Abstract：
OBJECTIVES:Sildenafil, a selective inhibitor of phosphodiesterase type 5, is widely used for the treatment of erectile dysfunction. Although cochlear effects of phosphodiesterase type 5 inhibitors remain still unclear because of inadequate data, some evidence that recently emerged indicates that these medications may be responsible for hearing impairment. In the present study, we aimed to examine the histopathologic effects of long-term sildenafil use on the cochlea in a rat model. METHODS:The study was performed with adult male Wistar albino rats. The control group was fed on standard laboratory diet. The study group was applied orally with sildenafil therapy, 1.5 mg/kg once a day for 45 days. Rats were anesthetized and decapitated. Each temporal bone was dissected, and the cochleas were removed en bloc. The inner-ear biopsy specimens were examined histologically with hematoxylin and eosin and caspase 3 immunoreaction under light microscopy. RESULTS:Hematoxylin and eosin staining showed no distinctive difference between the control group and the sildenafil group. With immunohistochemical examination, caspase 3 immunoreactivity was observed in the sildenafil group. In the control group, caspase 3 immunoreactivity was not observed. CONCLUSIONS:The caspase 3 immunoreactivity in the sildenafil group was strongly associated with an increase in apoptotic events in the cochlea. Long-term use of sildenafil can cause hearing impairment through increased apoptosis.
journal_name
Am J Otolaryngoljournal_title
American journal of otolaryngologyauthors
Bakir S,Firat U,Gün R,Bozkurt Y,Yorgancilar E,Kiniş V,Penbegül N,Gökalp O,Topçu Idoi
10.1016/j.amjoto.2012.04.005subject
Has Abstractpub_date
2012-11-01 00:00:00pages
667-72issue
6eissn
0196-0709issn
1532-818Xpii
S0196-0709(12)00085-3journal_volume
33pub_type
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