Abstract:
:Previous theoretical studies have shown that measuring the transverse current across DNA strands while they translocate through a nanopore or channel may provide a statistically distinguishable signature of the DNA bases, and may thus allow for rapid DNA sequencing. However, fluctuations of the environment, such as ionic and DNA motion, introduce important scattering processes that may affect the viability of this approach to sequencing. To understand this issue, we have analyzed a simple model that captures the role of this complex environment in electronic dephasing and its ability to remove charge carriers from current-carrying states. We find that these effects do not strongly influence the current distributions due to the off-resonant nature of tunneling through the nucleotides--a result we expect to be a common feature of transport in molecular junctions. In particular, only large scattering strengths, as compared to the energetic gap between the molecular states and the Fermi level, significantly alter the form of the current distributions. Since this gap itself is quite large, the current distributions remain protected from this type of noise, further supporting the possibility of using transverse electronic transport measurements for DNA sequencing.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Krems M,Zwolak M,Pershin YV,Di Ventra Mdoi
10.1016/j.bpj.2009.06.055subject
Has Abstractpub_date
2009-10-07 00:00:00pages
1990-6issue
7eissn
0006-3495issn
1542-0086pii
S0006-3495(09)01282-Xjournal_volume
97pub_type
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