Abstract:
:A structural model is suggested for axon membranes consisting of a double layer of lipid and phospholipid molecules in which the polar ends of certain phospholipids change their orientation and combining properties under the influence of an electric field. The phosphate groups act as ion exchange "gates" for the control of ion flow through the membrane. Expressions are developed for the calculation of membrane current components as functions of time, potential, and ionic environment. Approximate solutions show fairly good agreement with existing experimental data in a number of different respects such as steady-state current-voltage relations, the effect of calcium on steady-state current, potassium tracer flux ratios, initial current and rate of change of current, and the dependence of the time constants of current change on membrane potential.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
GOLDMANN DEdoi
10.1016/s0006-3495(64)86776-xsubject
Has Abstractpub_date
1964-05-01 00:00:00pages
167-88eissn
0006-3495issn
1542-0086pii
S0006-3495(64)86776-Xjournal_volume
4pub_type
杂志文章abstract::The domains of the giant muscle protein titin (connectin) provide interaction sites for other sarcomeric proteins and fulfill mechanical functions. In this paper we compare the unfolding forces of defined regions of different titin isoforms by single-molecule force spectroscopy. Constructs comprising six to eight immu...
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journal_title:Biophysical journal
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journal_title:Biophysical journal
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journal_title:Biophysical journal
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journal_title:Biophysical journal
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