Effects of Preconception and in Utero Inorganic Arsenic Exposure on the Metabolic Phenotype of Genetically Diverse Collaborative Cross Mice.

abstract：:Idiosyncratic drug reactions (IDRs) represent a major clinical problem, and at present, the mechanisms involved are still poorly understood. One animal model that we have used for mechanistic studies of IDRs is penicillamine-induced autoimmunity in Brown Norway (BN) rats. Previous work in our lab found that macrophage...

journal_title：Chemical research in toxicology

authors： Li J,Mannargudi B,Uetrecht JP

更新日期：2009-07-01 00:00:00

abstract：:A liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) method for the measurement of aflatoxin biomarkers in urine has been developed and validated. The two major aflatoxin-DNA adducts formed in rat tissues, aflatoxin N(7)-guanine and its imidazole ring opened derivative, 8,9-dihydro-8-(2,6-diami...

journal_title：Chemical research in toxicology

authors： Walton M,Egner P,Scholl PF,Walker J,Kensler TW,Groopman JD

更新日期：2001-07-01 00:00:00

abstract：:Thiol conjugates of isothiocyanates (thiol-ITCs) are metabolites of ITCs formed in the mercapturic acid pathway in mammals. They are effective chemopreventive agents in mouse lung tumor bioassays and in other models. Thiol-ITCs are inhibitors of P450s, but it has not been determined if P450 inhibition is due to conjug...

journal_title：Chemical research in toxicology

authors： Conaway CC,Krzeminski J,Amin S,Chung FL

更新日期：2001-09-01 00:00:00

abstract：:Human exposure to abacavir, a primary alcohol antiretroviral, is associated with the development of immunological drug reactions in individuals carrying the HLA risk allele B*57:01. Interaction of abacavir with antigen presenting cells results in cell activation through an Hsp70-mediated Toll-like receptor pathway and...

journal_title：Chemical research in toxicology

authors： Bell CC,Santoyo Castelazo A,Yang EL,Maggs JL,Jenkins RE,Tugwood J,O'Neill PM,Naisbitt DJ,Park BK

更新日期：2013-07-15 00:00:00

abstract：:Lapatinib (LAP), an oral tyrosine kinase inhibitor for the treatment of metastatic breast cancer, has been associated with idiosyncractic hepatotoxicity. Recent investigations have implicated the importance of P450 3A4/5 enzymes in the formation of an electrophilic quinone imine (LAPQI) metabolite generated through fu...

journal_title：Chemical research in toxicology

authors： Eno MR,El-Gendy Bel-D,Cameron MD

更新日期：2016-05-16 00:00:00

abstract：:Bezafibrate is a hypolipidemic drug that belongs to the group of peroxisome proliferators because it binds to peroxisome proliferator-activated receptors type alpha (PPARs). Peroxisome proliferators produce a myriad of extraperoxisomal effects, which are not necessarily dependent on their interaction with PPARs. An in...

journal_title：Chemical research in toxicology

authors： Scatena R,Bottoni P,Vincenzoni F,Messana I,Martorana GE,Nocca G,De Sole P,Maggiano N,Castagnola M,Giardina B

更新日期：2003-11-01 00:00:00

abstract：:Benzo[a]pyrene, a potent human carcinogen, is metabolized in vivo to a diol epoxide that reacts with the N2-position of guanine to produce N2-BP-dG adducts. These adducts are mutagenic causing G to T transversions. These adducts block replicative polymerases but can be bypassed by the Y-family translesion synthesis po...

journal_title：Chemical research in toxicology

authors： Gowda ASP,Krzeminski J,Amin S,Suo Z,Spratt TE

更新日期：2017-05-15 00:00:00

abstract：:8-Oxo-7,8-dihydroguanine (G(O), 8-hydroxyguanine) in DNA is one of the most important oxidatively damaged bases and causes G:C → T:A substitution mutations. The Werner syndrome protein (WRN) is a cancer-related RecQ DNA helicase and plays many roles in DNA replication and repair. To examine the relationships between G...

journal_title：Chemical research in toxicology

authors： Kamiya H,Yamazaki D,Nakamura E,Makino T,Kobayashi M,Matsuoka I,Harashima H

更新日期：2015-04-20 00:00:00

abstract：:Solutions of synthetic fecapentaene 12 (FP-12) intended for carcinogenicity studies were found to decompose extremely rapidly during customary dosage procedures. Apparent half-lives as short as 15 min were observed. While rates and even the qualitative course of decomposition were surprisingly variable in replicate ex...

journal_title：Chemical research in toxicology

authors： Streeter AJ,Donovan PJ,Anjo T,Ohannesian L,Sheffels PR,Wu PP,Keefer LK,Andrews AW,Bradford WW 3rd,Reist EJ

更新日期：1989-05-01 00:00:00

abstract：:Oxidation of low-density lipoproteins (LDL) is believed to contribute to the increased uptake of LDL by macrophages, which is an early event in atherosclerosis. Hypochlorous acid (HOCl) has been implicated as one of the major oxidants involved in these processes. In a previous study, the rates of reaction of HOCl with...

journal_title：Chemical research in toxicology

authors： Pattison DI,Hawkins CL,Davies MJ

更新日期：2003-04-01 00:00:00

abstract：:Polyunsaturated fatty acids (PUFA) are primary targets of free radical damage during oxidative stress. Diffusible electrophilic alpha,beta-unsaturated aldehydes, such as 4-hydroxynonenal (HNE), have been shown to modify proteins that mediate cell signaling (e.g., IKK and Keap1) and alter gene expression pathways respo...

journal_title：Chemical research in toxicology

authors： Vila A,Tallman KA,Jacobs AT,Liebler DC,Porter NA,Marnett LJ

更新日期：2008-02-01 00:00:00

abstract：:A new method was developed to quantify the levels of 1,3-butadiene (BD), butadiene monoxide (BDO), and butadiene diepoxide (BDO2) in blood. The method was based on vacuum distillation of tissues followed by analysis of the distillates using multidimensional GC/MS. Metabolites isolated from blood by vacuum distillation...

journal_title：Chemical research in toxicology

authors： Bechtold WE,Strunk MR,Thornton-Manning JR,Henderson RF

更新日期：1995-03-01 00:00:00

abstract：:Benzo[a]pyrene diol epoxides (BPDEs) are the ultimate carcinogenic species of benzo[a]pyrene, a prototype polycyclic aromatic hydrocarbon (PAH). BPDE-modified DNA duplexes can adopt multiple conformations depending on the nature of the modified bases, the stereochemistry at the location of the covalent linkage, and th...

journal_title：Chemical research in toxicology

authors： Yang T,Huang Y,Cho BP

更新日期：2006-02-01 00:00:00

abstract：:Skin protein modification (haptenation) is thought to be a key step in the manifestation of sensitization to low molecular mass chemicals (<500 g/mol). For sensitizing chemicals that are not protein reactive, it is hypothesised that metabolic activation can convert such chemicals into protein reactive toxins within th...

journal_title：Chemical research in toxicology

authors： Elahi EN,Wright Z,Hinselwood D,Hotchkiss SA,Basketter DA,Pease CK

更新日期：2004-03-01 00:00:00

abstract：:n-Hexane is metabolized to the gamma-diketone 2,5-hexanedione (2,5-HD), a derivative that covalently binds to lysine residues in neurofilament (NF) protein to yield 2,5-dimethylpyrrole adducts. Studies comparing the pyrrole-forming potential and neurotoxic potency of gamma-diketones have demonstrated that pyrrolylatio...

journal_title：Chemical research in toxicology

authors： Zhu M,Spink DC,Yan B,Bank S,DeCaprio AP

更新日期：1995-07-01 00:00:00

abstract：:We have recently shown that dithiocarbamate (DC) disulfides inhibit proteolytic processing of the caspase-3 proenzyme in Jurkat T lymphocytes treated with anti-CD95 (Fas/APO-1) antibody. Because the processing can be accomplished by caspase activity, we investigated the effect of DC disulfides, such as disulfiram (DSF...

journal_title：Chemical research in toxicology

authors： Nobel CS,Kimland M,Nicholson DW,Orrenius S,Slater AF

更新日期：1997-12-01 00:00:00

abstract：:Our laboratory previously reported the identification and quantification of depurinating DNA adducts of dibenzo[a,l]pyrene (DB[a,l]P) in vitro, which comprise about 84% of all the DNA adducts that are formed [Li, K.-M., et al. (1995) Biochemistry 34, 8043-8049]. To determine a complete adduct profile and identify both...

journal_title：Chemical research in toxicology

authors： Devanesan P,Ariese F,Jankowiak R,Small GJ,Rogan EG,Cavalieri EL

更新日期：1999-09-01 00:00:00

abstract：:Guidance from the Food and Drug Administration on drug interaction studies does not include a specific section on contributions of metabolites to observed inhibitory drug-drug interactions, and the quantitative role of drug metabolites in inhibitory drug-drug interactions is not presently known. The current work was u...

journal_title：Chemical research in toxicology

authors： Isoherranen N,Hachad H,Yeung CK,Levy RH

更新日期：2009-02-01 00:00:00

abstract：:Environmental stress induces the synthesis of glucose-regulated proteins (Grps) in the endoplasmic reticulum (ER) and heat shock proteins (Hsps) in the cytoplasm. Iodoacetamide (IDAM), a prototypical alkyating agent, induces both Grp and Hsp synthesis in renal epithelial cells and causes necrosis which is prevented by...

journal_title：Chemical research in toxicology

authors： van De Water B,Wang Y,Asmellash S,Liu H,Zhan Y,Miller E,Stevens JL

更新日期：1999-10-01 00:00:00

abstract：:A well-defined silica nanoparticle model system was developed to study the effect of the size and structure of aggregates on their membranolytic activity. The aggregates were stable and characterized using transmission electron microscopy, dynamic light scattering, nitrogen adsorption, small-angle X-ray scattering, in...

journal_title：Chemical research in toxicology

authors： Thomassen LC,Rabolli V,Masschaele K,Alberto G,Tomatis M,Ghiazza M,Turci F,Breynaert E,Martra G,Kirschhock CE,Martens JA,Lison D,Fubini B

更新日期：2011-11-21 00:00:00

abstract：:Both cooked red meat intake and chronic inflammation/infection are thought to play a role in the etiology of colon cancer. The heterocyclic amine 2-amino-3-methylimidazo[4,5-f ]quinoline (IQ) is formed during cooking of red meat and may be involved in initiation of colon cancer. Reactive nitrogen oxygen species (RNOS)...

journal_title：Chemical research in toxicology

authors： Lakshmi VM,Hsu FF,Zenser TV

更新日期：2002-08-01 00:00:00

abstract：:Bisphenol A (BPA) is used in the production of polycarbonate plastics and epoxy resins for baby bottles, liners of canned food, and many other consumer products. Previously, BPA has been shown to reduce the activity of several antioxidant enzymes, which may contribute to oxidative stress. However, the underlying mecha...

journal_title：Chemical research in toxicology

authors： Chepelev NL,Enikanolaiye MI,Chepelev LL,Almohaisen A,Chen Q,Scoggan KA,Coughlan MC,Cao XL,Jin X,Willmore WG

更新日期：2013-03-18 00:00:00

abstract：:To investigate the biological effects of the O(2)-alkylthymidines induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), we have replicated a plasmid containing O(2)-methylthymidine (O(2)-Me-dT) or O(2)-[4-(3-pyridyl-4-oxobut-1-yl]thymidine (O(2)-POB-dT) in Escherichia coli w...

journal_title：Chemical research in toxicology

authors： Jasti VP,Spratt TE,Basu AK

更新日期：2011-11-21 00:00:00

abstract：:A predominant pathway of xenobiotic-induced toxicity is initiated by bioactivation. Characterizing reactive intermediates will provide information on the structure of reactive species, thereby defining a potential bioactivation mechanism. Because most reactive metabolites are not stable, it is difficult to detect them...

journal_title：Chemical research in toxicology

authors： Li F,Lu J,Ma X

更新日期：2011-05-16 00:00:00

abstract：:Topoisomerase II regulates DNA topology by generating transient double-stranded breaks. The anticancer drug etoposide targets topoisomerase II and is associated with the formation of secondary leukemias in patients. The quinone and catechol metabolites of etoposide may contribute to strand breaks that trigger leukemic...

journal_title：Chemical research in toxicology

authors： Jacob DA,Gibson EG,Mercer SL,Deweese JE

更新日期：2013-08-19 00:00:00

abstract：:3-Methylindole (3MI) is a preferential pneumotoxicant found in cigarette smoke. A number of lung-expressed human cytochrome P450 enzymes, including 1A1, 2F1, and 2A13, catalyze the metabolism of 3MI to reactive intermediates that fragment DNA, measured with the Comet assay to assess DNA damage, in a cytochrome P450-de...

journal_title：Chemical research in toxicology

authors： Weems JM,Lamb JG,D'Agostino J,Ding X,Yost GS

更新日期：2010-11-15 00:00:00

abstract：:Because of the association between inhalation of airborne particulate matter (PM) and human respiratory and cardiovascular disease, it is necessary to understand the tissue damage induced by these particles. One of the cell types principally involved in the body's reaction to PM are macrophages, which remove particles...

journal_title：Chemical research in toxicology

authors： Santini MT,Rainaldi G,Ferrante A,Romano R,Clemente S,Motta A,De Berardis B,Balduzzi M,Paoletti L,Indovina PL

更新日期：2004-01-01 00:00:00

abstract：:Enzymatic methylation of cytosine residues in DNA, in conjunction with covalent histone modifications, establishes an epigenetic code essential for the proper control of gene expression in higher organisms. Once established during cellular differentiation, the epigenetic code must be faithfully transmitted to progeny ...

journal_title：Chemical research in toxicology

authors： Herring JL,Rogstad DK,Sowers LC

更新日期：2009-06-01 00:00:00

abstract：:Xenobiotics may activate the estrogen receptor, resulting in alteration of normal endocrine functions in animals and humans. Consequently, this necessitates development of assay end points capable of identifying estrogenic xenobiotics. In the present study, we screened the potential estrogenicity of chemicals via thei...

journal_title：Chemical research in toxicology

authors： Markell LK,Mingoia RT,Peterson HM,Yao J,Waters SM,Finn JP,Nabb DL,Han X

更新日期：2014-08-18 00:00:00

abstract：:For decades, many studies have linked maternal smoking to an increased risk of preterm birth. As a result, the scientific community has long hypothesized that exposure to environmental tobacco smoke (ETS), commonly referred to as second-hand smoke, is also associated with an increased risk of preterm birth. Multiple s...

journal_title：Chemical research in toxicology

authors： Elkin ER,O'Neill MS

更新日期：2017-07-17 00:00:00