Abstract：
OBJECTIVE:Tumors arising from different sites of the head and neck area have very different clinical behavior. Loss or reduction of expression of adhesion molecules has been assumed to play a critical role in the development of head and neck carcinomas. The aim of this study is to determine if there are differences in the expression of adhesion molecules E-cadherin, CD44s, and CD44v6 in pharyngeal and laryngeal squamous-cell carcinomas. MATERIALS AND METHODS:E-cadherin, CD44s, and CD44v6 expression was determined by immunohistochemistry in paraffin-embedded tissue specimens from 72 patients with squamous-cell carcinoma, 37 of the pharynx and 35 of the larynx. RESULTS:Expression of CD44s was significantly lower in pharyngeal than in laryngeal tumors (P =.01). No differences in the expression of E-cadherin and CD44v6 were observed between these sites. CONCLUSIONS:These data suggest that there are some differences at molecular level between the different subsites of head and neck cancer.
journal_name
Am J Otolaryngoljournal_title
American journal of otolaryngologyauthors
Rodrigo JP,Dominguez F,Alvarez C,Herrero A,Suarez Cdoi
10.1016/s0196-0709(03)00082-6subject
Has Abstractpub_date
2003-11-01 00:00:00pages
384-9issue
6eissn
0196-0709issn
1532-818Xpii
S0196070903000826journal_volume
24pub_type
杂志文章abstract：PURPOSE:To determine the neurologic morbidity and oncologic effectiveness of carotid resection in patients with advanced squamous cell carcinoma of the head and neck. METHODS:A retrospective review of all published cases of squamous cell carcinoma of the head and neck treated by carotid resection was performed. RESUL...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,meta分析
doi：10.1016/0196-0709(92)90079-9
更新日期：1992-11-01 00:00:00
abstract：OBJECTIVE:The aim of the study is to review the management of petrous apex cholesterol granuloma. The surgical approaches for drainage or total removal and the wait and see policy were analyzed, and outcomes were evaluated. METHODS:Retrospective charts of 27 patients managed for petrous apex cholesterol granuloma with...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2008.08.007
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:HPV-related oropharyngeal squamous cell carcinomas clearly represent a growing entity in the head and neck with distinct carcinogenesis, clinico-pathological presentation and survival profile. We aimed to compare the HPV prevalence rates and clinico-pathological correlations obtained with three distinct commonl...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2013.08.007
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVES:Several methods have been reported for inferior turbinate (IT) reduction. We describe office-based interstitial IT reduction using bipolar cautery and evaluate long-term efficacy. METHODS:Sixty patients with allergic and nonallergic rhinitis unresponsive to medical treatment underwent office IT reduction be...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2020.102449
更新日期：2020-01-01 00:00:00
abstract：:Two cases of trisomy 18 in which temporal bone defects were limited to the inner ears are described. Several abnormalities were present that have not been described previously in this syndrome. The first case involved a 1-month-old female infant who died of congenital heart defects. Cochlear nerve fibers were absent o...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(85)80018-1
更新日期：1985-09-01 00:00:00
abstract：OBJECTIVES:We aim to present two cases of a retained insertion stylet from nasal feeding tube bridle systems. STUDY DESIGN:Case series of two patients. METHODS:Patients were evaluated from 8/2012 to 9/2013 for retained bridle system insertion stylet. RESULTS:Two patients presented with a retained stylet from nasal t...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2014.10.033
更新日期：2015-03-01 00:00:00
abstract：:This clinical review presents a survey of the different types of epithelial neoplasms in the parotid gland. The incidence, histopathological classification, grade of malignancy, and staging system are discussed. Diagnostic procedures are reviewed and a scheme for treatment is proposed for the different types of epithe...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
doi：10.1016/s0196-0709(80)80011-1
更新日期：1980-02-01 00:00:00
abstract：BACKGROUND:Primary non-Hodgkin lymphomas (NHLs) of the sinonasal tract comprise a rare entity that constitutes 1.5% of all NHLs and 2.2% of extranodal lymphomas in the whites. Clinical diagnosis may be very challenging because of the variety and low specificity of the presenting symptoms and signs. METHODS-RESULTS:We ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2005.09.019
更新日期：2006-05-01 00:00:00
abstract：:Intense sounds were delivered to 11 subjects with normal hearing both before and during administration of standard doses of four nonsteroidal anti-inflammatory drugs. After four days of aspirin treatment (3.9 g daily), the subjects' resting hearing levels raised by about 10 dB. Administration of intense sounds that ha...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(84)80033-2
更新日期：1984-07-01 00:00:00
abstract：BACKGROUND:The surgical management of benign parotid tumors is aimed at complete extirpation of the mass with preservation of facial nerve function. There is a relative paucity of literature pertaining to complications after benign parotid surgery and related risk factors. We aim to critically review the outcomes follo...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2017.11.015
更新日期：2018-01-01 00:00:00
abstract：:Stimulus cues used to locate sounds in the median sagittal plane were investigated. Listeners first were required to report the location of noise bands 1.0 kHz wide whose center frequencies ranged from 4.0 through 14.0 kHz. It was found that the apparent locations of the stimuli depended on their frequency composition...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(83)80039-8
更新日期：1983-05-01 00:00:00
abstract：OBJECTIVES:Sildenafil, a selective inhibitor of phosphodiesterase type 5, is widely used for the treatment of erectile dysfunction. Although cochlear effects of phosphodiesterase type 5 inhibitors remain still unclear because of inadequate data, some evidence that recently emerged indicates that these medications may b...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2012.04.005
更新日期：2012-11-01 00:00:00
abstract：PURPOSE:We treated allergic rhinitis with trichloroacetic acid (TCA) applied to the inferior turbinates. Further clinical evaluations were made to determine the effect of TCA application on symptoms of allergic rhinitis. We also report the results of measurement of the mucociliary transit time (saccharin time) and nasa...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2006.12.006
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:Idiopathic sudden sensorineural hearing loss (ISSHL) is an emergency otological disease, and its definite prognostic factors remain unclear. This study applied machine learning methods to develop a new ISSHL prognosis prediction model. MATERIALS AND METHODS:This retrospective study reviewed the medical data of...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2020.102858
更新日期：2021-01-04 00:00:00
abstract：OUTCOME OBJECTIVES:METHODS: Case Report, April 2016. RESULTS:A 27-year-old female presented with a three-week history of flu-like symptoms including sore throat, myalgia and insidious nasal congestion. Her hospital course was complicated by pancytopenia, extensive GI bleed of unknown origin and fever. Radiographic stu...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2018.07.017
更新日期：2018-01-01 00:00:00
abstract：:We report a case of chondrosarcoma of the larynx, diagnosed by a percutaneous core-needle biopsy (CNB). Cartilaginous tumors of the larynx are usually diagnosed by biopsy with direct laryngomicroscopy under general anesthesia. However, patients find it difficult to undergo a biopsy under general anesthesia, for physic...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2014.03.013
更新日期：2014-07-01 00:00:00
abstract：:Denis Burkitt pioneered the association of viruses and cancer in humans with his observations of lymphomatous tumors in children in equatorial Africa. The Epstein-Barr virus (EBV), a human B lymphotrophic herpes virus, is strongly associated with undifferentiated carcinoma of the nasopharynx and African-type Burkitt's...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
doi：10.1053/ajot.2001.23429
更新日期：2001-05-01 00:00:00
abstract：:Recent technological advances and developments in surgical technique have made the craniocervical junction (CCJ) accessible through the transnasal surgical corridor. Endoscopic endonasal transclival and transodontoid approaches have been previously described in the literature. Traditionally, these approaches entail a ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2014.12.005
更新日期：2015-05-01 00:00:00
abstract：PURPOSE:1. Describe the presentation, imaging, and outcome of two cases of paraganglioma of the facial canal at our institution. 2. Summarize existing literature to better understand this lesion. 3. Clarify terminology. METHODS:Retrospective chart review at single tertiary academic referral center. Literature review u...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.amjoto.2014.08.006
更新日期：2014-11-01 00:00:00
abstract：PURPOSE:This study was performed to evaluate the usefulness of Hounsfield unit (HU) to better distinguish cholesteatoma from other inflammatory conditions in the mastoid ad antrum before primary mastoid surgery. MATERIALS AND METHODS:We enrolled 82 patients who underwent tympanomastoidectomy for treatment of chronic o...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2010.01.008
更新日期：2011-05-01 00:00:00
abstract：:This case report describes a patient who was found to have a cerebrospinal fluid (CSF) leak originating from the petrous apex. The patient initially presented with multiple bouts of meningitis. The patient was treated surgically via a middle cranial fossa approach but presented five years later with recurrent meningit...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2014.02.013
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVES:To review our results with elective superior mediastinal dissections for thyroid carcinomas. STUDY DESIGN:Retrospective review. METHODS:We searched operative case logs for all patients with thyroid carcinoma treated with an elective superior mediastinal dissection by the senior author (Y.D.) during a 6-yea...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2008.05.003
更新日期：2009-07-01 00:00:00
abstract：:Merkel cell carcinoma is a rare skin tumor that is thought to arise from epithelial cells that have undergone neuroendocrine differentiation. It usually presents in older adults and has a slight male predominance. The most frequent site of occurrence is in the head and neck. It is an aggressive disease that has a high...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2004.11.013
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:To investigate the combined use of a nanocarbon (NC) suspension and low-dose 99mTc-MIBI for parathyroid localization during surgery in patients with secondary hyperparathyroidism (sHPT). METHODS:Between March 2010 and September 2015, 40 patients with sHPT were enrolled in this study and were randomized to re...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.amjoto.2017.12.008
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:Determine the outcome of hearing in Meniere's Disease (MD) after antiviral treatment. STUDY DESIGN:Prospective study. SETTING:University Hospital. METHODS:Thirty one new patients with a diagnosis of MD were treated with antiviral drugs during 2012. Acyclovir or valacyclovir was used depending on insurance ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2014.03.016
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Pigmented villonodular synovitis (PVNS) is a rare/benign condition of the synovial joint lining. It most commonly presents in the knee but has also been reported to occur in the temporomandibular joint (TMJ). Although there are several series reporting the use of postoperative radiotherapy (PORT) for extremi...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.amjoto.2014.10.017
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:To evaluate the effects of increased endogenous Antisecretory Factor (AF) synthesis using specially processed cereals (SPC) in a sample of patients with defined unilateral Meniere's disease (MD), compared to the results of a treatment protocol of intravenous glycerol and dexamethasone. MATERIALS AND METHODS:Tw...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2020.102673
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:To compare the effect of Paracetamol/Prednisolone versus Paracetamol/Ibuprofen on post-operative recovery after adult tonsillectomy. BACKGROUND:Various analgesic protocols have been proposed for the control of post-tonsillectomy morbidity with need for better control in adult population for having higher sev...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2018.05.002
更新日期：2018-01-01 00:00:00
abstract：:A regional random pattern flap is described which may be used to cover the mastoid area in cases in which the inferior auricle and adjacent tissue have been removed by trauma or surgery. The viability of this vascularized tissue offers a distinct advantage over skin grafting when protection of exposed facial nerve and...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(88)80032-2
更新日期：1988-09-01 00:00:00
abstract：PURPOSE:To report our long-term results in surgical management of invasive intralabyrinthine cholesteatoma. MATERIAL AND METHODS:The study is a case series in a tertiary referral center. Retrospective chart review of all mastoid operations performed for chronic ear disease between 1994 and 2019 at University Health Ne...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2020.102407
更新日期：2020-01-01 00:00:00
