Kinetic study of the reaction of glutathione peroxidase with peroxynitrite.

abstract：:Senescence, which is irreversible cell cycle arrest, is induced by various types of DNA damage, including genotoxic stress. Senescent cells show dysregulation of tumor suppressor genes and other regulators of cellular proliferation. Activating transcription factor 3 (ATF3) plays a pleiotropic role in biological proces...

journal_title：Chemical research in toxicology

authors： Kim KH,Park B,Rhee DK,Pyo S

更新日期：2015-01-20 00:00:00

abstract：:Previously, we reported a new animal model of an idiosyncratic drug reaction in which nevirapine causes a skin rash in some rats that has characteristics similar to the reaction that occurs in humans. Strong evidence that the reaction is immune-mediated was found; specifically, low-dose pretreatment induced tolerance,...

journal_title：Chemical research in toxicology

authors： Shenton JM,Popovic M,Chen J,Masson MJ,Uetrecht JP

更新日期：2005-12-01 00:00:00

abstract：:Oxidative stress is a commonly cited mechanism of toxicity of environmental agents. Ubiquitous environmental chemicals such as the diesel exhaust component 1,2-naphthoquinone (1,2-NQ) induce oxidative stress by redox cycling, which generates hydrogen peroxide (H2O2). Cysteinyl thiolate residues on regulatory proteins ...

journal_title：Chemical research in toxicology

authors： Wages PA,Lavrich KS,Zhang Z,Cheng WY,Corteselli E,Gold A,Bromberg P,Simmons SO,Samet JM

更新日期：2015-12-21 00:00:00

abstract：:The biological response of bronchial epithelial cells to particles is associated with a sequestration of cell metal by the particle surface and a subsequent disruption in host iron homeostasis. The macrophage is the cell type resident in the respiratory tract that is most likely to make initial contact with inhaled pa...

journal_title：Chemical research in toxicology

authors： Ghio AJ,Soukup JM,Stonehuerner J,Tong H,Richards J,Gilmour MI,Madden MC,Shen Z,Kantrow SP

更新日期：2019-09-16 00:00:00

abstract：:Bisphenol A (BPA) is used in the production of polycarbonate plastics and epoxy resins for baby bottles, liners of canned food, and many other consumer products. Previously, BPA has been shown to reduce the activity of several antioxidant enzymes, which may contribute to oxidative stress. However, the underlying mecha...

journal_title：Chemical research in toxicology

authors： Chepelev NL,Enikanolaiye MI,Chepelev LL,Almohaisen A,Chen Q,Scoggan KA,Coughlan MC,Cao XL,Jin X,Willmore WG

更新日期：2013-03-18 00:00:00

abstract：:We have reported [Correia et al. (1987) Arch. Biochem. Biophys. 258, 436-443] that administration of 3,5-dicarbethoxy-4-ethyl-2,6-dimethyl-1,4-dihydropyridine (DDEP) to untreated, phenobarbital (PB) pretreated, or dexamethasone (DEX) pretreated rats results in relatively selective inactivation of cytochrome P-450 (P-4...

journal_title：Chemical research in toxicology

authors： Sugiyama K,Yao K,Rettie AE,Correia MA

更新日期：1989-11-01 00:00:00

abstract：:Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation in drug metabolism. Consequently, it is important to understand how metabolic capacity is influenced among patients. Cytochrome P450s (P450 or CYP for a specific isoform) catalyze the first m...

journal_title：Chemical research in toxicology

authors： Jones DR,Kim SY,Guderyon M,Yun CH,Moran JH,Miller GP

更新日期：2010-05-17 00:00:00

abstract：:We have recently shown that dithiocarbamate (DC) disulfides inhibit proteolytic processing of the caspase-3 proenzyme in Jurkat T lymphocytes treated with anti-CD95 (Fas/APO-1) antibody. Because the processing can be accomplished by caspase activity, we investigated the effect of DC disulfides, such as disulfiram (DSF...

journal_title：Chemical research in toxicology

authors： Nobel CS,Kimland M,Nicholson DW,Orrenius S,Slater AF

更新日期：1997-12-01 00:00:00

abstract：:Furan has been found in a number of heated food items and is carcinogenic in the liver of rats and mice. Estimates of human exposure on the basis of concentrations measured in food are not reliable because of the volatility of furan. A biomarker approach is therefore indicated. We searched for metabolites excreted in ...

journal_title：Chemical research in toxicology

authors： Kellert M,Wagner S,Lutz U,Lutz WK

更新日期：2008-03-01 00:00:00

abstract：:The first method for generating (*)NO and O(2)(*)(-) at any known, constant ratio has been developed. Spermine NONOate and di(4-carboxybenzyl)hyponitrite decay with first-order kinetics and exactly equal rate constants (half-lives of 80 min) at 37 degrees C and pH 7.5 to give 200 and 40 mol % (*)NO and O(2)(*)(-), res...

journal_title：Chemical research in toxicology

authors： Hodges GR,Marwaha J,Paul T,Ingold KU

更新日期：2000-12-01 00:00:00

abstract：:This work reveals a novel mechanism for triplet carbonyl formation (and hence chemiluminescence) during lipid peroxidation, whose chemiluminescence has been attributed to both triplet carbonyls and singlet oxygen. As a model for polyunsaturated fatty acid hydroperoxides, we have synthesized 3-hydroperoxy-2,3-dimethyl-...

journal_title：Chemical research in toxicology

authors： Tímmins GS,dos Santos RE,Whitwood AC,Catalani LH,Di Mascio P,Gilbert BC,Bechara EJ

更新日期：1997-10-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are formed during incomplete combustion of organic material and are ubiquitous environmental contaminants. High levels of PAHs are commonly found in soils at industrial sites, thereby constituting a risk for humans and the environment. However, this risk is often difficult to es...

journal_title：Chemical research in toxicology

authors： Niziolek-Kierecka M,Dreij K,Lundstedt S,Stenius U

更新日期：2012-04-16 00:00:00

abstract：:Reactive oxygen species (ROS), which can be produced during normal aerobic metabolism, can induce the formation of tandem DNA lesions, including 8,5'-cyclo-2'-deoxyadenosine (cyclo-dA) and 8,5'-cyclo-2'-deoxyguanosine (cyclo-dG). Previous studies have shown that cyclo-dA and cyclo-dG accumulate in cells and can block ...

journal_title：Chemical research in toxicology

authors： Swanson AL,Wang J,Wang Y

更新日期：2012-08-20 00:00:00

abstract：:DNA damage and mutations are a major primary cause of cancer. Chemical bombardment of DNA is a major contributor to DNA damage. The Division of Chemical Toxicology recently hosted a panel of researchers who provided updates on the field of chemical toxicology at the nexus of DNA damage and repair. ...

journal_title：Chemical research in toxicology

authors： Pathira Kankanamge LS,Perera HM,Griffin WC

更新日期：2021-01-28 00:00:00

abstract：:Adverse events resulting from drug therapy can be a cause of drug withdrawal, reduced and or restricted clinical use, as well as a major economic burden for society. To increase the safety of new drugs, there is a need to better understand the mechanisms causing the adverse events. One way to derive new mechanistic hy...

journal_title：Chemical research in toxicology

authors： Svensson F,Zoufir A,Mahmoud S,Afzal AM,Smit I,Giblin KA,Clements PJ,Mettetal JT,Pointon A,Harvey JS,Greene N,Williams RV,Bender A

更新日期：2018-11-19 00:00:00

abstract：:Prolonged ingestion of Yellow Starthistle (Centaurea solstitialis) and Russian Knapweed (Centaurea repens) by horses has been shown to result in a fatal neurodegenerative disorder called equine nigropallidal encephalomalacia (ENE). Bioassay-guided fractionation of extracts from Centaurea species using the PC12 cell li...

journal_title：Chemical research in toxicology

authors： Tukov FF,Anand S,Gadepalli RS,Gunatilaka AA,Matthews JC,Rimoldi JM

更新日期：2004-09-01 00:00:00

abstract：:Understanding the molecular basis of inorganic chemical toxicity has lagged behind the proliferation of detailed mechanisms that explain the biochemical toxicology of many organic xenobiotics. In this perspective, general barriers to explicating the bioinorganic chemistry of toxic metals are considered, followed by a ...

journal_title：Chemical research in toxicology

authors： Petering DH

更新日期：2017-01-17 00:00:00

abstract：:The major plant growth regulator ethephon degrades to ethylene and phosphate in aqueous solutions and plants and is spontaneously activated to a butyrylcholinesterase (BChE) inhibitor in alkaline solutions and animal tissues. In the present (31)P NMR kinetic study of the reactions of ethephon in pH 7.4 carbonate buffe...

journal_title：Chemical research in toxicology

authors： Lantz SR,Casida JE

更新日期：2013-09-16 00:00:00

abstract：:Exposure of proteins to radicals in the presence of O(2) brings about multiple changes in the target molecules. These alterations include oxidation of side chains, fragmentation, cross-linking, changes in hydrophobicity and conformation, altered susceptibility to proteolytic enzymes, and formation of new reactive grou...

journal_title：Chemical research in toxicology

authors： Headlam HA,Mortimer A,Easton CJ,Davies MJ

更新日期：2000-11-01 00:00:00

abstract：:2'-Deoxyoxanosine (dOxo) is a novel DNA lesion produced from dGuo by reaction with nitrous acid or nitric oxide [Suzuki, T., Yamaoka, R., Nishi, M., Ide, H., and Makino, K. (1996) J. Am. Chem. Soc. 118, 2515-2516]. We investigated the reaction of dOxo with glycine (Gly) under physiological conditions. When 5 mM dOxo w...

journal_title：Chemical research in toxicology

authors： Suzuki T,Yamada M,Ide H,Kanaori K,Tajima K,Morii T,Makino K

更新日期：2000-04-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic aromatic amine that is formed during the cooking of meats and poultry. PhIP is a carcinogen in rodents and a potential human carcinogen. Several short-term biomarkers of PhIP have been established for human biomonitoring, but validated long-term ...

journal_title：Chemical research in toxicology

authors： Peng L,Turesky RJ

更新日期：2011-11-21 00:00:00

abstract：:Topoisomerase II regulates DNA topology by generating transient double-stranded breaks. The anticancer drug etoposide targets topoisomerase II and is associated with the formation of secondary leukemias in patients. The quinone and catechol metabolites of etoposide may contribute to strand breaks that trigger leukemic...

journal_title：Chemical research in toxicology

authors： Jacob DA,Gibson EG,Mercer SL,Deweese JE

更新日期：2013-08-19 00:00:00

abstract：:Raloxifene (Evista) is a second generation selective estrogen receptor modulator used in the treatment of osteoporosis and for chemoprevention of breast cancer. It is bioactivated to reactive intermediates, which covalently bind to proteins and form GSH conjugates upon incubation with NADPH and GSH-supplemented human ...

journal_title：Chemical research in toxicology

authors： Dalvie D,Kang P,Zientek M,Xiang C,Zhou S,Obach RS

更新日期：2008-12-01 00:00:00

abstract：:The trichothecene mycotoxin T-2 toxin, which is produced by fungi of the Fusarium species, is a worldwide occurring contaminant of cereal based food and feed. The cytotoxic properties of T-2 toxin are already well described with apoptosis being a major mechanism of action in various cell lines as well as in primary ce...

journal_title：Chemical research in toxicology

authors： Weidner M,Lenczyk M,Schwerdt G,Gekle M,Humpf HU

更新日期：2013-03-18 00:00:00

abstract：:Previous reports indicate that 4-benzyl-1-methyl-1,2,3,6-tetrahydropyridine (BMTP), the benzyl analogue of the Parkinsonian inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), is not neurotoxic in the C-57 black mouse even when administered at a dose 10 times greater than the dose of MPTP required...

journal_title：Chemical research in toxicology

authors： Naiman N,Rollema H,Johnson E,Castagnoli N Jr

更新日期：1990-03-01 00:00:00

abstract：:Vinyl chloride and acrolein are important industrial chemicals. Both form DNA adducts, vinyl chloride after enzymatic oxidation to chlorooxirane and acrolein by direct reaction. Reaction at the N(2) position of guanine is a major pathway. The resulting 2-oxoethyl and 3-oxopropyl adducts cyclize spontaneously to hydrox...

journal_title：Chemical research in toxicology

authors： Nechev LV,Harris CM,Harris TM

更新日期：2000-05-01 00:00:00

abstract：:Isoeugenol is widely used by the cosmetic and fragrance industries, but it also represents a known cause of skin sensitization adverse effects. Although devoid of a structural alert, isoeugenol has been classified as prehapten in virtue of the presence of a pre-Michael acceptor domain. Isoeugenol oxidation could theor...

journal_title：Chemical research in toxicology

authors： Ahn J,Avonto C,Chittiboyina AG,Khan IA

更新日期：2020-04-20 00:00:00

abstract：:Exposures to sulfur mustard (HD; bis(2-chloroethyll) sulfide) are well-known to result in the formation of adducts with free aspartate and glutamate residues of plasma proteins (Lawrence, R. J., Smith, J. R., and Capacio, B. R. 2008 32, (1), 31-36). A modified version of the analytical method reported previously for t...

journal_title：Chemical research in toxicology

authors： Young SA,Capacio BR

更新日期：2020-07-20 00:00:00

abstract：:Diethylstilbestrol (DES) and hexestrol (HES) are carcinogenic synthetic estrogens. The major metabolites of these compounds are their catechol derivatives, 3'-OH-DES and 3'-OH-HES. Oxidation of these metabolites leads to the electrophilic quinones, which are presumably involved in the tumor-initiating process. A synth...

journal_title：Chemical research in toxicology

authors： Jan ST,Rogan EG,Cavalieri EL

更新日期：1998-05-01 00:00:00

abstract：:We report on the generation of computer-based models for the prediction of the chromosome-damaging potential of chemicals as assessed in the in vitro chromosome aberration (CA) test. On the basis of publicly available CA-test results of more than 650 chemical substances, half of which are drug-like compounds, we gener...

journal_title：Chemical research in toxicology

authors： Rothfuss A,Steger-Hartmann T,Heinrich N,Wichard J

更新日期：2006-10-01 00:00:00