Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of dichloromethane.

abstract：:The effect of adduct stereochemistry on the susceptibility to hydrolysis by snake venom (VPD) and bovine spleen (SPD) phosphodiesterases was investigated with short deoxyoligonucleotides containing defined adducts derived from alkylation of the exocyclic 6-amino group of dA by polycyclic aromatic hydrocarbon diol epox...

journal_title：Chemical research in toxicology

authors： Ilankumaran P,Pannell LK,Gebreselassie P,Pilcher AS,Yagi H,Sayer JM,Jerina DM

更新日期：2001-09-01 00:00:00

abstract：:The guidelines embodied in this document were revised by the editors of the Publication Division of the American Chemical Society in January 1994 and endorsed by the Society Committee on Publications. ...

journal_title：Chemical research in toxicology

authors：

更新日期：1994-07-01 00:00:00

abstract：:Estrogens and their oxidative metabolites, the catechol estrogens, have been implicated in the development of breast cancer; yet, relatively little is known about estrogen metabolism in the breast. To determine how the parent hormone, 17 beta-estradiol (E(2)), is metabolized, we used recombinant, purified phase I enzy...

journal_title：Chemical research in toxicology

authors： Dawling S,Hachey DL,Roodi N,Parl FF

更新日期：2004-09-01 00:00:00

abstract：:We report on the generation of computer-based models for the prediction of the chromosome-damaging potential of chemicals as assessed in the in vitro chromosome aberration (CA) test. On the basis of publicly available CA-test results of more than 650 chemical substances, half of which are drug-like compounds, we gener...

journal_title：Chemical research in toxicology

authors： Rothfuss A,Steger-Hartmann T,Heinrich N,Wichard J

更新日期：2006-10-01 00:00:00

abstract：:Exposure to arsenic affects large human populations worldwide and has been associated with a long list of human diseases, including skin, bladder, lung, and liver cancers, diabetes, and cardiovascular disorders. In addition, there are large individual differences in susceptibility to arsenic-induced diseases, which ar...

journal_title：Chemical research in toxicology

authors： Lu K,Cable PH,Abo RP,Ru H,Graffam ME,Schlieper KA,Parry NM,Levine S,Bodnar WM,Wishnok JS,Styblo M,Swenberg JA,Fox JG,Tannenbaum SR

更新日期：2013-12-16 00:00:00

abstract：:ZnO nanoparticles (NPs) are prone to dissolution, and uncertainty remains whether biological/cellular responses to ZnO NPs are solely due to the release of Zn(2+) or whether the NPs themselves have additional toxic effects. We address this by establishing ZnO NP solubility in dispersion media (Dulbecco's modified Eagl...

journal_title：Chemical research in toxicology

authors： Mu Q,David CA,Galceran J,Rey-Castro C,Krzemiński L,Wallace R,Bamiduro F,Milne SJ,Hondow NS,Brydson R,Vizcay-Barrena G,Routledge MN,Jeuken LJ,Brown AP

更新日期：2014-04-21 00:00:00

abstract：:Inhalation of environmental particulate matter (PM) is correlated with adverse health effects in humans, but gene products that couple detection with cellular responses, and the specific properties of PM that target different pathways, have not been fully elucidated. TRPA1 and V1 are two cation channels expressed by s...

journal_title：Chemical research in toxicology

authors： Deering-Rice CE,Romero EG,Shapiro D,Hughen RW,Light AR,Yost GS,Veranth JM,Reilly CA

更新日期：2011-06-20 00:00:00

abstract：:The initial step in the genesis of neuromelanin, a black polymeric pigment normally found in the cytoplasm of dopaminergic cell bodies in the substantia nigra (SN), is the autoxidation of dopamine (DA) to DA-o-quinone (1). In this investigation, it is demonstrated that in the presence of L-cysteine (CySH) o-quinone 1 ...

journal_title：Chemical research in toxicology

authors： Shen XM,Dryhurst G

更新日期：1996-06-01 00:00:00

abstract：:1,N6-ethenoadenine (εA) is a mutagenic lesion and biomarker observed in numerous cancerous tissues. Two pathways are responsible for its repair: base excision repair (BER) and direct reversal repair (DRR). Alkyladenine DNA glycosylase (AAG) is the primary enzyme that excises εA in BER, generating stable intermediates ...

journal_title：Chemical research in toxicology

authors： Caffrey PJ,Kher R,Bian K,Li D,Delaney S

更新日期：2020-07-20 00:00:00

abstract：:A series of studies was conducted to investigate the potential of (R)- and (S)-2-phenylpropionic acid (2-PPA) to undergo enantioselective covalent binding to protein in freshly isolated rat hepatocytes and to determine whether such covalent binding is dependent on acyl glucuronidation or acyl-CoA formation of 2-PPA. H...

journal_title：Chemical research in toxicology

authors： Li C,Benet LZ,Grillo MP

更新日期：2002-11-01 00:00:00

abstract：:A newly developed recombinant yeast strain, in which the human estrogen receptor has been stably integrated into the genome of the yeast, was used to gain information on the estrogenic activity of a large series of dietary flavonoids. Among 23 flavonoids investigated, 8 were found to markedly stimulate the transcripti...

journal_title：Chemical research in toxicology

authors： Breinholt V,Larsen JC

更新日期：1998-06-01 00:00:00

abstract：:Electrophilic DNA adducts produced following oxidative stress can form DNA-protein cross-links (DPCs), dramatically altering genomic maintenance pathways. Complete characterization of DPCs has been hindered, in part, because of a lack of comprehensive techniques for their analysis. We have, therefore, established a pr...

journal_title：Chemical research in toxicology

authors： Shuck SC,Rose KL,Marnett LJ

更新日期：2014-01-21 00:00:00

abstract：:Reaction of lysine with estrone 3,4-o-quinone gave a complex mixture of products. Six compounds were isolated and identified using spectroscopic techniques. Among the reaction products isolated were 4-hydroxyestrone (2), 3-aminoisoestrone (3), 3-(N-pentyl-5-amino)-isoestrone (4), 1-lysylestrone 3,4-o-iminoquinone (5),...

journal_title：Chemical research in toxicology

authors： Tabakovic K,Abul-Hajj YJ

更新日期：1994-09-01 00:00:00

abstract：:The mechanism of aromatic hydroxylation of estrogens by cytochrome P450 enzymes has been examined by comparing the oxidation of estrone with that of substrates carrying additional aromaticity such as equilenin and the structural analog 2-naphthol. Hamster liver microsomes preferentially catalyzed the conversion of est...

journal_title：Chemical research in toxicology

authors： Sarabia SF,Zhu BT,Kurosawa T,Tohma M,Liehr JG

更新日期：1997-07-01 00:00:00

abstract：:The syntheses of potentially important metabolites of benzo[b]naphtho[2,1-d]thiophene ([2,1]BNT)--trans-1,2-dihydroxy-1,2-dihydrobenzo[b]naphtho[2,1- d]thiophene ([2,1]BNT-1,2-diol) and trans-3,4-dihydroxy-3,4-dihydrobenzo[b]naphtho[2,1-d]thiophene ([2,1]BNT-3,4-diol)--are described. The syntheses involved preparation...

journal_title：Chemical research in toxicology

authors： Misra B,Amin S

更新日期：1990-03-01 00:00:00

abstract：:The environmental contaminant benzo[c]phenanthrene (B[c]Ph) has weak carcinogenic activity in rodent bioassays; however, the fjord region diol epoxides of B[c]Ph, B[c]Ph-3,4-diol 1,2-epoxides (B[c]PhDE), are potent carcinogens. To determine the role of cytochrome P450 isozymes in the activation of B[c]Ph in MCF-7 cell...

journal_title：Chemical research in toxicology

authors： Einolf HJ,Story WT,Marcus CB,Larsen MC,Jefcoate CR,Greenlee WF,Yagi H,Jerina DM,Amin S,Park SS,Gelboin HV,Baird WM

更新日期：1997-05-01 00:00:00

abstract：:To obtain definitive information about the mechanisms of urinary calculus formation and the structural characteristics of the calculi induced by biphenyl administration in rats, with a focus on the sex dependency, the constituents of the urinary calculi were analyzed by HPLC, inductively coupled plasma spectroscopy (I...

journal_title：Chemical research in toxicology

authors： Ohnishi M,Yajima H,Yamamoto S,Matsushima T,Ishii T

更新日期：2000-08-01 00:00:00

abstract：:Protein-xenobiotic adducts are byproducts of xenobiotic metabolism. While there is a correlation between protein adduction and target organ toxicity, a cause and effect relationship is not often clear. Naphthoquinone (NQ) and monocrotaline pyrrole (MCTP) are two pneumotoxic electrophiles that form covalent adducts wit...

journal_title：Chemical research in toxicology

authors： Nakayama Wong LS,Lamé MW,Jones AD,Wilson DW

更新日期：2010-09-20 00:00:00

abstract：:Environmental stress induces the synthesis of glucose-regulated proteins (Grps) in the endoplasmic reticulum (ER) and heat shock proteins (Hsps) in the cytoplasm. Iodoacetamide (IDAM), a prototypical alkyating agent, induces both Grp and Hsp synthesis in renal epithelial cells and causes necrosis which is prevented by...

journal_title：Chemical research in toxicology

authors： van De Water B,Wang Y,Asmellash S,Liu H,Zhan Y,Miller E,Stevens JL

更新日期：1999-10-01 00:00:00

abstract：:Premarin (Wyeth-Ayerst) is the estrogen replacement treatment of choice and continues to be one of the most widely dispensed prescriptions in the United States. In addition to endogenous estrogens, Premarin contains unsaturated estrogens including equilenin. We synthesized the catechol metabolite of equilenin, 4-hydro...

journal_title：Chemical research in toxicology

authors： Shen L,Qiu S,Chen Y,Zhang F,van Breemen RB,Nikolic D,Bolton JL

更新日期：1998-02-01 00:00:00

abstract：:Cytochrome P450 enzymes (CYPs) metabolize alkyl- and arylamines, generating several different products. For the primary and secondary amines, some of these reactions result in hydroxylated amines, which may be toxic. Thus, when designing new drugs containing amine groups, it is important to be able to predict if a giv...

journal_title：Chemical research in toxicology

authors： Seger ST,Rydberg P,Olsen L

更新日期：2015-04-20 00:00:00

abstract：:NADPH in microsomes reduces the hydroxocob(III)alamin form of vitamin B12 to cob(II)alamin and the supernucleophilic cob(I)alamin, which are both highly reactive toward xenobiotic epoxides formed by mammalian metabolism of dienes such as the industrially important chemicals chloroprene and 1,3-butadiene. With styrene,...

journal_title：Chemical research in toxicology

authors： Watson WP,Munter T,Golding BT

更新日期：2004-12-01 00:00:00

abstract：:Arsenic is one of the inorganic pollutants typically found in natural waters, and its toxic effects on the human body are currently of great concern. For this reason, the search for detoxifying agents that can be used in a so-called "chelation therapy" is of primary importance. However, to the aim of finding the therm...

journal_title：Chemical research in toxicology

authors： Chillè D,Cassone G,Giacobello F,Giuffrè O,Nardo VM,Ponterio RC,Saija F,Sponer J,Trusso S,Foti C

更新日期：2020-04-20 00:00:00

abstract：:Acetaminophen (AP) is a popularly recommended over-the-counter analgesic-antipyretic in clinical use. However, the drug is handicapped by the occurrence of hepatotoxic insult following acute ingestion. Consequently, AP-induced hepatotoxicity is often implicated in accidental or suicidal overdose. In the current study,...

journal_title：Chemical research in toxicology

authors： Sahu A,Das D,Sahu P,Mishra S,Sakthivel A,Gajbhiye A,Agrawal R

更新日期：2020-02-17 00:00:00

abstract：:The complex composition of welding fumes, multiplicity of molecular targets, diverse cellular effects, and lifestyles associated with laborers vastly complicate the assessment of welding fume exposure. The urinary metabolomic profiles of 35 male welders and 16 male office workers at a Taiwanese shipyard were character...

journal_title：Chemical research in toxicology

authors： Wang KC,Kuo CH,Tian TF,Tsai MH,Chiung YM,Hsiech CM,Tsai SJ,Wang SY,Tsai DM,Huang CC,Tseng YJ

更新日期：2012-03-19 00:00:00

abstract：:The development of a unique bioassay for cytotoxicity analysis of coal fly ash (CFA) particulate matter (PM) and its potential application for air quality monitoring is described. Using human cell lines, A549 and SK-MES-1, as live probes on microelectrode-embedded 96-well sensors, impedance changes over time are measu...

journal_title：Chemical research in toxicology

authors： Moe B,Yuan C,Li J,Du H,Gabos S,Le XC,Li XF

更新日期：2016-06-20 00:00:00

abstract：:Bezafibrate is a hypolipidemic drug that belongs to the group of peroxisome proliferators because it binds to peroxisome proliferator-activated receptors type alpha (PPARs). Peroxisome proliferators produce a myriad of extraperoxisomal effects, which are not necessarily dependent on their interaction with PPARs. An in...

journal_title：Chemical research in toxicology

authors： Scatena R,Bottoni P,Vincenzoni F,Messana I,Martorana GE,Nocca G,De Sole P,Maggiano N,Castagnola M,Giardina B

更新日期：2003-11-01 00:00:00

abstract：:There is strong epidemiologic evidence linking chronic exposure to inorganic arsenic (iAs) to myriad adverse health effects, including cancer of the bladder. We set out to identify DNA methylation patterns associated with arsenic and its metabolites in exfoliated urothelial cells (EUCs) that originate primarily from t...

journal_title：Chemical research in toxicology

authors： Rager JE,Tilley SK,Tulenko SE,Smeester L,Ray PD,Yosim A,Currier JM,Ishida MC,González-Horta Mdel C,Sánchez-Ramírez B,Ballinas-Casarrubias L,Gutiérrez-Torres DS,Drobná Z,Del Razo LM,García-Vargas GG,Kim WY,Zhou YH,Wright

更新日期：2015-06-15 00:00:00

abstract：:The present study describes a novel integrated approach for rapid analysis of reactive metabolites with a linear ion trap mass spectrometer (LTQ). In this approach, an isotope pattern-dependent scanning method was applied to the data acquisition of glutathione (GSH)-trapped reactive metabolites. Recorded full-scan MS ...

journal_title：Chemical research in toxicology

authors： Ma L,Wen B,Ruan Q,Zhu M

更新日期：2008-07-01 00:00:00

abstract：:The deposition and transport of toxicants on pulmonary surfactant are important processes in human health and medical care. We have introduced classical density functional theory (CDFT) to provide insight into this process. Nine typical toxicants in PM2.5 were considered, and their free energy and structural informati...

journal_title：Chemical research in toxicology

authors： Liu H,Liu Y,Shang Y,Liu H

更新日期：2018-12-17 00:00:00