Future of toxicology--lipid peroxidation in the future: from biomarker to etiology.

abstract：:The 1-octanol/water partition coefficients of a number of toxic and nontoxic analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were determined using centrifugal partition chromatography (CPC), a novel and effective technique for measuring lipophilicity, and found to be highly correlated with values calc...

journal_title：Chemical research in toxicology

authors： Altomare C,Carrupt PA,Gaillard P,el Tayar N,Testa B,Carotti A

更新日期：1992-05-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are one of the most refractory environmental pollutants. Because of their ubiquitous existence in the biological systems (including human body), it is important to investigate their toxic behavior. Our previous findings demonstrated that a high reactive metabolite of PCB, namely PCB29-...

journal_title：Chemical research in toxicology

authors： Dong W,Zhu Q,Yang B,Qin Q,Wang Y,Xia X,Zhu X,Liu Z,Song E,Song Y

更新日期：2019-06-17 00:00:00

abstract：:beta-Carotene and other carotenoids are thought to exert disease preventive actions by scavenging reactive free radicals, but the mechanisms of these reactions are poorly understood. We detected products formed by reaction of beta-carotene with alkoxyl, and alkylperoxyl free radicals generated by thermolysis of azobis...

journal_title：Chemical research in toxicology

authors： Liebler DC,McClure TD

更新日期：1996-01-01 00:00:00

abstract：:Vinyl chloride and acrolein are important industrial chemicals. Both form DNA adducts, vinyl chloride after enzymatic oxidation to chlorooxirane and acrolein by direct reaction. Reaction at the N(2) position of guanine is a major pathway. The resulting 2-oxoethyl and 3-oxopropyl adducts cyclize spontaneously to hydrox...

journal_title：Chemical research in toxicology

authors： Nechev LV,Harris CM,Harris TM

更新日期：2000-05-01 00:00:00

abstract：:Nucleotide excision repair (NER) removes lesions caused by environmental mutagens or UV light from DNA. A hallmark of NER is the extraordinarily wide substrate specificity, raising the question of how one set of proteins is able to recognize structurally diverse lesions. Two key features of good NER substrates are tha...

journal_title：Chemical research in toxicology

authors： Yeo JE,Khoo A,Fagbemi AF,Schärer OD

更新日期：2012-11-19 00:00:00

abstract：:(-)-Epigallocatechin gallate (EGCG) is the most abundant and biologically active polyphenol in green tea, and many of the therapeutic benefits of the beverage have been attributed to this compound. High concentrations of EGCG are cytotoxic and trigger genotoxic events in mammalian cells. Although this catechin affects...

journal_title：Chemical research in toxicology

authors： Bandele OJ,Osheroff N

更新日期：2008-04-01 00:00:00

abstract：:Bisphenol A (BPA) is ubiquitous in the environment and is reported to be present at high concentrations in placental tissue, where its presence raises concerns over its potential to disrupt placental function. This report investigates how BPA interferes with the survival of human choriocarcinoma BeWo cells (a model of...

journal_title：Chemical research in toxicology

authors： Ponniah M,Billett EE,De Girolamo LA

更新日期：2015-09-21 00:00:00

abstract：:A freely available Windows-based program, RNSim1A, is utilized to predict metal-independent reactive nitrogen species (RNS) chemistry (oxidation, nitrosation, and nitration) under simulated biological conditions and make the following specific predictions. (1) The peak in oxidative reactions that occurs in vitro with ...

journal_title：Chemical research in toxicology

authors： Lancaster JR Jr

更新日期：2006-09-01 00:00:00

abstract：:All pesticides must go through a rigorous risk assessment process in order to show that they are safe for use.With respect to dermal risk assessment for re-entry workers, the absorption value applied to predict systemic dose from this external exposure is obtained by testing liquid forms of the pesticide in vivo and/o...

journal_title：Chemical research in toxicology

authors： Clarke JF,Cordery SF,Morgan NA,Knowles PK,Guy RH

更新日期：2015-02-16 00:00:00

abstract：:DNA molecules utilize adenine, thymine, cytosine, and guanine for coding genetic information. In addition to these four canonical nucleobases, DNA molecules also contain a variety of modified nucleobases that can control and regulate gene expression and chromosome structure. Elucidating the functions of DNA modificati...

journal_title：Chemical research in toxicology

authors： Yuan BF

更新日期：2020-03-16 00:00:00

abstract：:Drug-induced myocardial infarction (DIMI) is one of the most serious adverse drug effects that often lead to death. Therefore, the identification of DIMI at the early stages of drug development is essential. For this purpose, the in vitro testing and in silico prediction of interactions between drug-like substances an...

journal_title：Chemical research in toxicology

authors： Ivanov SM,Lagunin AA,Pogodin PV,Filimonov DA,Poroikov VV

更新日期：2014-07-21 00:00:00

abstract：:Mitomycin C (MMC) is a genotoxic cancer chemotherapeutic agent that reacts principally at the N2 position of guanine to form one of two predominant monoadducts, or a G-G interstrand cross-link at CpG sites, or a G-G intrastrand cross-link at GpG sites. Previous studies of MMC adduction have principally used very short...

journal_title：Chemical research in toxicology

authors： Warren AJ,Hamilton JW

更新日期：1996-10-01 00:00:00

abstract：:The toxicity of the ubiquitous pollutant and endogenous metabolite, acrolein, is due in part to covalent protein modifications. Acrolein reacts readily with protein nucleophiles via Michael addition and Schiff base formation. Potential acrolein targets in protein include the nucleophilic side chains of cysteine, histi...

journal_title：Chemical research in toxicology

authors： Cai J,Bhatnagar A,Pierce WM Jr

更新日期：2009-04-01 00:00:00

abstract：:The location of carcinogen-modified nucleobases (DNA adducts) within DNA sequences is a critical factor affecting their promutagenic properties and persistence in DNA. We now report the use of controlled exonuclease digestion followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MAL...

journal_title：Chemical research in toxicology

authors： Tretyakova N,Matter B,Ogdie A,Wishnok JS,Tannenbaum SR

更新日期：2001-08-01 00:00:00

abstract：:Nitric oxide (NO) has been found to inhibit the copper-responsive yeast transcription factor Ace1 in an oxygen-dependent manner. However, the mechanism responsible for NO-dependent inhibition of Ace1 remains unestablished. In the present study, the chemical interaction of nitrogen oxide species with Ace1 was examined ...

journal_title：Chemical research in toxicology

authors： Shinyashiki M,Pan CJ,Switzer CH,Fukuto JM

更新日期：2001-12-01 00:00:00

abstract：:To reveal the roles of Y family DNA polymerases in the mutagenesis induced by oxidatively damaged DNA precursors, 2-hydroxy-dATP (2-OH-dATP) and 8-hydroxy-dGTP (8-OH-dGTP) were introduced into Escherichia coli strains deficient in the Y family polymerases, DNA polymerase IV (pol IV, encoded by the dinB gene) and DNA p...

journal_title：Chemical research in toxicology

authors： Satou K,Yamada M,Nohmi T,Harashima H,Kamiya H

更新日期：2005-08-01 00:00:00

abstract：:The ability of the carcinogenic mycotoxin ochratoxin A (OTA) to react with reduced glutathione (GSH) has been assessed using electrospray ionization (ES)-MS techniques. On the basis of the assumption that OTA undergoes biotransformation into the reactive quinone species OTQ (6), a synthetic sample of the reduced form ...

journal_title：Chemical research in toxicology

authors： Dai J,Park G,Wright MW,Adams M,Akman SA,Manderville RA

更新日期：2002-12-01 00:00:00

abstract：:Although many phenols and catechols found as polyphenol natural products are antioxidants and have putative disease-preventive properties, others have deleterious health effects. One possible route to toxicity is the bioactivation of the phenolic function to quinones that are electrophilic, redox-agents capable of mod...

journal_title：Chemical research in toxicology

authors： Tu T,Giblin D,Gross ML

更新日期：2011-09-19 00:00:00

abstract：:Guidance from the Food and Drug Administration on drug interaction studies does not include a specific section on contributions of metabolites to observed inhibitory drug-drug interactions, and the quantitative role of drug metabolites in inhibitory drug-drug interactions is not presently known. The current work was u...

journal_title：Chemical research in toxicology

authors： Isoherranen N,Hachad H,Yeung CK,Levy RH

更新日期：2009-02-01 00:00:00

abstract：:A series of tether-linked bis netropsins have been synthesized in order to assess the phasing problem, which arises because of the lack of dimensional correspondence between oligopeptides and oligonucleotides in DNA binding characteristics. The consequences of incorporating variable-length flexible and rigid tethers [...

journal_title：Chemical research in toxicology

authors： Kissinger KL,Dabrowiak JC,Lown JW

更新日期：1990-03-01 00:00:00

abstract：:Complex formation between nitrosoglutathione (GSNO) and Zn(II), Cd(II), and Ni(II) ions was studied by potentiometry and spectroscopic techniques. GSNO forms simple ML and ML2 type complexes (L = GSNO) with these ions. The stability of GSNO in HEPES buffer solution, pH 7.4, increased in the presence of both Zn(II) and...

journal_title：Chemical research in toxicology

authors： Krezel A,Bal W

更新日期：2004-03-01 00:00:00

abstract：:In vitro techniques have been utilized to investigate the microsomal enzymes involved in the metabolism of lauric acid and to establish conditions in which it can be used as a model substrate for both cytochrome P450 4A and cytochrome P450 2E1 in human liver microsomes. Studies of enzyme kinetics of lauric acid omega-...

journal_title：Chemical research in toxicology

authors： Clarke SE,Baldwin SJ,Bloomer JC,Ayrton AD,Sozio RS,Chenery RJ

更新日期：1994-11-01 00:00:00

abstract：:Carbon disulfide (CS2) induces embryo implantation disorders. Macrophages participate in the process of pregnancy. Therefore, we want to explore the effects of CS2 exposure on polarization and immune function of macrophages in pregnant mice uteri. The exposure times were gestation days 3 (GD3), 4 (GD4), and 5 (GD5), a...

journal_title：Chemical research in toxicology

authors： Zhang T,Hu C,Wu Y,Wang S,Liu X,Zhang D,Huang F,Gao H,Wang Z

更新日期：2019-10-21 00:00:00

abstract：:Exposure assessment in in vitro cell-based bioassays is challenging for ionizable organic chemicals (IOCs), because they are present as more than one chemical species in the bioassay medium. Furthermore, compared to neutral organic chemicals, their binding to medium proteins and lipids is driven by more complex molecu...

journal_title：Chemical research in toxicology

authors： Huchthausen J,Mühlenbrink M,König M,Escher BI,Henneberger L

更新日期：2020-07-20 00:00:00

abstract：:Cyclic imides are known for their antitumor activity, especially the naphthalimide derivatives, such as Mitonafide and Amonafide. Recently, we have demonstrated the cytotoxic effect of a series of naphthalimide derivatives against B16F10 melanoma cells. On the basis of this fact, we have developed a study starting fro...

journal_title：Chemical research in toxicology

authors： Machado KE,de Oliveira KN,Andreossi HM,Bubniak Ldos S,de Moraes AC,Gaspar PC,Andrade Eda S,Nunes RJ,Santos-Silva MC

更新日期：2013-12-16 00:00:00

abstract：:At high doses, green tea extracts and green tea's major active constituent, (-)-epigallocatechin gallate (EGCG), despite their generally perceived health benefits, have been suspected to cause hepatotoxicity in certain human populations. It has been reported that o-quinone metabolites of gallic acid or EGCG are causat...

journal_title：Chemical research in toxicology

authors： Pandey P,Avula B,Khan IA,Khan SI,Navarro VJ,Doerksen RJ,Chittiboyina AG

更新日期：2020-11-16 00:00:00

abstract：:A model protein, ribonuclease A (bovine pancreas), was examined for its ability to coordinate Ni2+ and promote selective oxidation. In the presence of a peracid such as monopersulfate, HSO5-, nickel induced the monomeric RNase A to form dimers, trimers, tetramers, and higher oligomers without producing fragmentation o...

journal_title：Chemical research in toxicology

authors： Gill G,Richter-Rusli AA,Ghosh M,Burrows CJ,Rokita SE

更新日期：1997-03-01 00:00:00

abstract：:2-Nitrosoamino-3,8-dimethylimidazo[4,5-f]quinoxaline (N-NO-MeIQx) is a nitrosation product of the food carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and is proposed to form in vivo under inflammatory conditions. This study evaluated the stability and reactivity of N-NO-MeIQx to assess its possible r...

journal_title：Chemical research in toxicology

authors： Lakshmi VM,Hsu FF,Schut HA,Zenser TV

更新日期：2006-02-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic aromatic amine that is formed during the cooking of meats. PhIP is a potential human carcinogen: it undergoes metabolic activation to form electrophilic metabolites that bind to DNA and proteins, including serum albumin (SA). The structures of Ph...

journal_title：Chemical research in toxicology

authors： Peng L,Dasari S,Tabb DL,Turesky RJ

更新日期：2012-10-15 00:00:00

abstract：:This study addresses the detection and characterization of the modification of human serum albumin (HSA) by amoxicillin (AX) in ex vivo samples from healthy subjects under oral amoxicillin administration (acute intake of 1 g every 8 h for 48 h). To reach this goal, we used an analytical strategy based on targeted and ...

journal_title：Chemical research in toxicology

authors： Garzon D,Ariza A,Regazzoni L,Clerici R,Altomare A,Sirtori FR,Carini M,Torres MJ,Pérez-Sala D,Aldini G

更新日期：2014-09-15 00:00:00