Abstract:
:As metals are ubiquitous in the environment, humans are continuously exposed to them. Although some metallic ions play key roles in human physiology, most metals are redundant and are actually hazardous to humans. A frequent event in the toxicological cascade triggered by nonessential metals concerns the abrogation of cellular signaling mediated by gap junctions. This paper provides a literature overview of the documented effects of mercury, cadmium, arsenic, aluminum, lead, nickel, vanadium, and indium on gap junctional intercellular communication. Whenever available, particular attention is paid to the mechanistic basis of this deleterious biological outcome, which may involve the gap junction activity level or may arise from modifications in the expression of the gap junction building stones, the connexins.
journal_name
Chem Res Toxicoljournal_title
Chemical research in toxicologyauthors
Vinken M,Ceelen L,Vanhaecke T,Rogiers Vdoi
10.1021/tx100276fsubject
Has Abstractpub_date
2010-12-20 00:00:00pages
1862-7issue
12eissn
0893-228Xissn
1520-5010journal_volume
23pub_type
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