Abstract：
:Liver microsomes from uninduced hogs catalyzed the NADPH-dependent N-oxidation of the hydroxylamine (Z)-3-(4-bromophenyl)-N-hydroxy-N-methyl-3-(3-pyridyl)allylamine. The conjugated nitrone N-[(2Z)-3-(4-bromophenyl)-3-(3-pyridyl)-2-propenylidene]methylamin e N-oxide was the principal product and accounted for 90-95% of the total hydroxylamine metabolized by microsomes. The nitrone had a relatively high chemical stability which was investigated at various conditions. Studies of the biochemical mechanisms for N-oxidation of N-hydroxy-norzimeldine showed that the reaction was catalyzed by the flavin-containing monooxygenase. This conclusion was based on studies with the purified hog liver flavin-containing monooxygenase and hog liver microsomes. Purified rat liver cytochrome P-450IIB-1 was ineffective at catalyzing N-oxidation of N-hydroxynorzimeldine.
journal_name
Chem Res Toxicoljournal_title
Chemical research in toxicologyauthors
Cashman JR,Yang ZC,Högberg Tdoi
10.1021/tx00017a007subject
Has Abstractpub_date
1990-09-01 00:00:00pages
428-32issue
5eissn
0893-228Xissn
1520-5010journal_volume
3pub_type
杂志文章abstract：:Ochratoxin A (OTA) is a mycotoxin that shows potent nephrotoxicity and renal carcinogenicity in rodents. One hypothesis for OTA-induced tumor formation is based on its genotoxic properties that are promoted by oxidative metabolism. Like other chlorinated phenols, OTA undergoes an oxidative dechlorination process to ge...
journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx060138g
更新日期：2006-09-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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更新日期：2013-03-18 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx00029a015
更新日期：1992-09-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx00026a022
更新日期：1992-03-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx0502387
更新日期：2005-11-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/acs.chemrestox.8b00286
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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更新日期：2004-02-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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更新日期：2012-10-15 00:00:00
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journal_title：Chemical research in toxicology
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更新日期：2005-12-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx0498206
更新日期：2004-12-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx970075p
更新日期：1997-10-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/acs.chemrestox.0c00422
更新日期：2021-01-26 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx010172p
更新日期：2002-04-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx015556u
更新日期：2001-11-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx00001a008
更新日期：1988-01-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/acs.chemrestox.8b00346
更新日期：2019-03-18 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/acs.chemrestox.6b00362
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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journal_title：Chemical research in toxicology
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更新日期：1990-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-09-20 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx00037a013
更新日期：1994-01-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx00024a012
更新日期：1991-11-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx500028x
更新日期：2014-05-19 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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更新日期：2014-04-21 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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更新日期：2010-12-20 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx00020a019
更新日期：1991-03-01 00:00:00
abstract：:Nevirapine (NVP) treatment is associated with a significant incidence of skin rash in humans, and it also causes a similar immune-mediated skin rash in Brown Norway (BN) rats. We have shown that the sulfate of a major oxidative metabolite, 12-OH-NVP, covalently binds in the skin. The fact that the sulfate metabolite i...
journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx400098z
更新日期：2013-05-20 00:00:00
abstract：:Exposure to both endogenous and exogenous formaldehyde has been established to be carcinogenic, likely by virtue of forming nucleic acid and proteins adducts such as N6-formyllysine. To better assess N6-formyllysine as a biomarker of formaldehyde exposure, we studied accumulation of N6-formyllysine adducts in tissues ...
journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/acs.chemrestox.7b00075
更新日期：2017-08-21 00:00:00
