Comparative mapping in the beige-satin region of mouse chromosome 13.

Abstract:

:The proximal end of mouse chromosome (Chr) 13 contains regions conserved on human chromosomes 1q42-q44, 6p23-p21, and 7p22-p13. This region also contains mutations that may be models for human disease, including beige (human Chediak-Higashi syndrome). An interspecific backcross of SB/Le and Mus spretus mice was used to generate a molecular genetic linkage map of mouse chromosome 13 with an emphasis on the proximal region including beige (bg) and satin (sa). This map provides the gene order of the two phenotypic markers bg and sa relative to restriction fragment length polymorphisms and simple sequence length polymorphisms in 131 backcross animals. In parallel, we have created a physical map of the region using Nidogen (Nid) as a molecular starting point for cloning a YAC contig that was used to identify the beige gene. The physical map provides the fine-structure order of genes and anonymous DNA fragments that was not resolved by the genetic linkage mapping. The results show that the bg region of mouse Chr 13 is highly conserved on human Chr 1q42-q44 and provide a starting point for a complete functional analysis of the entire bg-sa interval.

journal_name

Genomics

journal_title

Genomics

authors

Perou CM,Perchellet A,Jago T,Pryor R,Kaplan J,Justice MJ

doi

10.1006/geno.1996.4478

subject

Has Abstract

pub_date

1997-01-15 00:00:00

pages

136-46

issue

2

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(96)94478-X

journal_volume

39

pub_type

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