Abstract：
:Methyleugenol (ME), an alkenylbenzene compound, is a natural ingredient of several herbs and is used as flavoring agent in foodstuffs and fragrance in cosmetics. The hepatotoxicity, cytotoxicity, and carcinogenesis of ME have been well documented, and metabolic activation has been suggested to involve in ME-induced toxicities. The objective of this study was to identify chemical identity of interactions of protein with reactive metabolites of ME. Modification of cysteine residues of protein was observed in microsomal incubations and mice after exposure to ME. Three types of protein modification derived from the corresponding epoxide, α,β-unsaturated aldehyde, and carbonium ion of ME were detected in vitro and in vivo. The protein adduction took place in time- and dose-dependent manners. Dexamethasone, ketoconazole, and l-buthionine sulfoximine increased the protein modification induced by ME, which was proportional to the hepatotoxicity of ME. The findings facilitate the understanding of mechanism action of ME toxicities.
journal_name
Chem Res Toxicoljournal_title
Chemical research in toxicologyauthors
Feng Y,Wang H,Wang Q,Huang W,Peng Y,Zheng Jdoi
10.1021/acs.chemrestox.6b00290subject
Has Abstractpub_date
2017-02-20 00:00:00pages
564-573issue
2eissn
0893-228Xissn
1520-5010journal_volume
30pub_type
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journal_title：Chemical research in toxicology
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更新日期：2009-10-01 00:00:00
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更新日期：2011-08-15 00:00:00
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更新日期：1999-09-01 00:00:00
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doi：10.1021/acs.chemrestox.7b00275
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pub_type： 杂志文章
doi：10.1021/acs.chemrestox.9b00372
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pub_type： 杂志文章
doi：10.1021/tx990105j
更新日期：1999-12-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx00029a003
更新日期：1992-09-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx980086y
更新日期：1998-12-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx010102i
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2004-11-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1993-03-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx00035a007
更新日期：1993-09-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/acs.chemrestox.5b00093
更新日期：2015-09-21 00:00:00
abstract：:Although many phenols and catechols found as polyphenol natural products are antioxidants and have putative disease-preventive properties, others have deleterious health effects. One possible route to toxicity is the bioactivation of the phenolic function to quinones that are electrophilic, redox-agents capable of mod...
journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx200140s
更新日期：2011-09-19 00:00:00
