Abstract：
:The hepatotoxicity of Troglitazone (TGZ) has been ascribed to the formation of reactive metabolites, and the primary reactive metabolite of TGZ has been confirmed to be an o-quinone methide. Oxidation of the chromane moiety is also known to produce quinone containing metabolites. Quantum chemical studies have been performed to analyze the possible reaction pathways for the metabolism of the TGZ side chain, 6-hydroxy-2,2,5,7,8-pentamethylchromane (HPMC). From this analysis, a new pathway including oxidation at the C13 and C14 atoms of HPMC has been proposed for the formation of o-quinone methide (M2), while oxidation at the hydroxyl group leads to the formation of the quinone metabolite (M7). o-Quinone methide reactive metabolites have been shown to be more electrophilic at the reactive methylene center using quantum chemically estimated parameters.
journal_name
Chem Res Toxicoljournal_title
Chemical research in toxicologyauthors
Dixit VA,Bharatam PVdoi
10.1021/tx200110hsubject
Has Abstractpub_date
2011-07-18 00:00:00pages
1113-22issue
7eissn
0893-228Xissn
1520-5010journal_volume
24pub_type
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