Use of Zebrafish in Drug Discovery Toxicology.

abstract：:The urine from mice exposed to styrene vapors (600 and 1200 mg/m(3), 6 h) was analyzed for ring-oxidized metabolites of styrene. To facilitate the identification of metabolites in urine, the following potential metabolites were prepared: 2-, 3-, and 4-vinylphenol (2-, 3-, and 4-VP), 4-vinylpyrocatechol, and 2-, 3-, an...

journal_title：Chemical research in toxicology

authors： Linhart I,Mráz J,Scharff J,Krouzelka J,Dusková S,Nohová H,Vodicková L

更新日期：2010-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly population, above 65 years of age. Multiple lines of evidence confirm the central role of 40-42 residue Abeta peptides in the pathogenesis of AD, but exact mechanisms of Abeta toxicity remain unclear. Recently, evidence has accumulat...

journal_title：Chemical research in toxicology

authors： Rózga M,Bal W

更新日期：2010-02-15 00:00:00

abstract：:Smoked cigarettes are the most prevalent form of litter worldwide, often finding their way into oceans and inland waterways. Cigarette smoke contains more than 4000 individual chemicals, some of them carcinogenic or otherwise toxic. We examined the cytotoxicity, genotoxicity, aryl hydrocarbon receptor (AhR), estrogen ...

journal_title：Chemical research in toxicology

authors： Xu EG,Richardot WH,Li S,Buruaem L,Wei HH,Dodder NG,Schick SF,Novotny T,Schlenk D,Gersberg RM,Hoh E

更新日期：2019-08-19 00:00:00

abstract：:2'-Deoxyoxanosine (dOxo) is a novel DNA lesion produced from dGuo by reaction with nitrous acid or nitric oxide [Suzuki, T., Yamaoka, R., Nishi, M., Ide, H., and Makino, K. (1996) J. Am. Chem. Soc. 118, 2515-2516]. We investigated the reaction of dOxo with glycine (Gly) under physiological conditions. When 5 mM dOxo w...

journal_title：Chemical research in toxicology

authors： Suzuki T,Yamada M,Ide H,Kanaori K,Tajima K,Morii T,Makino K

更新日期：2000-04-01 00:00:00

abstract：:Rutaevin is one of the major bioactive constituents isolated from Evodia rutaecarpa, a well-known herbal medicine that has been widely prescribed for the treatment of gastrointestinal disorders in China. However, oral administration of rutaevin has been shown to cause hepatotoxicity in mice. Bioactivation was suggeste...

journal_title：Chemical research in toxicology

authors： Liu Y,Liu C,Liu Y,Ge Q,Sun C

更新日期：2020-12-21 00:00:00

abstract：:Implementation of the Clinical Data Interchange Standards Consortium (CDISC)'s Standard for Exchange of Nonclinical Data (SEND) by the United States Food and Drug Administration Center for Drug Evaluation and Research (US FDA CDER) has created large quantities of SEND data sets and a tremendous opportunity to apply la...

journal_title：Chemical research in toxicology

authors： Carfagna MA,Anderson J,Eley C,Fukushima T,Horvath J,Houser W,Larsen B,Page T,Russo D,Sloan C,Snyder K,Thompson R,Ullmann G,Whittaker M

更新日期：2020-12-16 00:00:00

abstract：:ZnO nanoparticles (NPs) are prone to dissolution, and uncertainty remains whether biological/cellular responses to ZnO NPs are solely due to the release of Zn(2+) or whether the NPs themselves have additional toxic effects. We address this by establishing ZnO NP solubility in dispersion media (Dulbecco's modified Eagl...

journal_title：Chemical research in toxicology

authors： Mu Q,David CA,Galceran J,Rey-Castro C,Krzemiński L,Wallace R,Bamiduro F,Milne SJ,Hondow NS,Brydson R,Vizcay-Barrena G,Routledge MN,Jeuken LJ,Brown AP

更新日期：2014-04-21 00:00:00

abstract：:N-Methyl-N-nitrosourea (MNU) is a reactive, mutagenic methylating agent. MNU methylates DNA at various sites, including guanine N7, guanine O6, and adenine N3. Dixit and Gold [(1986) Proc. Natl. Acad. Sci. U.S.A. 83, 8039-8043] reported that ellagic acid, a phenolic natural product, inhibited the mutagenicity of MNU i...

journal_title：Chemical research in toxicology

authors： Lord HL,Josephy PD,Snieckus VA

更新日期：1990-05-01 00:00:00

abstract：:Estrogens and their oxidative metabolites, the catechol estrogens, have been implicated in the development of breast cancer; yet, relatively little is known about estrogen metabolism in the breast. To determine how the parent hormone, 17 beta-estradiol (E(2)), is metabolized, we used recombinant, purified phase I enzy...

journal_title：Chemical research in toxicology

authors： Dawling S,Hachey DL,Roodi N,Parl FF

更新日期：2004-09-01 00:00:00

abstract：:Exposure to arsenic affects large human populations worldwide and has been associated with a long list of human diseases, including skin, bladder, lung, and liver cancers, diabetes, and cardiovascular disorders. In addition, there are large individual differences in susceptibility to arsenic-induced diseases, which ar...

journal_title：Chemical research in toxicology

authors： Lu K,Cable PH,Abo RP,Ru H,Graffam ME,Schlieper KA,Parry NM,Levine S,Bodnar WM,Wishnok JS,Styblo M,Swenberg JA,Fox JG,Tannenbaum SR

更新日期：2013-12-16 00:00:00

abstract：:A model protein, ribonuclease A (bovine pancreas), was examined for its ability to coordinate Ni2+ and promote selective oxidation. In the presence of a peracid such as monopersulfate, HSO5-, nickel induced the monomeric RNase A to form dimers, trimers, tetramers, and higher oligomers without producing fragmentation o...

journal_title：Chemical research in toxicology

authors： Gill G,Richter-Rusli AA,Ghosh M,Burrows CJ,Rokita SE

更新日期：1997-03-01 00:00:00

abstract：:Butadiene monoxide, a toxic metabolite of 1,3-butadiene, is a substrate for the human placental glutathione (GSH) S-transferase. The products have been identified as S-(2-hydroxy-3-buten-1-yl)glutathione (I) and S-(1-hydroxy-3-buten-2-yl)glutathione (II). S-(4-hydroxy-2-buten-1-yl)glutathione (III), which was formed c...

journal_title：Chemical research in toxicology

authors： Sharer JE,Duescher RJ,Elfarra AA

更新日期：1991-07-01 00:00:00

abstract：:In humans and mice, in utero exposure to inorganic arsenic (iAs) is associated with adverse health outcomes later in life. The contribution of preconception exposure to the adverse outcomes in offspring has never been studied. Here combined in utero and postnatal exposures produce insulin resistance in two collaborati...

journal_title：Chemical research in toxicology

authors： Fry RC,Addo KA,Bell TA,Douillet C,Martin E,Stýblo M,Pardo-Manuel de Villena F

更新日期：2019-08-19 00:00:00

abstract：:It has previously been shown that malonaldehyde forms conjugates with acetaldehyde and that these conjugates react with nucleobases forming so-called conjugate adducts. In the current study, it is shown that conjugate adducts are also formed in calf thymus DNA when incubated simultaneously with malonaldehyde and aceta...

journal_title：Chemical research in toxicology

authors： Pluskota-Karwatka D,Pawłowicz AJ,Kronberg L

更新日期：2006-07-01 00:00:00

abstract：:The present work aimed to elucidate whether the toxic effects of nickel oxide (NiO) nanoparticles (NPs) on the yeast Saccharomyces cerevisiae were associated with oxidative stress (OS) and what mechanisms may have contributed to this OS. Cells exposed to NiO NPs accumulated superoxide anions and hydrogen peroxide, whi...

journal_title：Chemical research in toxicology

authors： Sousa CA,Soares HMVM,Soares EV

更新日期：2018-08-20 00:00:00

abstract：:In this study, the HPLC, UV-vis, LC-MS, and 1H NMR characteristics of 14 different phase II mono- and mixed conjugates of quercetin were determined, providing a useful tool in the identification of quercetin phase II metabolite patterns in various biological systems. Using these data, the phase II metabolism of querce...

journal_title：Chemical research in toxicology

authors： van der Woude H,Boersma MG,Vervoort J,Rietjens IM

更新日期：2004-11-01 00:00:00

abstract：:The PI3K/Akt/mTOR pathway is considered to be an attractive target for the development of novel anticancer molecules. This paper reports for the first time that a small molecule, antrocin (MW = 234), from Antrodia camphorata was a potent antagonist in various cancer types, being highest in metastatic breast cancer MDA...

journal_title：Chemical research in toxicology

authors： Rao YK,Wu AT,Geethangili M,Huang MT,Chao WJ,Wu CH,Deng WP,Yeh CT,Tzeng YM

更新日期：2011-02-18 00:00:00

abstract：:The .CCl3 radical generated during the metabolism of CCl4 is readily spin trapped in vivo and in vitro by phenyl N-tert-butylnitrone (PBN) to form the stable PBN/.CCl3 radical adduct, which can then be extracted into organic solvents and detected by ESR spectroscopy. We have used this technique to examine the proposed...

journal_title：Chemical research in toxicology

authors： Hanna PM,Kadiiska MB,Jordan SJ,Mason RP

更新日期：1993-09-01 00:00:00

abstract：:Iron (Fe) chelation therapy was initially designed to alleviate the toxic effects of excess Fe evident in Fe-overload diseases. However, the novel toxicological properties of some Fe chelator-metal complexes have shifted appreciable focus to their application in cancer chemotherapy. Redox-inactive Fe chelator complexe...

journal_title：Chemical research in toxicology

authors： Kalinowski DS,Richardson DR

更新日期：2007-05-01 00:00:00

abstract：:Thioredoxin reductase (TR), an NADPH-dependent flavoenzyme that catalyzes the reduction of many disulfide-containing substrates, plays an important role in the cellular response to oxidative stress. Trivalent arsenicals, especially methyl As that contains trivalent arsenic (MAs(III)), are potent noncompetitive inhibit...

journal_title：Chemical research in toxicology

authors： Lin S,Del Razo LM,Styblo M,Wang C,Cullen WR,Thomas DJ

更新日期：2001-03-01 00:00:00

abstract：:Organically modified rectorite (OREC) micro/nanoparticles can be synthesized by organic modification from calcium rectorite (Ca(2+)-REC or REC), a common form of rectorite in nature. Although REC and OREC have potential applications in food packing and drug delivery, their cytotoxicity is not clear. In the present stu...

journal_title：Chemical research in toxicology

authors： Liu Y,Deng H,Xiao C,Xie C,Zhou X

更新日期：2014-08-18 00:00:00

abstract：:Polyunsaturated fatty acids (PUFA) are primary targets of free radical damage during oxidative stress. Diffusible electrophilic alpha,beta-unsaturated aldehydes, such as 4-hydroxynonenal (HNE), have been shown to modify proteins that mediate cell signaling (e.g., IKK and Keap1) and alter gene expression pathways respo...

journal_title：Chemical research in toxicology

authors： Vila A,Tallman KA,Jacobs AT,Liebler DC,Porter NA,Marnett LJ

更新日期：2008-02-01 00:00:00

abstract：:Water samples from the Waka River, which runs through an area housing many chemical industry facilities in Wakayama, Japan, have been found to show significant mutagenicity, especially without a mammalian metabolic activation system (S9 mix) in the Salmonella typhimurium YG1024 strain. Mutagens in the river water were...

journal_title：Chemical research in toxicology

authors： Takamura-Enya T,Watanabe T,Tada A,Hirayama T,Nukaya H,Sugimura T,Wakabayashi K

更新日期：2002-03-01 00:00:00

abstract：:The crystal structure of Rad4/Rad23, the yeast homolog of the human nucleotide excision repair (NER) lesion recognition factor XPC-RAD23B ( Min , J. H. and Pavletich , N. P. ( 2007 ) Nature 449 , 570 - 575 ) reveals that the lesion-partner base is flipped out of the helix and binds to amino acids of the protein. This ...

journal_title：Chemical research in toxicology

authors： Cai Y,Zheng H,Ding S,Kropachev K,Schwaid AG,Tang Y,Mu H,Wang S,Geacintov NE,Zhang Y,Broyde S

更新日期：2013-07-15 00:00:00

abstract：:Trichloroethylene (TCE), a widely used industrial solvent, is a common environmental contaminant. We previously reported that TCE-induced changes in DNA methylation and miRNA expression contributed to the development of a liver tumor in mice. In this study, we investigated the role of long intergenic noncoding RNA (Li...

journal_title：Chemical research in toxicology

authors： Ren F,Wang J,Aniagu S,Li J,Jiang Y,Chen T

更新日期：2020-06-15 00:00:00

abstract：:β-Lapachone (β-lap) is a promising antitumoral agent. DNA base oxidation and alkylation are among the expected damages by β-lap. Herein, we have explored the role that the homologous recombination pathway (HR), a critical DNA repair process in Saccharomyces cerevisiae, has in the cytotoxic profile of β-lap. We have fu...

journal_title：Chemical research in toxicology

authors： Quevedo O,García-Luis J,Lorenzo-Castrillejo I,Machín F

更新日期：2011-12-19 00:00:00

abstract：:Derivatives of methyl 3-(1-methyl-5-(1-methyl-5-(propylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylamino)-3-oxopropane-1-sulfonate (1), a peptide-based DNA minor groove binding methylating agent, were synthesized and characterized. In all cases, the N-terminus was appended with an O-methyl sulfonate ester, while...

journal_title：Chemical research in toxicology

authors： Iyer P,Srinivasan A,Singh SK,Mascara GP,Zayitova S,Sidone B,Fouquerel E,Svilar D,Sobol RW,Bobola MS,Silber JR,Gold B

更新日期：2013-01-18 00:00:00

abstract：:Cryogenic (4-10 K) laser-induced vibrationless ground state and vibronic excited state fluorescence emission spectra of the adducts resulting from reaction in vitro of human serum albumin and the carcinogen (+-)-r-7,t-8-dihydroxy-c-9,c-10-epoxy-7,8,9,10- tetrahydrobenzo[a]-pyrene were recorded in order to determine th...

journal_title：Chemical research in toxicology

authors： Day BW,Doxtader MM,Rich RH,Skipper PL,Singh K,Dasari RR,Tannenbaum SR

更新日期：1992-01-01 00:00:00

abstract：:The skeleton is a target organ for most metals. This leads to their bioaccumulation, either as storage of useful oligoelements or as a protection against damage by toxic elements. The different events leading to their accumulation in this organ, under constant remodeling, are not fully understood, nor the full subsequ...

journal_title：Chemical research in toxicology

authors： Vidaud C,Bourgeois D,Meyer D

更新日期：2012-06-18 00:00:00

abstract：:The wide pH range reported for electronic cigarette (ECIG) liquids indicates that nicotine may be present in one or more chemical forms. The nicotine form affects the bioavailability and delivery of nicotine from inhaled products. Protonated nicotine is normally associated with counteranions in tobacco products. The c...

journal_title：Chemical research in toxicology

authors： El-Hellani A,El-Hage R,Salman R,Talih S,Shihadeh A,Saliba NA

更新日期：2017-08-21 00:00:00