Reevaluation of the effect of ellagic acid on N-methyl-N-nitrosourea DNA alkylation and mutagenicity.

abstract：:The present study investigated the oxidative metabolism of 2-naphthyl isothiocyanate catalyzed by rat liver microsomes. Incubation of 2-naphthyl isothiocyanate, microsomes, and NADPH yielded either N,N'-di-2-naphthylurea or, on inclusion of 2-aminofluorene in the incubations, N-2-naphthyl-N'-2-fluorenylurea. These ure...

journal_title：Chemical research in toxicology

authors： Lee MS

更新日期：1992-11-01 00:00:00

abstract：:Four novel cadmium-chelating agents N,N'di(D-glucosyl)alkanediamine-N,N'-bis(carbodithioates) 4a-e were prepared as disodium salts of the general formula (CH2)n[N(CS2Na)CH2(CHOH)4CH2OH]2, where n = 7, 8, 10, and 12. They were synthesized by the reductive coupling of 2 mol of alpha-D-(+)-glucose (1) with 1 mol of the c...

journal_title：Chemical research in toxicology

authors： Singh PK,Jones MM,Kostial K,Blanusa M,Piasek M

更新日期：1996-01-01 00:00:00

abstract：:DNA copy number variants are associated with the development of complex neurological diseases and disorders including autism spectrum disorder, schizophrenia, Alzheimer's disease, and Parkinson's disease. Exposure to multiple environmental chemicals including various heavy metals is suggested as a risk factor in these...

journal_title：Chemical research in toxicology

authors： Lee J,Freeman JL

更新日期：2020-08-17 00:00:00

abstract：:Because of the association between inhalation of airborne particulate matter (PM) and human respiratory and cardiovascular disease, it is necessary to understand the tissue damage induced by these particles. One of the cell types principally involved in the body's reaction to PM are macrophages, which remove particles...

journal_title：Chemical research in toxicology

authors： Santini MT,Rainaldi G,Ferrante A,Romano R,Clemente S,Motta A,De Berardis B,Balduzzi M,Paoletti L,Indovina PL

更新日期：2004-01-01 00:00:00

abstract：:Divinyl sulfone (DVS) is an important oxidative metabolic product of sulfur mustard (SM) in vitro and in vivo. Although DVS is not a classical blister agent, its high reactivity and toxicity induced by vinyl groups can also cause blisters like SM upon contact with the skin, eyes, and respiratory organs. The purpose of...

journal_title：Chemical research in toxicology

authors： Lv S,Zhang Y,Xu B,Xu H,Zhao Y,Chen J,Gao Z,Wu J,Xie J

更新日期：2017-10-16 00:00:00

abstract：:Estrogen exposure through early menarche, late menopause, and hormone replacement therapy increases the risk factor for hormone-dependent cancers. Although the molecular mechanisms are not completely established, DNA damage by quinone electrophilic reactive intermediates, derived from estrogen oxidative metabolism, is...

journal_title：Chemical research in toxicology

authors： Chandrasena RE,Edirisinghe PD,Bolton JL,Thatcher GR

更新日期：2008-07-01 00:00:00

abstract：:Carcinogenic polycyclic aromatic hydrocarbons (PAH), e.g., benzo[a]pyrene (BaP), possess a bay region comprising an ortho-fused benzene ring. Benzo[ghi]perylene (BghiP) represents the group of PAHs lacking such a "classic" bay region and hence cannot be metabolically converted like BaP to bay region dihydrodiol epoxid...

journal_title：Chemical research in toxicology

authors： Platt KL,Grupe S

更新日期：2005-04-01 00:00:00

abstract：:In the present study, values of the binding energy (BE) were calculated for the rat androgen receptor on a data set of 25 steroidal and nonsteroidal compounds for which published values of the observed binding affinity (K(i)) are available. A correlation between BE and pK(i) was evident (r(2) = 0.50) for the entire da...

journal_title：Chemical research in toxicology

authors： Ai N,DeLisle RK,Yu SJ,Welsh WJ

更新日期：2003-12-01 00:00:00

abstract：:DNA oxidation damage has been regarded as one of the possible mechanisms for the hepatic carcinogenesis of dioxin-like compounds (DLCs). In this study, we evaluated the toxic equivalency factor (TEF) from the standpoint of induced DNA oxidation products and their relationship to toxicity and carcinogenicity. Nine DNA ...

journal_title：Chemical research in toxicology

authors： Gao L,Mutlu E,Collins LB,Walker NJ,Hartwell HJ,Olson JR,Sun W,Gold A,Ball LM,Swenberg JA

更新日期：2017-03-20 00:00:00

abstract：:Epidemiologic studies have shown causal relationships between air pollution particles and adverse health effects in susceptible subpopulations. Fly ash particles (containing water-soluble and insoluble metals) are a component of ambient air particulate pollution and may contribute to particulate-induced health effects...

journal_title：Chemical research in toxicology

authors： Prahalad AK,Inmon J,Ghio AJ,Gallagher JE

更新日期：2000-10-01 00:00:00

abstract：:2,3-dimethoxy-1,4-naphthoquinone (CAS-RN 6959-96-3) (DMNQ) and 2-methyl-1,4-naphthoquinone (CAS-RN 58-27-5) (MNQ:menadione) are effective one electron redox cycling chemicals in vitro. In addition, in vitro MNQ forms a thioether conjugate with glutathione by nucleophilic attack at the third carbon. In contrast, here w...

journal_title：Chemical research in toxicology

authors： Parry JD,Pointon AV,Lutz U,Teichert F,Charlwood JK,Chan PH,Athersuch TJ,Taylor EL,Singh R,Luo J,Phillips KM,Vetillard A,Lyon JJ,Keun HC,Lutz WK,Gant TW

更新日期：2009-04-01 00:00:00

abstract：:On the basis of a large number of reports concerning the detection of lipid peroxidation products as biomarkers in human diseases, there is no doubt that their steady-state levels increase under pathophysiological states associated with oxidative stress. The key question is whether they play any causative roles. This ...

journal_title：Chemical research in toxicology

authors： Uchida K

更新日期：2007-01-01 00:00:00

abstract：:The synthesis of a series of 1,2,4-triazole-containing oligopeptide lexitropsins related to the natural antitumor antibiotic distamycin is described. The binding properties of these new agents to both native DNAs and synthetic polydeoxyribonucleotides were determined by UV absorption and circular dichroism studies. Th...

journal_title：Chemical research in toxicology

authors： Rao KE,Krowicki K,Burckhardt G,Zimmer C,Lown JW

更新日期：1991-03-01 00:00:00

abstract：:Our long-term oral administration of dimethylarsinic acid (DMAV) in rats revealed that three unidentified metabolites, M-1, M-2, and M-3, were detected in urine and feces. DMAV and trimethylarsine oxide (TMAO) were converted to M-2 and M-3 and M-1 by Escherichia coli strain A3-6 isolated from the ceca of DMAV-administ...

journal_title：Chemical research in toxicology

authors： Yoshida K,Kuroda K,Zhou X,Inoue Y,Date Y,Wanibuchi H,Fukushima S,Endo G

更新日期：2003-09-01 00:00:00

abstract：:The conjugation of reactive drug metabolites to GSH is considered an important detoxification mechanism that can be spontaneous and/or mediated by glutathione S-transferases (GSTs). In case GSTs play an important role in GSH conjugation, genetically determined deficiencies in GSTs may be a risk factor for adverse drug...

journal_title：Chemical research in toxicology

authors： Dragovic S,Boerma JS,van Bergen L,Vermeulen NP,Commandeur JN

更新日期：2010-09-20 00:00:00

abstract：:To reveal the roles of Y family DNA polymerases in the mutagenesis induced by oxidatively damaged DNA precursors, 2-hydroxy-dATP (2-OH-dATP) and 8-hydroxy-dGTP (8-OH-dGTP) were introduced into Escherichia coli strains deficient in the Y family polymerases, DNA polymerase IV (pol IV, encoded by the dinB gene) and DNA p...

journal_title：Chemical research in toxicology

authors： Satou K,Yamada M,Nohmi T,Harashima H,Kamiya H

更新日期：2005-08-01 00:00:00

abstract：:Nitroaromatic compounds represent a major class of industrial chemicals that are also found in nature. Polycyclic derivatives are regarded as potent mutagens and carcinogens following bioactivation to produce nitrenium electrophiles that covalently modify DNA to afford N-linked C8-2'-deoxyguanosine (C8-dG) lesions tha...

journal_title：Chemical research in toxicology

authors： Manning TW,Al-Abdul-Wahid MS,Manderville RA,Josephy PD,Kung RW,Wetmore SD

更新日期：2020-02-17 00:00:00

abstract：:Organic electrophiles have been recognized as important components of the exposome that can be characterized as cumulative totality of exposure in the organism in response to environmental perturbation. For such compounds, chemical reactivity may contribute significantly to the toxicological profile through covalent a...

journal_title：Chemical research in toxicology

authors： Böhme A,Laqua A,Schüürmann G

更新日期：2016-06-20 00:00:00

abstract：:Studies on the metabolic bioactivation of the psychotomimetic amine phencyclidine have been pursued through the characterization of a new metabolite which is formed via initial cytochrome P-450 catalyzed oxidation of the parent drug to the corresponding iminium species. CI mass spectrometric and diode array UV and 1H ...

journal_title：Chemical research in toxicology

authors： Hoag MK,Schmidt-Peetz M,Lampen P,Trevor A,Castagnoli N Jr

更新日期：1988-03-01 00:00:00

abstract：:Catechol estrogens (CE) are among the major metabolites of estrone (E1) and 17 beta-estradiol (E2). Oxidation of these metabolites to semiquinones and quinones could generate ultimate carcinogenic forms of E1 and E2. The 2,3- and 3,4-quinones of E1 and E2 were synthesized by MnO2 oxidation of the corresponding CE, fol...

journal_title：Chemical research in toxicology

authors： Dwivedy I,Devanesan P,Cremonesi P,Rogan E,Cavalieri E

更新日期：1992-11-01 00:00:00

abstract：:With CO2 present in excess, ONOO- reacts to form an adduct in solution and in the solid state, most likely ONOOCO2-. In solution, the adduct appears within 2 ms and absorbs at 300 with an extinction coefficient, which is either 50% or 100% (preferred) of that of ONOO-, 1.70 × 103 M-1 cm-1, and at 685 nm with an extinc...

journal_title：Chemical research in toxicology

authors： Serrano-Luginbuehl S,Kissner R,Koppenol WH

更新日期：2018-08-20 00:00:00

abstract：:DNA molecules utilize adenine, thymine, cytosine, and guanine for coding genetic information. In addition to these four canonical nucleobases, DNA molecules also contain a variety of modified nucleobases that can control and regulate gene expression and chromosome structure. Elucidating the functions of DNA modificati...

journal_title：Chemical research in toxicology

authors： Yuan BF

更新日期：2020-03-16 00:00:00

abstract：:Ferroptosis is a form of cell death that requires phospholipid peroxidation and has attracted increased attention, both as a means to eradicate tumors resistant to standard chemotherapy and for its potential contribution to tissue damage such as in ischemia/reperfusion. The center stage taken by phospholipid peroxidat...

journal_title：Chemical research in toxicology

authors： Friedmann Angeli JP,Miyamoto S,Schulze A

更新日期：2019-03-18 00:00:00

abstract：:Allyl alcohol (AA) is one of the environmental pollutants used as a herbicide and industrial chemical. AA undergoes enzymatic oxidation in vivo to form Acrolein (Acr), a highly reactive and ubiquitous environmental toxicant. The exposure to AA/Acr has detrimental effects on cells and is highly fatal. In corroboration ...

journal_title：Chemical research in toxicology

authors： Golla U,Bandi G,Tomar RS

更新日期：2015-06-15 00:00:00

abstract：:Many herbal medicines such as epimedium have been reported to cause adverse effects, and icaritin is the common aglycone of many glucosides in epimedium. Our present work aimed at the clarification of the metabolic activation of icaritin possibly responsible for the adverse effects of epimedium. A quinone methide meta...

journal_title：Chemical research in toxicology

authors： Chen Y,Guo X,Ma Y,Hu X,Peng Y,Zheng J

更新日期：2019-06-17 00:00:00

abstract：:The kinetics and mechanisms of the hydrolysis of cysteine thiosulfinate ester (CyS(O)SCy ( x- ), x = 0-2) have been investigated by stopped-flow spectrophotometry between pH 6 and pH 14. The rate-limiting reaction of hydroxide is observed for pH < 13. More complicated kinetics are observed above pH 13, where the hydro...

journal_title：Chemical research in toxicology

authors： Nagy P,Ashby MT

更新日期：2007-09-01 00:00:00

abstract：:Nickel(II) compounds are established human carcinogens, but the molecular mechanisms underlying their activity are only partially known. One mechanism may include mediation by nickel of promutagenic oxidative DNA damage that depends on Ni(II) binding to chromatin. To characterize such binding at the histone moiety of ...

journal_title：Chemical research in toxicology

authors： Bal W,Lukszo J,Jezowska-Bojczuk M,Kasprzak KS

更新日期：1995-07-01 00:00:00

abstract：:The .CCl3 radical generated during the metabolism of CCl4 is readily spin trapped in vivo and in vitro by phenyl N-tert-butylnitrone (PBN) to form the stable PBN/.CCl3 radical adduct, which can then be extracted into organic solvents and detected by ESR spectroscopy. We have used this technique to examine the proposed...

journal_title：Chemical research in toxicology

authors： Hanna PM,Kadiiska MB,Jordan SJ,Mason RP

更新日期：1993-09-01 00:00:00

abstract：:Polyunsaturated fatty acids (PUFA) are primary targets of free radical damage during oxidative stress. Diffusible electrophilic alpha,beta-unsaturated aldehydes, such as 4-hydroxynonenal (HNE), have been shown to modify proteins that mediate cell signaling (e.g., IKK and Keap1) and alter gene expression pathways respo...

journal_title：Chemical research in toxicology

authors： Vila A,Tallman KA,Jacobs AT,Liebler DC,Porter NA,Marnett LJ

更新日期：2008-02-01 00:00:00

abstract：:N-Nitrosopyrrolidine (NPYR) is a well-established hepatocarcinogen in the rat. NPYR requires metabolic activation by cytochrome P450-catalyzed alpha-hydroxylation to express its carcinogenic activity. This produces alpha-hydroxyNPYR (2), which spontaneously ring opens to 4-oxobutanediazohydroxide (4), a highly reactiv...

journal_title：Chemical research in toxicology

authors： Wang M,Lao Y,Cheng G,Shi Y,Villalta PW,Hecht SS

更新日期：2007-04-01 00:00:00