Unchanged striatal dopamine transporter availability in narcolepsy: a PET study with [11C]-CFT.

Abstract:

OBJECTIVE:To investigate dopamine reuptake sites (dopamine transporter) in the caudate nucleus and putamen in narcolepsy. PATIENTS AND METHODS:Ten patients with narcolepsy and 15 controls were studied with positron emission tomography. A cocaine analogue [11C]-CFT was used as a radioligand. RESULTS:The uptake of[11C]-CFT was within normal limits (89% of age-adjusted control mean in the caudate nucleus and 91% in the putamen) in patients with narcolepsy. CONCLUSIONS:No evidence of altered striataldopamine transporter availability was found in narcolepsy.

journal_name

Acta Neurol Scand

authors

Rinne JO,Hublin C,Någren K,Helenius H,Partinen M

doi

10.1034/j.1600-0404.2003.00175.x

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

52-5

issue

1

eissn

0001-6314

issn

1600-0404

pii

175

journal_volume

109

pub_type

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