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Intratympanic dexamethasone plus melatonin versus melatonin only in the treatment of unilateral acute idiopathic tinnitus.

Abstract：

PURPOSE:The aim of our study was to determine whether the combination of intratympanic (IT) corticosteroid with melatonin could be associated with decreased tinnitus in patients with unilateral acute idiopathic tinnitus developed within 3months. MATERIALS AND METHODS:We evaluated this hypothesis through a prospective, randomized, controlled, double-blinded trial. Patients included in the study were randomly allocated into two groups: Group A - comprising 30 patients, received melatonin and IT dexamethazone, and Group B - including 30 patients receiving melatonin alone. After 3 months, improvement in tinnitus was assessed using different outcome measures: tinnitus loudness score, tinnitus awareness score, Tinnitus Handicap Inventory (THI), Pittsburgh Sleep Quality Index (PSQI) and Beck Depression Inventory (BDI). RESULTS:We have demonstrated significant improvements in each of the above mentioned outcomes subsequent to treatment in both groups. However, patients in the IT dexamathazone and melatonin group attained statistically significant better outcomes. Besides, the differences in improvement rate and cure rate were highly significant between the two groups, favoring the IT dexamethazone and melatonin group. CONCLUSIONS:Our preliminary study demonstrated that IT dexamethazone plus melatonin is efficient in improvement of idiopathic unilateral tinnitus developed within 3 months.

journal_name

Am J Otolaryngol

journal_title

American journal of otolaryngology

authors

Albu S,Chirtes F

doi

10.1016/j.amjoto.2014.06.009

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

617-22

issue

5

eissn

0196-0709

issn

1532-818X

pii

S0196-0709(14)00142-2

journal_volume

35

pub_type

杂志文章,随机对照试验

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