Signaling proteins in the axoglial apparatus of sciatic nerve nodes of Ranvier.

abstract：:In mammalian brain peripheral benzodiazepine (PBZD) receptors are predominantly localized on astroglial cells. Previous studies utilizing whole membrane preparations from brain and peripheral organs of various species have indicated several distinctions between the drug-receptor interactions of the two prototypic PBZD...

journal_title：Glia

authors： Itzhak Y,Baker L,Norenberg MD

更新日期：1993-11-01 00:00:00

abstract：:Neuroadapted Sindbis Virus (NSV) is a neuronotropic virus that causes hindlimb paralysis in susceptible mice and rats. The authors and others have demonstrated that though death of infected motor neurons occurs, bystander death of uninfected neurons also occurs and both contribute to the paralysis that ensues followin...

journal_title：Glia

authors： Carmen J,Gowing G,Julien JP,Kerr D

更新日期：2006-08-01 00:00:00

abstract：:The production of insulin-like growth factor (IGF)-I and -II and their binding proteins (BPs) has been studied in new-born rat astroblasts at confluency in primary culture. Under the influence of fibroblast growth factors (FGFs) (acidic and basic), the morphology of the astroblasts was altered, 125I-deoxyuridine incor...

journal_title：Glia

authors： Loret C,Janet T,Labourdette G,Schneid H,Binoux M

更新日期：1991-01-01 00:00:00

abstract：:Based on their typical pattern of membrane currents, four populations of glial cells could be identified in thin brain slices of the postnatal hippocampus. In the present study, we applied the patch-clamp technique to glial cells in the hippocampal CA1 region, which are characterized by a complex pattern of different ...

journal_title：Glia

authors： Akopian G,Kressin K,Derouiche A,Steinhäuser C

更新日期：1996-07-01 00:00:00

abstract：:The nervous system of echinoderms has long been considered too unique to be directly comparable to the nervous system of other Deuterostomia. Using two novel monoclonal antibodies in combination with epifluorescence, confocal, and electron microscopy, we demonstrate here that the central nervous system of the sea cucu...

journal_title：Glia

authors： Mashanov VS,Zueva OR,Garcia-Arraras JE

更新日期：2010-10-01 00:00:00

abstract：:The amyloid hypothesis of Alzheimer's disease (AD) suggests that soluble amyloid β (Aβ) is an initiator of a cascade of events eventually leading to neurodegeneration. Recently, we reported that Aβ deranged Ca(2+) homeostasis specifically in hippocampal astrocytes by targeting key elements of Ca(2+) signaling, such as...

journal_title：Glia

authors： Lim D,Iyer A,Ronco V,Grolla AA,Canonico PL,Aronica E,Genazzani AA

更新日期：2013-07-01 00:00:00

abstract：:Human astrocytes provide trophic as well as structural support to the surrounding brain cells. Furthermore, they have been implicated in many physiological processes important for central nervous system function. Traditionally astrocytes have been considered to be a homogeneous class of cells, however, it has increasi...

journal_title：Glia

authors： de Majo M,Koontz M,Rowitch D,Ullian EM

更新日期：2020-04-01 00:00:00

abstract：:Neurogenesis persists in the adult subventricular zone (SVZ) of the mammalian brain. During aging, the SVZ neurogenic capacity undergoes a progressive decline, which is attributed to a decrease in the population of neural stem cells (NSCs). However, the behavior of the NSCs that remain in the aged brain is not fully u...

journal_title：Glia

authors： Capilla-Gonzalez V,Cebrian-Silla A,Guerrero-Cazares H,Garcia-Verdugo JM,Quiñones-Hinojosa A

更新日期：2014-05-01 00:00:00

abstract：:Cells of the adaptive and innate immune systems in the brain parenchyma and in the meningeal spaces contribute to physiologic functions and disease states in the central nervous system (CNS). Animal studies have demonstrated the involvement of immune constituents, along with major histocompatibility complex (MHC) mole...

journal_title：Glia

authors： Healy LM,Yaqubi M,Ludwin S,Antel JP

更新日期：2020-04-01 00:00:00

abstract：:Our previous studies demonstrated the involvement of quinone formation in dopaminergic neuron dysfunction in the L-DOPA-treated parkinsonian model and in methamphetamine (METH) neurotoxicity. We further reported that the cysteine-rich metal-binding metallothionein (MT) family of proteins protects dopaminergic neurons ...

journal_title：Glia

authors： Miyazaki I,Asanuma M,Kikkawa Y,Takeshima M,Murakami S,Miyoshi K,Sogawa N,Kita T

更新日期：2011-03-01 00:00:00

abstract：:Focal ischemic stroke (FIS) is a leading cause of human death. Glial scar formation largely caused by reactive astrogliosis in peri-infarct region (PIR) is the hallmark of FIS. Glial cell-derived neurotrophic factor (GDNF) was originally isolated from a rat glioma cell-line supernatant and is a potent survival neurotr...

journal_title：Glia

authors： Zhang N,Zhang Z,He R,Li H,Ding S

更新日期：2020-11-01 00:00:00

abstract：:Oxidative stress is the main cause of neuronal damage in traumatic brain injury, hypoxia/reperfusion injury, and neurodegenerative disorders. Although extracellular nucleosides, especially adenosine, are well known to protect against neuronal damage in such pathological conditions, the effects of these nucleosides or ...

journal_title：Glia

authors： Shinozaki Y,Koizumi S,Ishida S,Sawada J,Ohno Y,Inoue K

更新日期：2005-01-15 00:00:00

abstract：:Inflammatory changes have been found in Parkinson's disease, in humans intoxicated with the parkinsonian toxin MPTP, and in animal models of the disease. However, it is still not known whether inflammatory changes are responsible for active nerve cell death or if they have a protective role against neurodegeneration. ...

journal_title：Glia

authors： Barcia C,Sánchez Bahillo A,Fernández-Villalba E,Bautista V,Poza Y Poza M,Fernández-Barreiro A,Hirsch EC,Herrero MT

更新日期：2004-05-01 00:00:00

abstract：:Two types of glial cells occur in the retina, Müller cells and astrocytes. These cells share several structural features such as extending endfeet onto blood vessels of the retina. Retinal vessels express a tight blood-retinal barrier which is comparable to the blood-brain barrier (BBB) of the CNS. While astrocytes ha...

journal_title：Glia

authors： Small RK,Watkins BA,Munro PM,Liu D

更新日期：1993-02-01 00:00:00

abstract：:Oligodendrocytes, the myelinating cells of the CNS, are derived postnatally from oligodendrocyte precursors (OPs) of the subventricular zone (SVZ). However, the mechanisms that regulate their generation from SVZ neural stem cells (NSC) are poorly understood. Here, we have examined the role of glycogen synthase kinase ...

journal_title：Glia

authors： Azim K,Rivera A,Raineteau O,Butt AM

更新日期：2014-05-01 00:00:00

abstract：:Inflammation has been linked to the induction of apneas and Sudden Infant Death Syndrome, whereas proinflammatory mediators inhibit breathing when applied peripherally or directly into the CNS. Considering that peripheral inflammation can activate microglia in the CNS and that this cell type can directly release all p...

journal_title：Glia

authors： Lorea-Hernández JJ,Morales T,Rivera-Angulo AJ,Alcantara-Gonzalez D,Peña-Ortega F

更新日期：2016-04-01 00:00:00

abstract：:Bmi1 is a polycomb group (Pc-G) protein involved in heritable gene repression, maintenance of cell identity, and proliferation. During the development of the central nervous system, Bmi1 is crucial for self-renewal of neural stem cells and for proliferation of neuronal (granule cell) progenitors of the cerebellum. Her...

journal_title：Glia

authors： Zhang X,Santuccione A,Leung C,Marino S

更新日期：2011-07-01 00:00:00

abstract：:Aquaporin 4 (AQP4) is a predominant water channel protein in mammalian brains, localized in the astrocyte plasma membrane. The regulation of AQP4 is believed to be important for the homeostasis of water in the brain, but the AQP4 regulatory mechanisms are not yet known. In this study, we investigated the effect of a p...

journal_title：Glia

authors： Nakahama K,Nagano M,Fujioka A,Shinoda K,Sasaki H

更新日期：1999-02-01 00:00:00

abstract：:Th17 cells and interleukin-17 (IL-17) have been found to play an important role in the pathology of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Response to IL-17, reactive astrocytes accompany with immune cells infiltration and axonal damage in MS/EAE. However, the ro...

journal_title：Glia

authors： Liu X,Zhou F,Yang Y,Wang W,Niu L,Zuo D,Li X,Hua H,Zhang B,Kou Y,Guo J,Kong F,Pan W,Gao D,Meves JM,Sun H,Xue M,Zhang Q,Wang Y,Tang R

更新日期：2019-01-01 00:00:00

abstract：:Historically, the human brain has been conceptually segregated from the periphery and further dichotomized into gray matter (GM) and white matter (WM) based on the whitish appearance of the exceptionally high lipid content of the myelin sheaths encasing neuronal axons. These simplistic dichotomies were unfortunately e...

journal_title：Glia

authors： Haroutunian V,Katsel P,Roussos P,Davis KL,Altshuler LL,Bartzokis G

更新日期：2014-11-01 00:00:00

abstract：:Astrocytes play an important role in neuroprotective responses. Recent studies indicate that endothelin-1, a neuropeptide upregulated during brain injury, increases levels of the endocannabinoid anandamide, a lipid with neuroprotective properties, in astrocytes in primary cultures. However, whether this neuropeptide a...

journal_title：Glia

authors： Walter L,Stella N

更新日期：2003-10-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) is a platelet-derived bioactive sphingolipid that evokes a variety of biological responses. To understand the role of S1P in the central nervous system, we have examined the effect of S1P on the production of glial cell line-derived neurotrophic factor (GDNF) and growth regulation of cort...

journal_title：Glia

authors： Yamagata K,Tagami M,Torii Y,Takenaga F,Tsumagari S,Itoh S,Yamori Y,Nara Y

更新日期：2003-01-15 00:00:00

abstract：:Neuroprotective M2-skewed microglia appear as promising to alter the course of neurodegenerative diseases and G protein-coupled receptors (GPCRs) are potential targets to achieve such microglial polarization. A common feature of adenosine A2A (A2A R) and cannabinoid CB2 (CB2 R) GPCRs in microglia is that their express...

journal_title：Glia

authors： Franco R,Reyes-Resina I,Aguinaga D,Lillo A,Jiménez J,Raïch I,Borroto-Escuela DO,Ferreiro-Vera C,Canela EI,Sánchez de Medina V,Del Ser-Badia A,Fuxe K,Saura CA,Navarro G

更新日期：2019-12-01 00:00:00

abstract：:It has become evident recently only that microglia are not only responsible for immunomodulatory functions in the brain but represent vital components of the larger synaptic formation, which also includes pre and postsynaptic neurones as well as astrocytes. Microglia critically contribute to CNS homeostasis by their a...

journal_title：Glia

authors： Blank T,Prinz M

更新日期：2013-01-01 00:00:00

abstract：:Much of the cell death following episodes of anoxia and ischemia in the mammalian central nervous system has been attributed to extracellular accumulation of glutamate and ATP, which causes a rise in [Ca(2+)](i), loss of mitochondrial potential, and cell death. However, restoration of blood flow and reoxygenation are ...

journal_title：Glia

authors： Domercq M,Mato S,Soria FN,Sánchez-gómez MV,Alberdi E,Matute C

更新日期：2013-03-01 00:00:00

abstract：:This report describes the development of a new panel of monoclonal antibodies produced following immunization of mice with cultured rat microglial cells. Using these new reagents and previously defined antibodies that bind to microglia or macrophages, the responses of parenchymal microglia, perivascular "microglial" c...

journal_title：Glia

authors： Flaris NA,Densmore TL,Molleston MC,Hickey WF

更新日期：1993-01-01 00:00:00

abstract：:Apart from dedicated oligodendroglial progenitor cells, adult neural stem cells (aNSCs) can also give rise to new oligodendrocytes in the adult central nervous system (CNS). This process mainly confers myelinating glial cell replacement in pathological situations and can hence contribute to glial heterogeneity. Our pr...

journal_title：Glia

authors： Beyer F,Jadasz J,Samper Agrelo I,Schira-Heinen J,Groh J,Manousi A,Bütermann C,Estrada V,Reiche L,Cantone M,Vera J,Viganò F,Dimou L,Müller HW,Hartung HP,Küry P

更新日期：2020-02-01 00:00:00

abstract：:To study the role of L-type voltage-gated Ca++ channels in oligodendrocyte development, we used a mouse model of Timothy syndrome (TS) in which a gain-of-function mutation in the α1 subunit of the L-type Ca++ channel Cav1.2 gives rise to an autism spectrum disorder (ASD). Oligodendrocyte progenitor cells (OPCs) isolat...

journal_title：Glia

authors： Cheli VT,Santiago González DA,Zamora NN,Lama TN,Spreuer V,Rasmusson RL,Bett GC,Panagiotakos G,Paez PM

更新日期：2018-11-01 00:00:00

abstract：:Astrocytes releasing glucose- and/or glycogen-derived lactate and glutamine play a crucial role in shaping neuronal function and plasticity. Little is known, however, how metabolic functions of astrocytes, e.g., their ability to degrade glucosyl units, are affected by the presence of neurons. To address this issue we ...

journal_title：Glia

authors： Mamczur P,Borsuk B,Paszko J,Sas Z,Mozrzymas J,Wiśniewski JR,Gizak A,Rakus D

更新日期：2015-02-01 00:00:00

abstract：:The pro-apoptotic sphingolipid ceramide plays an emergent role in the etiology of Alzheimer's disease (AD), although its function for neurodegeneration is not known. We determined the concentration and composition of ceramide in hippocampal tissue from newborn presenilin 1 (PS1) knock-in (PS1M146V) mice, a mouse model...

journal_title：Glia

authors： Wang G,Silva J,Dasgupta S,Bieberich E

更新日期：2008-03-01 00:00:00