Nickel Oxide (NiO) Nanoparticles Induce Loss of Cell Viability in Yeast Mediated by Oxidative Stress.

abstract：:We have recently shown that dithiocarbamate (DC) disulfides inhibit proteolytic processing of the caspase-3 proenzyme in Jurkat T lymphocytes treated with anti-CD95 (Fas/APO-1) antibody. Because the processing can be accomplished by caspase activity, we investigated the effect of DC disulfides, such as disulfiram (DSF...

journal_title：Chemical research in toxicology

authors： Nobel CS,Kimland M,Nicholson DW,Orrenius S,Slater AF

更新日期：1997-12-01 00:00:00

abstract：:Thiacetazone (TAZ) and ethionamide (ETA) are, respectively, thiourea- and thioamide-containing second line antitubercular prodrugs for which there is an extensive clinical history of cross-resistance in Mycobacterium tuberculosis. EtaA, a recently identified flavin-containing monooxygenase (FMO), is responsible for th...

journal_title：Chemical research in toxicology

authors： Qian L,Ortiz de Montellano PR

更新日期：2006-03-01 00:00:00

abstract：:Protein-xenobiotic adducts are byproducts of xenobiotic metabolism. While there is a correlation between protein adduction and target organ toxicity, a cause and effect relationship is not often clear. Naphthoquinone (NQ) and monocrotaline pyrrole (MCTP) are two pneumotoxic electrophiles that form covalent adducts wit...

journal_title：Chemical research in toxicology

authors： Nakayama Wong LS,Lamé MW,Jones AD,Wilson DW

更新日期：2010-09-20 00:00:00

abstract：:Exposure to fine particulate matter (PM2.5), of which secondary organic aerosol (SOA) is a major constituent, is linked to adverse health outcomes, including cardiovascular disease, lung cancer, and preterm birth. Atmospheric oxidation of isoprene, the most abundant nonmethane hydrocarbon emitted into Earth's atmosphe...

journal_title：Chemical research in toxicology

authors： Eaves LA,Smeester L,Hartwell HJ,Lin YH,Arashiro M,Zhang Z,Gold A,Surratt JD,Fry RC

更新日期：2020-02-17 00:00:00

abstract：:Electrochemical oxidation of drug molecules is a useful tool to generate several different types of metabolites. In the present study we developed a model system involving electrochemical oxidation followed by characterization of the oxidation products and their propensity to modify peptides. The CB1 antagonist rimona...

journal_title：Chemical research in toxicology

authors： Thorsell A,Isin EM,Jurva U

更新日期：2014-10-20 00:00:00

abstract：:A correct estimate of ligand binding modes and a ratio of their occupancies is crucial for calculations of binding free energies. The newly developed method BLUES combines molecular dynamics with nonequilibrium candidate Monte Carlo. Nonequilibrium candidate Monte Carlo generates a plethora of possible binding modes a...

journal_title：Chemical research in toxicology

authors： Jandova Z,Gill SC,Lim NM,Mobley DL,Oostenbrink C

更新日期：2019-07-15 00:00:00

abstract：:The tumorigenic activity of manufactured gas plant residue (MGP) was evaluated in female A/J mice using a F0927 basal gel diet system. Adulterated diets containing MGP (0.10% or 0.25%) or benzo[a]pyrene (B[alpha]P; 16 or 98 ppm) were fed for 260 days. A negative control group was maintained on a nonadulterated basal g...

journal_title：Chemical research in toxicology

authors： Weyand EH,Chen YC,Wu Y,Koganti A,Dunsford HA,Rodriguez LV

更新日期：1995-10-01 00:00:00

abstract：:Hemoglobin adducts have been used to assess exposure to carcinogenic compounds in tobacco smoke. However, because of background levels in nonsmokers, most adducts that have been studied are not useful for monitoring low-level exposure. Bergmark [(1997) Chem. Res. Toxicol. 10, 78-84] showed that the level of adducts of...

journal_title：Chemical research in toxicology

authors： Pérez HL,Segerbäck D,Osterman-Golkar S

更新日期：1999-10-01 00:00:00

abstract：:Human exposure to abacavir, a primary alcohol antiretroviral, is associated with the development of immunological drug reactions in individuals carrying the HLA risk allele B*57:01. Interaction of abacavir with antigen presenting cells results in cell activation through an Hsp70-mediated Toll-like receptor pathway and...

journal_title：Chemical research in toxicology

authors： Bell CC,Santoyo Castelazo A,Yang EL,Maggs JL,Jenkins RE,Tugwood J,O'Neill PM,Naisbitt DJ,Park BK

更新日期：2013-07-15 00:00:00

abstract：:A database containing maximum daily doses of 1841 marketed oral drugs was used to examine the influence of physicochemical properties on dose and hepatotoxicity (drug induced liver injury, DILI). Drugs in the highest ∼20% dose range had significantly reduced mean lipophilicity and molecular weight, increased fractiona...

journal_title：Chemical research in toxicology

authors： Leeson PD

更新日期：2018-06-18 00:00:00

abstract：:Understanding the molecular basis of inorganic chemical toxicity has lagged behind the proliferation of detailed mechanisms that explain the biochemical toxicology of many organic xenobiotics. In this perspective, general barriers to explicating the bioinorganic chemistry of toxic metals are considered, followed by a ...

journal_title：Chemical research in toxicology

authors： Petering DH

更新日期：2017-01-17 00:00:00

abstract：:A new and efficient method is described for the synthesis in gram quantities of the benzo[a]pyrene (B[a]P) metabolic adducts of 2'-deoxyguanosine (dG) and 2'-deoxyadenosine (dA) substituted, respectively, at the N(2)- and N(6)- positions. When the racemic form of the tris(benzoyloxy)amine 5 (related to the notoriously...

journal_title：Chemical research in toxicology

authors： Johnson F,Bonala R,Tawde D,Torres MC,Iden CR

更新日期：2002-12-01 00:00:00

abstract：:Skin protein modification (haptenation) is thought to be a key step in the manifestation of sensitization to low molecular mass chemicals (<500 g/mol). For sensitizing chemicals that are not protein reactive, it is hypothesised that metabolic activation can convert such chemicals into protein reactive toxins within th...

journal_title：Chemical research in toxicology

authors： Elahi EN,Wright Z,Hinselwood D,Hotchkiss SA,Basketter DA,Pease CK

更新日期：2004-03-01 00:00:00

abstract：:Genotoxic chemicals act by causing DNA damage, which, if left unrepaired, can have deleterious consequences for cell survival. DNA damage response (DDR) gets activated to repair or mitigate the effects of DNA damage. Histone H2AX and H3 phosphorylation biomarkers (γ-H2AX and p-H3) have attracted great attention as the...

journal_title：Chemical research in toxicology

authors： Qu M,Xu H,Chen J,Zhang Y,Xu B,Guo L,Xie J

更新日期：2020-08-17 00:00:00

abstract：:Previous studies suggested that lamotrigene (LTG) underwent bioactivation to a reactive aryl epoxide intermediate in rats. Nevertheless, definitive structures of these thioether conjugates, which are often needed to substantiate the mechanism of bioactivation and identity of reactive intermediate(s), were not fully es...

journal_title：Chemical research in toxicology

authors： Chen H,Grover S,Yu L,Walker G,Mutlib A

更新日期：2010-01-01 00:00:00

abstract：:Interstrand cross-links are minor components of the collection of products formed in DNA by ionizing radiation. Through their formation by other damaging agents, it is known that interstrand cross-links exert significant effects on replication and transcription. The structures of DNA interstrand cross-links produced a...

journal_title：Chemical research in toxicology

authors： Ding H,Greenberg MM

更新日期：2007-11-01 00:00:00

abstract：:Xenobiotics may activate the estrogen receptor, resulting in alteration of normal endocrine functions in animals and humans. Consequently, this necessitates development of assay end points capable of identifying estrogenic xenobiotics. In the present study, we screened the potential estrogenicity of chemicals via thei...

journal_title：Chemical research in toxicology

authors： Markell LK,Mingoia RT,Peterson HM,Yao J,Waters SM,Finn JP,Nabb DL,Han X

更新日期：2014-08-18 00:00:00

abstract：:The major plant growth regulator ethephon degrades to ethylene and phosphate in aqueous solutions and plants and is spontaneously activated to a butyrylcholinesterase (BChE) inhibitor in alkaline solutions and animal tissues. In the present (31)P NMR kinetic study of the reactions of ethephon in pH 7.4 carbonate buffe...

journal_title：Chemical research in toxicology

authors： Lantz SR,Casida JE

更新日期：2013-09-16 00:00:00

abstract：:The Salmonella typhimurium (TA100) mutagenic compound, mucochloric acid [3,4-dichloro-5-hydroxy-2(5H)-furanone (MCA)], was inactivated by in vitro N-acetylcysteine (NAC). The reaction of MCA with NAC at pH7 was second order and gave products 4, 5, and 6a that resulted from the displacement of chlorine from C-3 or C-4 ...

journal_title：Chemical research in toxicology

authors： LaLonde RT,Xie S

更新日期：1992-09-01 00:00:00

abstract：:Senescence, which is irreversible cell cycle arrest, is induced by various types of DNA damage, including genotoxic stress. Senescent cells show dysregulation of tumor suppressor genes and other regulators of cellular proliferation. Activating transcription factor 3 (ATF3) plays a pleiotropic role in biological proces...

journal_title：Chemical research in toxicology

authors： Kim KH,Park B,Rhee DK,Pyo S

更新日期：2015-01-20 00:00:00

abstract：:The administration of 3'-hydroxyacetanilide, a regioisomer of acetaminophen, to mice failed to produce hepatotoxicity even after the administration of diethyl maleate. In contrast, hepatotoxicity did occur when 3'-hydroxyacetanilide was administered to buthionine sulfoximine pretreated mice. Although the administratio...

journal_title：Chemical research in toxicology

authors： Tirmenstein MA,Nelson SD

更新日期：1991-03-01 00:00:00

abstract：:Developmental and reproductive toxicity (DART) end points are important hazard end points that need to be addressed in the risk assessment of chemicals to determine whether or not they are the critical effects in the overall risk assessment. These hazard end points are difficult to predict using current in silico tool...

journal_title：Chemical research in toxicology

authors： Wu S,Fisher J,Naciff J,Laufersweiler M,Lester C,Daston G,Blackburn K

更新日期：2013-12-16 00:00:00

abstract：:The risk factors for women developing breast and endometrial cancers are all associated with a lifetime of estrogen exposure. Estrogen replacement therapy in particular has been correlated with a slight increased cancer risk. Previously, we showed that equilenin, a minor component of Premarin (Wyeth-Ayerst), was metab...

journal_title：Chemical research in toxicology

authors： Zhang F,Chen Y,Pisha E,Shen L,Xiong Y,van Breemen RB,Bolton JL

更新日期：1999-02-01 00:00:00

abstract：:Isoeugenol is widely used by the cosmetic and fragrance industries, but it also represents a known cause of skin sensitization adverse effects. Although devoid of a structural alert, isoeugenol has been classified as prehapten in virtue of the presence of a pre-Michael acceptor domain. Isoeugenol oxidation could theor...

journal_title：Chemical research in toxicology

authors： Ahn J,Avonto C,Chittiboyina AG,Khan IA

更新日期：2020-04-20 00:00:00

abstract：:Many of the protective responses observed for flavonoids in the gastrointestinal track resemble aryl hydrocarbon receptor (AhR)-mediated effects. Therefore, we examined the structure-activity relationships of isoflavones and isomeric flavone and flavanones as AhR ligands on the basis of their induction of CYP1A1, CYP1...

journal_title：Chemical research in toxicology

authors： Park H,Jin UH,Orr AA,Echegaray SP,Davidson LA,Allred CD,Chapkin RS,Jayaraman A,Lee K,Tamamis P,Safe S

更新日期：2019-11-18 00:00:00

abstract：:Aminoglutethimide (AMG) is an aromatic amine aromatase inhibitor associated with a high incidence of idiosyncratic blood dyscrasias, especially agranulocytosis. Animal models of idiosyncratic drug reactions (IDRs) represent essential tools to study these reactions; however, there is currently no valid model of idiosyn...

journal_title：Chemical research in toxicology

authors： Ng W,Uetrecht J

更新日期：2013-08-19 00:00:00

abstract：:It has previously been shown that malonaldehyde forms conjugates with acetaldehyde and that these conjugates react with nucleobases forming so-called conjugate adducts. In the current study, it is shown that conjugate adducts are also formed in calf thymus DNA when incubated simultaneously with malonaldehyde and aceta...

journal_title：Chemical research in toxicology

authors： Pluskota-Karwatka D,Pawłowicz AJ,Kronberg L

更新日期：2006-07-01 00:00:00

abstract：:Acrolein is a bifunctional electrophile, present as an ubiquitous environmental pollutant and an endogenous cellular product of lipid peroxidation. Reaction of acrolein with deoxyguanosine produces two regioisomeric DNA adducts, specifically gamma-hydroxypropanodeoxyguanosine (gamma-HOPdG) and alpha-hydroxypropanodeox...

journal_title：Chemical research in toxicology

authors： Sanchez AM,Minko IG,Kurtz AJ,Kanuri M,Moriya M,Lloyd RS

更新日期：2003-08-01 00:00:00

abstract：:Hexavalent chromium is a human carcinogen activated primarily by direct reduction with cellular ascorbate and to a lesser extent, by glutathione. Cr(III), the final product of Cr(VI) reduction, forms six bonds allowing intermolecular cross-linking. In this work, we investigated the ability of Cr(VI) to cause interstra...

journal_title：Chemical research in toxicology

authors： Morse JL,Luczak MW,Zhitkovich A

更新日期：2013-10-21 00:00:00

abstract：:Proton pump inhibitors (PPIs) are extensively used for the treatment of gastric acid-related disorders. PPIs appear to be well tolerated and almost have no short-term side effects. However, the clinical adverse reactions of long-term PPI usage are increasingly reported in recent years. So far, there is no study that e...

journal_title：Chemical research in toxicology

authors： Wu D,Qiu T,Zhang Q,Kang H,Yuan S,Zhu L,Zhu R

更新日期：2015-03-16 00:00:00