Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6.


:Hematopoietic cell phosphatase (Hcph) was identified by amplification of conserved protein tyrosine phosphatase sequences from a myeloid cell line and is predominantly expressed in hematopoietic cells. Hcph is unique in containing two, tandemly repeated, src-homology 2 domains in the amino terminal region of the phosphatase. Using a genomic probe in interspecific backcross analysis, the murine Hcph gene maps to mouse Chromosome 6 and is tightly linked to the Tnfr-2 and Ly-4 genes.






Yi T,Gilbert DJ,Jenkins NA,Copeland NG,Ihle JN




Has Abstract


1992-11-01 00:00:00
















  • Mapping on human and mouse chromosomes of the gene for the beta-galactoside-binding protein, an autocrine-negative growth factor.

    abstract::The structural gene for beta-galactoside-binding protein (Lgals-1), a cell growth regulatory molecule and cystostatic factor, is assigned to the E-region of mouse chromosome 15 and to the region q12-q13.1 of human chromosome 22. The evolutionary conservation of these two regions has been previously suggested from comp...


    pub_type: 杂志文章


    authors: Baldini A,Gress T,Patel K,Muresu R,Chiariotti L,Williamson P,Boyd Y,Casciano I,Wells V,Bruni CB

    更新日期:1993-01-01 00:00:00

  • Transcription map of Xq27: candidates for several X-linked diseases.

    abstract::Human Xq27 contains candidate regions for several disorders, yet is predicted to be a gene-poor cytogenetic band. We have developed a transcription map for the entire cytogenetic band to facilitate the identification of the relatively small number of expected candidate genes. Two approaches were taken to identify gene...


    pub_type: 杂志文章


    authors: Zucchi I,Jones J,Affer M,Montagna C,Redolfi E,Susani L,Vezzoni P,Parvari R,Schlessinger D,Whyte MP,Mumm S

    更新日期:1999-04-15 00:00:00

  • Ontological Discovery Environment: a system for integrating gene-phenotype associations.

    abstract::The wealth of genomic technologies has enabled biologists to rapidly ascribe phenotypic characters to biological substrates. Central to effective biological investigation is the operational definition of the process under investigation. We propose an elucidation of categories of biological characters, including diseas...


    pub_type: 杂志文章


    authors: Baker EJ,Jay JJ,Philip VM,Zhang Y,Li Z,Kirova R,Langston MA,Chesler EJ

    更新日期:2009-12-01 00:00:00

  • Homozygosity and physical mapping of the autosomal recessive retinitis pigmentosa locus (RP14) on chromosome 6p21.3.

    abstract::Retinitis pigmentosa (RP) is a heterogeneous genetic disorder with autosomal dominant, autosomal recessive, and X-linked forms. We previously mapped an additional arRP locus to chromosome 6p21 (RP14) in a single extended kinship from the Dominican Republic. Aided by a second linked RP pedigree from the same region of ...


    pub_type: 杂志文章


    authors: Banerjee P,Lewis CA,Kleyn PW,Shugart YY,Ross BM,Penchaszadeh GK,Ott J,Jacobson SG,Gilliam TC,Knowles JA

    更新日期:1998-03-01 00:00:00

  • Transcriptome profiling of different developmental stages of corpus luteum during the estrous cycle in pigs.

    abstract::To better understand the molecular basis of corpus luteum (CL) development and function RNA-Seq was utilized to identify differentially expressed genes (DEGs) in porcine CL during different physiological stages of the estrous cycle viz. early (EL), mid (ML), late (LL) and regressed (R) luteal. Stage wise comparisons o...


    pub_type: 杂志文章


    authors: Bharati J,Mohan NH,Kumar S,Gogoi J,Kumar S,Jose B,Punetha M,Borah S,Kumar A,Sarkar M

    更新日期:2021-01-01 00:00:00

  • Comparison of normalization methods with microRNA microarray.

    abstract::MicroRNAs (miRNAs) are a group of RNAs that play important roles in regulating gene expression and protein translation. In a previous study, we established an oligonucleotide microarray platform to detect miRNA expression. Because it contained only hundreds of probes, data normalization was difficult. In this study, t...


    pub_type: 杂志文章


    authors: Hua YJ,Tu K,Tang ZY,Li YX,Xiao HS

    更新日期:2008-08-01 00:00:00

  • The human immediate early gene BRF1 maps to chromosome 14q22-q24.

    abstract::BRF1 (Butyrate response factor 1) is a member of an immediate early gene family specifying putative nuclear transcription factors. A repeat motif incorporating two Cys and two His is highly conserved between family members identified from yeast, Drosophila, mouse, rat, and human. The chromosome localization of none of...


    pub_type: 杂志文章


    authors: Maclean KN,See CG,McKay IA,Bustin SA

    更新日期:1995-11-01 00:00:00

  • Physical mapping by PFGE localizes the COL3A1 and COL5A2 genes to a 35-kb region on human chromosome 2.

    abstract::The genes encoding the alpha 1 chain of Type III collagen (COL3A1) and the alpha 2 chain of Type V (COL5A2) collagen have been mapped to the long arm of human chromosome 2. Linkage analysis in CEPH families indicated that these two genes are close to each other, with no recombination in 37 informative meioses. In the ...


    pub_type: 杂志文章


    authors: Cutting GR,McGinniss MJ,Kasch LM,Tsipouras P,Antonarakis SE

    更新日期:1990-10-01 00:00:00

  • Plant-pathogen interactions: MicroRNA-mediated trans-kingdom gene regulation in fungi and their host plants.

    abstract::MicroRNAs (miRNAs) have been prevalently studied in plants, animals, and viruses. However, recent studies show evidences of miRNA-like RNAs (milRNAs) in fungi as well. It is known that after successful infection, pathogens hijack the host machinery and use it for their own growth and multiplication. Alternatively, res...


    pub_type: 杂志文章


    authors: Mathur M,Nair A,Kadoo N

    更新日期:2020-09-01 00:00:00

  • Statistical power for identifying nucleotide markers associated with quantitative traits in genome-wide association analysis using a mixed model.

    abstract::Use of mixed models is in the spotlight as an emerging method for genome-wide association studies (GWASs). This study investigated the statistical power for identifying nucleotide variants associated with quantitative traits using the mixed model methodology. Quantitative traits were simulated through design of herita...


    pub_type: 杂志文章


    authors: Shin J,Lee C

    更新日期:2015-01-01 00:00:00

  • Transcriptome sequencing of Chinese and Caucasian population identifies ethnic-associated differential transcript abundance of heterogeneous nuclear ribonucleoprotein K (hnRNPK).

    abstract::Gene expression variations (GEV) among different ethnic groups have been a subject matter for extensive study. Relatively less known is the extent of alternative splicing variations (ASV) in the context of ethnicity. We conducted a transcriptome sequencing study of 20 lymphoblastoid cell lines obtained from Caucasian ...


    pub_type: 杂志文章


    authors: Li JW,Lai KP,Ching AK,Chan TF

    更新日期:2014-01-01 00:00:00

  • TrioMDR: Detecting SNP interactions in trio families with model-based multifactor dimensionality reduction.

    abstract::Single nucleotide polymorphism (SNP) interactions can explain the missing heritability of common complex diseases. Many interaction detection methods have been proposed in genome-wide association studies, and they can be divided into two types: population-based and family-based. Compared with population-based methods,...


    pub_type: 杂志文章


    authors: Liu J,Yu G,Ren Y,Guo M,Wang J

    更新日期:2019-09-01 00:00:00

  • Physical mapping and YAC contig analysis of the region surrounding Xist on the mouse X chromosome.

    abstract::The Xist sequence has been proposed as a potential candidate for the X-inactivation center based both on its localization within the candidate region for the X-inactivation center in man and mouse and on its unique pattern of expression from the inactive X chromosome. We have cloned 550 kb of DNA surrounding the mouse...


    pub_type: 杂志文章


    authors: Heard E,Simmler MC,Larin Z,Rougeulle C,Courtier B,Lehrach H,Avner P

    更新日期:1993-03-01 00:00:00

  • Syntenic assignments of visual transduction genes in cattle.

    abstract::To establish syntenic relationships of phototransduction genes, we have mapped the genes encoding the alpha-, beta-, and gamma-subunits of rod cGMP phosphodiesterase (PDE) (PDEA, PDEB, PDEG), the alpha'-subunit of cone PDE (PDEA2), and the rod cGMP-gated channel (CNCG) to bovine syntenic groups. The rod cGMP PDE alpha...


    pub_type: 杂志文章


    authors: Gallagher DS Jr,Womack JE,Baehr W,Pittler SJ

    更新日期:1992-11-01 00:00:00

  • Homozygosity mapping in an Irish ALS case-control cohort describes local demographic phenomena and points towards potential recessive risk loci.

    abstract::Runs of homozygosity are common in European populations and are indicative of consanguinity, restricted population size and recessively inherited traits. Here, we map runs of homozygosity (ROHs) in an Irish case-control cohort for amyotrophic lateral sclerosis (ALS), a devastating neurological condition with high heri...


    pub_type: 杂志文章


    authors: McLaughlin RL,Kenna KP,Vajda A,Heverin M,Byrne S,Donaghy CG,Cronin S,Bradley DG,Hardiman O

    更新日期:2015-04-01 00:00:00

  • Inactive allele-specific methylation and chromatin structure of the imprinted gene U2af1-rs1 on mouse chromosome 11.

    abstract::The imprinted U2af1-rs1 gene that maps to mouse chromosome 11 is predominately expressed from the paternal allele. We examined the methylation of genomic sequences in and around the U2af1-rs1 locus to establish the extent of sequence modifications that accompanied the silencing of the maternal allele. The analysis of ...


    pub_type: 杂志文章


    authors: Shibata H,Yoshino K,Sunahara S,Gondo Y,Katsuki M,Ueda T,Kamiya M,Muramatsu M,Murakami Y,Kalcheva I,Plass C,Chapman VM,Hayashizaki Y

    更新日期:1996-07-01 00:00:00

  • Rapid isolation of DNA probes within specific chromosome regions by interspersed repetitive sequence polymerase chain reaction.

    abstract::A method was recently developed for the specific amplification of human DNA sequences from interspecific somatic cell hybrids by the polymerase chain reaction (PCR) using primers directed to Alu, a short interspersed repeat element (SINE). We now show human-specific amplification using a primer to the 3' end of the hu...


    pub_type: 杂志文章


    authors: Ledbetter SA,Nelson DL,Warren ST,Ledbetter DH

    更新日期:1990-03-01 00:00:00

  • DXS165 detects a translocation breakpoint in a woman with choroideremia and a de novo X; 13 translocation.

    abstract::The search for the gene for choroideremia (MIM 30310), a rare retinal dystrophy, has been of great interest due to the existence of several choroideremia patients with well-defined structural chromosome aberrations, thus providing the basis for a reverse genetics approach to the isolation of this disease gene. This re...


    pub_type: 杂志文章


    authors: Merry DE,Lesko JG,Siu V,Flintoff WF,Collins F,Lewis RA,Nussbaum RL

    更新日期:1990-04-01 00:00:00

  • Core proteome mediated therapeutic target mining and multi-epitope vaccine design for Helicobacter pylori.

    abstract::Helicobacter pylori is a Gram-negative spiral-shaped bacterium that infects half of the human population worldwide and causes chronic inflammation. In the present study, we used the art of computational biology for therapeutic drug targets identification and a multi-epitope vaccine against multi-strains of H. pylori. ...


    pub_type: 杂志文章


    authors: Rahman N,Ajmal A,Ali F,Rastrelli L

    更新日期:2020-09-01 00:00:00

  • Primary structure of the goat beta-globin locus control region.

    abstract::The goat beta-globin cluster is composed of a triplicated four-gene set. A locus control region (LCR) containing elements homologous to 5'DNase I hypersensitive sites (HS) 1, 2, and 3 of the human beta-globin LCR has been identified at the 5' end of this locus. We determined 10.2 kb of nucleotide sequence from the goa...


    pub_type: 杂志文章


    authors: Li Q,Zhou B,Powers P,Enver T,Stamatoyannopoulos G

    更新日期:1991-03-01 00:00:00

  • Conservation of position and sequence of a novel, widely expressed gene containing the major human alpha-globin regulatory element.

    abstract::We have determined the cDNA and genomic structure of a gene (-14 gene) that lies adjacent to the human alpha-globin cluster. Although it is expressed in a wide range of cell lines and tissues, a previously described erythroid-specific regulatory element that controls expression of the alpha-globin genes lies within in...


    pub_type: 杂志文章


    authors: Vyas P,Vickers MA,Picketts DJ,Higgs DR

    更新日期:1995-10-10 00:00:00

  • The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26.

    abstract::We have mapped the mouse protein tyrosine phosphatase epsilon (PTP epsilon, gene symbol Ptpre) gene to the distal region of chromosome 7 by linkage analysis using two sets of multilocus genetic crosses. The human PTP epsilon gene (gene symbol PTPRE) was mapped to chromosome 10q26 by fluorescence in situ hybridization....


    pub_type: 杂志文章


    authors: Elson A,Kozak CA,Morton CC,Weremowicz S,Leder P

    更新日期:1996-02-01 00:00:00

  • Haplotype variation at Badh2, the gene determining fragrance in rice.

    abstract::Fragrance is an important component of end-use quality in rice. A set of 516 fragrant rice accessions were genotyped and over 80% of them carried the badh2.7 allele. A subset of 144 mostly fragrant accessions, including nine of Oryza rufipogon, was then subjected to a detailed diversity and haplotype analysis. The lev...


    pub_type: 杂志文章


    authors: Shao G,Tang S,Chen M,Wei X,He J,Luo J,Jiao G,Hu Y,Xie L,Hu P

    更新日期:2013-02-01 00:00:00

  • The DNF15S2 locus at 3p21 is transcribed in normal lung and small cell lung cancer.

    abstract::Small cell lung cancer (SCLC) has been associated with a deletion of the short arm of chromosome 3. One SCLC cell line, H748, has an interstitial deletion of chromosome 3p and shows allele loss for the DNF15S2 locus detected by the probe lambda H3. Conservation of DNF15S2 sequences in mouse indicated that this human g...


    pub_type: 杂志文章


    authors: Naylor SL,Marshall A,Hensel C,Martinez PF,Holley B,Sakaguchi AY

    更新日期:1989-04-01 00:00:00

  • Human collagen gene COL5A1 maps to the q34.2----q34.3 region of chromosome 9, near the locus for nail-patella syndrome.

    abstract::Type V collagen is a fibrillar collagen that is widely distributed in tissues as a minor component of extracellular matrix and is usually composed of one pro alpha 2 (V) and two pro alpha 1 (V) chains. In this report, recently isolated cDNA and genomic clones, which encode the pro alpha 1 (V) chain, are used as probes...


    pub_type: 杂志文章


    authors: Greenspan DS,Byers MG,Eddy RL,Cheng W,Jani-Sait S,Shows TB

    更新日期:1992-04-01 00:00:00

  • Discovery of a null mutation in a human trace amine receptor gene.

    abstract::G-protein-coupled receptors (GPCRs) are important mediators of signal transduction, and mutations in GPCR-encoding genes can lead to disease states. Here we describe a null mutation in an orphan GPCR-encoding gene that is predicted to inactivate completely the encoded receptor. The TA(3) receptor is a putative member ...


    pub_type: 杂志文章


    authors: Vanti WB,Muglia P,Nguyen T,Cheng R,Kennedy JL,George SR,O'Dowd BF

    更新日期:2003-11-01 00:00:00

  • Identification and characterization of an Xq26-q27 duplication in a family with spina bifida and panhypopituitarism suggests the involvement of two distinct genes.

    abstract::We investigated a family with a duplication, dup(X)q26-q27, that was present in two brothers, their mother, and their maternal grandmother. The brothers carrying the duplication displayed spina bifida and panhypopituitarism, whereas a third healthy brother inherited the normal X chromosome. Preferential inactivation o...


    pub_type: 杂志文章


    authors: Hol FA,Schepens MT,van Beersum SE,Redolfi E,Affer M,Vezzoni P,Hamel BC,Karnes PS,Mariman EC,Zucchi I

    更新日期:2000-10-15 00:00:00

  • A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate.

    abstract::Biologic effects of androgen on target cells are mediated in part by transcriptional regulation of androgen-regulated genes (ARGs) by androgen receptor. Using serial analysis of gene expression (SAGE), we have identified a comprehensive repertoire of ARGs in LNCaP cells. One of the SAGE-derived tags exhibiting homolog...


    pub_type: 杂志文章


    authors: Xu LL,Shanmugam N,Segawa T,Sesterhenn IA,McLeod DG,Moul JW,Srivastava S

    更新日期:2000-06-15 00:00:00

  • Striking bimodal methylation of the repeat unit of the tandem array encoding human U2 snRNA (the RNU2 locus).

    abstract::The genes encoding human U2 small nuclear RNA are arrayed in tandem (the RNU2 locus) and have undergone concerted evolution for >35 Myr. Tandem organization of repetitive sequences may facilitate recombination that underlies concerted evolution, but could risk instability. Since DNA methylation plays a crucial role in...


    pub_type: 杂志文章


    authors: Jiang C,Liao D

    更新日期:1999-12-15 00:00:00

  • Effect of selenocystine on gene expression profiles in human keloid fibroblasts.

    abstract::In this study, selenocystine, a nutritionally available selenoamino acid, was identified for the first time as a novel agent with anti proliferative activity on human keloids. The 20 μM concentration after 48 h treatment used here was the most effective to reduce keloid fibroblast growth. We analyzed the gene expressi...


    pub_type: 杂志文章


    authors: De Felice B,Garbi C,Wilson RR,Santoriello M,Nacca M

    更新日期:2011-05-01 00:00:00