Abstract:
:It has been estimated that approximately 37% of the US population judged to be at high risk for developing coronary artery disease (CAD), based on the National Cholesterol Education Program guidelines, have increased plasma lipoprotein(a) [Lp(a)], whereas Lp(a) is increased in only 14% of those judged to be at low risk. Therefore, the importance of establishing a better understanding of the relative contribution of Lp(a) to the risk burden for CAD and other forms of vascular disease, as well as the underlying mechanisms, is clearly evident. However, the structural complexity and size heterogeneity of Lp(a) have hindered the development of immunoassays to accurately measure Lp(a) concentrations in plasma. The large intermethod variation in Lp(a) values has made it difficult to compare data from different clinical studies and to achieve a uniform interpretation of clinical data. A workshop was recently convened by the National Heart, Lung, and Blood Institute (NHLBI) to evaluate our current understanding of Lp(a) as a risk factor for atherosclerotic disorders; to determine how future studies could be designed to more clearly define the extent to which, and mechanisms by which, Lp(a) participates in these processes; and to present the results of the NHLBI-supported program for the evaluation and standardization of Lp(a) immunoassays. This report includes the most recent data presented by the workshop participants and the resulting practical and research recommendations.
journal_name
Clin Chemjournal_title
Clinical chemistryauthors
Marcovina SM,Koschinsky ML,Albers JJ,Skarlatos Sdoi
10.1373/clinchem.2003.023689subject
Has Abstractpub_date
2003-11-01 00:00:00pages
1785-96issue
11eissn
0009-9147issn
1530-8561journal_volume
49pub_type
abstract::We have assessed the technical performance and robustness of NycoCard CRP Whole Blood, a near-patient test for C-reactive protein (CRP), when used in realistic daily routine situations in general practice clinics (GPC). Thirteen GPCs participated, five of them with technician staff. From 898 patients, split-sample mea...
journal_title:Clinical chemistry
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journal_title:Clinical chemistry
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journal_title:Clinical chemistry
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doi:10.1373/clinchem.2007.099424
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journal_title:Clinical chemistry
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journal_title:Clinical chemistry
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journal_title:Clinical chemistry
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更新日期:1986-09-01 00:00:00
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journal_title:Clinical chemistry
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journal_title:Clinical chemistry
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更新日期:1984-03-01 00:00:00
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journal_title:Clinical chemistry
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更新日期:1984-03-01 00:00:00
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journal_title:Clinical chemistry
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doi:
更新日期:1984-04-01 00:00:00
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journal_title:Clinical chemistry
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doi:
更新日期:2002-12-01 00:00:00
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doi:10.1373/clinchem.2007.091488
更新日期:2007-12-01 00:00:00
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journal_title:Clinical chemistry
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
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journal_title:Clinical chemistry
pub_type: 杂志文章
doi:
更新日期:1985-03-01 00:00:00
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journal_title:Clinical chemistry
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doi:
更新日期:1992-10-01 00:00:00
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journal_title:Clinical chemistry
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doi:
更新日期:1975-09-01 00:00:00
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journal_title:Clinical chemistry
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doi:10.1373/clinchem.2008.113530
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doi:10.1373/clinchem.2016.256768
更新日期:2016-07-01 00:00:00
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journal_title:Clinical chemistry
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doi:
更新日期:1992-07-01 00:00:00
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journal_title:Clinical chemistry
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doi:
更新日期:1983-11-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Clinical chemistry
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doi:
更新日期:2000-04-01 00:00:00
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journal_title:Clinical chemistry
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doi:
更新日期:1999-03-01 00:00:00
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journal_title:Clinical chemistry
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更新日期:2002-08-01 00:00:00
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journal_title:Clinical chemistry
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doi:
更新日期:1977-08-01 00:00:00
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journal_title:Clinical chemistry
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doi:
更新日期:1988-09-01 00:00:00
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journal_title:Clinical chemistry
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