Abstract:
:The present study was performed in order to follow the response of rat cerebellum astroglial cells (Bergmann glial cells and astrocytes) to long-term portacaval shunt (PCS), by means of glial fibrillary acidic protein (GFAP) and vimentin immunoreactivities. Bergmann glia accumulated GFAP in response to PCS, whereas astrocytes decreased GFAP immunoreactivity when compared to control rats. The increase of GFAP occurs in cells located in the cerebellar layer where glutamate is mainly released. Since the vimentin content remained unaltered in response to PCS, when compared to control rats, it can be concluded that only the GFAP filaments are affected by PCS. Nevertheless, GFAP immunoreactivity presents regional differences in the cerebellar astroglial population, and the factors responsible for these variations are still unknown.
journal_name
Gliajournal_title
Gliaauthors
Suárez I,Bodega G,Arilla E,Rubio M,Villalba R,Fernández Bdoi
10.1002/glia.440060304subject
Has Abstractpub_date
1992-01-01 00:00:00pages
172-9issue
3eissn
0894-1491issn
1098-1136journal_volume
6pub_type
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