Hepatotoxicity after 3'-hydroxyacetanilide administration to buthionine sulfoximine pretreated mice.

abstract：:ZnO nanoparticles (NPs) are prone to dissolution, and uncertainty remains whether biological/cellular responses to ZnO NPs are solely due to the release of Zn(2+) or whether the NPs themselves have additional toxic effects. We address this by establishing ZnO NP solubility in dispersion media (Dulbecco's modified Eagl...

journal_title：Chemical research in toxicology

authors： Mu Q,David CA,Galceran J,Rey-Castro C,Krzemiński L,Wallace R,Bamiduro F,Milne SJ,Hondow NS,Brydson R,Vizcay-Barrena G,Routledge MN,Jeuken LJ,Brown AP

更新日期：2014-04-21 00:00:00

abstract：:The urine from mice exposed to styrene vapors (600 and 1200 mg/m(3), 6 h) was analyzed for ring-oxidized metabolites of styrene. To facilitate the identification of metabolites in urine, the following potential metabolites were prepared: 2-, 3-, and 4-vinylphenol (2-, 3-, and 4-VP), 4-vinylpyrocatechol, and 2-, 3-, an...

journal_title：Chemical research in toxicology

authors： Linhart I,Mráz J,Scharff J,Krouzelka J,Dusková S,Nohová H,Vodicková L

更新日期：2010-01-01 00:00:00

abstract：:So far, there is limited information on biotransformation mechanisms and products of polar contaminants in freshwater crustaceans. In the present study, metabolites of biocides and pharmaceuticals formed in Gammarus pulex and Daphnia magna were identified using liquid chromatography-high resolution mass spectrometry. ...

journal_title：Chemical research in toxicology

authors： Jeon J,Kurth D,Hollender J

更新日期：2013-03-18 00:00:00

abstract：:Idiosyncratic adverse drug reactions due to the anti-inflammatory drug diclofenac have been proposed to be caused by the generation of reactive acyl glucuronides and oxidative metabolites. For the oxidative metabolism of diclofenac by cytochromes P450 at least five different reactive intermediates have been proposed p...

journal_title：Chemical research in toxicology

authors： Dragovic S,Boerma JS,Vermeulen NP,Commandeur JN

更新日期：2013-11-18 00:00:00

abstract：:The hepatic metabolism of microcystins (MCs), potent cyclic peptide hepatotoxins produced by cyanobacteria, was studied by i.p. injection in mice and rats. An immunoaffinity purification method using an anti-MC-LR monoclonal antibody showed a remarkable effect on the removal of contaminants in the hepatic cytosol and ...

journal_title：Chemical research in toxicology

authors： Kondo F,Matsumoto H,Yamada S,Ishikawa N,Ito E,Nagata S,Ueno Y,Suzuki M,Harada K

更新日期：1996-12-01 00:00:00

abstract：:3'-Hydroxyacetanilide (AMAP) is a nonhepatotoxic regioisomer of acetaminophen (APAP) that nonetheless does form reactive metabolites which bind to hepatic proteins. Because differences in the nature of reactive metabolites formed from AMAP and APAP may explain differences in their propensity to cause hepatotoxicity, c...

journal_title：Chemical research in toxicology

authors： Rashed MS,Nelson SD

更新日期：1989-01-01 00:00:00

abstract：:Sudoxicam and meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs) from the enol-carboxamide class. While the only structural difference between the two NSAIDs is the presence of a methyl group on the C5-position of the 2-carboxamidothiazole motif in meloxicam, a marked difference in their toxicological profile...

journal_title：Chemical research in toxicology

authors： Obach RS,Kalgutkar AS,Ryder TF,Walker GS

更新日期：2008-09-01 00:00:00

abstract：:To prevent the accumulation of reactive oxygen species and limit associated damage to biological macromolecules, cells express a variety of oxidant-detoxifying enzymes, including peroxiredoxins. In Saccharomyces cerevisiae, the peroxiredoxin Tsa1 plays a key role in peroxide clearance and maintenance of genome stabili...

journal_title：Chemical research in toxicology

authors： Loberg MA,Hurtig JE,Graff AH,Allan KM,Buchan JA,Spencer MK,Kelly JE,Clodfelter JE,Morano KA,Lowther WT,West JD

更新日期：2019-03-18 00:00:00

abstract：:Cryogenic (4-10 K) laser-induced vibrationless ground state and vibronic excited state fluorescence emission spectra of the adducts resulting from reaction in vitro of human serum albumin and the carcinogen (+-)-r-7,t-8-dihydroxy-c-9,c-10-epoxy-7,8,9,10- tetrahydrobenzo[a]-pyrene were recorded in order to determine th...

journal_title：Chemical research in toxicology

authors： Day BW,Doxtader MM,Rich RH,Skipper PL,Singh K,Dasari RR,Tannenbaum SR

更新日期：1992-01-01 00:00:00

abstract：:The reactions of calf thymus DNA with four 1,3-dialkyl-3-acyltriazenes were studied alone or in the presence of pig liver esterase in pH 7.4 phosphate buffer for varying lengths of time. The best alkylating agent in the absence of esterase was determined to be 1,3-dimethyl-3-carbethoxytriazene (DMC), followed in order...

journal_title：Chemical research in toxicology

authors： Kroeger-Koepke MB,Michejda CJ,Smith RH Jr

更新日期：1992-07-01 00:00:00

abstract：:A database containing maximum daily doses of 1841 marketed oral drugs was used to examine the influence of physicochemical properties on dose and hepatotoxicity (drug induced liver injury, DILI). Drugs in the highest ∼20% dose range had significantly reduced mean lipophilicity and molecular weight, increased fractiona...

journal_title：Chemical research in toxicology

authors： Leeson PD

更新日期：2018-06-18 00:00:00

abstract：:Nitrogen mustards (NM) are an important class of chemotherapeutic drugs used in the treatment of malignant tumors. The accepted mechanism of action of NM is through the alkylation of DNA bases. NM-adducts block DNA replication in cancer cells by forming cytotoxic DNA interstrand cross-links. We previously characterize...

journal_title：Chemical research in toxicology

authors： Chen H,Cui Z,Hejazi L,Yao L,Walmsley SJ,Rizzo CJ,Turesky RJ

更新日期：2020-04-20 00:00:00

abstract：:Acetaminophen (AP) is a popularly recommended over-the-counter analgesic-antipyretic in clinical use. However, the drug is handicapped by the occurrence of hepatotoxic insult following acute ingestion. Consequently, AP-induced hepatotoxicity is often implicated in accidental or suicidal overdose. In the current study,...

journal_title：Chemical research in toxicology

authors： Sahu A,Das D,Sahu P,Mishra S,Sakthivel A,Gajbhiye A,Agrawal R

更新日期：2020-02-17 00:00:00

abstract：:4-Carboxyl-substituted analogues of trans-3'-hydroxycotinine were synthesized to be covalently linked to macromolecules for antibody production. 3-Pyridyl-N-methylnitrone was condensed with dimethyl fumarate to give two isomeric isoxazolidines. Hydrogenolysis of the major product [2RS-(2 alpha,3 alpha,3 beta)]-3-carbo...

journal_title：Chemical research in toxicology

authors： Desai DH,Amin S

更新日期：1991-09-01 00:00:00

abstract：:The metabolic pathway of tetrodotoxin (TTX), a powerful and specific voltage-gated sodium channel blocker, has not been well-clarified either in TTX-poisoned patients or in puffer fish. 4-S-CysteinylTTX (4-CysTTX) was isolated from the liver of the puffer fish, Fugu pardalis, as the first adduct of TTX with thiol. The...

journal_title：Chemical research in toxicology

authors： Yotsu-Yamashita M,Goto A,Nakagawa T

更新日期：2005-05-01 00:00:00

abstract：:Mitomycin C (MMC) is a genotoxic cancer chemotherapeutic agent that reacts principally at the N2 position of guanine to form one of two predominant monoadducts, or a G-G interstrand cross-link at CpG sites, or a G-G intrastrand cross-link at GpG sites. Previous studies of MMC adduction have principally used very short...

journal_title：Chemical research in toxicology

authors： Warren AJ,Hamilton JW

更新日期：1996-10-01 00:00:00

abstract：:Human exposure to engineered nanomaterials (ENMs) is inevitable due to the plethora of applications for which they are being manufactured and integrated within. ENMs demonstrate plentiful advantages in terms of industrial approaches as well as from a consumer perspective. However, despite such positives, doubts remain...

journal_title：Chemical research in toxicology

authors： Cronin JG,Jones N,Thornton CA,Jenkins GJS,Doak SH,Clift MJD

更新日期：2020-05-18 00:00:00

abstract：:1,2,3,4-Diepoxybutane (DEB) is a prominent carcinogenic metabolite of 1,3-butadiene (1,3-BD), an important industrial chemical and an environmental pollutant found in cigarette smoke and automobile exhaust. DEB is capable of inducing a variety of genotoxic effects, including point mutations, large deletions, and chrom...

journal_title：Chemical research in toxicology

authors： Park S,Hodge J,Anderson C,Tretyakova N

更新日期：2004-12-01 00:00:00

abstract：:Two hemorrhagic proteases, Lachesis hemorrhagic toxins a and b (LHTa and LHTb), were isolated from the venom of Lachesis muta, which is distributed in Central and South America. One protease showed strong hemorrhagic action, while the other showed weak hemorrhagic activity even though the two enzymes are very similar ...

journal_title：Chemical research in toxicology

authors： Ran YL,Zheng SD,Tu AT

更新日期：1988-11-01 00:00:00

abstract：:The synthesis of a series of 1,2,4-triazole-containing oligopeptide lexitropsins related to the natural antitumor antibiotic distamycin is described. The binding properties of these new agents to both native DNAs and synthetic polydeoxyribonucleotides were determined by UV absorption and circular dichroism studies. Th...

journal_title：Chemical research in toxicology

authors： Rao KE,Krowicki K,Burckhardt G,Zimmer C,Lown JW

更新日期：1991-03-01 00:00:00

abstract：:In the present study, values of the binding energy (BE) were calculated for the rat androgen receptor on a data set of 25 steroidal and nonsteroidal compounds for which published values of the observed binding affinity (K(i)) are available. A correlation between BE and pK(i) was evident (r(2) = 0.50) for the entire da...

journal_title：Chemical research in toxicology

authors： Ai N,DeLisle RK,Yu SJ,Welsh WJ

更新日期：2003-12-01 00:00:00

abstract：:The rat esophagus is strikingly sensitive to tumor induction by nitrosamines, and it has been hypothesized that this tissue contains cytochrome P450 enzymes (P450s) which catalyze the metabolic activation of these carcinogens. The metabolic capacity of the esophagus is not well characterized. In the study described he...

journal_title：Chemical research in toxicology

authors： von Weymarn LB,Murphy SE

更新日期：2001-10-01 00:00:00

abstract：:Pentachlorophenol (PCP) was shown to function as a reducing substrate for horseradish peroxidase (HRP) and to stimulate the HRP-catalyzed reduction of 5-phenyl-4-penten-1-yl hydroperoxide (PPHP) to 5-phenyl-4-penten-1-ol. HRP catalyzed the hydroperoxide-dependent oxidation of PCP, using H2O2, PPHP, or ethyl hydroperox...

journal_title：Chemical research in toxicology

authors： Samokyszyn VM,Freeman JP,Maddipati KR,Lloyd RV

更新日期：1995-04-01 00:00:00

abstract：:Benzo[a]pyrene, a potent human carcinogen, is metabolized in vivo to a diol epoxide that reacts with the N2-position of guanine to produce N2-BP-dG adducts. These adducts are mutagenic causing G to T transversions. These adducts block replicative polymerases but can be bypassed by the Y-family translesion synthesis po...

journal_title：Chemical research in toxicology

authors： Gowda ASP,Krzeminski J,Amin S,Suo Z,Spratt TE

更新日期：2017-05-15 00:00:00

abstract：:2,5-Hexanedione (2,5-HD) is the neurotoxic gamma-diketone metabolite of the industrial solvent n-hexane. Substantial evidence indicates that 2,5-HD reacts with neurofilament protein lysine epsilon-amines to yield 2,5-dimethylpyrrole adducts and that this reaction is critical to the mechanism of toxicity. Alkylpyrroles...

journal_title：Chemical research in toxicology

authors： Zhu M,Spink DC,Yan B,Bank S,DeCaprio AP

更新日期：1994-07-01 00:00:00

abstract：:The toxic alpha,beta-unsaturated aldehyde acrolein readily attacks proteins, generating adducts at cysteine, histidine, and lysine residues. In this study, rabbit antiserum was raised against acrolein-modified keyhole limpet hemocyanin in the expectation that it would allow immunodetection of adducted proteins in biol...

journal_title：Chemical research in toxicology

authors： Burcham PC,Fontaine FR,Petersen DR,Pyke SM

更新日期：2003-10-01 00:00:00

abstract：:As COVID-19 swept across the world, it created a global pandemic and an unpredictable and challenging job market. This article discusses the future of the 2020-2021 job market in both academia and industry in the midst and aftermath of this pandemic. ...

journal_title：Chemical research in toxicology

authors： Perera HM,Griffin WC,Kankanamage RNT,Pathira Kankanamge LS

更新日期：2020-12-23 00:00:00

abstract：:Dibenzo[a,l]pyrene (DB[a,l]P) is one of the most potent carcinogens ever tested in mouse skin and rat mammary gland. DB[a,l]P is present in cigarette smoke and, presumably, in other environmental pollutants. Metabolism and mutagenicity studies of this compound compared to the weak carcinogen dibenzo[a,e]pyrene (DB[a,e...

journal_title：Chemical research in toxicology

authors： Devanesan PD,Cremonesi P,Nunnally JE,Rogan EG,Cavalieri EL

更新日期：1990-11-01 00:00:00

abstract：:Recent reports by Galeazzi and co-workers demonstrated the susceptibility of Abeta(1-42) to undergo dityrosine formation via peroxidase-catalyzed tyrosine cross-linking. We have formed dityrosine cross-links in Abeta(1-40) using these enzymatic conditions as well as a copper-H(2)O(2) method. The efficiency of dityrosi...

journal_title：Chemical research in toxicology

authors： Yoburn JC,Tian W,Brower JO,Nowick JS,Glabe CG,Van Vranken DL

更新日期：2003-04-01 00:00:00

abstract：:A series of (alkylthio)trifluoropropanones containing a heterocyclic moiety was synthesized. The compounds were tested for in vitro inhibition of four hydrolytic enzymes including insect juvenile hormone esterase (JHE), eel acetylcholinesterase (AChE), yeast lipase (LP), and bovine alpha-chymotrypsin. The I50 values r...

journal_title：Chemical research in toxicology

authors： Székács A,Halarnkar PP,Olmstead MM,Prag KA,Hammock BD

更新日期：1990-07-01 00:00:00