Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF7 cell proliferation assay.

abstract：:The location of carcinogen-modified nucleobases (DNA adducts) within DNA sequences is a critical factor affecting their promutagenic properties and persistence in DNA. We now report the use of controlled exonuclease digestion followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MAL...

journal_title：Chemical research in toxicology

authors： Tretyakova N,Matter B,Ogdie A,Wishnok JS,Tannenbaum SR

更新日期：2001-08-01 00:00:00

abstract：:Peroxynitrite (ONOO-), the reaction product of superoxide (O2.-) and nitric oxide (.NO), nitrates tyrosine and other phenolics. We report herein that tryptophan is also nitrated by peroxynitrite in the absence of transition metals to one predominant isomer of nitrotryptophan, as determined from spectral characteristic...

journal_title：Chemical research in toxicology

authors： Alvarez B,Rubbo H,Kirk M,Barnes S,Freeman BA,Radi R

更新日期：1996-03-01 00:00:00

abstract：:There is interest in the relative toxicities of emissions from electronic cigarettes and tobacco cigarettes. Lists of cigarette smoke priority toxicants have been developed to focus regulatory initiatives. However, a comprehensive assessment of e-cigarette chemical emissions including all tobacco smoke Harmful and Pot...

journal_title：Chemical research in toxicology

authors： Margham J,McAdam K,Forster M,Liu C,Wright C,Mariner D,Proctor C

更新日期：2016-10-17 00:00:00

abstract：:The issue of the safety of drug metabolites in humans is a complex one. In this commentary, a proposal is made regarding how to deal with drug metabolites observed in humans such that the safety of these molecules can be assured. The human radiolabeled ADME study, in which metabolites are identified and quantified in ...

journal_title：Chemical research in toxicology

authors： Smith DA,Obach RS

更新日期：2006-12-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), 1-nitropyrene (1-NP), and benzo[a]pyrene (BaP) are toxic environmental pollutants. TCDD was shown to suppress p53 expression in response to genotoxic stress and hypoxic conditions. However, the mechanism of TCDD's actions is not clearly understood. Our data showed that pretr...

journal_title：Chemical research in toxicology

authors： Su JG,Huang MC,Chen FY

更新日期：2011-12-19 00:00:00

abstract：:DNA copy number variants are associated with the development of complex neurological diseases and disorders including autism spectrum disorder, schizophrenia, Alzheimer's disease, and Parkinson's disease. Exposure to multiple environmental chemicals including various heavy metals is suggested as a risk factor in these...

journal_title：Chemical research in toxicology

authors： Lee J,Freeman JL

更新日期：2020-08-17 00:00:00

abstract：:Hydrophobic and volatile chemicals have proven to be difficult to dose in cell assays. Cosolvents are often needed to dissolve these chemicals in cell culture medium. Moreover, the free concentration of these chemicals in culture medium may diminish over time due to metabolism, evaporation, and nonspecific binding to ...

journal_title：Chemical research in toxicology

authors： Kramer NI,Busser FJ,Oosterwijk MT,Schirmer K,Escher BI,Hermens JL

更新日期：2010-11-15 00:00:00

abstract：:Cancer-associated mutations often lead to perturbed cellular energy metabolism and accumulation of potentially harmful oncometabolites. One example is the chiral molecule 2-hydroxyglutarate (2HG); its two stereoisomers (d- and l-2HG) have been found at abnormally high concentrations in tumors featuring anomalous metab...

journal_title：Chemical research in toxicology

authors： Chen F,Bian K,Tang Q,Fedeles BI,Singh V,Humulock ZT,Essigmann JM,Li D

更新日期：2017-04-17 00:00:00

abstract：:Methylmercury (MeHg) reacts readily with GSH, leading to the formation of a MeHg-SG adduct that is excreted into extracellular space through multidrug-resistance-associated protein (MRP), which is regulated by the transcription factor Nrf2. We previously reported that MeHg covalently modifies Keap1 and activates Nrf2 ...

journal_title：Chemical research in toxicology

authors： Yoshida E,Abiko Y,Kumagai Y

更新日期：2014-10-20 00:00:00

abstract：:Derivatives of methyl 3-(1-methyl-5-(1-methyl-5-(propylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylamino)-3-oxopropane-1-sulfonate (1), a peptide-based DNA minor groove binding methylating agent, were synthesized and characterized. In all cases, the N-terminus was appended with an O-methyl sulfonate ester, while...

journal_title：Chemical research in toxicology

authors： Iyer P,Srinivasan A,Singh SK,Mascara GP,Zayitova S,Sidone B,Fouquerel E,Svilar D,Sobol RW,Bobola MS,Silber JR,Gold B

更新日期：2013-01-18 00:00:00

abstract：:Ferroptosis is a form of cell death that requires phospholipid peroxidation and has attracted increased attention, both as a means to eradicate tumors resistant to standard chemotherapy and for its potential contribution to tissue damage such as in ischemia/reperfusion. The center stage taken by phospholipid peroxidat...

journal_title：Chemical research in toxicology

authors： Friedmann Angeli JP,Miyamoto S,Schulze A

更新日期：2019-03-18 00:00:00

abstract：:The crystal structure of Rad4/Rad23, the yeast homolog of the human nucleotide excision repair (NER) lesion recognition factor XPC-RAD23B ( Min , J. H. and Pavletich , N. P. ( 2007 ) Nature 449 , 570 - 575 ) reveals that the lesion-partner base is flipped out of the helix and binds to amino acids of the protein. This ...

journal_title：Chemical research in toxicology

authors： Cai Y,Zheng H,Ding S,Kropachev K,Schwaid AG,Tang Y,Mu H,Wang S,Geacintov NE,Zhang Y,Broyde S

更新日期：2013-07-15 00:00:00

abstract：:The formation of 8-oxo-7,8-dihydroguanine (G(O), 8-hydroxyguanine) in DNA and in the nucleotide pool results in G:C→T:A and A:T→C:G substitution mutations, respectively, since G(O) can pair with both C and A. In this study, the role of DNA polymerase κ in the mutagenicity of G(O) was investigated, using a supF shuttle...

journal_title：Chemical research in toxicology

authors： Kamiya H,Kurokawa M

更新日期：2012-08-20 00:00:00

abstract：:Nevirapine (NVP) treatment is associated with a significant incidence of skin rash in humans, and it also causes a similar immune-mediated skin rash in Brown Norway (BN) rats. We have shown that the sulfate of a major oxidative metabolite, 12-OH-NVP, covalently binds in the skin. The fact that the sulfate metabolite i...

journal_title：Chemical research in toxicology

authors： Sharma AM,Novalen M,Tanino T,Uetrecht JP

更新日期：2013-05-20 00:00:00

abstract：:Cholyl adenylate is a putative intermediate for biosynthesis of cholic acid-coenzyme A (CoA) thioester conjugates by acyl-CoA synthetase. Early studies showed the conjugated acid anhydride moiety of cholyl adenylate to be reactive, attacking proteins to form protein-cholic acid adducts. In the present study, to clarif...

journal_title：Chemical research in toxicology

authors： Takamura-Enya T,Mano N,Kawahara N,Goto J,Wakabayashi K

更新日期：2005-11-01 00:00:00

abstract：:Aryl radicals can react at the C8-site of 2'-deoxyguanosine (dG) to produce DNA adducts with a C8-C linkage (denoted C-linked). Such adducts are structurally distinct from those possessing a flexible amine (N-linked) or ether (O-linked) linkage, which separates the C8-aryl moiety from the guanine nucleobase. In the cu...

journal_title：Chemical research in toxicology

authors： Sproviero M,Verwey AM,Witham AA,Manderville RA,Sharma P,Wetmore SD

更新日期：2015-08-17 00:00:00

abstract：:Epidemiological studies have implicated a role for airborne particulates of <2.5 microm diameter in the development/exacerbation of chronic cardiopulmonary disease; however, specific pathogenic mechanisms and the etiological significance of particle physicochemical properties remain unresolved. Using a microporous alu...

journal_title：Chemical research in toxicology

authors： Kristovich R,Knight DA,Long JF,Williams MV,Dutta PK,Waldman WJ

更新日期：2004-10-01 00:00:00

abstract：:Enzyme-linked immunosorbent assays (ELISAs) are reported for the detection of atrazine and its principle metabolite in human urine. The ELISAs can be used with crude urine or following extraction and partial purification by methods described in this report. GC, MS, and HPLC techniques were used to confirm and compleme...

journal_title：Chemical research in toxicology

authors： Lucas AD,Jones AD,Goodrow MH,Saiz SG,Blewett C,Seiber JN,Hammock BD

更新日期：1993-01-01 00:00:00

abstract：:A potentiometric and spectroscopic (UV/vis and CD) study of Cu(II) and Ni(II) binding to the N-terminal pentadecapeptide of human protamine HP2 (HP2(1-15)) was performed. The results indicate that the N-terminal tripeptide motif Arg-Thr-His is the exclusive binding site for both metal ions at a metal to HP2(1-15) mola...

journal_title：Chemical research in toxicology

authors： Bal W,Jezowska-Bojczuk M,Kasprzak KS

更新日期：1997-08-01 00:00:00

abstract：:As metals are ubiquitous in the environment, humans are continuously exposed to them. Although some metallic ions play key roles in human physiology, most metals are redundant and are actually hazardous to humans. A frequent event in the toxicological cascade triggered by nonessential metals concerns the abrogation of...

journal_title：Chemical research in toxicology

authors： Vinken M,Ceelen L,Vanhaecke T,Rogiers V

更新日期：2010-12-20 00:00:00

abstract：:Adverse effects of drugs (AEDs) continue to be a major cause of drug withdrawals in both development and postmarketing. While liver-related AEDs are a major concern for drug safety, there are few in silico models for predicting human liver toxicity for drug candidates. We have applied the quantitative structure-activi...

journal_title：Chemical research in toxicology

authors： Rodgers AD,Zhu H,Fourches D,Rusyn I,Tropsha A

更新日期：2010-04-19 00:00:00

abstract：:Exposure of proteins to radicals in the presence of O(2) brings about multiple changes in the target molecules. These alterations include oxidation of side chains, fragmentation, cross-linking, changes in hydrophobicity and conformation, altered susceptibility to proteolytic enzymes, and formation of new reactive grou...

journal_title：Chemical research in toxicology

authors： Headlam HA,Mortimer A,Easton CJ,Davies MJ

更新日期：2000-11-01 00:00:00

abstract：:meso-2,3-Dimercaptosuccinic acid is an orally active chelating agent useful for the treatment of lead intoxication. Since it is believed to be extracellular in its distribution, analogs have been synthesized in a search for one that will enter the cell and successfully complete for firmly bound intracellular toxic hea...

journal_title：Chemical research in toxicology

authors： Aposhian HV,Levine DJ,Rivera M,Fernando Q

更新日期：1993-03-01 00:00:00

abstract：:Caffeine on alkaline hydrolysis produces caffeidine [1-methyl-4-(methylamino)-5-(N-methylcarbamoyl)imidazole] and caffeidine acid [N-[4-(5-carboxy-1-methylimidazolyl)]-N,N'-dimethylurea]. We now report the synthesis and chemical characterization of mononitrosocaffeidine [1-methyl-4-(N-methyl-N-nitrosoamino)-5-(N-methy...

journal_title：Chemical research in toxicology

authors： Kumar R,Wacker CD,Mende P,Spiegelhalder B,Preussmann R,Siddiqi M

更新日期：1993-01-01 00:00:00

abstract：:There is limited and sometimes contradictory information about the genotoxicity of the polycyclic aromatic hydrocarbon benzo[ghi]perylene (B[ghi]P). Using recently developed metabolic toxicity screening arrays and a biocolloid reactor-LC-MS/MS approach, both featuring films of DNA and human metabolic enzymes, we demon...

journal_title：Chemical research in toxicology

authors： Pan S,Li D,Zhao L,Schenkman JB,Rusling JF

更新日期：2013-08-19 00:00:00

abstract：:The guidelines embodied in this document were revised by the editors of the Publication Division of the American Chemical Society in January 1994 and endorsed by the Society Committee on Publications. ...

journal_title：Chemical research in toxicology

authors：

更新日期：1994-07-01 00:00:00

abstract：:Titanium dioxide nanoparticles (Nano-TiO2) are gradually being used extensively in clinical settings, industry, and daily life. Accumulation studies showed that Nano-TiO2 exposure is able to cause injuries in various animal organs, including the lung, liver, spleen, and kidney. However, it remains unclear whether expo...

journal_title：Chemical research in toxicology

authors： Huang KT,Wu CT,Huang KH,Lin WC,Chen CM,Guan SS,Chiang CK,Liu SH

更新日期：2015-03-16 00:00:00

abstract：:Hepatotoxicity of allyl alcohol involves its bioactivation to acrolein and subsequent protein sulfhydryl loss and lipid peroxidation. However, the links between these events and hepatocellular death are not known. The purpose of these studies was to examine whether specific signal transduction pathways are associated ...

journal_title：Chemical research in toxicology

authors： Maddox JF,Roth RA,Ganey PE

更新日期：2003-05-01 00:00:00

abstract：:Previous studies have demonstrated that reactive dicarbonyl compounds [e.g., methylglyoxal (MGO) and glyoxal (GO)] irreversibly and progressively modify proteins over time and yield advanced glycation end products (AGEs), which are thought to contribute to the development of diabetes mellitus and its subsequent compli...

journal_title：Chemical research in toxicology

authors： Sang S,Shao X,Bai N,Lo CY,Yang CS,Ho CT

更新日期：2007-12-01 00:00:00

abstract：:1,2,3,4-Diepoxybutane (DEB) is a prominent carcinogenic metabolite of 1,3-butadiene (1,3-BD), an important industrial chemical and an environmental pollutant found in cigarette smoke and automobile exhaust. DEB is capable of inducing a variety of genotoxic effects, including point mutations, large deletions, and chrom...

journal_title：Chemical research in toxicology

authors： Park S,Hodge J,Anderson C,Tretyakova N

更新日期：2004-12-01 00:00:00