Kf1 = 1.1 (±0.6) × 105 M-1 and Kf2 = 8.5 (±0.1) × 104 M-1, or an overall cyanide binding constant of ∼1 × 1010 M-2. In comparison, the cyanide binding constants for cobalamin and a fully oxi...

journal_title：Chemical research in toxicology

authors： Yuan Q,Pearce LL,Peterson J

更新日期：2017-12-18 00:00:00

abstract：:1H NMR spectroscopic and pattern recognition (PR)-based methods were used to investigate the biochemical variability in urine obtained from control rats and from rats treated with a hydrazine (a model hepatotoxin) or HgCl(2) (a model renal cortical toxin). The 600 MHz (1)H NMR spectra of urine samples obtained from ve...

journal_title：Chemical research in toxicology

authors： Holmes E,Nicholls AW,Lindon JC,Connor SC,Connelly JC,Haselden JN,Damment SJ,Spraul M,Neidig P,Nicholson JK

更新日期：2000-06-01 00:00:00

abstract：:The hydroperoxide of linoleic acid (13-HPODE) degrades to 9,12-dioxo-10(E)-dodecenoic acid (DODE), which readily modifies proteins. This study identified the major proteins in MCF7 cells modified by DODE. To reduce false positives, three methods were used to identify DODE-modified proteins. First, cells were treated w...

journal_title：Chemical research in toxicology

authors： Slade PG,Williams MV,Brahmbhatt V,Dash A,Wishnok JS,Tannenbaum SR

更新日期：2010-03-15 00:00:00

abstract：:A database containing maximum daily doses of 1841 marketed oral drugs was used to examine the influence of physicochemical properties on dose and hepatotoxicity (drug induced liver injury, DILI). Drugs in the highest ∼20% dose range had significantly reduced mean lipophilicity and molecular weight, increased fractiona...

journal_title：Chemical research in toxicology

authors： Leeson PD

更新日期：2018-06-18 00:00:00

abstract：:Hydrophobic and volatile chemicals have proven to be difficult to dose in cell assays. Cosolvents are often needed to dissolve these chemicals in cell culture medium. Moreover, the free concentration of these chemicals in culture medium may diminish over time due to metabolism, evaporation, and nonspecific binding to ...

journal_title：Chemical research in toxicology

authors： Kramer NI,Busser FJ,Oosterwijk MT,Schirmer K,Escher BI,Hermens JL

更新日期：2010-11-15 00:00:00

abstract：:Polycyclic aromatic hydrocarbons, such as benzo[a]pyrene, are widespread environmental carcinogens of human concern. Several enzymatic systems have been shown to activate benzo[a]pyrene 7, 8-dihydrodiol, the proximate carcinogenic metabolite of benzo[a]pyrene, to a reactive species which produces both a chemiluminesce...

journal_title：Chemical research in toxicology

authors： Stansbury KH,Noll DM,Groopman JD,Trush MA

更新日期：2000-11-01 00:00:00

abstract：:The urine from mice exposed to styrene vapors (600 and 1200 mg/m(3), 6 h) was analyzed for ring-oxidized metabolites of styrene. To facilitate the identification of metabolites in urine, the following potential metabolites were prepared: 2-, 3-, and 4-vinylphenol (2-, 3-, and 4-VP), 4-vinylpyrocatechol, and 2-, 3-, an...

journal_title：Chemical research in toxicology

authors： Linhart I,Mráz J,Scharff J,Krouzelka J,Dusková S,Nohová H,Vodicková L

更新日期：2010-01-01 00:00:00

abstract：:The DNA alkylating mechanism of PNU-159682 (PNU), a highly potent metabolite of the anthracycline nemorubicin, was investigated by gel-electrophoretic, HPLC-UV, and micro-HPLC/mass spectrometry (MS) measurements. PNU quickly reacted with double-stranded oligonucleotides, but not with single-stranded sequences, to form...

journal_title：Chemical research in toxicology

authors： Scalabrin M,Quintieri L,Palumbo M,Riccardi Sirtori F,Gatto B

更新日期：2017-02-20 00:00:00

abstract：:Chemical and structural alterations to lysozyme (LYSO), glucose 6-phosphate dehydrogenase (G6PD), and bovine eye lens proteins (BLP) promoted by peroxyl radicals generated by the thermal decomposition of 2,2'-azobis(2-amidinopropane) hydrochloride (AAPH) under aerobic conditions were investigated. SDS-PAGE analysis of...

journal_title：Chemical research in toxicology

authors： Arenas A,López-Alarcón C,Kogan M,Lissi E,Davies MJ,Silva E

更新日期：2013-01-18 00:00:00

abstract：:A newly developed recombinant yeast strain, in which the human estrogen receptor has been stably integrated into the genome of the yeast, was used to gain information on the estrogenic activity of a large series of dietary flavonoids. Among 23 flavonoids investigated, 8 were found to markedly stimulate the transcripti...

journal_title：Chemical research in toxicology

authors： Breinholt V,Larsen JC

更新日期：1998-06-01 00:00:00

abstract：:The genotoxicity of the dihydrofurans aflatoxin B1 (AFB1), aflatoxin G1 (AFG1), and sterigmatocystin (STG) was examined in a bacterial system in which the induction of SOS repair is monitored with the umuC gene linked to a lacZ reporter gene in plasmid pSK1002. Human liver microsomal cytochrome P-450NF oxidized the di...

journal_title：Chemical research in toxicology

authors： Baertschi SW,Raney KD,Shimada T,Harris TM,Guengerich FP

更新日期：1989-03-01 00:00:00

abstract：:Our long-term oral administration of dimethylarsinic acid (DMAV) in rats revealed that three unidentified metabolites, M-1, M-2, and M-3, were detected in urine and feces. DMAV and trimethylarsine oxide (TMAO) were converted to M-2 and M-3 and M-1 by Escherichia coli strain A3-6 isolated from the ceca of DMAV-administ...

journal_title：Chemical research in toxicology

authors： Yoshida K,Kuroda K,Zhou X,Inoue Y,Date Y,Wanibuchi H,Fukushima S,Endo G

更新日期：2003-09-01 00:00:00

abstract：:Proton pump inhibitors (PPIs) are extensively used for the treatment of gastric acid-related disorders. PPIs appear to be well tolerated and almost have no short-term side effects. However, the clinical adverse reactions of long-term PPI usage are increasingly reported in recent years. So far, there is no study that e...

journal_title：Chemical research in toxicology

authors： Wu D,Qiu T,Zhang Q,Kang H,Yuan S,Zhu L,Zhu R

更新日期：2015-03-16 00:00:00

abstract：:Implementation of the Clinical Data Interchange Standards Consortium (CDISC)'s Standard for Exchange of Nonclinical Data (SEND) by the United States Food and Drug Administration Center for Drug Evaluation and Research (US FDA CDER) has created large quantities of SEND data sets and a tremendous opportunity to apply la...

journal_title：Chemical research in toxicology

authors： Carfagna MA,Anderson J,Eley C,Fukushima T,Horvath J,Houser W,Larsen B,Page T,Russo D,Sloan C,Snyder K,Thompson R,Ullmann G,Whittaker M

更新日期：2020-12-16 00:00:00

abstract：:Lumiracoxib (Prexige; 2-[(2-fluoro-6-chlorophenyl)amino]-5-methyl-benzeneacetic acid) is a cyclooxygenase-2 selective inhibitor for the symptomatic treatment of osteoarthritis. Recently, the drug has been withdrawn in several countries due to serious liver side effects. Li et al. recently have shown that lumiracoxib i...

journal_title：Chemical research in toxicology

authors： Kang P,Dalvie D,Smith E,Renner M

更新日期：2009-01-01 00:00:00

abstract：:The recent guidance on "Safety Testing of Drug Metabolites" issued by the U.S. Food and Drug Administration, Center for Drug Evaluation and Research (CDER) has highlighted the importance of identifying and characterizing drug metabolites as early as possible in drug discovery and development. Furthermore, upon identif...

journal_title：Chemical research in toxicology

authors： Vishwanathan K,Babalola K,Wang J,Espina R,Yu L,Adedoyin A,Talaat R,Mutlib A,Scatina J

更新日期：2009-02-01 00:00:00

abstract：:Spin-trapping with 5,5-dimethyl-1-pyrroline 1-oxide (DMPO) was used to demonstrate that 3-nitrotyrosine (nitrotyrosine) promotes the formation of substantial amounts of reactive oxygen species (O2.- and *OH), when incubated with NAD(H)-cytochrome c reductase and a corresponding electron donor. Spin adduct formation is...

journal_title：Chemical research in toxicology

authors： Krainev AG,Williams TD,Bigelow DJ

更新日期：1998-05-01 00:00:00

abstract：:Water samples from the Waka River, which runs through an area housing many chemical industry facilities in Wakayama, Japan, have been found to show significant mutagenicity, especially without a mammalian metabolic activation system (S9 mix) in the Salmonella typhimurium YG1024 strain. Mutagens in the river water were...

journal_title：Chemical research in toxicology

authors： Takamura-Enya T,Watanabe T,Tada A,Hirayama T,Nukaya H,Sugimura T,Wakabayashi K

更新日期：2002-03-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are one of the most refractory environmental pollutants. Because of their ubiquitous existence in the biological systems (including human body), it is important to investigate their toxic behavior. Our previous findings demonstrated that a high reactive metabolite of PCB, namely PCB29-...

journal_title：Chemical research in toxicology

authors： Dong W,Zhu Q,Yang B,Qin Q,Wang Y,Xia X,Zhu X,Liu Z,Song E,Song Y

更新日期：2019-06-17 00:00:00

abstract：:Hypoxia-inducible factor-1α (HIF-1α) is a critical regulator of cellular responses to hypoxia. Under normoxic conditions, the cellular HIF-1α level is regulated by hydroxylation by prolyl hydroxylases (PHDs), ubiquitylation, and proteasomal degradation. During hypoxia, degradation decreases, and its intracellular leve...

journal_title：Chemical research in toxicology

authors： Chowdhury R,Godoy LC,Thiantanawat A,Trudel LJ,Deen WM,Wogan GN

更新日期：2012-10-15 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly population, above 65 years of age. Multiple lines of evidence confirm the central role of 40-42 residue Abeta peptides in the pathogenesis of AD, but exact mechanisms of Abeta toxicity remain unclear. Recently, evidence has accumulat...

journal_title：Chemical research in toxicology

authors： Rózga M,Bal W

更新日期：2010-02-15 00:00:00

abstract：:Estrogen replacement therapy has been correlated with an increased risk of developing breast or endometrial cancer. 4-Hydroxyequilenin (4-OHEN) is a catechol metabolite of equilenin which is a minor component of the estrogen replacement formulation marketed under the name of Premarin (Wyeth-Ayerst). Previously, we sho...

journal_title：Chemical research in toxicology

authors： Chen Y,Liu X,Pisha E,Constantinou AI,Hua Y,Shen L,van Breemen RB,Elguindi EC,Blond SY,Zhang F,Bolton JL

更新日期：2000-05-01 00:00:00

abstract：:We have reported [Correia et al. (1987) Arch. Biochem. Biophys. 258, 436-443] that administration of 3,5-dicarbethoxy-4-ethyl-2,6-dimethyl-1,4-dihydropyridine (DDEP) to untreated, phenobarbital (PB) pretreated, or dexamethasone (DEX) pretreated rats results in relatively selective inactivation of cytochrome P-450 (P-4...

journal_title：Chemical research in toxicology

authors： Sugiyama K,Yao K,Rettie AE,Correia MA

更新日期：1989-11-01 00:00:00