Determination of in vitro- and in vivo-formed DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline by capillary liquid chromatography/microelectrospray mass spectrometry.

abstract：:Skin protein modification (haptenation) is thought to be a key step in the manifestation of sensitization to low molecular mass chemicals (<500 g/mol). For sensitizing chemicals that are not protein reactive, it is hypothesised that metabolic activation can convert such chemicals into protein reactive toxins within th...

journal_title：Chemical research in toxicology

authors： Elahi EN,Wright Z,Hinselwood D,Hotchkiss SA,Basketter DA,Pease CK

更新日期：2004-03-01 00:00:00

abstract：:The activation of phospholipase A2 (PLA2) by lipid ozonation products is reported. The principal products from the ozonation of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) are 1-palmitoyl-2-[8-[3(5-octyl-1,2,4-trioxolan-3-yl)octanoyl]--sn-gly cero-3- phosphocholine (PC-Criegee ozonide) and 1-palmitoyl-2-(9...

journal_title：Chemical research in toxicology

authors： Salgo MG,Squadrito GL,Pryor WA

更新日期：1994-05-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic aromatic amine that is formed during the cooking of meats. PhIP is a potential human carcinogen: it undergoes metabolic activation to form electrophilic metabolites that bind to DNA and proteins, including serum albumin (SA). The structures of Ph...

journal_title：Chemical research in toxicology

authors： Peng L,Dasari S,Tabb DL,Turesky RJ

更新日期：2012-10-15 00:00:00

abstract：:Kinetic simulation can help obtain deeper insight into the molecular mechanisms of complex processes, such as lipid peroxidation (LPO) in low-density lipoprotein (LDL). We have previously set up a single-compartment model of this process, initiating with radicals generated externally at a constant rate to show the int...

journal_title：Chemical research in toxicology

authors： Abuja PM,Albertini R,Esterbauer H

更新日期：1997-06-01 00:00:00

abstract：:Our laboratory previously reported the identification and quantification of depurinating DNA adducts of dibenzo[a,l]pyrene (DB[a,l]P) in vitro, which comprise about 84% of all the DNA adducts that are formed [Li, K.-M., et al. (1995) Biochemistry 34, 8043-8049]. To determine a complete adduct profile and identify both...

journal_title：Chemical research in toxicology

authors： Devanesan P,Ariese F,Jankowiak R,Small GJ,Rogan EG,Cavalieri EL

更新日期：1999-09-01 00:00:00

abstract：:We report on the generation of computer-based models for the prediction of the chromosome-damaging potential of chemicals as assessed in the in vitro chromosome aberration (CA) test. On the basis of publicly available CA-test results of more than 650 chemical substances, half of which are drug-like compounds, we gener...

journal_title：Chemical research in toxicology

authors： Rothfuss A,Steger-Hartmann T,Heinrich N,Wichard J

更新日期：2006-10-01 00:00:00

abstract：:The 2'-deoxyguanosine adduct of the dietary mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) has been synthesized and incorporated into DNA using solid state synthesis technology. The key step to obtaining the C8-dG adduct is a palladium (Xantphos-chelated)-catalyzed N-arylation (Buchwald-Hartwig reactio...

journal_title：Chemical research in toxicology

authors： Bonala R,Torres MC,Iden CR,Johnson F

更新日期：2006-06-01 00:00:00

abstract：:Thalidomide is an infamous teratogen and it is continuously being explored for its anticancer properties. Fibroblast growth factor receptors (FGFRs) are implicated in embryo development and cancer pathophysiology. With striking similarities observed between FGFR implicated conditions and thalidomide embryopathy, we hy...

journal_title：Chemical research in toxicology

authors： Sundaresan L,Kumar P,Manivannan J,Balaguru UM,Kasiviswanathan D,Veeriah V,Anishetty S,Chatterjee S

更新日期：2019-04-15 00:00:00

abstract：:Copper is a physiologically important, redox-active metal that may be involved in endogenous DNA damage and mutagenesis. To understand the factors that affect the location and quantity of copper-induced oxidative DNA damage in cells, we used the 5S rDNA nucleosome as a model to assess the effect of chromatin structure...

journal_title：Chemical research in toxicology

authors： Liang Q,Dedon PC

更新日期：2001-04-01 00:00:00

abstract：:The location of carcinogen-modified nucleobases (DNA adducts) within DNA sequences is a critical factor affecting their promutagenic properties and persistence in DNA. We now report the use of controlled exonuclease digestion followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MAL...

journal_title：Chemical research in toxicology

authors： Tretyakova N,Matter B,Ogdie A,Wishnok JS,Tannenbaum SR

更新日期：2001-08-01 00:00:00

abstract：:The risk of potential human exposure to mixed nanomaterials in consumer, occupational, and medicinal settings is increasing as nanomaterials enter both the workplace and the marketplace. In this study, we investigated the toxicity of mixed engineered carbon black (ECB) and maghemite iron oxide (Fe(2)O(3)) nanoparticle...

journal_title：Chemical research in toxicology

authors： Berg JM,Ho S,Hwang W,Zebda R,Cummins K,Soriaga MP,Taylor R,Guo B,Sayes CM

更新日期：2010-12-20 00:00:00

abstract：:A potentiometric and spectroscopic (UV/vis and CD) study of Cu(II) and Ni(II) binding to the N-terminal pentadecapeptide of human protamine HP2 (HP2(1-15)) was performed. The results indicate that the N-terminal tripeptide motif Arg-Thr-His is the exclusive binding site for both metal ions at a metal to HP2(1-15) mola...

journal_title：Chemical research in toxicology

authors： Bal W,Jezowska-Bojczuk M,Kasprzak KS

更新日期：1997-08-01 00:00:00

abstract：:Human hemoglobin was alkylated with (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) and then treated with aqueous (+/-)-3-amino-1,2-propanediol to convert alkylated carboxyl side chains to N-(2,3-dihydroxypropyl) amides. Tryptic peptides produced from the modified protein...

journal_title：Chemical research in toxicology

authors： Day BW,Skipper PL,Rich RH,Naylor S,Tannenbaum SR

更新日期：1991-05-01 00:00:00

abstract：:Because of the association between inhalation of airborne particulate matter (PM) and human respiratory and cardiovascular disease, it is necessary to understand the tissue damage induced by these particles. One of the cell types principally involved in the body's reaction to PM are macrophages, which remove particles...

journal_title：Chemical research in toxicology

authors： Santini MT,Rainaldi G,Ferrante A,Romano R,Clemente S,Motta A,De Berardis B,Balduzzi M,Paoletti L,Indovina PL

更新日期：2004-01-01 00:00:00

abstract：:Estrogens, including the natural hormones estrone (E(1)) and estradiol (E(2)), are thought to be involved in tumor induction. Specifically, catechol estrogen quinones (CEQs) derived from the catechol estrogens 4-hydroxyestrone (4-OHE(1)) and 4-hydroxyestradiol (4-OHE(2)) react with DNA and form DNA adducts (Cavalieri,...

journal_title：Chemical research in toxicology

authors： Jankowiak R,Markushin Y,Cavalieri EL,Small GJ

更新日期：2003-03-01 00:00:00

abstract：:Benzo[a]pyrene diol epoxides (BPDEs) are the ultimate carcinogenic species of benzo[a]pyrene, a prototype polycyclic aromatic hydrocarbon (PAH). BPDE-modified DNA duplexes can adopt multiple conformations depending on the nature of the modified bases, the stereochemistry at the location of the covalent linkage, and th...

journal_title：Chemical research in toxicology

authors： Yang T,Huang Y,Cho BP

更新日期：2006-02-01 00:00:00

abstract：:Unpredicted human safety events in clinical trials for new drugs are costly in terms of human health and money. The drug discovery industry attempts to minimize those events with diligent preclinical safety testing. Current standard practices are good at preventing toxic compounds from being tested in the clinic; howe...

journal_title：Chemical research in toxicology

authors： Cassar S,Adatto I,Freeman JL,Gamse JT,Iturria I,Lawrence C,Muriana A,Peterson RT,Van Cruchten S,Zon LI

更新日期：2020-01-21 00:00:00

abstract：:Dimethylarsinic acid (DMAs(V)), the major urinary metabolite of inorganic arsenic, is weakly cytotoxic, whereas its reduced form, dimethylarsinous acid (DMAs(III)), is highly toxic. Although glutathione S-transferase omega 1 (GSTO1) and arsenic methyltransferase have been shown or thought to catalyze DMAs(V) reduction...

journal_title：Chemical research in toxicology

authors： Németi B,Gregus Z

更新日期：2013-03-18 00:00:00

abstract：:Lindane and paraquat induce biochemical changes in the liver. In order to specify their molecular impact at the cellular level, a 300 MHz 1H NMR investigation of hepatoma cell lines Hep 3B and Hep G2 responses was performed. Cells were exposed over 24 h to 50 mg/L lindane (0.178 mM) or to 100 mg/L (0.389 mM) paraquat ...

journal_title：Chemical research in toxicology

authors： Descampiaux B,Imbenotte M,Desenclos V,Vermeersch G,Lhermitte M,Erb F

更新日期：1997-01-01 00:00:00

abstract：:Among the cellular components that can react directly with peroxynitrite in the presence of physiological CO(2) concentrations are sulfur-, selenium-, and metal-containing proteins, in particular hemoproteins. We have previously shown that the reactions of peroxynitrite with oxymyoglobin (MbFeO(2)) and oxyhemoglobin p...

journal_title：Chemical research in toxicology

authors： Herold S,Exner M,Boccini F

更新日期：2003-03-01 00:00:00

abstract：:Reactive oxygen species can induce the formation of tandem DNA lesions. We recently showed that the treatment of calf thymus DNA with Cu2+/H2O2/ascorbate could result in the efficient formation of a tandem lesion where a 5,6-dihydroxy-5,6-dihydrothymidine (or thymidine glycol) is situated on the 5' side of an 8-oxo-7,...

journal_title：Chemical research in toxicology

authors： Jiang Y,Wang Y,Wang Y

更新日期：2009-03-16 00:00:00

abstract：:A diverse series of aliphatic alpha,beta-unsaturated esters, ketones, and aldehydes were evaluated for reactivity with the model nucleophile sulfhydryl group in the form of the cysteine residue of the tripeptide glutathione; the reactive end point (RC50) was then related to aquatic toxicity (IGC50) assessed in the Tet...

journal_title：Chemical research in toxicology

authors： Yarbrough JW,Schultz TW

更新日期：2007-03-01 00:00:00

abstract：:By the action of UVA light, fluphenazine reacted with nucleophiles through a mechanism involving defluorination of its trifluoromethyl group, giving rise to carboxylic acid derivatives that were easily detected by electrospray mass spectrometry. This photoreaction took place with alcohols, sulphydryls, and amines. Whe...

journal_title：Chemical research in toxicology

authors： Caffieri S,Miolo G,Seraglia R,Dalzoppo D,Toma FM,van Henegouwen GM

更新日期：2007-10-01 00:00:00

abstract：:Formyl chloride has been indirectly implicated as an intermediate in the oxidation of CH(2)Cl(2) and proposed to be a product of the oxidation of some other compounds. Formyl chloride was synthesized and added to aqueous solutions, with CO formed as a product. The presence of glutathione (GSH) did not reduce the yield...

journal_title：Chemical research in toxicology

authors： Watanabe K,Guengerich FP

更新日期：2006-08-01 00:00:00

abstract：:Marine toxins such as brevetoxins and ciguatoxins are produced by dinoflagellates and can accumulate in seafood. These toxins affect humans through seafood consumption. Intoxication is mainly characterized by gastrointestinal and neurological disorders and, in most severe cases, by cardiovascular problems. To prevent ...

journal_title：Chemical research in toxicology

authors： Louzao MC,Vieytes MR,Yasumoto T,Botana LM

更新日期：2004-04-01 00:00:00

abstract：:Spin adducts are observed when the unfiltered smoke produced during the aerobic pyrolysis of perfluoro polymers (PFP) is bubbled through a solution of the ESR spin trap alpha-phenyl-N-tert-butylnitrone (PBN). The spin adducts include those from an oxy radical and the fluorine atom, and in addition the spin trap is oxi...

journal_title：Chemical research in toxicology

authors： Lachocki TM,Nuggehalli SK,Scherer KV,Church DF,Pryor WA

更新日期：1989-05-01 00:00:00

abstract：:Iron (Fe) chelation therapy was initially designed to alleviate the toxic effects of excess Fe evident in Fe-overload diseases. However, the novel toxicological properties of some Fe chelator-metal complexes have shifted appreciable focus to their application in cancer chemotherapy. Redox-inactive Fe chelator complexe...

journal_title：Chemical research in toxicology

authors： Kalinowski DS,Richardson DR

更新日期：2007-05-01 00:00:00

abstract：:To prevent the accumulation of reactive oxygen species and limit associated damage to biological macromolecules, cells express a variety of oxidant-detoxifying enzymes, including peroxiredoxins. In Saccharomyces cerevisiae, the peroxiredoxin Tsa1 plays a key role in peroxide clearance and maintenance of genome stabili...

journal_title：Chemical research in toxicology

authors： Loberg MA,Hurtig JE,Graff AH,Allan KM,Buchan JA,Spencer MK,Kelly JE,Clodfelter JE,Morano KA,Lowther WT,West JD

更新日期：2019-03-18 00:00:00

abstract：:As COVID-19 swept across the world, it created a global pandemic and an unpredictable and challenging job market. This article discusses the future of the 2020-2021 job market in both academia and industry in the midst and aftermath of this pandemic. ...

journal_title：Chemical research in toxicology

authors： Perera HM,Griffin WC,Kankanamage RNT,Pathira Kankanamge LS

更新日期：2020-12-23 00:00:00

abstract：:Finger 3 of transcription factor IIIA of Xenopus laevis was synthesized and constituted with Zn(2+) or Cd(2+). The C-block element of the internal control region of the promoter of the 5S rRNA gene binds to the Zn-F3 and Cd-F3 with dissociation constants of 2.6 x 10(-5) and 1.5 x 10(-4) M, respectively. According to N...

journal_title：Chemical research in toxicology

authors： Krepkiy D,Försterling FH,Petering DH

更新日期：2004-07-01 00:00:00