Esophagitis impairs esophageal smooth muscle reactivity in the rat model: an in vitro study.

Abstract:

:The present study investigated how reflux-induced esophagitis affects the smooth muscle reactivity of the esophageal body. Two different esophagitis models were used: acid gastric and mixed duodenogastric reflux. All test animals apart from the controls developed gross and histologic evidence of esophagitis. Contractile (carbachol and KCI) and relaxant (isoproterenol) esophageal smooth muscle responses were significantly decreased in the presence of acid- and mixed reflux-induced esophagitis. Similar relaxant responses to serotonin and papaverine were found in the three groups. Our study demonstrated impaired esophageal smooth muscle reactivity when esophagitis was induced by acid or mixed reflux. These changes may correspond to the functional motor abnormalities of the esophagus seen in patients with reflux esophagitis.

journal_name

Dig Dis Sci

authors

Tugay M,Yildiz F,Utkan T,Müezzinoğlu B,Erden F,Gacar N,Ulak G

doi

10.1023/b:ddas.0000004518.98825.6c

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

2147-52

issue

11

eissn

0163-2116

issn

1573-2568

journal_volume

48

pub_type

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