Abstract:
BACKGROUND:In vitro experiments have shown that holmium laser energy can effectively ablate even calcified plaque in human arterial vessels. Because high-energy densities from holmium lasers can easily be transmitted through quartz fibers, this solid-state laser has been suggested as an alternative intraluminal treatment of atherosclerotic plaque. METHODS AND RESULTS:To develop an intimal plaque, 35 New Zealand White rabbits underwent electrical stimulation of their right carotid artery for 28 days. Subsequently, in 25 rabbits, holmium laser angioplasty (wavelength, 2.12 microns; pulse duration, 150 microseconds; energy density, 350 mJ/mm2) was performed. To study the morphological results, the vessels were excised after 7, 14, 28, and 42 days. Cross sections were analyzed in regard to laser-specific injury. Staining of alpha-actin was used to identify smooth muscle cells (SMCs). After bromodeoxyuridine labeling, the extent of proliferation (number of cells undergoing DNA synthesis) was determined by using a monoclonal antibody. Holmium laser ablation resulted in an initial decrease of the numbers of intimal cell layers in the early group (7 days after treatment: 5 +/- 1 cell layers with 76 +/- 39 microns; control: 13 +/- 3 cell layers with 144 +/- 44 microns). Quantification of SMCs undergoing DNA synthesis in the intima (control: 51 +/- 19 cells/mm2) showed a significant increase of labeled cells after 7 (216 +/- 74 cells/mm2, p = 0.003) and 14 days (281 +/- 139 cells/mm2, p = 0.011). Integrity of the internal elastic lamina was disrupted in all animals after intervention. Seven and 14 days after treatment, a considerable reduction of medial cell nuclei was found in 10 of 12 animals. SMC proliferation in the medial layer was increased within the first 2 weeks after laser ablation (168 +/- 113 cells/mm2; control: 8 +/- 4 cells/mm2; p = 0.023). Six weeks after holmium laser angioplasty, SMC proliferation had returned to control levels in the intima and remained increased in the medial layer. This proliferative response resulted in a significant increase of intimal thickening within 6 weeks after laser ablation (30 +/- 6 cell layers, 375 +/- 97 microns resp.; p = 0.001 each). CONCLUSIONS:Holmium laser treatment leads to considerable vessel wall injury and results in SMC proliferation in the intimal and medial layer with a maximum of proliferative activity within the first 2 weeks. Subsequently, this results in considerable intimal and medial hyperplasia within 6 weeks after treatment.
journal_name
Circulationjournal_title
Circulationauthors
Hassenstein S,Hanke H,Kamenz J,Oberhoff M,Hanke S,Riessen R,Haase KK,Betz E,Karsch KRdoi
10.1161/01.cir.86.5.1575subject
Has Abstractpub_date
1992-11-01 00:00:00pages
1575-83issue
5eissn
0009-7322issn
1524-4539journal_volume
86pub_type
杂志文章相关文献
CIRCULATION文献大全abstract::Two patients with supraventricular parasystole (one atrioventricular and one auricular) are reported. In both patients, reentrant extrasystoles appeared to occur as the result of Mobitz type I second-degree entrance block. We believe that when a sinus impulse fell soon after the absolute refractory period of the pathw...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.65.1.208
更新日期:1982-01-01 00:00:00
abstract::Echocardiography and Doppler ultrasound are useful in evaluating a variety of pathological conditions affecting the pericardium. Cardiac tamponade results in right atrial collapse and right ventricular diastolic collapse detectable by echocardiography. These echocardiographic signs have a high degree of sensitivity an...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract::Eighteen of 388 patients with chronic bundle branch block, studied electrophysiologically and followed prospectively, had H-V intervals of 80 msec or greater. Five patients were functional class I, five class II, seven class III, and one class IV. Follow-up ranged from 103 to 1919 days (mean 711 +/- 118). Three patien...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.53.4.600
更新日期:1976-04-01 00:00:00
abstract:BACKGROUND:Because of the marked difference in the incidence and severity of cardiovascular diseases between men and premenopausal women, several groups have studied the effect of sex steroids, particularly estrogen, on vascular endothelial prostacyclin (PGI2) release. No previous studies have addressed the effect of e...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.90.5.2519
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Current two-dimensional echocardiographic measures of right ventricular volume are limited by the asymmetrical and crescentic shape of the ventricle and by difficulty in obtaining standardized views. Three-dimensional echocardiographic reconstruction, which does not require geometric assumptions or standardi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.5.2342
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:The alpha1-adrenergic receptors (alpha1-ARs) play a key role in cardiovascular homeostasis. However, the functional role of alpha1-AR subtypes in vivo is still unclear. The aim of this study was to evaluate the cardiovascular influences of alpha1b-AR. METHODS AND RESULTS:In transgenic mice lacking alpha1-AR...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000012750.08480.55
更新日期:2002-04-09 00:00:00
abstract:BACKGROUND:For a long time, enteroviruses have been considered to be the most common cause of acute viral myocarditis (MC), with possible transition from MC to dilated cardiomyopathy (DCM). Recent investigations have shown, however, that other viruses are also frequently encountered in MC patients, suggesting that pers...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000155616.07901.35
更新日期:2005-02-22 00:00:00
abstract:BACKGROUND:Alterations in the balance of matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) are involved in left ventricular (LV) remodeling. Whether their expression is related to interstitial fibrosis or LV dysfunction in patients with chronic pressure overload-induced LV hypertrophy, howev...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.104.516963
更新日期:2005-08-23 00:00:00
abstract:BACKGROUND:We wished to test previous hypotheses that sex-related differences in mortality and morbidity may be due to differences in the cause of heart failure or in left ventricular ejection fraction (LVEF) by comparing fatal and nonfatal outcomes in women and men with heart failure and a broad spectrum of left ventr...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.106.673442
更新日期:2007-06-19 00:00:00
abstract::Integrated ultrasonic backscatter (IB) is a noninvasive measure of the acoustic properties of myocardium. Previous experimental studies have indicated that altered acoustic properties of the myocardium are reflected by the magnitude of variation of IB during the cardiac cycle. In our study, cardiac cycle-dependent var...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.80.4.925
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:Cardiac arrest without evident cardiac disease may be caused by subclinical genetic conditions. Provocative testing to unmask a phenotype is often necessary to detect primary electrical disease, direct genetic testing, and perform family screening. METHODS AND RESULTS:Patients with apparently unexplained ca...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.109.853143
更新日期:2009-07-28 00:00:00
abstract:BACKGROUND:The renin-angiotensin system regulates blood pressure through its effects on vascular tone, renal hemodynamics, and renal sodium and fluid balance. METHODS AND RESULTS:Using data from a large population-based sample of 1488 siblings having a mean age of 14.8 years and belonging to the youngest generation of...
journal_title:Circulation
pub_type: 评论,杂志文章
doi:10.1161/01.cir.97.18.1773
更新日期:1998-05-12 00:00:00
abstract:BACKGROUND:Precise noninvasive evaluation of pulmonary artery (PA) morphology is extremely important for medical and surgical management of patients with cyanotic heart disease. In this study, the accuracy of two-dimensional echocardiography combined with color Doppler flow mapping to assess the size, stenosis, and atr...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.3.1306
更新日期:1994-03-01 00:00:00
abstract::One of the noninvasive methods of evaluating left ventricular performance is the measurement of left ventricular systolic time intervals (LVSTI). However, noninvasive measurement of right ventricular systole by this technique has been unreliable because of the inability to accurately time the onset of right ventricula...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.51.2.304
更新日期:1975-02-01 00:00:00
abstract::In 15 of 126 (12%) patients with truncus arteriosus who were catheterized at the Mayo Clinic from 1967 through 1975, natural agenesis of one pulmonary artery was present. Ten truncus patients with either natural or acquired absence of one pulmonary artery have undergone definitive operation. The criteria for operabili...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.4.641
更新日期:1977-04-01 00:00:00
abstract::Two-dimensional echocardiography can provide serial cross-sectional images of the left ventricular cavity. We examined whether such serial images from steady-state ejecting hearts would allow three-dimensional reconstruction and accurate volume estimation without major geometric assumptions. Cross-circulated, paced do...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.60.2.320
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:Nitric oxide signaling plays a key role in the regulation of vascular tone and platelet activation. Here, we seek to understand the impact of a genetic predisposition to enhanced nitric oxide signaling on risk for cardiovascular diseases, thus informing the potential utility of pharmacological stimulation of...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.117.028021
更新日期:2018-01-16 00:00:00
abstract:BACKGROUND:Dual antiplatelet therapy with aspirin and a P2Y12 inhibitor has been shown to reduce the risk of major adverse cardiovascular events (MACE) compared with aspirin alone after percutaneous coronary intervention (PCI) or acute coronary syndrome but with increased risk of bleeding. The safety of discontinuing a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.120.046251
更新日期:2020-08-11 00:00:00
abstract:BACKGROUND:Although the dominant product of vascular Cyclooxygenase-2 (COX-2), prostacyclin (PGI(2)), restrains atherogenesis, inhibition and deletion of COX-2 have yielded conflicting results in mouse models of atherosclerosis. Floxed mice were used to parse distinct cellular contributions of COX-2 in macrophages and ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.910687
更新日期:2010-06-22 00:00:00
abstract:BACKGROUND:We measured cardiovagal baroreflex gain and its vascular mechanical and neural components during dynamic baroreflex engagement in 10 young untrained men, 6 older untrained men, and 12 older, physically active men. METHODS AND RESULTS:Our newly developed assessment of beat-to-beat carotid diameters during ba...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.20.2424
更新日期:2001-05-22 00:00:00
abstract:BACKGROUND:In the monocrotaline (MCT)-treated rat, there is marked stimulation of DNA synthesis and megalocytosis of pulmonary arterial endothelial cells (PAECs) within 3 to 4 days, followed by pulmonary hypertension (PH) 10 to 14 days later. Growing evidence implicates caveolin-1 (cav-1) in plasma membrane rafts as a ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000141576.39579.23
更新日期:2004-09-14 00:00:00
abstract::Cardiovascular disease continues to be the leading cause of death among women in the United States. One of the barriers to improving cardiovascular disease outcomes in women is the lack of reliable, effective screening modalities. Breast arterial calcification has emerged as a potential risk stratification tool. Local...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.118.038092
更新日期:2019-02-19 00:00:00
abstract:BACKGROUND:Long-standing aortic stenosis causes significant left ventricular (LV) dysfunction, which may progress irreversibly. In many cases, LV function can be salvaged by aortic valve surgery, although debate exists regarding the best valve prosthesis to use. METHODS AND RESULTS:We studied 33 patients retrospective...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.suppl_2.ii-1
更新日期:1999-11-09 00:00:00
abstract:BACKGROUND:Fortilin, a recently characterized nuclear antiapoptotic factor structurally distinct from inhibitor of apoptosis proteins (IAPs) and Bcl-2 family member proteins, has been suggested to be involved in cell survival and regulation of apoptosis within the cardiovascular system. In this continued investigation,...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000047675.86603.eb
更新日期:2003-01-07 00:00:00
abstract:BACKGROUND:In the last decades, interest has increased in the potential deleterious atherogenic effects of some cellular elastase activities. The results of experimental and clinical investigations were inconsistent. In this report, we assessed the associations of serum elastase activity and serum elastase inhibitors w...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000017329.51160.ef
更新日期:2002-06-04 00:00:00
abstract::Total anomalous pulmonary venous connection (TAPVC) is a rare cardiac congenital abnormality which usually results in death in infancy or early childhood. We describe a 52-year-old man with TAPVC and severe calcific pulmonic stenosis. Both diagnoses were suspected clinically and from the chest X-ray. Cardiac catheteri...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.1.206
更新日期:1977-01-01 00:00:00
abstract::The acute coronary hemodynamic and metabolic effects of intravenous dipyridamole were studied in 13 patients. Total left ventricular (LV), anterior (supplied by the left anterior descending coronary artery) and inferior (supplied by circumflex and right coronary arteries) regional flows and metabolic responses were as...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.64.2.333
更新日期:1981-08-01 00:00:00
abstract::The pericardium, because of the nature of its pressure-volume relation, can influence left ventricular diastolic and systolic pump function. During an acute increase in heart size that results in the stretching of the pericardium, the elastic properties of the pericardium restrict further cardiac dilatation and curtai...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
abstract::End-systolic pressure (PES), volume (VES), wall tension (TES) and circumference (CES) of the human left ventricle were studied at cardiac catheterization in 24 subjects with varying degrees of left ventricular dysfunction. Acute alterations in systolic load consistently resulted in changes in VES and CES, with a small...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.56.5.845
更新日期:1977-11-01 00:00:00
abstract:BACKGROUND:The genetic basis of left ventricular (LV) image-derived phenotypes, which play a vital role in the diagnosis, management, and risk stratification of cardiovascular diseases, is unclear at present. METHODS:The LV parameters were measured from the cardiovascular magnetic resonance studies of the UK Biobank. ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.119.041161
更新日期:2019-10-15 00:00:00