Botulinum toxin: A review of the mode of action in migraine.

Abstract:

:Botulinum toxin serotype A (BoNT/A) was originally used in neurology for the treatment of dystonia and blepharospasms, but is now clinically used worldwide for the treatment of chronic migraine. Still, the possible mode of action of BoNT/A in migraine is not fully known. However, the mode of action of BoNT/A has been investigated in experimental pain as well as migraine models, which may elucidate the underlying mechanisms in migraine. The aim of this study was to review studies on the possible mode of action of BoNT/A in relation to chronic migraine treatment. Observations suggest that the mode of action of BoNT/A may not be limited to the injection site, but also includes anatomically connected sites due to axonal transport. The mechanisms behind the effect of BoNT/A in chronic migraine may also include modulation of neurotransmitter release, changes in surface expression of receptors and cytokines as well as enhancement of opioidergic transmission. Clinical and experimental studies with botulinum toxin in the last decade have advanced our understanding of headache and other pain states. More research into botulinum toxin as treatment for headache is warranted as it can be an attractive alternative for patients who do not respond positively to other drugs.

journal_name

Acta Neurol Scand

authors

Do TP,Hvedstrup J,Schytz HW

doi

10.1111/ane.12906

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

442-451

issue

5

eissn

0001-6314

issn

1600-0404

journal_volume

137

pub_type

杂志文章,评审
  • Prediction of cerebral outcome after extracorporeal circulation.

    abstract::50 open-heart patients were investigated using simultaneous clinical, electroencephalographical (EEG) and neuropsychological evaluation in order to assess the possibilities of predicting the postoperative outcome with preoperative measures. The presence of one or more of the following indices was prognostically unfavo...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1982.tb04535.x

    authors: Sotaniemi K

    更新日期:1982-12-01 00:00:00

  • Favorable change of lipid profile after carbamazepine withdrawal.

    abstract:OBJECTIVE:Patients treated with carbamazepine (CBZ) have increased serum levels of total cholesterol (TC), high-density lipoproteins (HDL), and low-density lipoproteins (LDL). We aimed to investigate whether these changes of serum lipids are reversible after CBZ withdrawal. MATERIAL AND METHODS:We used a prospective, ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ane.12534

    authors: Lossius MI,Nakken KO,Mowinckel P,Taubøll E,Gjerstad L

    更新日期:2016-09-01 00:00:00

  • Nicotinic α4β2 acetylcholine receptors and cognitive function in Parkinson's disease.

    abstract:BACKGROUND:Idiopathic Parkinson's disease (IPD) is characterized by the clinical motor symptoms of hypokinesia, rigidity, and tremor. Apart from these motor symptoms, cognitive deficits often occur in IPD. The positive effect of cholinesterase inhibitors on cognitive deficits in IPD and findings of earlier molecular im...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12259

    authors: Lorenz R,Samnick S,Dillmann U,Schiller M,Ong MF,Faßbender K,Buck A,Spiegel J

    更新日期:2014-09-01 00:00:00

  • Impact of five SNPs in dopamine-related genes on executive function.

    abstract:OBJECTIVES:Dopamine neurotransmission is a critical factor for executive function, which is controlled by the prefrontal cortex in humans. Although the contribution of genetic factors to the regulation of brain dopaminergic activity is widely acknowledged, identification of a genotype-phenotype association has not yet ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2012.01673.x

    authors: Mitaki S,Isomura M,Maniwa K,Yamasaki M,Nagai A,Nabika T,Yamaguchi S

    更新日期:2013-01-01 00:00:00

  • Composition of free amino acids in brain tumors.

    abstract::The composition of the free amino acid pools in various brain tumors and in normal brains obtained at surgery or at autopsy is determined with an automatic amino acid analyzer and the results statistically evaluated. The tumors have lower ratios of GABA in the pools than the normal brain; tumors with higher GABA ratio...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1979.tb02985.x

    authors: Shibasaki T,Uki J,Kanoh T,Kawafuchi J

    更新日期:1979-01-01 00:00:00

  • Chronic experimental allergic neuritis (EAN) in juvenile guinea pigs: immunological comparison with acute EAN in adult guinea pigs.

    abstract::In order to approach the mechanism of chronic or relapsing course in human chronic inflammatory demyelinating polyradiculoneuropathy, we established a chronic model of experimental allergic neuritis (EAN) in juvenile guinea pigs, and investigated the underlying cellular immune phenomenon in comparison with acute EAN i...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1985.tb03214.x

    authors: Suzumura A,Sobue G,Sugimura K,Matsuoka Y,Sobue I

    更新日期:1985-05-01 00:00:00

  • Antiepileptic drugs and depression during pregnancy in women with epilepsy.

    abstract:OBJECTIVES:To assess the possibility that the occurrence of seizures or the use of antiepileptic drug (AED) therapy might have influenced the rate of occurrence of volunteered histories of patient-recognized depression during pregnancy in women with epilepsy. MATERIALS AND METHODS:Analysis of data from 2039 pregnancie...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13315

    authors: Vajda FJE,O'Brien TJ,Graham JE,Hitchcock AA,Mitchell J,Horgan D,Lander CM,Eadie MJ

    更新日期:2020-10-01 00:00:00

  • Measurement of glial fibrillary acidic protein (GFAP) and anti-GFAP antibodies by solid-phase radioimmunoassays.

    abstract::A solid-phase radioimmunoassay was developed for the detection of glial fibrillary acidic protein (GFAP) and GFAP-specific immunoglobulin G (IgG) antibodies. In antibody assays purified GFAP was absorbed onto polystyrene beads, followed by incubation in dilutions of serum. (125-I)-labelled human anti-IgG was used to q...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1981.tb00783.x

    authors: Ruutiainen J,Newcombe J,Salmi A,Dahl D,Frey H

    更新日期:1981-05-01 00:00:00

  • Population-based incidence and clinical characteristics of idiopathic intracranial hypertension.

    abstract:OBJECTIVE:To validate the diagnosis of idiopathic intracranial hypertension (IIH) from the Swedish National Patient Register (NPR) and investigate the incidence of IIH, as well as co-morbidities and medication use in a large Swedish population-based sample. METHODS:We searched the NPR to find all patients ≥18 years ol...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12742

    authors: Sundholm A,Burkill S,Sveinsson O,Piehl F,Bahmanyar S,Nilsson Remahl AIM

    更新日期:2017-11-01 00:00:00

  • Perampanel, an AMPA receptor antagonist: From clinical research to practice in clinical settings.

    abstract::Epileptic seizures are refractory to treatment in approximately one-third of patients despite the recent introduction of many newer antiepileptic drugs (AEDs). Development of novel AEDs therefore remains a high priority. Perampanel is a first-in-class non-competitive selective AMPA receptor antagonist with a unique me...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/ane.12879

    authors: Tsai JJ,Wu T,Leung H,Desudchit T,Tiamkao S,Lim KS,Dash A

    更新日期:2018-04-01 00:00:00

  • Circulating nociceptin and CGRP in medication-overuse headache.

    abstract:BACKGROUND:Previous studies found low serum levels of nociceptin in migraine patients but high serum levels of calcitonin gene-related peptide (CGRP). CGRP can elicit migraine-like headache. Medication-Overuse Headache (MOH) often has migraine features and can mimic chronic migraine. We therefore hypothesized that as i...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13053

    authors: Munksgaard SB,Ertsey C,Frandsen E,Bendtsen L,Tekes K,Jensen RH

    更新日期:2019-03-01 00:00:00

  • Public stroke awareness and intent to call 112 in Sweden.

    abstract:BACKGROUND AND AIMS:Recognition of stroke symptoms and activation of emergency services are essential in minimizing delay for acute stroke treatments. In this study, we assessed public stroke awareness in Sweden. METHODS:One thousand and five hundred residents aged 18-79 years participated in a telephone survey. Open-...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12293

    authors: Nordanstig A,Jood K,Rosengren L

    更新日期:2014-12-01 00:00:00

  • Incidence of aneurysmal subarachnoid hemorrhage in Norway, 1999-2007.

    abstract:OBJECTIVE:To investigate changes and regional variations in annual incidence rates of aneurysmal subarachnoid hemorrhage (SAH) in Norway between 1999 and 2007. METHODS:The authors retrospectively reviewed data from the Norwegian Patient Register for the period 1999-2007. RESULTS:Crude incidence of aneurysmal SAH was ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2010.01336.x

    authors: Lindekleiv HM,Njølstad I,Ingebrigtsen T,Mathiesen EB

    更新日期:2011-01-01 00:00:00

  • Cerebrospinal fluid cytotoxicity does not affect survival in amyotrophic lateral sclerosis.

    abstract:OBJECTIVES:Cerebrospinal fluid (CSF) from some patients with amyotrophic lateral sclerosis (ALS) has been demonstrated to significantly reduce the neuronal viability of primary cell cultures of motor neurons. We aimed to study the potential clinical consequences associated with the cytotoxicity of CSF in a cohort of pa...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12717

    authors: Galán L,Matías-Guiu J,Matias-Guiu JA,Yáñez M,Pytel V,Guerrero-Sola A,Vela-Souto A,Arranz-Tagarro JA,Gómez-Pinedo U,García AG

    更新日期:2017-09-01 00:00:00

  • Vitamin D and multiple sclerosis—from epidemiology to prevention.

    abstract::In the present review, we discuss observational and experimental data suggesting a protective effect from sun exposure and/or vitamin D in multiple sclerosis (MS). These data include geographic variations in MS occurrence, temporal trends, genetics, biobank, and questionnaire data. We look more closely at the differen...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/ane.12432

    authors: Sundström P,Salzer J

    更新日期:2015-01-01 00:00:00

  • Neuroacanthocytosis--the variability of presenting symptoms in two siblings.

    abstract::Neuroacanthocytosis is a progressive multisystem disease with a wide range of symptoms. The involuntary movements mainly include chorea and orofaciolingual dyskinesias. The descriptive name of the disease refers to the presence of abnormal erythrocytes in peripheral blood. Two siblings are presented. One young female ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1999.tb00404.x

    authors: Aasly J,Skandsen T,Rø M

    更新日期:1999-11-01 00:00:00

  • N-terminal ACTH fragments increase the CSF beta-EP content in Alzheimer type dementia.

    abstract::Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF beta-endorphin (beta-EP) levels was found, while ACTH and beta-lipoprotein remain unaffected. The possi...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1988.tb03636.x

    authors: Nappi G,Facchinetti F,Martignoni E,Petraglia F,Sinforiani E,Bono G,Genazzani AR

    更新日期:1988-08-01 00:00:00

  • Comparative study of visual evoked potentials in spinocerebellar ataxias and multiple sclerosis.

    abstract::Visual evoked potentials (VEPs) were delayed in 11 out of 18 patients with Friedreich's ataxia, in 1 out of 8 patients with Strumpell's hereditary spastic ataxia, in 2 out of 5 cases with cerebellar atrophy and in 42 out of 50 patients with multiple sclerosis (MS). Responses were normal in 5 cases with Pierre Marie's ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1985.tb03197.x

    authors: Ghezzi A,Montanini R

    更新日期:1985-03-01 00:00:00

  • The course of alcoholic-nutritional peripheral neuropathy.

    abstract::63 patients with alcoholic-nutritional peripheral neuropathy were given neurologic, electrophysiologic and nutritional examinations. 24 of these patients were reexamined later in the course of their disease, after from 2 to 72 months (mean 33). Alcoholic-nutritional neuropathy appeared and worsened after bouts of heav...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1982.tb03146.x

    authors: Hawley RJ,Kurtzke JF,Armbrustmacher VW,Saini N,Manz H

    更新日期:1982-11-01 00:00:00

  • Valproate-associated foetal malformations-Rates of occurrence, risks in attempted avoidance.

    abstract:OBJECTIVES:To gain insight into the main advantages and disadvantages that might result from valproate being unavailable for women who intend to become pregnant. MATERIALS AND METHODS:Analysis of data from the Australian Pregnancy Register concerning pregnancies exposed to valproate (N = 501) and pregnancies where pre...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13005

    authors: Vajda FJE,O'Brien TJ,Graham JE,Hitchcock AA,Lander CM,Eadie MJ

    更新日期:2019-01-01 00:00:00

  • Quality of life in chronic inflammatory demyelinating polyneuropathy patients treated with subcutaneous immunoglobulin.

    abstract:BACKGROUND:Subcutaneous immunoglobulin (SCIG) is effective treatment of chronic inflammatory demyelinating polyneuropathy (CIDP). Quality of life (QoL) increases following switch from intravenous administration to SCIG, but its correlation with clinical functioning is sparsely studied. AIMS OF THE STUDY:The aim of thi...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13322

    authors: Ryltoft AK,Al-Zuhairy A,Sindrup SH,Andersen H,Markvardsen LK

    更新日期:2020-12-01 00:00:00

  • Dopaminergic agonist Ro 8-4650 in Parkinson's disease. II. Patients not treated with dopa.

    abstract::An isoquinolone derivative Ro 8-4650 (rac-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methylisoquinoline hydrochloride) with dopaminergic properties was studied in a randomized crossover trial. The group studied comprised 37 patients with idiopathic parkinsonism, not previously treated with levodopa or dopam...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0404.1978.tb02863.x

    authors: Presthus J,Ankerhus J,Burén A,Bøttcher J,Holmsen R,Mikkelsen B,Mikkelsen BO,Nyberg-Hansen R,Riman E,Severin B,Aarli JA

    更新日期:1978-07-01 00:00:00

  • Vascular risk factors for atherosclerotic lesions of the middle cerebral artery detected by magnetic resonance angiography (MRA).

    abstract:OBJECTIVES:To examine the relationship between atherosclerotic lesions of the middle cerebral artery (MCA) detected on MRA and vascular risk factors. MATERIAL AND METHODS:We retrospectively assessed 279 patients (mean age, 69.0+/-11.3 years) who visited the Department of Neurology of Masuda Red Cross Hospital and unde...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1999.tb01059.x

    authors: Takahashi K,Kitani M,Fukuda H,Kobayashi S

    更新日期:1999-12-01 00:00:00

  • Predictors of headache 22 years after hospitalization for head injury.

    abstract:OBJECTIVES:To assess predictors of headache in patients who had sustained a head injury 22 years earlier. MATERIALS AND METHODS:A questionnaire about headache was sent to 361 subjects hospitalized for head injury in 1974-1975. RESULTS:A total of 249 patients (69%) responded to the questionnaire. The prevalence of hea...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2005.00344.x

    authors: Nestvold K,Lundar T,Mowinckel P,Stavem K

    更新日期:2005-07-01 00:00:00

  • Botulinum toxin-A injections vs radiotherapy for drooling in ALS.

    abstract:OBJECTIVES:Botulinum neurotoxin (BoNT) injections in the salivary glands and radiotherapy (RT) on these glands are commonly used to alleviate severe drooling in patients with amyotrophic lateral sclerosis (ALS). This study compares BoNT type A with RT based on patient-rated evaluations. MATERIALS & METHODS:A prospecti...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ane.12559

    authors: Weikamp JG,Schinagl DA,Verstappen CC,Schelhaas HJ,de Swart BJ,Kalf JG

    更新日期:2016-09-01 00:00:00

  • The POEMS syndrome among Chinese: association with Castleman's disease and some immunological abnormalities.

    abstract::POEMS or Crow-Fukase syndrome is a multisystemic, clinically malignant disorder of obscure etiology. Peripheral neuropathy and plasma cell dyscrasia are central features. The authors now report 7 Chinese patients with this syndrome in which PCD or paraproteinemia were absent in 6, and 2 had a lymph node histology rese...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1989.tb03916.x

    authors: Thajeb P,Chee CY,Lo SF,Lee N

    更新日期:1989-12-01 00:00:00

  • Neuropathological postmortem evaluation of BNCT for GBM.

    abstract:BACKGROUND:Thirty patients with glioblastoma multiforme (GBM) were treated by boron neutron capture therapy (BNCT) at the Studsvik facility in Sweden, in a clinical trial exploring a procedure in which 900 mg p-boronophenylalanine (BPA) per kilo body weight was infused in 6 h. OBJECTIVE:The present study was designed ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2007.00837.x

    authors: H-Stenstam B,Pellettieri L,Sköld K,Rezaei A,Brun A

    更新日期:2007-09-01 00:00:00

  • Clinical and neurophysiological abnormalities before and after reconstruction of the anterior cruciate ligament of the knee.

    abstract:OBJECTIVES:We aimed to study knee proprioception and somatosensory evoked potentials (SEPs) to stimulation of the common peroneal nerve (CPN) in 7 patients with lesion of the anterior cruciate ligament (ACL) before and after ACL reconstruction. MATERIALS AND METHODS:We recorded the spinal N14 and scalp P27 potentials ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1999.tb00680.x

    authors: Valeriani M,Restuccia D,Di Lazzaro V,Franceschi F,Fabbriciani C,Tonali P

    更新日期:1999-05-01 00:00:00

  • Different fates of excessive daytime sleepiness: survival analysis for remission.

    abstract:BACKGROUND:Excessive daytime sleepiness (EDS) is a symptom frequently presented in sleep clinics. Only a paucity of data has addressed clinical courses of sleep disorders with EDS. Therefore, we sought to compare clinical outcomes of patients presenting EDS. METHODS:A retrospective observational study was performed in...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12504

    authors: Kim T,Lee JH,Lee CS,Yoon IY

    更新日期:2016-07-01 00:00:00

  • Creutzfeldt-Jakob disease segregating in a three generation Danish family.

    abstract::A three generation family is presented in which rapidly progressive, early-onset Creutzfeldt-Jakob disease without typical EEG changes segregates as an autosomal dominant disease. An aspartic acid to asparagine mutation at codon 178 of the prion gene, PRNP, co-segregates with the disease. As expected, the disease alle...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2001.103003139.x

    authors: Holm IE,Abelskov K,Bojsen-Møller M,Nielsen AL,Jørgensen AL

    更新日期:2001-03-01 00:00:00