当前位置： SCI文献检索 > CHEMICAL RESEARCH IN TOXICOLOGY期刊下所有文献 > Quartz Disrupts Iron Homeostasis in Alveolar Macrophages To Impact a Pro-Inflammatory Effect.

Quartz Disrupts Iron Homeostasis in Alveolar Macrophages To Impact a Pro-Inflammatory Effect.

Abstract：

:The biological response of bronchial epithelial cells to particles is associated with a sequestration of cell metal by the particle surface and a subsequent disruption in host iron homeostasis. The macrophage is the cell type resident in the respiratory tract that is most likely to make initial contact with inhaled particles. We tested the postulates that (1) silica, a prototypical particle, disrupts iron homeostasis in alveolar macrophages (AMs); and (2) the altered iron homeostasis results in both an oxidative stress and pro-inflammatory effects. Human AMs (1.0 × 106/mL) demonstrated an increased import of iron following particle exposure with nonheme iron concentrations of 0.57 ± 0.03, 1.72 ± 0.09, 0.88 ± 0.09, and 3.21 ± 0.11 ppm in cells exposed for 4 h to media, 500 μM ferric ammonium citrate (FAC), 100 μg/mL silica, and both silica and FAC, respectively. Intracellular ferritin concentrations and iron release were similarly increased after AM exposure to FAC and silica. Silica increased oxidant generation by AMs measured using both dichlorofluorescein diacetate fluorescence and reduction of nitroblue tetrazolium salt. Concentrations of interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor-α in macrophage supernatant increased following 100 μg/mL silica exposure for 24 h. Treatment of AMs with 500 μM FAC decreased both oxidant generation and cytokine release associated with silica exposure, supporting a dependence of these effects on sequestration of cell metal by the particle surface. We conclude that (1) silica exposure disrupts iron homeostasis resulting in increased import, accumulation, and release of the metal; and (2) the altered iron homeostasis following silica exposure impacts oxidant generation and pro-inflammatory effects.

journal_name

Chem Res Toxicol

journal_title

Chemical research in toxicology

authors

Ghio AJ,Soukup JM,Stonehuerner J,Tong H,Richards J,Gilmour MI,Madden MC,Shen Z,Kantrow SP

doi

10.1021/acs.chemrestox.8b00301

subject

Has Abstract

pub_date

2019-09-16 00:00:00

pages

1737-1747

issue

9

eissn

0893-228X

issn

1520-5010

journal_volume

32

pub_type

杂志文章

相关文献

CHEMICAL RESEARCH IN TOXICOLOGY文献大全
  • Model system to study the influence of aggregation on the hemolytic potential of silica nanoparticles.

    abstract：:A well-defined silica nanoparticle model system was developed to study the effect of the size and structure of aggregates on their membranolytic activity. The aggregates were stable and characterized using transmission electron microscopy, dynamic light scattering, nitrogen adsorption, small-angle X-ray scattering, in...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx2002178

    authors： Thomassen LC,Rabolli V,Masschaele K,Alberto G,Tomatis M,Ghiazza M,Turci F,Breynaert E,Martra G,Kirschhock CE,Martens JA,Lison D,Fubini B

    更新日期：2011-11-21 00:00:00

  • Catechin metabolism: glutathione conjugate formation catalyzed by tyrosinase, peroxidase, and cytochrome p450.

    abstract：:The metabolic pathways of dietary flavonoids are still largely unknown. In the present work, mass spectrometry and UV-vis spectroscopy studies were used to show that the naturally occurring flavonoid catechin underwent enzymatic oxidation by tyrosinase in the presence of glutathione (GSH) to form mono-, bi-, and tri-g...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx000235o

    authors： Moridani MY,Scobie H,Salehi P,O'Brien PJ

    更新日期：2001-07-01 00:00:00

  • Assessing Toxicity and in Vitro Bioactivity of Smoked Cigarette Leachate Using Cell-Based Assays and Chemical Analysis.

    abstract：:Smoked cigarettes are the most prevalent form of litter worldwide, often finding their way into oceans and inland waterways. Cigarette smoke contains more than 4000 individual chemicals, some of them carcinogenic or otherwise toxic. We examined the cytotoxicity, genotoxicity, aryl hydrocarbon receptor (AhR), estrogen ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.9b00201

    authors： Xu EG,Richardot WH,Li S,Buruaem L,Wei HH,Dodder NG,Schick SF,Novotny T,Schlenk D,Gersberg RM,Hoh E

    更新日期：2019-08-19 00:00:00

  • Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes.

    abstract：:Thiol conjugates of isothiocyanates (thiol-ITCs) are metabolites of ITCs formed in the mercapturic acid pathway in mammals. They are effective chemopreventive agents in mouse lung tumor bioassays and in other models. Thiol-ITCs are inhibitors of P450s, but it has not been determined if P450 inhibition is due to conjug...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx010029w

    authors： Conaway CC,Krzeminski J,Amin S,Chung FL

    更新日期：2001-09-01 00:00:00

  • Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions.

    abstract：:Today much is known about cytochrome P450 (P450) enzymes and their catalytic specificity, but the range of reactions catalyzed by each still continues to surprise. Historically, P450s had been considered to be involved in either the metabolism of xenobiotics or endogenous chemicals, in the former case playing a genera...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.6b00226

    authors： Guengerich FP

    更新日期：2017-01-17 00:00:00

  • Studies on the chemical reactivity of 2-phenylpropionic acid 1-O-acyl glucuronide and S-acyl-CoA thioester metabolites.

    abstract：:Chemically reactive species formed from the metabolism of carboxylic acid-containing compounds have been proposed as mediators of their toxic side-effects. Two alternative metabolic pathways known to be involved in the generation of reactive acylating metabolites of carboxylic acids are acyl glucuronidation and acyl-C...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx020013l

    authors： Li C,Benet LZ,Grillo MP

    更新日期：2002-10-01 00:00:00

  • Analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts in human exfoliated oral mucosa cells by liquid chromatography-electrospray ionization-tandem mass spectrometry.

    abstract：:Quantitation of DNA adducts could provide critical information on the relationship between exposure to tobacco smoke and cancer risk in smokers. In this study, we developed a robust and sensitive liquid chromatography-tandem mass spectrometry method for the analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasin...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx300282k

    authors： Stepanov I,Muzic J,Le CT,Sebero E,Villalta P,Ma B,Jensen J,Hatsukami D,Hecht SS

    更新日期：2013-01-18 00:00:00

  • Notopterygium forbesii boiss extract and its active constituents increase reactive species and heme oxygenase-1 in human fetal hepatocytes: mechanisms of action.

    abstract：:Notopterygium forbesii Boiss (NF) has been used as a traditional Chinese medicine for the treatment of common cold and rheumatism. However, there has been limited research on the biological properties of NF, and the mechanisms of action remain unknown. Here, we aimed to study the mechanism of NF-induced heme oxygenase...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx800301f

    authors： Tang SY,Wang H,Zhang W,Halliwell B

    更新日期：2008-12-01 00:00:00

  • Nitration of Tyrosine Residue Y10 of Aβ1-42 Significantly Inhibits Its Aggregation and Cytotoxicity.

    abstract：:Amyloid-β plaques and oxidative stress are the major hallmarks of Alzheimer's disease. Our previous study found that the heme-Aβ complex enhanced the catalytic effect of free heme on protein tyrosine nitration in the presence of hydrogen peroxide (H2O2) and nitrite (NO2-). Y10 in Aβ could be the first target to be nit...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.6b00447

    authors： Zhao J,Wu J,Yang Z,Li H,Gao Z

    更新日期：2017-04-17 00:00:00

  • Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3.

    abstract：:The regulation of cellular stress responses to electrophiles and oxidants is mediated by the transcription factor NF-E2-related factor 2 (Nrf2), which, in turn, is regulated by CUL-E3 (CUL3) ligase-mediated ubiquitylation. The Kelch-like ECH-associated protein 1 (Keap1) serves as an adapter between CUL3 and Nrf2. We u...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx700302s

    authors： Rachakonda G,Xiong Y,Sekhar KR,Stamer SL,Liebler DC,Freeman ML

    更新日期：2008-03-01 00:00:00

  • Redox properties and activity of iron-citrate complexes: evidence for redox cycling.

    abstract：:Iron in iron overload disease is present as non-transferrin-bound iron, consisting of iron, citrate, and albumin. We investigated the redox properties of iron citrate by electrochemistry, by the kinetics of its reaction with ascorbate, by ESR, and by analyzing the products of reactions of ascorbate with iron citrate c...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx500377b

    authors： Adam FI,Bounds PL,Kissner R,Koppenol WH

    更新日期：2015-04-20 00:00:00

  • Connecting the chemical and biological properties of nitric oxide.

    abstract：:Nitric oxide (NO(•); nitrogen monoxide) is known to be a critical regulator of cell and tissue function through mechanisms that utilize its unique physicochemical properties as a small and uncharged free radical with limited reactivity. Here, the basic chemistry and biochemistry of NO(•) are summarized through the des...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章,评审

    doi：10.1021/tx300042g

    authors： Toledo JC Jr,Augusto O

    更新日期：2012-05-21 00:00:00

  • Epoxide ring opening and related reactivities of cyclopenta polycyclic aromatic hydrocarbons: quantum mechanical studies.

    abstract：:A series of 13 cyclopenta polycyclic aromatic hydrocarbons have been studied using quantum mechanical methods. The three-dimensional molecular structure of each carbocation that might result from the opening of a protonated epoxide ring formed between the carbon atoms completing the cyclopenta ring was computed with A...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00026a022

    authors： Rabinowitz JR,Little SB

    更新日期：1992-03-01 00:00:00

  • Genotoxicity evaluation of nanomaterials: dna damage, micronuclei, and 8-hydroxy-2-deoxyguanosine induced by magnetic doped CdSe quantum dots in male mice.

    abstract：:Quantum dots (QDs) are a novel class of inorganic fluorophores which are gaining widespread recognition as a result of their exceptional photophysical properties and their applications as a biomarker and in molecular biomedical imaging. The aim of this study was to evaluate the in vivo genotoxicity in mice exposed to ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx2000015

    authors： Khalil WK,Girgis E,Emam AN,Mohamed MB,Rao KV

    更新日期：2011-05-16 00:00:00

  • Pathophysiological insights of methylglyoxal induced type-2 diabetes.

    abstract：:Diabetes mellitus is a metabolic disorder constituting a major health problem whose prevalence has gradually increased worldwide over the past few decades. Type 2 diabetes mellitus (T2DM) remains more complex and heterogeneous and arises as a combination of insulin resistance and inadequate functional β-cell mass and ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章,评审

    doi：10.1021/acs.chemrestox.5b00171

    authors： Dornadula S,Elango B,Balashanmugam P,Palanisamy R,Kunka Mohanram R

    更新日期：2015-09-21 00:00:00

  • Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical.

    abstract：:Premarin (Wyeth-Ayerst) is the estrogen replacement treatment of choice and continues to be one of the most widely dispensed prescriptions in the United States. In addition to endogenous estrogens, Premarin contains unsaturated estrogens including equilenin. We synthesized the catechol metabolite of equilenin, 4-hydro...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx970181r

    authors： Shen L,Qiu S,Chen Y,Zhang F,van Breemen RB,Nikolic D,Bolton JL

    更新日期：1998-02-01 00:00:00

  • Contrasting effects of metal ions on S-nitrosoglutathione, related to coordination equilibria: GSNO decomposition assisted by Ni(II) vs stability Increase in the presence of Zn(II) and Cd(II).

    abstract：:Complex formation between nitrosoglutathione (GSNO) and Zn(II), Cd(II), and Ni(II) ions was studied by potentiometry and spectroscopic techniques. GSNO forms simple ML and ML2 type complexes (L = GSNO) with these ions. The stability of GSNO in HEPES buffer solution, pH 7.4, increased in the presence of both Zn(II) and...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx034194i

    authors： Krezel A,Bal W

    更新日期：2004-03-01 00:00:00

  • Lysine Adduction by Reactive Metabolite(s) of Monocrotaline.

    abstract：:Pyrrolizidine alkaloids (PAs) are known hepatotoxins. The execution of the toxicities of the alkaloids requires metabolic activation. Protein modification by reactive metabolites of PAs has been suggested to be an important mechanism of the toxic actions of PAs. The objectives of the present study were to define the i...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.5b00488

    authors： Li W,Wang K,Lin G,Peng Y,Zheng J

    更新日期：2016-03-21 00:00:00

  • Inactivation of rat hepatic cytochrome P-450 isozymes by 3,5-dicarbethoxy- 2,6-dimethyl-4-ethyl-1,4-dihydropyridine.

    abstract：:We have reported [Correia et al. (1987) Arch. Biochem. Biophys. 258, 436-443] that administration of 3,5-dicarbethoxy-4-ethyl-2,6-dimethyl-1,4-dihydropyridine (DDEP) to untreated, phenobarbital (PB) pretreated, or dexamethasone (DEX) pretreated rats results in relatively selective inactivation of cytochrome P-450 (P-4...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00012a008

    authors： Sugiyama K,Yao K,Rettie AE,Correia MA

    更新日期：1989-11-01 00:00:00

  • Cu(II)/H2O2-induced DNA damage is enhanced by packaging of DNA as a nucleosome.

    abstract：:Copper is a physiologically important, redox-active metal that may be involved in endogenous DNA damage and mutagenesis. To understand the factors that affect the location and quantity of copper-induced oxidative DNA damage in cells, we used the 5S rDNA nucleosome as a model to assess the effect of chromatin structure...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx0002278

    authors： Liang Q,Dedon PC

    更新日期：2001-04-01 00:00:00

  • Comparison of the Base Excision and Direct Reversal Repair Pathways for Correcting 1,N6-Ethenoadenine in Strongly Positioned Nucleosome Core Particles.

    abstract：:1,N6-ethenoadenine (εA) is a mutagenic lesion and biomarker observed in numerous cancerous tissues. Two pathways are responsible for its repair: base excision repair (BER) and direct reversal repair (DRR). Alkyladenine DNA glycosylase (AAG) is the primary enzyme that excises εA in BER, generating stable intermediates ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.0c00089

    authors： Caffrey PJ,Kher R,Bian K,Li D,Delaney S

    更新日期：2020-07-20 00:00:00

  • In vitro reaction with DNA of the fjord-region diol epoxides of benzo[g]chrysene and benzo[c]phenanthrene as studied by 32P-postlabeling.

    abstract：:The chemical reactivities of the optically-pure fjord-region syn- and anti-benzo[g]chrysene 11,12-dihydrodiol 13,14-epoxides (B[g]CDEs) toward DNA in vitro have been compared with those of the optically-pure fjord-region syn- and anti-benzo[c]phenanthrene 3,4-dihydrodiol 1,2-epoxides (B[c]PhDEs), using the standard 32...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00046a014

    authors： Giles AS,Seidel A,Phillips DH

    更新日期：1995-06-01 00:00:00

  • Nitric oxide produced endogenously is responsible for hypoxia-induced HIF-1α stabilization in colon carcinoma cells.

    abstract：:Hypoxia-inducible factor-1α (HIF-1α) is a critical regulator of cellular responses to hypoxia. Under normoxic conditions, the cellular HIF-1α level is regulated by hydroxylation by prolyl hydroxylases (PHDs), ubiquitylation, and proteasomal degradation. During hypoxia, degradation decreases, and its intracellular leve...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx300274a

    authors： Chowdhury R,Godoy LC,Thiantanawat A,Trudel LJ,Deen WM,Wogan GN

    更新日期：2012-10-15 00:00:00

  • A molecular motif required for the activation of rat neutrophil phospholipase A(2) by organochlorine compounds.

    abstract：:Organochlorine (OC) compounds are some of the main toxicants present in the food web and target several cellular systems including the nonspecific immune system. The objective of this study was to test the hypothesis that OC compounds that activate neutrophils share common structural features. Using activation of phos...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx0155449

    authors： Olivero J,Bezdecny SA,Ganey PE

    更新日期：2002-02-01 00:00:00

  • Enzyme-linked immunosorbent assay for the specific detection of the mercapturic acid metabolites of naphthalene.

    abstract：:The measurement of metabolites constitutes a useful tool for detection of exposure and in pharmacokinetic studies. Epoxidation with subsequent glutathione conjugation and mercapturic acid formation is an important deactivation pathway for naphthalene, a toxin which presumably causes lung disease. The mercapturic acid ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00033a006

    authors： Marco MP,Nasiri M,Kurth MJ,Hammock BD

    更新日期：1993-05-01 00:00:00

  • Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[a,l]pyrene by HPLC-MS/MS.

    abstract：:Tobacco smoking is one of the leading causes for oral cancer. Dibenzo[a,l]pyrene (DB[a,l]P), an environmental pollutant and a tobacco smoke constituent, is the most carcinogenic polycyclic aromatic hydrocarbon (PAH) tested to date in several animal models (target organs: skin, lung, ovary, and mammary tissues). We hav...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx200188j

    authors： Zhang SM,Chen KM,Aliaga C,Sun YW,Lin JM,Sharma AK,Amin S,El-Bayoumy K

    更新日期：2011-08-15 00:00:00

  • Metabolism of the food-borne mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans.

    abstract：:The metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) was investigated in five human volunteers given a dietary equivalent of 14C-labeled MeIQx. The amount of the dose excreted in urine ranged from 20.2% to 58.6%, with unmetabolized MeIQx accounting for 0.7-2.8% of the dose. Five principal metabolite...

    journal_title：Chemical research in toxicology

    pub_type： 临床试验,杂志文章

    doi：10.1021/tx9701891

    authors： Turesky RJ,Garner RC,Welti DH,Richoz J,Leveson SH,Dingley KH,Turteltaub KW,Fay LB

    更新日期：1998-03-01 00:00:00

  • Synthesis and characterization of bay region halohydrins derived from Benzo[a]pyrene diol epoxide and their role as intermediates in halide-catalyzed cis adduct formation.

    abstract：:The bay region epoxide of benzo[a]pyrene (anti-BPDE) alkylates DNA to form adducts with >98% trans stereochemistry. Halide ions catalyze this reaction; however, this pathway is characterized by the formation of adducts with altered cis stereochemistry. Bay region halohydrins are possible intermediates in these reactio...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx980056v

    authors： Song Q,Negrete GR,Wolfe AR,Wang K,Meehan T

    更新日期：1998-09-01 00:00:00

  • Enantioselective covalent binding of 2-phenylpropionic Acid to protein in vitro in rat hepatocytes.

    abstract：:A series of studies was conducted to investigate the potential of (R)- and (S)-2-phenylpropionic acid (2-PPA) to undergo enantioselective covalent binding to protein in freshly isolated rat hepatocytes and to determine whether such covalent binding is dependent on acyl glucuronidation or acyl-CoA formation of 2-PPA. H...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx025600l

    authors： Li C,Benet LZ,Grillo MP

    更新日期：2002-11-01 00:00:00

  • Oxanosine Monophosphate Is a Covalent Inhibitor of Inosine 5'-Monophosphate Dehydrogenase.

    abstract：:Reactive nitrogen species (RNS) are produced during infection and inflammation, and the effects of these agents on proteins, DNA, and lipids are well recognized. In contrast, the effects of RNS damaged metabolites are less appreciated. 5-Amino-3-β-(d-ribofuranosyl)-3 H-imidazo-[4,5- d][1,3]oxazine-7-one (oxanosine) an...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.8b00342

    authors： Yu R,Kim Y,Maltseva N,Braunstein P,Joachimiak A,Hedstrom L

    更新日期：2019-03-18 00:00:00